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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tackling Viral Resistance—Advances in Mechanisms, Detection, and Control

edited by

Nuno Taveira

and Claudia Palladino

submission deadline 31 Dec 2025 | Viewed by 253 | Submission Open

Keywords: viral resistance; antiviral therapies; drug resistance mechanisms; epidemiology; diagnostic advancements; clinical management

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viral Immunology in Transplant Patients

edited by

Alessandro Perrella

submission deadline 31 Dec 2025 | Viewed by 220 | Submission Open

Keywords: viral infections; transplant patients; immunocompromised; immune response; host– pathogen interactions; immunotherapies; diagnostic approaches; preventive strategies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Modeling Zoonotic and Vector-Borne Viruses in Evolving Ecological Systems

edited by

Salihu S. Musa

, Sani Isah Abba and Ismail Abdulrashid

submission deadline 31 Dec 2025 | Viewed by 210 | Submission Open

Keywords: zoonotic viruses; vector-borne diseases; climate change and disease dynamics; epidemiological modeling; outbreak forecasting and control; human behavior; virus– host– vector interactions

(This special issue belongs to the Section Animal Viruses)

Experimental Animal and Organoid-Based Lethal Virus Infection Models for Human, Companion Animals and Livestock

edited by

Tomomi Takano

submission deadline 31 Dec 2025 | Viewed by 201 | Submission Open

Keywords: organoid models; experimental animals; lethal virus infections; pathogenesis; vaccine development; therapeutic drugs; in vitro models; in vivo models; human viral infections; companion animal viral infections; livestock viral infections; viral infection models; ferret; hamster; transgenic mouse

(This special issue belongs to the Section General Virology)

Oncogenic Infections and Cancer: Clinical Insights and Emerging Therapeutics

edited by G. Hossein Ashrafi and Mustafa Ozdogan

submission deadline 31 Dec 2025 | Viewed by 195 | Submission Open

Keywords: oncogenesis; viral oncology; bacterial oncogenesis; human papillomavirus (HPV); Epstein– Barr virus (EBV); Kaposi’ s sarcoma-associated herpesvirus (KSHV); hepatitis B virus (HBV); hepatitis C virus (HCV); human T-lymphotropic virus (HTLV-1); Helicobacter pylori; infection-driven cancers; molecular mechanisms; tumor microenvironment; immunotherapy; viral persistence; antiviral therapies; CRISPR-based treatments; cancer prevention; vaccine development; immune checkpoint inhibitors; diagnostic biomarkers; personalized medicine; translational oncology; therapeutic resistance; emerging therapeutics

(This special issue belongs to the Section Human Virology and Viral Diseases)

Picornavirus Evolution, Host Adaptation and Antiviral Strategies

edited by

Leyi Wang

submission deadline 31 Dec 2025 | Viewed by 171 | Submission Open

Keywords: virus evolution; new picornavirus; variant picornavirus; host adaptation; vaccine immunization; antiviral drugs

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Virus Infection Fate Regulation

edited by Andreas Meyerhans and

Gennady Bocharov

submission deadline 31 Dec 2025 | Viewed by 143 | Submission Open

Keywords: virus infection fate; dynamics; immune response; cellular response; regulation

(This special issue belongs to the Section General Virology)

Spotlight on Bocavirus and Other Parvoviruses, and Overlooked Respiratory Viruses

edited by

Suncanica Ljubin‐Sternak

and

Tatjana Vilibic-Cavlek

submission deadline 31 Dec 2025 | Viewed by 137 | Submission Open

Keywords: bocavirus; Parvovirus B19; canine parvovirus; porcine parvovirus; metapneumovirus; rhinovirus Planned Papers 1. Molecular detection of Porcine cytomegalovirus (PCMV) and Porcine parvovirus (PPV) in domestic pigs and wild boars from Croatia 2. Protoparvovirus carnivoran 1 outbreak in golden jackals in Croatia 3. Epidemiology of parvovirus B19 in Croatian childbearing-aged women: A ten-year seroprevalence study

(This special issue belongs to the Section Animal Viruses)

Interferon-Stimulated Genes in Antiviral Immunity

edited by

Chen Liang

submission deadline 31 Dec 2025 | Viewed by 91 | Submission Open

Keywords: interferon-stimulated genes; ISGs; non-coding RNA; viral replication; deep learning tools

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Innovative Drug Discovery for Emerging Viral Diseases, 2nd Edition

edited by Chaoping Chen

submission deadline 31 Dec 2025 | Viewed by 88 | Submission Open

Keywords: antivirals; drug discovery; high-throughput screen; SARS-CoV-2; influenza virus; RSV; zika; ebola virus; chikungunya virus; emerging/re-emerging RNA viral pathogens; host-directed therapies; immunomodulator

(This special issue belongs to the Section General Virology)

Antigenic Drift in Respiratory Viruses

edited by

Gabriel Gonzalez

submission deadline 31 Dec 2025 | Viewed by 86 | Submission Open

Keywords: respiratory viruses; virus diversity; viral recombination; reassortment; zoonotic viruses; wastewater pathogen surveillance; viral sequencing; virus evolutionary characterization; animal viruses

(This special issue belongs to the Section Human Virology and Viral Diseases)

Mechanisms of Ribozyviria Transmission in Animal and Vegetal Holobionts

edited by

Maurizia Rossana Brunetto

and Ferruccio Bonino

submission deadline 31 Dec 2025 | Viewed by 52 | Submission Open

Keywords: viroid-like RNAs; holobionts; RNA viruses; circular RNA genomes; satellite viruses; HBsAg (hepatitis b surface antigen)

(This special issue belongs to the Section General Virology)

Arboviral Diseases in Livestock

edited by

Estelle Venter

and

Antoinette Van Schalkwyk

submission deadline 15 Jan 2026 | 2 articles | Viewed by 2445 | Submission Open

Keywords: arbovirus; epidemiology; diagnostics; vaccines

(This special issue belongs to the Section Animal Viruses)

Progress and Prospects in Oncolytic Virotherapy 2025

edited by

Arianna Calistri

and

Sandra Tuyaerts

submission deadline 15 Jan 2026 | Viewed by 270 | Submission Open

Keywords: oncovirotherapy; chemotherapy; preclinical studies; clinical trials; combinatory strategy; safety profile; therapeutic efficacy; immunotherapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Phage–Antibiotic Combination Therapy

edited by

Prasanth Manohar

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1142 | Submission Open

Keywords: bacteriophage; antibiotics; phage therapy; phage– antibiotic synergy; combination therapy; in vitro study; sub-lethal dose; emerging alternative; bacteria-killing

(This special issue belongs to the Section Bacterial Viruses)

Viral Infections in Hematopoietic Stem Cell Transplant and Cellular Therapy Recipients, 2nd Edition

edited by Sanjeet Singh Dadwal

submission deadline 30 Jan 2026 | Viewed by 67 | Submission Open

Keywords: HSCT; GVHD; HHV6; CMV; adenovirus; BK and JC virus (polyomaviruses); HIV

(This special issue belongs to the Section Human Virology and Viral Diseases)

Phage Cocktails: Promising Approaches Against Infections

edited by Jin Woo Jun

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5912 | Submission Open

Keywords: phage cocktail; phage therapy; prophylaxis; infectious diseases; veterinary medicine; agriculture; food industry; zoonoses

(This special issue belongs to the Section Bacterial Viruses)

Plant Virus Spillovers

edited by

Steve Wylie

and

Nuredin Habili

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5387 | Submission Open

Keywords: spillover; emergence; replication; wild-plant virus; transmission; virus-cell interaction; vector

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

TMPRSS2 and Other Host Factors in Influenza Virus and Coronavirus Infections

edited by

Judy Wai Ping Yam

and Sze Keong Tey

submission deadline 31 Jan 2026 | 2 articles | Viewed by 5371 | Submission Open

Keywords: TMPRSS2; host factors; influenza virus; coronavirus; viral infection; treatment of viral diseases

(This special issue belongs to the Section Human Virology and Viral Diseases)

Tick-Borne Viruses: Transmission and Surveillance, 2nd Edition

edited by

Anna Papa

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4260 | Submission Open

Keywords: tick-borne viruses; transmissibility; vector competence; virulence; interactions; surveillance; discovery; replication; pathogenesis; vaccine development

(This special issue belongs to the Section Invertebrate Viruses)

Novel Strategies to Identify and Eliminate Latent HIV Cells

edited by

Francesco Andrea Procopio

submission deadline 31 Jan 2026 | 1 articles | Viewed by 3597 | Submission Open

Keywords: HIV; HIV-1 infection; antiretroviral therapy (ART); HIV single cell analysis; HIV reservoir; HIV cure

(This special issue belongs to the Section Human Virology and Viral Diseases)

SARS-CoV-2 Neutralizing Antibodies 3rd Edition

edited by Youchun Wang

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2548 | Submission Open

Keywords: SARS-CoV-2; neutralizing antibodies; neutralization assays; standards; monoclonal antibodies; vaccines; viral variants

(This special issue belongs to the Section Coronaviruses)

Role of Lectins in Viral Infections and Antiviral Intervention

edited by Yuan Guo

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2105 | Submission Open

Keywords: lectin– glycan interaction; membrane fusion; immune evasion; multivalency; glycan conjugates; lectin constructs; antivirals

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Host Defense, Viruses and Cell Death Pathways

edited by

Pascale Krejbich-Trotot

submission deadline 31 Jan 2026 | 1 articles | Viewed by 864 | Submission Open

Keywords: virus– host; programmed cell death; apoptosis; necroptosis; pyroptosis; viral factors and cell death effector interplay; oncolytic

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

HIV and Drugs of Abuse, 4th Edition

edited by

Maria Cecilia Garibaldi Marcondes

and

Marcus Kaul

submission deadline 31 Jan 2026 | 1 articles | Viewed by 735 | Submission Open

Keywords: substance use disorders; HIV; HAND; methamphetamine

(This special issue belongs to the Section Human Virology and Viral Diseases)

Long-Acting Antiretrovirals

edited by Camilla Muccini and Antonella Castagna

submission deadline 31 Jan 2026 | 1 articles | Viewed by 665 | Submission Open

Keywords: HIV infection; HIV prevention; long-acting; antiretroviral therapy; clinical studies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Emerging Controversies and Advances in Neurovirology

edited by

Karolina Akinosoglou

submission deadline 31 Jan 2026 | 1 articles | Viewed by 550 | Submission Open

Keywords: neurovirology; viral encephalitis; persistent viral infection; neuroinflammation; viral latency; oncolytic viruses; brain tumors; neurodegeneration; SARS-CoV-2; long COVID; zoonotic viruses; neural organoids; microglia activation; virus– host interactions; viral neuropathogenesis; central nervous system infections; herpesviruses; immune-mediated neurodegeneration; viral reactivation; ethical issues in neurovirology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Bornaviruses 2025: News, Gaps and Future Directions

edited by

Christiane E. Herden

submission deadline 31 Jan 2026 | Viewed by 354 | Submission Open

Keywords: bornaviruses; zoonotic; epidemiology; transmission; molecular infection mechanisms; pathogenesis; antiviral

(This special issue belongs to the Section Animal Viruses)

Emerging and Re-Emerging Plant Viruses and Vector Complexes: Advances in Characterization, Surveillance, and Mitigation

edited by

Judith K. Brown

and

Jiban Kumar Kundu

submission deadline 31 Jan 2026 | 1 articles | Viewed by 150 | Submission Open

Keywords: climate change and emerging/re-emerging virus threats; impact of virus evolution on the emerging/re-emerging virus diseases; innovative virus detection and surveillance methods; plant defense and virus resistance mechanisms responding to new outbreaks; plant defenses that respond to virus infection in lieu of extreme climate circumstances; plant virus diseases; plant– virus and/or plant– vector interactions; including tritrophic interactions; plant/crop resistance to viruses and/or arthropod vectors; strategies for management of viruses and vectors; virus– vector interactions; specific scenarios of emerging and reemerging viruses:; insect or mite-transmitted viruses of plants; seed-borne or seed-transmitted viruses of plants; soil-borne or soil-transmitted viruses; viruses infecting nursery crops and trees; water-borne or water-transmitted plant viruses

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Viral Dynamics in Aquatic Environments: Pathogens, Transmission and Impacts

edited by

Jesús L. Romalde

submission deadline 31 Jan 2026 | Viewed by 122 | Submission Open

Keywords: waterborne viruses; emerging pathogens; human and animal health; viral dynamics; viral ecology; bacteriophages; transmission

(This special issue belongs to the Section General Virology)

Viruses in the Reproductive Tract

edited by

Mimi Ghosh

Raina Nakova Fichorova

and Christina Farr

submission deadline 31 Jan 2026 | Viewed by 119 | Submission Open

Keywords: reproductive tract virome; viruses in pregnancy; virus infections and adverse fetal health; virus-associated malignancies of the reproductive tract; immune response to viruses of the reproductive tract; antiviral biomarkers; antiviral vaccines and drugs; hormonal regulation of virus infections

(This special issue belongs to the Section General Virology)

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus: 2nd Edition

edited by Tongqing An and Xingyang Cui

submission deadline 31 Jan 2026 | Viewed by 84 | Submission Open

Keywords: PRRSV; genetic evolution; replication regulation; immunological or pathogenic mechanism; vaccine development; prevention and control

(This special issue belongs to the Section Animal Viruses)

Bluetongue, Epizootic Haemorrhagic Disease, and Other Emerging Orbiviruses, 2nd Edition

edited by

Ludovic Martinelle

submission deadline 31 Jan 2026 | Viewed by 78 | Submission Open

Keywords: bluetongue; epizootic haemorrhagic disease; orbiviruses; African horse sickness; vector-borne diseases

(This special issue belongs to the Section Animal Viruses)

Congenital Cytomegalovirus Infection, 3rd Edition

edited by

Giovanni Nigro

submission deadline 31 Jan 2026 | Viewed by 75 | Submission Open

Keywords: primary cytomegalovirus infection; pregnancy; CMV screening; hyperimmune globulin; valaciclovir

(This special issue belongs to the Section Human Virology and Viral Diseases)

Antiviral Drugs and Biologics Targeting HIV: Drug Resistance to Newer Treatment and Pre-Exposure Prophylaxis (PrEP) Options: 2nd Edition

edited by

Bluma G. Brenner

submission deadline 31 Jan 2026 | Viewed by 62 | Submission Open

Keywords: HIV; antiretroviral therapy (ART); pre-exposure prophylaxis (PrEP); antiviral drugs; drug resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Cellular Immune Response to Hepatitis Viruses

edited by

Armando Andres Roca Suarez

submission deadline 31 Jan 2026 | Viewed by 53 | Submission Open

Keywords: viral hepatitis; viral/host interactions; immune response; immune evasion; immunopathogenesis; immunomodulatory therapy; pre-clinical models

(This special issue belongs to the Section Human Virology and Viral Diseases)

Rift Valley Fever Virus: New Insights into a One Health Archetype

edited by

Rebekah C. Kading

, Juliette Lewis and Brian H. Bird

submission deadline 31 Jan 2026 | Viewed by 48 | Submission Open

Keywords: One Health; emerging infectious diseases; mosquito; bunyavirus; arbovirus; medical entomology; medical countermeasures; livestock

(This special issue belongs to the Section Animal Viruses)

Baculovirus as Vaccine Vectors, RNA Interference Mediators, and Gene Delivery Vectors: 2nd Edition

edited by

Hung-Jen Liu

submission deadline 31 Jan 2026 | Viewed by 46 | Submission Open

Keywords: baculovirus; vaccine vectors; subunit vaccine; baculovirus display vectors; RNA interference mediators; gene delivery vectors

(This special issue belongs to the Section Invertebrate Viruses)

Insect-Specific Viruses and Biological Control of Arboviruses

edited by

Valéria Lima Carvalho

and

Carlos A.M. Carvalho

submission deadline 6 Feb 2026 | Viewed by 202 | Submission Open

Keywords: insect-specific virus; mosquito-specific virus; arbovirus; evolution; vaccine; biological control; interference

(This special issue belongs to the Section Invertebrate Viruses)

Infectious Disease Epidemiology: Current Updates and Perspectives

edited by

Agata Skrzat-Klapaczynska

and

Justyna Dominika Kowalska

submission deadline 10 Feb 2026 | Viewed by 41 | Submission Open

Keywords: infection prevention and control; infectious diseases epidemiology; public health; novel treatments

(This special issue belongs to the Section General Virology)

Role of Bacteriophage in Intestine Microbial Communities

edited by Yi Duan

submission deadline 15 Feb 2026 | 1 articles | Viewed by 561 | Submission Open

Keywords: bacteriophage; intestinal microbiome; virome; microbial homeostasis; phage therapy; gut ecology; intestinal dysbiosis; antimicrobial resistance; microbiome engineering; host– microbe interactions

(This special issue belongs to the Section Bacterial Viruses)

PANoptosis in Viral Infection

edited by

Thirumala-Devi Kanneganti

submission deadline 28 Feb 2026 | 4 articles | Viewed by 10337 | Submission Open

Keywords: • Viruses• Inflammation• PANoptosis• PANoptosome

(This special issue belongs to the Section General Virology)

Evolution and Adaptation of Avian Viruses

edited by

Giovanni Franzo

and

Matteo Legnardi

submission deadline 28 Feb 2026 | 6 articles | Viewed by 10129 | Submission Open

Keywords: virus; poultry; evolution; genetics; diagnosis; host; epidemiology; control; vaccine

(This special issue belongs to the Section Animal Viruses)

Viral Diseases of Domestic Animals

edited by

Scott P. Kenney

submission deadline 28 Feb 2026 | 4 articles | Viewed by 3873 | Submission Open

Keywords: viral diseases; emerging infections; domestic animals; epidemiology; pathogenesis

(This special issue belongs to the Section Animal Viruses)

Virus-Host Protein Interactions

edited by

Benoit Coulombe

submission deadline 28 Feb 2026 | 3 articles | Viewed by 3581 | Submission Open

Keywords: protein– protein interactions; antiviral drug discovery; protein target inhibitors

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Bacteriophage Diversity, 2nd Edition

edited by Bert Ely

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1306 | Submission Open

Keywords: bacteriophages phage; diversity genome; evolution; new genera; phage-host interactions

(This special issue belongs to the Section Bacterial Viruses)

Pharmacology of Antiviral Drugs, 2nd Edition

edited by

David E. Martin

submission deadline 28 Feb 2026 | 1 articles | Viewed by 763 | Submission Open

Keywords: pharmacology; clinical pharmacology; antiviral therapy; antiviral prophylaxis; human viruses; animal viruses; pharmacokinetics; pharmacodynamics; drug resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Endogenous Retrovirus Proteins and Their Functions, 2nd Edition

edited by

Benoit Barbeau

submission deadline 28 Feb 2026 | Viewed by 425 | Submission Open

Keywords: endogenous retrovirus; ERV envelope protein; receptor; cell fusion; cancer; pre-eclampsia; obstetric disorder; diagnosis; evolutionary conservation; gene regulation

(This special issue belongs to the Section Human Virology and Viral Diseases)

Synanthropy and Zoonotic Viral Spillover

edited by

João R. Mesquita

submission deadline 28 Feb 2026 | Viewed by 423 | Submission Open

Keywords: zoonoses; synanthropic interactions; virus; emergence; spillover

(This special issue belongs to the Section Animal Viruses)

Foot-and-Mouth Disease Virus

edited by