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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Host Cell-Virus Interaction, 4th Edition

edited by

Parikshit Bagchi

and

Anupam Mukherjee

submission deadline 30 Sep 2025 | 6 articles | Viewed by 8036 | Submission Open

Keywords: virus; viral proteins; virus entry; viral replication and pathogenesis; virus assembly and egress; intracellular trafficking of virus; host cell; cellular signaling; interferon pathway; inflammasome; viral immune evasion; immune response; cell death; apoptosis; autophagy; host-virus interaction; anti-viral strategies; direct acting antivirals; broad-spectrum antiviral agents; RNAi; microRNAs; neutralizing antibodies; molecular mechanisms of antivirals; molecular mechanisms of drug-resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Insect Viruses and Pest Management, the Third Edition

edited by

Miguel López-Ferber

submission deadline 30 Sep 2025 | 5 articles | Viewed by 6666 | Submission Open

Keywords: insect-specific viruses; pest control; virus-based biocontrol agents; quality control; industrial production; resistance development to virus-based biocontrol agents

(This special issue belongs to the Section Invertebrate Viruses)

JC Polyomavirus

edited by

Sébastien Lhomme

and Anne-Sophie L'Honneur

submission deadline 30 Sep 2025 | 3 articles | Viewed by 4475 | Submission Open

Keywords: JC polyomavirus; progressive multifocal leukoencephalopathy (PML); neurotropic variants; viral genomic rearrangements

(This special issue belongs to the Section Human Virology and Viral Diseases)

RSV Epidemiological Surveillance: 2nd Edition

edited by Emanuele Castagno and Irene Raffaldi

submission deadline 30 Sep 2025 | 1 articles | Viewed by 2423 | Submission Open

Keywords: respiratory syncytial virus (RSV); epidemiological surveillance; bronchiolitis; children; newborns; infants

(This special issue belongs to the Section Human Virology and Viral Diseases)

Mechanisms of Herpesvirus Resistance

edited by

Graciela Andrei

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1721 | Submission Open

Keywords: human herpesviruses; cytomegalovirus; drug resistance; antiviral agents; immunocompromised host; novel anti-herpesvirus therapies; DNA polymerase; terminase

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Coronaviruses Pathogenesis, Immunity, and Antivirals (2nd Edition)

edited by

Wentao Li

and Fei Yu

submission deadline 30 Sep 2025 | 4 articles | Viewed by 1693 | Submission Open

Keywords: coronavirus; pathogenesis; molecular; vaccines; evolution; immunity; antivirals

(This special issue belongs to the Section Coronaviruses)

Viral Diseases of Livestock and Diagnostics, 2nd Edition

edited by

Scott P. Kenney

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1648 | Submission Open

Keywords: viral disease; zoonosis; zooanthroponosis; production animal

(This special issue belongs to the Section Animal Viruses)

Application of Plant Viruses in Biotechnology

edited by

Kathleen Hefferon

and

Srividhya Venkataraman

submission deadline 30 Sep 2025 | 1 articles | Viewed by 1500 | Submission Open

Keywords: plant viruses; viral nanoparticles; plant viral vectors; biotechnological applications

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Diversity and Evolution of Viruses in Ecosystem 2025

edited by

René Kallies

submission deadline 30 Sep 2025 | 2 articles | Viewed by 1266 | Submission Open

Keywords: environmental virology; viral metagenomics; viral metatranscriptomics; phage genomics; virus evolution and phylogeny

(This special issue belongs to the Section General Virology)

Dual Nature of Bacteriophages: Friends or Enemies in Food Industry?

edited by

Barbara Sokolowska

Ewa Jończyk-Matysiak

and

Michał Wójcicki

submission deadline 30 Sep 2025 | 2 articles | Viewed by 979 | Submission Open

Keywords: bacteriophages; biocontrol; biosensors; food safety; foodborne bacterial pathogens; food quality; foodborne sapro-phytic bacteria

(This special issue belongs to the Section Bacterial Viruses)

Animal Herpesvirus 2025

edited by

Shafiqul Chowdhury

submission deadline 30 Sep 2025 | 2 articles | Viewed by 936 | Submission Open

Keywords: herpesviruses; innate immune responses; host adaptive immune responses; herpesvirus-host; interactions; susceptibility

(This special issue belongs to the Section Animal Viruses)

Pathogenesis of Viral Infections

edited by

Cheng-Wen Lin

submission deadline 30 Sep 2025 | Viewed by 256 | Submission Open

Keywords: human and zoonotic viral diseases; viral pathogenesis; systems-level analyses; immune response; protein– protein interactions

(This special issue belongs to the Section General Virology)

Viral Diseases of Sheep and Goats

edited by Ramsés Reina and Álex Gómez

submission deadline 30 Sep 2025 | Viewed by 227 | Submission Open

Keywords: small ruminants; viral immunopathogenesis; infection; transmission; epidemiology; control strategies; vaccines

(This special issue belongs to the Section Animal Viruses)

Human Leukocyte Antigen (HLA) in Viral Infections

edited by Nicholas Borcherding

submission deadline 30 Sep 2025 | Viewed by 163 | Submission Open

Keywords: HLA; viral infection; immune response; T cells; antigen presentation; viral evasion; immunogenetics; polymorphism; disease susceptibility; vaccine development

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Molecular Epidemiology of SARS-CoV-2, 4th Edition

edited by

Marta Giovanetti

submission deadline 30 Sep 2025 | Viewed by 161 | Submission Open

Keywords: SARS-CoV-2; genomic monitoring; phylodynamic; molecular epidemiology

(This special issue belongs to the Section Coronaviruses)

Viral Strategies to Regulate Host Immunity or Signal Pathways 2nd Edition

edited by

Bumsuk Hahm

submission deadline 30 Sep 2025 | Viewed by 150 | Submission Open

Keywords: virus– host interaction; viral immunity; viral pathogenesis; immune evasion; innate immunity; adaptive immunity; signal pathway

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Therapeutic Interfering Particles (TIPs): A Promising Treatment for Viral Infections

edited by

Jason William Botten

and Rebekah Honce

submission deadline 30 Sep 2025 | Viewed by 138 | Submission Open

Keywords: defective interfering particles; defective viral genomes; therapeutic interfering particles; DIPs; DVGs; TIPs

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Development of Diagnostics and Therapeutic Interventions for Viral Infections of the Central Nervous System

edited by Karin E. Peterson and Amanda E. Calvert

submission deadline 30 Sep 2025 | Viewed by 118 | Submission Open

Keywords: encephalitis; arbovirus; diagnosis; treatment; neurovirology; antibody therapeutics; agnostic therapeutics; point of care diagnostics; rapid diagnostics

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Mechanism of Receptor Recognition in Coronavirus, 2nd Edition

edited by

Qibin Geng

submission deadline 30 Sep 2025 | Viewed by 117 | Submission Open

Keywords: receptor recognition; spike protein adaptations; receptor-binding domain (RBD); host range and zoonotic transmission; viral evolution and immune evasion; glycosylation and co-receptors; proteolytic activation; therapeutic and vaccine strategies; cross-species viral transmission; pandemic preparedness and surveillance

(This special issue belongs to the Section Animal Viruses)

Giant, Jumbo and Mega Phages

edited by

Julie Thomas

submission deadline 30 Sep 2025 | Viewed by 104 | Submission Open

Keywords: long-genome phage; giant phage; jumbo phage; mega phage; genomes; structure/assembly; infection strategies; ecology; evolution; applications

(This special issue belongs to the Section Bacterial Viruses)

Viral Pathogenesis and Novel Vaccines for Fish Viruses

edited by Vikram Vakharia

submission deadline 30 Sep 2025 | Viewed by 81 | Submission Open

Keywords: fish; RNA viruses; viral pathogenesis; virulence; reverse genetics; recombinant vaccines; oral vaccines

(This special issue belongs to the Section Animal Viruses)

Recent Advances in Anti-HCV, Anti-HBV and Anti-Flavivirus Agents, 2nd Edition

edited by

Grigoris Zoidis

submission deadline 30 Sep 2025 | Viewed by 72 | Submission Open

Keywords: medicinal chemistry of anti-HCV; anti-HBV and anti-flavivirus agents; synthesis; structure activity relationships (SAR); antiviral drug discovery; HBV; HCV; Dengue (DENV); Yellow Fever (YFV); West Nile (WNV); Zika (ZIKV); mechanism of action; drug targets; in silico studies

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Advances in Understanding Viral Pathogenesis and Host Immune Responses to Arboviruses and Respiratory Viruses

edited by

Laura Beatriz Talarico

and

Claudia Filomatori

submission deadline 30 Sep 2025 | Viewed by 59 | Submission Open

Keywords: arboviruses; respiratory viruses; viral pathogenesis; host immune responses; innate immunity; adaptive immunity; viral immune evasion; cytokine storm; interferon response; viral replication; viral transmission; immunopathology; neutralizing antibodies; host– virus interactions

(This special issue belongs to the Section Animal Viruses)

Women in Virology 2025

edited by

Mariana Baz

Barbara Baker

, Priti Kumar and Ulrike Lange

submission deadline 1 Oct 2025 | 5 articles | Viewed by 9915 | Submission Open

Keywords: human; animal; and plant viruses; virus replication; pathogenesis; transmission; antivirals; antiviral resistance; drug discovery; vaccine development and evaluation; animal models; high-risk populations

(This special issue belongs to the Section General Virology)

Viral Infection in Airway Epithelial Cells

edited by Camille Ehré and Raymond J. Pickles

submission deadline 1 Oct 2025 | 1 articles | Viewed by 683 | Submission Open

Keywords: respiratory viral infections; airway epithelial cells; virus– host interactions; viral pathogenesis; immune responses; Influenza viruses; respiratory syncytial virus (rsv); coronaviruses; SARS-CoV-2; respiratory tract

(This special issue belongs to the Section Animal Viruses)

Viral RNA and Its Interaction with the Host

edited by

Redmond Smyth

and Neva Caliskan

submission deadline 24 Oct 2025 | 2 articles | Viewed by 1479 | Submission Open

Keywords: virus life cycle; host-virus interactions; viral RNA; RNA structures; RNA binding proteins; translational control; RNA modifications; immune evasion; RNA localization

(This special issue belongs to the Section General Virology)

Pestivirus 2025

edited by

Benjamin J. Lamp

and Christiane M. Riedel

submission deadline 30 Oct 2025 | 1 articles | Viewed by 310 | Submission Open

Keywords: pestiviruses; classical swine fever virus; bovine viral diarrhea virus; BVDV-1; BVDV-2; CSF

(This special issue belongs to the Section Animal Viruses)

Mosquito-Borne Encephalitis Viruses

edited by

John Mackenzie

Allison Imrie

and

Marietjie Venter

submission deadline 31 Oct 2025 | 9 articles | Viewed by 14447 | Submission Open

Keywords: mosquito-borne arboviruses; encephalitic togaviruses; encephalitic flaviviruses; encephalitic bunyaviruses; mosquito vectors; laboratory diagnostics; one health approaches to arbovirus ecology; arbovirus surveillance; vaccines to encephalitic arboviruses

(This special issue belongs to the Section Human Virology and Viral Diseases)

Innate and Adaptive Immune Responses to Arbovirus Infections

edited by Manuela Sales Lima Nascimento, Paulo Marcos da Matta Guedes and

Rafael Freitas de Oliveira França

submission deadline 31 Oct 2025 | 2 articles | Viewed by 5973 | Submission Open

Keywords: arbovirus; innate immunity; adaptive immunity; immunotherapeutic; immunoprophylaxis; vaccines

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

HIV-1 Infection and Immunometabolism: Relevance to HIV Pathogenesis and Persistence 3.0

edited by

Sonia Moretti

submission deadline 31 Oct 2025 | 3 articles | Viewed by 3749 | Submission Open

Keywords: immunometabolism; HIV-1; inflammation; immune activation; HIV pathogenesis; HIV latency; innate/adaptive immunity; metabolic diseases; non-AIDS-associated comorbidities

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viruses Associated with Gastroenteritis

edited by

Celso Cunha

and

Claudia Istrate

submission deadline 31 Oct 2025 | 4 articles | Viewed by 2210 | Submission Open

Keywords: vaccines; therapeutic approaches; virus replication; molecular epidemiology; immune response; microbiome; diagnosis

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Hemorrhagic Disease

edited by Joseph W. Golden and Aura R. Garrison

submission deadline 31 Oct 2025 | 3 articles | Viewed by 2184 | Submission Open

Keywords: host factors contributing to severe disease; immune correlates of protection; animal models; persistent infections; surveillance of hemorrhagic fever viruses; prophylactic and therapeutic development against hemorrhagic fever viruses

(This special issue belongs to the Section Animal Viruses)

HIV Neurological Disorders: 2nd Edition

edited by

Frank Denaro

submission deadline 31 Oct 2025 | 2 articles | Viewed by 1998 | Submission Open

Keywords: neuroinflammation; chronic HIV inflammation; HIV reservoir; HIV proteins; HIV receptors; HIV models; drugs of abuse; AIDS dementia complex; HIV noninfectious comorbidities; HIV healthcare disparities; HIV neuropathology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular Epidemiology of Re-Emerging Arboviruses: Genetics and Ecology Insights

edited by

Marta Giovanetti

submission deadline 31 Oct 2025 | 1 articles | Viewed by 1105 | Submission Open

Keywords: arboviruses; climate change; epidemic– pandemic preparedness; genomic surveillance

(This special issue belongs to the Section Animal Viruses)

Bunyaviruses 2025

edited by Natasha L. Tilston-Lunel, Kenneth A. Stapleford and Ryan F. Relich

submission deadline 31 Oct 2025 | 1 articles | Viewed by 959 | Submission Open

Keywords: bunyaviruses; viral evolution; reassortment; vector biology; pathogenesis; animal models; vaccines and therapeutics

(This special issue belongs to the Section General Virology)

Advances in Research on HIV Drug Resistance and Other Determinants of Treatment Success: 3rd Edition

edited by

Alberto Borghetti

submission deadline 31 Oct 2025 | 1 articles | Viewed by 870 | Submission Open

Keywords: HIV; antiretroviral therapies; virological failure; HIV drug resistance; HIV reservoir; HIV viral subtype; predictors of virological failure

(This special issue belongs to the Section Human Virology and Viral Diseases)

Emerging and Re-emerging Infections: Impact on Substances of Human Origin (SoHO)

edited by

Ilaria Pati

and

Simonetta Pupella

submission deadline 31 Oct 2025 | Viewed by 455 | Submission Open

Keywords: substances of human origin (SoHO); infectious diseases; emerging and re-emerging infections; transmission risk

(This special issue belongs to the Section Human Virology and Viral Diseases)

Virus Infections and Host Metabolism 2025

edited by

Kuan Rong Chan

Yaw Shin Ooi

and Liang Cui

submission deadline 31 Oct 2025 | Viewed by 285 | Submission Open

Keywords: host– virus interactions; host response to viruses; immunometabolism; viral pathogenesis; metabolic reprogramming; metabolome; metabolism; lipidomics

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

One Health Approach: Tackling the Spillover of Zoonotic Viruses from Wildlife to Humans

edited by Gilberto Sabino-Santos,

Jamie Kristine Reaser

and

Kirk Douglas

submission deadline 31 Oct 2025 | Viewed by 273 | Submission Open

Keywords: One Health; spillover; viruses; emerging viruses

(This special issue belongs to the Section Animal Viruses)

The Immunosocial Approach to Emerging and Re-Emerging Viral Infections

edited by

Yiu Wing (Jason) Kam

submission deadline 31 Oct 2025 | Viewed by 253 | Submission Open

Keywords: viral infections; immunosocial approach; public health

(This special issue belongs to the Section General Virology)

Regulation of HIV-1 Transcription and Latency, 2nd Edition

edited by Uri Mbonye

submission deadline 31 Oct 2025 | Viewed by 163 | Submission Open

Keywords: HIV provirus; HIV latency; latency reversal; HIV transcription initiation; HIV transcription elongation; transcription factors; epigenetic silencing; posttranscriptional control of HIV gene expression; transcriptomic analysis of HIV infection; HIV reservoir

(This special issue belongs to the Section Human Virology and Viral Diseases)

Vaccines and Antiviral Drugs Against Viral Diseases in Domestic Animals

edited by

Jing Zhang

submission deadline 31 Oct 2025 | Viewed by 123 | Submission Open

Keywords: vaccines; antiviral drugs; domestic animals; virus

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Influenza Viruses in Wildlife 2025

edited by

Rebecca Poulson

and Wendy Blay Puryear

submission deadline 31 Oct 2025 | Viewed by 105 | Submission Open

Keywords: avian influenza; wild birds; wildlife; influenza epidemiology; surveillance; HPAI

(This special issue belongs to the Section Animal Viruses)

Vesicular Stomatitis Virus (VSV) 2025

edited by Michael A. Whitt,

Chad Mire

, Luis L. Rodriguez and

Andrea Marzi

submission deadline 31 Oct 2025 | Viewed by 103 | Submission Open

Keywords: pathogenesis; innate immune evasion; virus– vector interactions; virus– host interactions; epidemiology; entry; assembly; replication; transcription; vaccine; oncolytic

(This special issue belongs to the Section Animal Viruses)

Enteric Viruses in Environment and Humans: Identification, Surveillance and Control

edited by

Rita De Cássia Compagnoli Carmona

and Maria Inês Zanoli Sato

submission deadline 31 Oct 2025 | Viewed by 96 | Submission Open

Keywords: enteric viruses; wastewater-based epidemiology; human-based epidemiology; One Health

(This special issue belongs to the Section Human Virology and Viral Diseases)

2nd Edition: How to Adjust the Action Steps for Achieving the Global Hepatitis Virus (HBV/HCV/HDV) Elimination Targets?

edited by Ferruccio Bonino

submission deadline 31 Oct 2025 | Viewed by 67 | Submission Open

Keywords: antivirals; chronic viral hepatitis infections; HBV; HBV; functional cure; HCV; HCV vaccine; HDV; HDV-RNA; anti-HD

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Multiscale Modeling and Forecasting of COVID-19 and Respiratory Virus Dynamics

edited by

Gerardo Chowell

and Sunmi Lee

submission deadline 31 Oct 2025 | Viewed by 39 | Submission Open

Keywords: COVID-19 modeling; respiratory virus dynamics modeling; epidemic forecasting; parameter identifiability; multiscale transmission dynamics

(This special issue belongs to the Section General Virology)

Economically Important Viruses in African Crops

edited by James Peter Legg, Stephen Winter,

Rudolph Rufini Shirima

and

Samar Sheat

submission deadline 31 Oct 2025 | Viewed by 28 | Submission Open

Keywords: economically important viruses; african crops; cassava; banana; potato; yams; beans; cowpeas; maize; cacao; tomatoes; peppers; rice yellow mottle virus; chili; okra

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Neurocognitive Dynamics and Biomarkers in HIV

edited by Mattia Trunfio and Carmela Pinnetti

submission deadline 1 Nov 2025 | 1 articles | Viewed by 514 | Submission Open

Keywords: HIV infection; neurodegeneration; biomarkers; neuroinflammation; cognitive performance; mood; central nervous system

(This special issue belongs to the Section Human Virology and Viral Diseases)

Opportunistic Viral Infections, 3rd Edition

edited by

Carlo Contini

submission deadline 7 Nov 2025 | Viewed by 44 | Submission Open

Keywords: epidemiology of opportunistic viral infections; immunocompromised individuals (HIV/AIDS; transplants; tumors; chemotherapeutics; biotechnological drugs; etc.); advances in diagnosis; management and treatment of opportunistic viral infections; JC virus; HPV; CMV; EBV and other herpesvirus; human T-cell leukemia virus type 1 (HTLV-1); hepatitis B virus (HBV) and hepatitis C virus (HCV); polyomavirus; new Coronavirus including SARS-CoV-2; emerging viruses (arbovirus other zoonotic virus)

(This special issue belongs to the Section General Virology)

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