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13 Results Found

  • Article
  • Open Access
2 Citations
2,625 Views
12 Pages

Development and Validation of a Concise Objectifiable Risk Evaluation Score for Non-Relapse Mortality after Allogeneic Hematopoietic Stem Cell Transplantation

  • Gunnar Weise,
  • Radwan Massoud,
  • Rolf Krause,
  • Silke Heidenreich,
  • Dietlinde Janson,
  • Evgeny Klyuchnikov,
  • Christine Wolschke,
  • Gaby Zeck,
  • Nicolaus Kröger and
  • Francis Ayuk

25 January 2024

We aimed to develop a concise objectifiable risk evaluation (CORE) tool for predicting non-relapse mortality (NRM) and overall survival (OS) after allogeneic hematopoietic stem cell transplantation (allo-HCT). A total of 1120 adult patients who had u...

(This article belongs to the Special Issue Blood Stem Cell and Hematological Malignancies)
  • Article
  • Open Access
5 Citations
3,181 Views
12 Pages

2 April 2020

Background: Patient-related factors, namely comorbidities, impact the clinical outcome of patients with diffuse large B-cell lymphoma (DLBCL). Methods: The prevalence and prognostic impact of comorbidities were examined using the validated scores Cha...

(This article belongs to the Section Hematology)
  • Article
  • Open Access
3 Citations
3,086 Views
10 Pages

The Association between Elevated Hematocrit and Retinal Artery Occlusion in Adult Patients

  • Wei-Yu Lai,
  • Pei-Chin Lin,
  • Chun-Hao Yin,
  • Kuang-Tsu Yang,
  • En-Jie Shih and
  • Jin-Shuen Chen

17 October 2022

Retinal artery occlusion (RAO) is most commonly caused by embolism. Evidence showed that hematocrit (Hct) levels are often associated with embolic events. In this study, we aim to investigate the relationship between Hct levels and RAO. This retrospe...

(This article belongs to the Section Cardiovascular Medicine)
  • Article
  • Open Access
2 Citations
1,939 Views
14 Pages

Incorporation of a Comorbidity Index in Treatment Decisions for Elderly AML Patients Can Lead to Better Disease Management—A Single-Center Experience

  • Cristina Negotei,
  • Iuliana Mitu,
  • Silvana Angelescu,
  • Florentina Gradinaru,
  • Cristina Mambet,
  • Oana Stanca,
  • Mihai-Emilian Lapadat,
  • Cristian Barta,
  • Georgian Halcu and
  • Andrei Colita
  • + 5 authors

3 December 2024

Introduction: Acute myeloid leukemia (AML) is a form of cancer originating from precursor cells within the bone marrow. Elderly patients with acute leukemia require a personalized approach, considering age, performance status, and comorbidities, to d...

  • Article
  • Open Access
7 Citations
4,576 Views
13 Pages

Increased Intestinal Permeability and Stool Zonulin, Calprotectin and Beta-Defensin-2 Concentrations in Allogenic Hematopoietic Cell Transplantation Recipients

  • Martyna Tyszka,
  • Dominika Maciejewska-Markiewicz,
  • Jarosław Biliński,
  • Arkadiusz Lubas,
  • Ewa Stachowska and
  • Grzegorz W. Basak

15 December 2022

Significant progress has been made in understanding the connection between intestinal barrier function and allogenic hematopoietic cell transplantation (allo-HCT) recipients’ outcomes. The purpose of this study was to further evaluate gut barri...

(This article belongs to the Section Molecular Immunology)
  • Article
  • Open Access
8 Citations
3,803 Views
8 Pages

Donor Age and Non-Relapse Mortality: Study of Their Association after HLA-Matched Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome

  • Yasmine Kadri,
  • Michelle Phan,
  • Nadia Bambace,
  • Léa Bernard,
  • Sandra Cohen,
  • Jean-Sébastien Delisle,
  • Thomas Kiss,
  • Sylvie Lachance,
  • Denis-Claude Roy and
  • Imran Ahmad
  • + 3 authors

22 August 2022

The purpose of this retrospective study was to study the correlation between donor age (DA) and non-relapse mortality (NRM) and relapse incidence (RI) among patients treated with allogeneic hematopoietic cell transplantation (aHCT) for acute myeloid...

(This article belongs to the Section Cell Therapy)
  • Article
  • Open Access
1 Citations
2,661 Views
12 Pages

Allogeneic Hematopoietic Cell Transplant for B-Cell Lymphomas in the Era of Novel Cellular Therapies: Experience from a Tertiary Canadian Center

  • Mathias Castonguay,
  • Jean Roy,
  • Jean-Sébastien Claveau,
  • Sylvie Lachance,
  • Jean-Sébastien Delisle,
  • Thomas Kiss,
  • Sandra Cohen,
  • Isabelle Fleury,
  • Luigina Mollica and
  • Olivier Veilleux
  • + 5 authors

Background: Allogeneic hematopoietic cell transplant (alloHCT) is a curative option for relapsed/refractory B-cell lymphomas (BCLs), but its role in the evolving field of cellular therapy is increasingly unclear as recent advances in transplant proce...

(This article belongs to the Section Hematology)
  • Article
  • Open Access
19 Citations
5,103 Views
16 Pages

21 January 2022

Background and Objectives: This study aimed to investigate the important factors that affect COPD prognosis. Materials and Methods: We included 160 hospitalized patients with COPD exacerbation in the study. The hemoglobin (HB), hematocrit (HCT), leuk...

(This article belongs to the Special Issue Current Management Challenges in Chronic Obstructive Pulmonary Disease (COPD))
  • Article
  • Open Access
11 Citations
4,370 Views
16 Pages

Cladribine Combined with Low-Dose Cytarabine as Frontline Treatment for Unfit Elderly Acute Myeloid Leukemia Patients: Results from a Prospective Multicenter Study of Polish Adult Leukemia Group (PALG)

  • Bożena Katarzyna Budziszewska,
  • Aleksander Salomon-Perzyński,
  • Katarzyna Pruszczyk,
  • Joanna Barankiewicz,
  • Agnieszka Pluta,
  • Grzegorz Helbig,
  • Anna Janowska,
  • Marta Kuydowicz,
  • Łukasz Bołkun and
  • Ewa Lech-Marańda
  • + 19 authors

20 August 2021

Acute myeloid leukemia (AML) in older unfit patients is a therapeutic challenge for clinical hematologists. We evaluated the efficacy and safety of a novel low-intensity regimen consisting of low-dose cytarabine and cladribine (LD-AC+cladribine) in f...

(This article belongs to the Special Issue Preclinical and Clinical Studies of Novel Therapies in Leukemia and Lymphoma)
  • Article
  • Open Access
1 Citations
2,298 Views
22 Pages

Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Prolymphocytic Leukemia

  • Christina Groiss,
  • Stefanie Kreissl,
  • Irene Strassl,
  • Olga Saini,
  • Dagmar Wipplinger,
  • Robert Milanov,
  • Emine Kaynak,
  • Petra Hasengruber,
  • Christoph Aichinger and
  • Johannes Clausen
  • + 9 authors

19 April 2025

Background: T-prolymphocytic leukemia (T-PLL) is a rare lymphoid neoplasm with particularly poor prognosis. Although it is no longer recognized as a distinct entity by the World Health Organization (WHO), B-prolymphocytic leukemia (B-PLL) comprises c...

(This article belongs to the Section Hematology)
  • Article
  • Open Access
1 Citations
1,193 Views
15 Pages

Development of a Simplified Geriatric Score-4 (SGS-4) to Predict Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation in Patients Aged over 50

  • Eugenia Accorsi Buttini,
  • Alberto Zucchelli,
  • Paolo Tura,
  • Gianluca Bianco,
  • Daniele Avenoso,
  • Giovanni Campisi,
  • Mirko Farina,
  • Gabriele Magliano,
  • Enrico Morello and
  • Michele Malagola
  • + 4 authors

10 October 2025

Background: The Comprehensive Geriatric Assessment (CGA) has proven to be a valuable tool for providing a more comprehensive health evaluation of allogeneic stem cell transplantation (allo-SCT) recipients. Methods: We prospectively developed and test...

(This article belongs to the Special Issue New Challenges in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia)
  • Article
  • Open Access
3,934 Views
11 Pages

Comparison of Outcomes of Haploidentical Peripheral Blood Stem Cell Transplantation with Post-Transplant Cyclophosphamide in Older Versus Younger Patients

  • Giacomo Adoncecchi,
  • Ambuj Kumar,
  • Krishnakar Mogili,
  • Rawan Faramand,
  • Hien Liu,
  • Farhad Khimani,
  • Asmita Mishra,
  • Michael Nieder,
  • Taiga Nishihori and
  • Hany Elmariah
  • + 8 authors

19 January 2025

Background: Previous studies have shown that allogeneic peripheral blood stem cell transplantation (PBSCT) from an HLA haploidentical (haplo) donor followed by graft-versus-host disease (GVHD) prophylaxis with post-transplant cyclophosphamide (PTCy)...

(This article belongs to the Section Transplant Oncology)
  • Article
  • Open Access
14 Citations
3,770 Views
10 Pages

Impact of Cryopreservation of Peripheral Blood Stem Cells (PBSC) in Transplantation from Matched Unrelated Donor (MUD)

  • Gabriele Facchin,
  • Chiara Savignano,
  • Marta Lisa Battista,
  • Miriam Isola,
  • Maria De Martino,
  • Giuseppe Petruzzellis,
  • Chiara Rosignoli,
  • Umberto Pizzano,
  • Michela Cerno and
  • Francesca Patriarca
  • + 4 authors

15 July 2022

Background: Cryopreservation of PBSC for allogenic hematopoietic stem cell transplantation (allo-HSCT) was implemented due to the current Coronavirus 2019 pandemic. The impact of match unrelated donor (MUD) graft freezing on the outcome of allo-HSCT...

(This article belongs to the Special Issue Hematopoietic Stem Cell Transplantation: Current Status and Future Research)