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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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RNA Viruses Replication and Innate Immunity

edited by

Griffith Parks

submission deadline 31 May 2025 | Viewed by 240 | Submission Open

Keywords: RNA virus replication and transcription; pathogen-associated molecular patterns; interferons; cytokines; signaling pathways

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Bornaviruses 2025: News, Gaps and Future Directions

edited by

Christiane E. Herden

submission deadline 31 May 2025 | Viewed by 138 | Submission Open

Keywords: bornaviruses; zoonotic; epidemiology; transmission; molecular infection mechanisms; pathogenesis; antiviral

(This special issue belongs to the Section Animal Viruses)

Viral Resistance

edited by

Maria Antonia De Francesco

submission deadline 13 Jun 2025 | 1 articles | Viewed by 1720 | Submission Open

Keywords: antiviral drugs; resistance; mechanism; mutations; viral escape; viral adaptation; variability; combination therapy

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Discovery, Classification, and Early Research on the Lipid-Containing, Double-Stranded RNA Bacteriophage φ6

edited by

Paul Gottlieb

and Aleksandra Alimova

submission deadline 15 Jun 2025 | 7 articles | Viewed by 18032 | Submission Open

Keywords: procapsid; nucleocapsid; polymerase complex; assembly; replication; recombination; packaging10

(This special issue belongs to the Section Bacterial Viruses)

Long-Acting Antiretrovirals

edited by Camilla Muccini and Antonella Castagna

submission deadline 15 Jun 2025 | Viewed by 171 | Submission Open

Keywords: HIV infection; HIV prevention; long-acting; antiretroviral therapy; clinical studies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Recent Advances on Arboviruses Pathogenesis and Evolution

edited by Mariana Sequetin Cunha

submission deadline 17 Jun 2025 | 1 articles | Viewed by 1275 | Submission Open

Keywords: virus outbreaks; phylogeny; virus evolution; pathology

(This special issue belongs to the Section Invertebrate Viruses)

Bacteriophage Lytic Proteins

edited by

Madalena Pimentel

submission deadline 20 Jun 2025 | 3 articles | Viewed by 5438 | Submission Open

Keywords: bacteriophage; phage lysis; holins; endolysins; spanins; mycolil esterases; antimicrobials

(This special issue belongs to the Section Bacterial Viruses)

Conquering Antiviral Drug Resistance via Development of Novel Antivirals and New Testing Methods for Drug Resistance: From Bench to Bedside

edited by

Benjamin M. Liu

Jun Wang

and David Hillyard

submission deadline 20 Jun 2025 | Viewed by 303 | Submission Open

Keywords: antivirals; viral hepatitis; HIV; Mpox; influenza; enterovirus; chronic viral infections; acute viral infections; diagnosis; antiviral drug resistance; antiviral drug mutations; antiviral drug development; viral evolution; treatment

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Dengue, Zika and Yellow Fever Virus Replication

edited by

Rosa M. Del Angel

submission deadline 25 Jun 2025 | Viewed by 345 | Submission Open

Keywords: flavivirus; dengue; Zika; yellow fever; virus replication; virus entry; genome replication; host cell factors; replication structures

(This special issue belongs to the Section Invertebrate Viruses)

Canine Distemper Virus

edited by Monica G. Candela and

Nieves Ortega Hernández

submission deadline 30 Jun 2025 | 7 articles | Viewed by 10683 | Submission Open

Keywords: CDV taxonomy (lineages); new hosts of CDV; CDV pathogenesis; CDV epidemiology (risk factors; distribution; and prevalence); CDV prevention/risk mitigation

(This special issue belongs to the Section Animal Viruses)

Viral Sepsis: Pathogenesis, Diagnostics and Therapeutics

edited by

Karolina Akinosoglou

and

Charalambos Gogos

submission deadline 30 Jun 2025 | 6 articles | Viewed by 9374 | Submission Open

Keywords: viral sepsis; HIV; HBV; HCV; EBV; HDV; HEV; CMV; HSV; HPV; influenza; RSV; COVID-19; SARS-CoV-2; other viruses; viral infection; sepsis; pathogenesis; diagnosis; therapy; biomarkers; vaccination

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Controlling Zoonotic Viral Diseases from One Health Perspective 2025

edited by

Maureen T. Long

and Erika Schwarz-Collins

submission deadline 30 Jun 2025 | 4 articles | Viewed by 9268 | Submission Open

Keywords: one health; viral zoonoses; control; vaccine; surveillance; epidemiology

(This special issue belongs to the Section Animal Viruses)

Cellular Restriction Factors against Viral Infection

edited by

Stephen Barr

submission deadline 30 Jun 2025 | 2 articles | Viewed by 9230 | Submission Open

Keywords: cellular restriction factors; antiviral proteins; viral antagonists; intrinsic immunity; interferon response; innate immunity; evolution of restriction factors; evolution of viral antagonists; viral antagonists as druggable targets

(This special issue belongs to the Section General Virology)

Vertical Transmission of Human Papillomavirus Infections

edited by

Stina Syrjänen

submission deadline 30 Jun 2025 | 3 articles | Viewed by 9057 | Submission Open

(This special issue belongs to the Section Animal Viruses)

Advances in Alphavirus and Flavivirus Research, 2nd Edition

edited by

Young Chan Kim

and

Arturo Reyes-Sandoval

submission deadline 30 Jun 2025 | 9 articles | Viewed by 8504 | Submission Open

Keywords: arbovirus; alphavirus; flavivirus; Chikungunya; Mayaro; Zika; dengue; diagnostics; surveillance; vaccine; antivirals; animal models

(This special issue belongs to the Section General Virology)

Immune Modulation by Human Cytomegalovirus

edited by

Davide Abate

submission deadline 30 Jun 2025 | 6 articles | Viewed by 8150 | Submission Open

Keywords: human cytomegalovirus (CMV); molecular and cellular mechanisms; cell-intrinsic immunity; adaptive immunity; innate immunity

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Hepatitis and Liver Diseases

edited by

Carlo Smirne

submission deadline 30 Jun 2025 | 6 articles | Viewed by 7217 | Submission Open

Keywords: chronic viral infection; viral hepatitis; liver fibrosis; hepatocellular carcinoma; hepatitis B virus; hepatitis C virus; hepatitis delta virus co-infection; hepatitis E virus; flavivirus; molecular mechanisms; epidemiological investigations

(This special issue belongs to the Section Human Virology and Viral Diseases)

Diversity and Coinfections of Plant or Fungal Viruses, 3rd Edition

edited by

Islam Hamim

Ken Komatsu

and

Hiromitsu Moriyama

submission deadline 30 Jun 2025 | 3 articles | Viewed by 4164 | Submission Open

Keywords: diagnosis; surveillance; molecular mechanism; viroid; subviral agents; mycoviruses; biological control; pesticide resistance; antiviral defense mechanism; population genetics; recombination; gene expressions; host range

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Coronaviruses and Influenza Viruses: Evolution, Cross-Species Transmission, and Recombination

edited by

Maged Gomaa Hemida

submission deadline 30 Jun 2025 | 4 articles | Viewed by 4134 | Submission Open

Keywords: coronaviruses; influenza viruses; highly pathogenic influenza viruses; species jump; avian coronaviruses; porcine coronaviruses; vaccines; diagnostic assays; one health; virus/host interaction.

(This special issue belongs to the Section Coronaviruses)

Plant Virus Spillovers

edited by

Steve Wylie

and

Nuredin Habili

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3977 | Submission Open

Keywords: spillover; emergence; replication; wild-plant virus; transmission; virus-cell interaction; vector

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Viruses and Eye Diseases

edited by Homayon Ghiasi and

Deepak Shukla

submission deadline 30 Jun 2025 | 3 articles | Viewed by 3941 | Submission Open

Keywords: ocular health; herpesviruses; herpes simplex virus (HSV); varicella zoster virus (VZV); adenovirus; respiratory viruses; Zika virus; cytomegalovirus (CMV); virus– ocular tissue interactions

(This special issue belongs to the Section Human Virology and Viral Diseases)

Computational Biology of Viruses: From Molecules to Epidemics, Volume 2

edited by

Viktor Müller

submission deadline 30 Jun 2025 | 4 articles | Viewed by 3251 | Submission Open

Keywords: mathematical modeling; simulation modeling; molecular processes; within-host dynamics; epidemiological models; multiscale models

(This special issue belongs to the Section General Virology)

Biotechnological Applications of Phage and Phage-Derived Proteins 2025

edited by

Silvio Santos

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3192 | Submission Open

Keywords: bacteriophage; biotechnological applications; genetic engineering; antimicrobials; diagnostic

(This special issue belongs to the Section Bacterial Viruses)

Interplay Between Influenza Virus and Host Factors

edited by

Matloob Husain

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3101 | Submission Open

Keywords: influenza virus; host factors; proviral host factors; antiviral host factors; host adaptation; virus entry; virus assembly; virus release; innate antiviral response; interferon-stimulated genes; post-translational protein modifications

(This special issue belongs to the Section Animal Viruses)

Molecular Virus-Insect Interactions, 2nd Edition

edited by Li-Long Pan

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2614 | Submission Open

Keywords: plant virus-insect vector interactions; virus transmission; entomopathogenic virus-insect host interactions; insect-specific viruses; induction and suppression of immune responses

(This special issue belongs to the Section Invertebrate Viruses)

Zoonotic Viral Diseases: Drivers, Causes, Prevention and Cure, 2nd Edition

edited by

Claude Saegerman

submission deadline 30 Jun 2025 | 4 articles | Viewed by 2323 | Submission Open

Keywords: zoonotic viral diseases; drivers of emergence; disease mechanism and pathogenesis in reservoir host and end host; prevention mitigation measures; treatment

(This special issue belongs to the Section Animal Viruses)

HIV Protease

edited by

Gail E. Fanucci

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1896 | Submission Open

Keywords: HIV protease; antiretroviral therapy; drug resistance; inhibitor development; viral maturation; viral co-evolution; natural polymorphism

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Virological and Immunological Factors Underlying HBV Functional Cure and HBV Reactivation

edited by

Valentina Svicher

submission deadline 30 Jun 2025 | Viewed by 518 | Submission Open

Keywords: HBV persistence; HBV functional cure; cccDNA; immunology of HBV; HBV reactivation; immune-escape mutations

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Manipulation of Plant Stress Responses

edited by

Miguel A. Aranda

and Manuel Miras

submission deadline 30 Jun 2025 | Viewed by 439 | Submission Open

Keywords: virus– plant interactions; virus– host– vector interactions; immune responses; hormone signaling; evolutionary adaptations; crop protection; stress responses

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Viral Infection and Platelets’ Disorders

edited by

Pierpaolo Di Micco

Alessandro Perrella

and

Giuseppe Camporese

submission deadline 30 Jun 2025 | Viewed by 299 | Submission Open

Keywords: viral infections; thrombosis; thrombotic microangiopathies; disseminated intravascular coagulation; low molecular weight heparin; bleedings; acute infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advancing Research of Anelloviruses, Second Edition

edited by

Fabrizio Maggi

and

Pietro Giorgio Spezia

submission deadline 30 Jun 2025 | Viewed by 295 | Submission Open

Keywords: TTV; TTMV; TTMDV; virome; viral species; immune system; orphan virus

(This special issue belongs to the Section Human Virology and Viral Diseases)

Interferon Signaling in Viral Pathogenesis

edited by Lishan Su

submission deadline 30 Jun 2025 | Viewed by 253 | Submission Open

Keywords: type I interferons; virus replication; viral pathogenesis; autoimmune diseases; inflamation-induced cancer; immunotherapy

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Bacteriophage Diversity, 2nd Edition

edited by Bert Ely

submission deadline 30 Jun 2025 | Viewed by 102 | Submission Open

Keywords: bacteriophages phage; diversity genome; evolution; new genera; phage-host interactions

(This special issue belongs to the Section Bacterial Viruses)

Epigenetic Modifications in Viral Infections, Volume II

edited by

Matloob Husain

and

Farjana Ahmed

submission deadline 1 Jul 2025 | Viewed by 323 | Submission Open

Keywords: viral pathogenesis; virus– host interaction; epigenetic modifications; acetylation; methylation; proteomics; genomics

(This special issue belongs to the Section General Virology)

Glycans in Virus-Host Interactions

edited by Rahul Raman

submission deadline 15 Jul 2025 | 4 articles | Viewed by 13546 | Submission Open

Keywords: glycoeptiope; glycan receptors; viruses; antibodies; lectins

(This special issue belongs to the Section Animal Viruses)

Unraveling the Pathogenesis of Persistent Virus Infection

edited by

Yasuko Tsunetsugu-Yokota

and Mie Kobayashi-Ishihara

submission deadline 15 Jul 2025 | 6 articles | Viewed by 11336 | Submission Open

Keywords: pathophysiology; persistent virus infections; chronic diseases; latency; reactivation

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Flow Virometry: A New Tool for Studying Viruses

edited by John Yin

submission deadline 15 Jul 2025 | 5 articles | Viewed by 7541 | Submission Open

Keywords: flow virometry; virus particle detection; virus counting; virus labeling/staining; virus-like particles; scanning ion occlusion sensing

(This special issue belongs to the Section General Virology)

Arboviral Diseases in Livestock

edited by

Estelle Venter

and

Antoinette Van Schalkwyk

submission deadline 15 Jul 2025 | 2 articles | Viewed by 1749 | Submission Open

Keywords: arbovirus; epidemiology; diagnostics; vaccines

(This special issue belongs to the Section Animal Viruses)

Advances in Small-Molecule Viral Inhibitors

edited by Chiara Bertagnin

submission deadline 15 Jul 2025 | Viewed by 145 | Submission Open

Keywords: small-molecule inhibitors; PROTACs; antiviral compounds; drug discovery; protein– protein interaction inhibitors; enzymatic inhibitors

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Spumaretroviruses: Research and Applications

edited by

Arifa S. Khan

, Marcelo A. Soares,

Dirk Lindemann

and Martin Löchelt

submission deadline 30 Jul 2025 | Viewed by 595 | Submission Open

Keywords: ancient retroviruses; antivirals; complex retroviruses; endogenous elements; foamy viruses; foamy virus-host interactions; foamy virus prevalence; foamy virus vectors; immune responses; molecular biology and replication; natural infections; nonhuman primates and non-primates; restriction factors spumaretroviruses; structural biology; taxonomy; viral proteins; virus detection assays; zoonoses

(This special issue belongs to the Section Animal Viruses)

COVID-19 Complications and Co-infections

edited by Amir Sohail,

Abu Baker Sheikh

and

Adeel Nasrullah

submission deadline 31 Jul 2025 | 16 articles | Viewed by 25060 | Submission Open

Keywords: SARS-CoV-2; COVID-19; complications; co-infections; hospitalization

(This special issue belongs to the Section Coronaviruses)

Bovine Influenza

edited by Dan Wang and

Feng Li

submission deadline 31 Jul 2025 | 5 articles | Viewed by 15187 | Submission Open

Keywords: cattle; influenza viruses; avian influenza; replication; virulence; transmission; host adaptation; reservoir; epidemiology; one health; vaccine; immune response

(This special issue belongs to the Section Animal Viruses)

Herpesviruses and Associated Diseases

edited by

Sherif T.S. Hassan

submission deadline 31 Jul 2025 | 9 articles | Viewed by 10584 | Submission Open

Keywords: human herpesviruses; animal herpesviruses; viral latency and reactivation; immune evasion strategies; herpesvirus– host interactions; herpesvirus biology and pathogenesis; herpesvirus diagnosis; environmental factors; herpesvirus-associated diseases; prevention and treatment strategies; antiviral therapies; vaccine development

(This special issue belongs to the Section Human Virology and Viral Diseases)

Saliva in the Diagnosis of Viral Diseases

edited by

Anna Rosa Garbuglia

and

Licia Bordi

submission deadline 31 Jul 2025 | 6 articles | Viewed by 9888 | Submission Open

Keywords: saliva; diagnosis; pathogen detection; immunity; biomarkers

(This special issue belongs to the Section Human Virology and Viral Diseases)

The Application of Viruses to Biotechnology 3.0

edited by

Carla Varanda

and

Patrick Materatski

submission deadline 31 Jul 2025 | 5 articles | Viewed by 9862 | Submission Open

Keywords: viral vectors; plant protection; gene therapy; virus-based vaccines; viral nanotechnology; phage display; viral gene delivery; virus-mediated gene editing; virus-like particles (VLPs)

(This special issue belongs to the Section General Virology)

Evolution and Adaptation of Avian Viruses

edited by

Giovanni Franzo

and

Matteo Legnardi

submission deadline 31 Jul 2025 | 4 articles | Viewed by 7612 | Submission Open

Keywords: virus; poultry; evolution; genetics; diagnosis; host; epidemiology; control; vaccine

(This special issue belongs to the Section Animal Viruses)

Virus Assembly and Genome Packaging

edited by

Mauricio Comas-Garcia

submission deadline 31 Jul 2025 | 2 articles | Viewed by 3779 | Submission Open

Keywords: viral assembly; genome packaging; viral structural proteins; host protein; viral– host interactions; antiviral therapies

(This special issue belongs to the Section General Virology)

Novel Strategies to Identify and Eliminate Latent HIV Cells

edited by

Francesco Andrea Procopio

submission deadline 31 Jul 2025 | 1 articles | Viewed by 2706 | Submission Open

Keywords: HIV; HIV-1 infection; antiretroviral therapy (ART); HIV single cell analysis; HIV reservoir; HIV cure

(This special issue belongs to the Section Human Virology and Viral Diseases)

Virus-Host Protein Interactions

edited by

Benoit Coulombe

submission deadline 31 Jul 2025 | 2 articles | Viewed by 2184 | Submission Open

Keywords: protein– protein interactions; antiviral drug discovery; protein target inhibitors

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

HIV Assembly, Release and Maturation

edited by Siddhartha Datta

submission deadline 31 Jul 2025 | 1 articles | Viewed by 2076 | Submission Open

Keywords: HIV assembly and maturation; capsid stability; inositol hexakisphosphate (IP6); genome recognition; endogenous reverse transcription; reorganization; maturation inhibitors; flexibility and dynamics

(This special issue belongs to the Section Human Virology and Viral Diseases)

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