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36 Results Found

  • Article
  • Open Access
13 Citations
6,657 Views
11 Pages

Genetic Authentication of Gardenia jasminoides Ellis var. grandiflora Nakai by Improved RAPD-Derived DNA Markers

  • Zhiqiang Mei,
  • Boxu Zhou,
  • Chunli Wei,
  • Jingliang Cheng,
  • Saber Imani,
  • Hanchun Chen and
  • Junjiang Fu

10 November 2015

The evergreen shrub, Gardenia jasminoides Ellis var. grandiflora Nakai is one of the most popular garden-plants, with significant ornamental importance. Here, we have cloned improved random amplified polymorphic DNA (RAPD) derived fragments into T-vec...

  • Article
  • Open Access
7 Citations
2,778 Views
18 Pages

Integration of Deep Learning and Sequential Metabolism to Rapidly Screen Dipeptidyl Peptidase (DPP)-IV Inhibitors from Gardenia jasminoides Ellis

  • Huining Liu,
  • Shuang Yu,
  • Xueyan Li,
  • Xinyu Wang,
  • Dongying Qi,
  • Fulu Pan,
  • Xiaoyu Chai,
  • Qianqian Wang,
  • Yanli Pan and
  • Yang Liu
  • + 1 author

1 November 2023

Traditional Chinese medicine (TCM) possesses unique advantages in the management of blood glucose and lipids. However, there is still a significant gap in the exploration of its pharmacologically active components. Integrated strategies encompassing...

  • Article
  • Open Access
11 Citations
4,067 Views
17 Pages

28 February 2024

Gardenia jasminoides Ellis is abundant in crocin and has a longstanding historical usage both as a dietary and natural ethnic medicine. Enhanced studies have increasingly revealed the intricate interplay between glycolipid metabolism and gut microbio...

  • Article
  • Open Access
13 Citations
3,669 Views
14 Pages

14 December 2022

Gardenia jasminoides Ellis is an aromatic and medicinal plant of high economic value. Much research has focused on the phytochemistry and biological activities of Gardenia fruit extracts; however, the potential of the Gardenia plant in vitro cultures...

  • Article
  • Open Access
23 Citations
5,917 Views
13 Pages

Alveolar macrophage is the predominant cell type in the lung and is thought to be the major target for anti-inflammatory therapy in chronic obstructive pulmonary disease (COPD). Aromatherapy using natural essential oils with anti-inflammatory effects...

  • Article
  • Open Access
21 Citations
3,933 Views
24 Pages

17 April 2023

For many centuries, Gardenia (Gardenia jasminoides Ellis) was highly valued as a food homologous Chinese herbal medicine with various bioactive compounds, including crocin I and geniposide. However, the functional mechanism underlying the hypoglycemi...

  • Article
  • Open Access
2 Citations
1,982 Views
12 Pages

Genome-Wide Resequencing Reveals Genetic Relationships between Main Gardenia jasminoides Ellis Cultivars

  • Kangqin Li,
  • Liqin Gao,
  • Xiaoli Yang,
  • Meixia Wang,
  • Xiaotao Feng and
  • Shaoyong Deng

Nineteen samples of Gardenia jasminoides Ellis from China were used for genome resequencing. The clean Q30 base rates ranged from 91.19% to 92.94%. When mapping with the reference genome, a total of 7,568,199 inDel sites and 61,535,595 SNP sites were...

  • Article
  • Open Access
9 Citations
4,429 Views
14 Pages

The Impacts of Plant Growth Regulators on the Rapid Propagation of Gardenia jasminoides Ellis. in Tissue Culture

  • Yang Ai,
  • Yunzhu Chen,
  • Shuixuan Zhu,
  • Lijuan Jiang,
  • Jingzhen Chen,
  • Changzhu Li,
  • Peiwang Li,
  • Wenbin Zeng,
  • Ding Kuang and
  • Yan Yang
  • + 1 author

26 February 2024

The optimization of explant selection and adjustment of plant growth regulators (PGRs) ratio may enhance the efficiency of micro-propagation of Gardenia jasminoides Ellis. The findings of the study suggest that the shoot tip proved to be the optimal...

  • Article
  • Open Access
24 Citations
4,789 Views
10 Pages

14 October 2020

Gardenia jasminoides Ellis is a famous fragrant flower in China. Previous pharmacological research mainly focuses on its fruit. In this study, the essential oil of the flower of ‘Shanzhizi’, which was a major variety for traditional Chine...

  • Article
  • Open Access
2 Citations
2,724 Views
18 Pages

Genetic Characterization of Gardenia jasminoides Ellis Genotypes Derived from Seeds and Selection Based on Their Morphological Traits and Flower Aromatic Substances

  • Vasiliki Anastasiadi,
  • Stefanos Hatzilazarou,
  • Emmanouil-Nikolaos Papadakis,
  • Aikaterini-Angeliki Kotoula,
  • Nikolaos Tsalouchos,
  • Taxiarchis Labis,
  • Athanasios Economou and
  • Stefanos Kostas

Gardenia jasminoides Ellis is an evergreen shrub with white fragrant flowers, and it is cultivated for its ornamental, aromatic and medicinal value. The present study aimed to select desirable genotypes for potential commercial exploitation as pot pl...

  • Article
  • Open Access
17 Citations
4,118 Views
18 Pages

20 May 2021

The present study demonstrates the potential of the alginate encapsulation of shoot tips and nodal segments of Gardenia jasminoides Ellis, the short-term cold storage of artificial seeds and subsequent successful conversion to desirable, uniform and...

  • Article
  • Open Access
15 Citations
4,237 Views
11 Pages

1 July 2020

Thrips hawaiiensis is a common thrips pest of various plant flowers with host preference. Plant volatiles provide important information for host-searching in insects. We examined the behavioral responses of T. hawaiiensis adults to the floral volatil...

  • Article
  • Open Access
5 Citations
3,360 Views
14 Pages

30 September 2022

To produce gardenia blue pigment (GBP) by natural fermentation, a novel bacteria, Leifsonia sp. ZF2019, was isolated from the larvae of a pest of Gardenia jasminoides Ellis fruits and shown to be able to convert gardenia yellow waste production (GYWP...

  • Article
  • Open Access
1 Citations
830 Views
17 Pages

10 October 2025

This study investigated the protective effects of Gardenia jasminoides Ellis polysaccharides (GP) on lipopolysaccharide (LPS)-induced immunosuppression and oxidative stress in mice and explored how GP modulates macrophage polarization through the TLR...

  • Article
  • Open Access
14 Citations
4,827 Views
14 Pages

Extraction of Natural Pigments from Gardenia Jasminoides J.Ellis Fruit Pulp Using CO2-Expanded Liquids and Direct Sonication

  • Hiroki Sakai,
  • Kento Ono,
  • Shinichi Tokunaga,
  • Tanjina Sharmin,
  • Taku Michael Aida and
  • Kenji Mishima

In this work, a carbon dioxide-expanded liquid (CXL) extraction system was used with or without direct sonication for the extraction of highly polar natural pigments (crocin-1 and crocin-2) from Gardenia jasminoides Ellis fruit pulp. The effects of d...

  • Article
  • Open Access
21 Citations
5,094 Views
12 Pages

The crocin in gardenia, as a medical plant, has drawnthe attention of researchers and scientists due to its color and high antioxidant activity. To optimize the extraction parameters of crocin from gardenia fruits, response surface methodology (RSM)...

  • Article
  • Open Access
66 Citations
7,410 Views
19 Pages

Metabolite Profiling of Methanolic Extract of Gardenia jaminoides by LC-MS/MS and GC-MS and Its Anti-Diabetic, and Anti-Oxidant Activities

  • Kandasamy Saravanakumar,
  • SeonJu Park,
  • Anbazhagan Sathiyaseelan,
  • Kil-Nam Kim,
  • Su-Hyeon Cho,
  • Arokia Vijaya Anand Mariadoss and
  • Myeong-Hyeon Wang

28 January 2021

In this study, the methanolic extract from seeds of Gardenia jasminoides exhibited strong antioxidant and enzyme inhibition activities with less toxicity to NIH3T3 and HepG2 cells at the concentration of 100 µg/mL. The antioxidant activities (DPPH an...

  • Article
  • Open Access
1 Citations
824 Views
17 Pages

Geniposide Inhibits Oral Squamous Cell Carcinoma by Regulating PI3K-Akt Signaling-Mediated Apoptosis: A Multi-Method Validation Study

  • Xue Wang,
  • Jianbo Wang,
  • Hua Hua,
  • Ping Wei,
  • Xue Chen,
  • Yusheng Peng,
  • Li Liu,
  • Dongmei Yu,
  • Xiaozhou You and
  • Siye Yang

Gardenia jasminoides J.Ellis is an important medicinal and edible resource. The fruit of Gardenia jasminoides J.Ellis contains a natural iridoid called geniposide, which has the ability to dramatically suppress the growth of a number of cancer cell l...

  • Review
  • Open Access
25 Citations
4,917 Views
14 Pages

Genipin is an important monoterpene iridoid compound isolated from Gardenia jasminoides J.Ellis fruits and from Genipa americana fruits, or genipap. It is a precursor of a blue pigment which may be attractive alternative to existing food dyes and it...

  • Article
  • Open Access
3 Citations
1,571 Views
22 Pages

In order to explore the effect and mechanism of trehalose (Tre) on the growth and cold resistance of gardenia jasminoides Ellis under low-temperature stress, 15 mmol/L of Tre was used on gardenia seedlings under different degrees of low-temperature s...

  • Review
  • Open Access
43 Citations
5,748 Views
13 Pages

Genipin is a protein cross-linking agent extracted from Gardenia (Gardenia jasminoides Ellis) fruits. This fruit has conventionally been used as a Chinese herbal medicine for the treatment of inflammation and jaundice and as an edible colorant in ori...

  • Article
  • Open Access
1 Citations
1,997 Views
12 Pages

Photoprotective Effect and Potential Mechanisms of Gardeniae Fructus Extract in UVB-Irradiated HaCaT Cells

  • Kaile Zong,
  • Xiang Li,
  • Fangni Zhou,
  • Junzi Dong,
  • Qing Huang and
  • Jianxin Wu

Gardeniae Fructus (GF), the desiccative mature fruitage of Gardenia jasminoides J. Ellis (G. jasminoides), is a traditional herbal medicine in China with potential value against skin photodamage. However, the phytochemical basis and mechanisms underl...

  • Article
  • Open Access
17 Citations
7,351 Views
12 Pages

Insight of Saffron Proteome by Gel-Electrophoresis

  • Gianluca Paredi,
  • Samanta Raboni,
  • Francesco Marchesani,
  • Stella A. Ordoudi,
  • Maria Z. Tsimidou and
  • Andrea Mozzarelli

29 January 2016

Saffron is a spice comprised of the dried stigmas and styles of Crocus sativus L. flowers and, since it is very expensive, it is frequently adulterated. So far, proteomic tools have never been applied to characterize the proteome of saffron or identi...

  • Article
  • Open Access
833 Views
12 Pages

Heterologous Biosynthesis of Crocin I in Solanum lycopersicum L.

  • Lei Xie,
  • Jingjing Liao,
  • Chongnan Wang,
  • Xunli Jia,
  • Yimei Zang,
  • Changming Mo,
  • Xiaojun Ma and
  • Zuliang Luo

14 October 2025

Crocins are high-value apocarotenoid pigments with broad applications in pharmaceuticals, foods, and personal-care products, and they exhibit diverse bioactivities, including antioxidant, antidepressant, and antidementia effects. In this study, we ac...

  • Review
  • Open Access
60 Citations
6,480 Views
20 Pages

Updated Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of Natural Product Geniposide

  • Liping Liu,
  • Qin Wu,
  • Yuping Chen,
  • Guoxiang Gu,
  • Runan Gao,
  • Bo Peng,
  • Yue Wang,
  • Anbang Li,
  • Jipeng Guo and
  • Jihu Sun
  • + 4 authors

At present, the potential of natural products in new drug development has attracted more and more scientists’ attention, and natural products have become an important source for the treatment of various diseases or important lead compounds. Gen...

  • Article
  • Open Access
26 Citations
3,950 Views
14 Pages

A New Geniposidic Acid Derivative Exerts Antiaging Effects through Antioxidative Stress and Autophagy Induction

  • Ying Wang,
  • Yanjun Pan,
  • Yanan Liu,
  • Dejene Disasa,
  • Matsuura Akira,
  • Lan Xiang and
  • Jianhua Qi

Two compounds that can prolong the replicative lifespan of yeast, geniposidic acid (Compound 1) and geniposide (Compound 2), were isolated from Gardenia jasminoides Ellis. Compared with Compound 1, Compound 2 was different at C11 and showed better bi...

  • Essay
  • Open Access
19 Citations
4,970 Views
16 Pages

Microdialysis, a sampling method for pharmacokinetics–pharmacodynamics (PK–PD) modeling in preclinical and clinical studies, is a convenient in vivo sampling technique. Geniposide (GE), an iridoid glycoside compound, is the major active ingredient of...

  • Article
  • Open Access
30 Citations
3,800 Views
18 Pages

Structural Characteristics of Polysaccharide GP2a in Gardenia jasminoides and Its Immunomodulatory Effect on Macrophages

  • Pingdong Lin,
  • Lifei Chen,
  • Xiaojing Huang,
  • Fangnan Xiao,
  • Lei Fu,
  • Dingding Jing,
  • Jingjing Wang,
  • Hong Zhang,
  • Lifang Sun and
  • Yunkun Wu

24 September 2022

Here, we elucidated the structural characteristics of a polysaccharide isolated from Gardenia jasminoides Ellis (labeled as GP2a) and its immunomodulatory activity. GP2a is an acidic polysaccharide with a molecular weight of 44.8 kDa, mostly comprisi...

  • Article
  • Open Access
59 Citations
9,834 Views
16 Pages

Genetic and Epigenetic Approaches for the Possible Detection of Adulteration and Auto-Adulteration in Saffron (Crocus sativus L.) Spice

  • Giovanna Soffritti,
  • Matteo Busconi,
  • Rosa Ana Sánchez,
  • Jean-Marie Thiercelin,
  • Moschos Polissiou,
  • Marta Roldán and
  • José Antonio Fernández

Saffron (Crocus sativus L.) is very expensive and, because of this, often subject to adulteration. Modern genetic fingerprinting techniques are an alternative low cost technology to the existing chemical techniques, which are used to control the puri...

  • Article
  • Open Access
33 Citations
5,567 Views
20 Pages

31 January 2019

With traditional Chinese medicine (TCM) becoming widespread globally, its safety has increasingly become a concern, especially its hepatoxicity. For example, Gardenia jasminoides Ellis is a key ingredient in the Zhi-Zi-Hou-Po decoction (ZZHPD), which...

  • Article
  • Open Access
7 Citations
6,274 Views
13 Pages

6 December 2016

Artemisia capillaries Thunb, Gardenia jasminoides Ellis, and Rheum officinale Baill have been combined to treat jaundice for thousands of years. Studies have revealed that these herbs induce anti-hepatic fibrosis and anti-hepatic apoptosis and allevi...

  • Article
  • Open Access
4 Citations
2,412 Views
24 Pages

29 August 2023

Genipin, an aglycone of geniposide, is a rich iridoid component in the fruit of Gardenia jasminoides Ellis and has numerous biological activities. However, its metabolic profiles in vivo and vitro remain unclear. In this study, an effective analytica...

  • Article
  • Open Access
24 Citations
4,861 Views
14 Pages

Immunosuppressive Effect of Geniposide on Mitogen-Activated Protein Kinase Signalling Pathway and Their Cross-Talk in Fibroblast-Like Synoviocytes of Adjuvant Arthritis Rats

  • Feng Li,
  • Miaomiao Dai,
  • Hong Wu,
  • Ran Deng,
  • Jun Fu,
  • Zhengrong Zhang,
  • Li Dai,
  • Wenyu Wang,
  • Xuejing Dai and
  • Yan Wang
  • + 1 author

Geniposide (GE), an iridoid glycoside compound derived from Gardenia jasminoides Ellis fruit, is known to have anti-inflammatory and immunoregulatory activities. The aim of this study was to investigate the protective mechanism of GE in the regulatio...

  • Article
  • Open Access
2 Citations
2,348 Views
24 Pages

GENI as an AMPK Activator Binds α and γ Subunits and Improves the Memory Dysfunction of Alzheimer’s Disease Mouse Models via Autophagy and Neuroprotection

  • Ying Wang,
  • Lanjie Li,
  • Danni Chen,
  • Jiaheng Shan,
  • Meijuan Yi,
  • Hiroyuki Osada,
  • Minoru Yoshida,
  • Lan Xiang and
  • Jianhua Qi

Geniposidic 4-isoamyl ester (GENI) with anti-aging effects is a new iridoid glycoside derivative from Gardenia jasminoides Ellis found in our previous study. In this study, to indicate whether this compound has anti-Alzheimer’s disease (AD) eff...

  • Article
  • Open Access
10 Citations
3,236 Views
14 Pages

30 December 2022

Gardeniae Fructus (GF, the dried ripe fruits of Gardenia jasminoides Ellis) has traditionally been used to treat various diseases in East Asian countries, such as liver disease. Silymarin is a well-known medicine used to treat numerous liver dis...

  • Article
  • Open Access
17 Citations
3,859 Views
16 Pages

Evaluation of the Inhibitory Effects of Genipin on the Fluoxetine-Induced Invasive and Metastatic Model in Human HepG2 Cells

  • Yu-Syuan Tian,
  • Kuan-Chou Chen,
  • Nor Diana Zulkefli,
  • Rida S. Maner and
  • Chiu-Lan Hsieh

14 December 2018

Metastasis of hepatocellular carcinoma (HCC) is usually unrecognized before any pathological examination, resulting in time-taking treatment and poor prognosis. As a consequence, HCC patients usually show symptoms of depression. In order to suppress...