Human Adenovirus (HAdV) Infection in Children

A Special Issue of Viruses (ISSN 1999-4915) belonging to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: closed (31 July 2026) | Viewed by 1929

Editors


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Guest Editor
Lovelace Biomedical Research Institute, Albuquerque, NM 87108, USA
Interests: adenovirus; genetic variability; molecular epidemiology and pathogenesis of human adenovirus acute respiratory infections
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Immunology and Microbial Science, Scripps Research Institute, La Jolla, CA 92037, USA
Interests: virus–host receptor interactions; adenovirus structural biology; adenovirus–innate immune interactions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Adenoviruses are common pediatric pathogens causing acute respiratory illness and gastroenteritis in children under 5 years of age and are also associated with disseminated infection and disease in pediatric transplant recipients and other immunocompromised patients. In this Special Issue, we would like to showcase epidemiology studies, case reports of unusual clinical presentations and courses of disease, descriptions of novel adenoviruses detected in cases of pediatric infection, nosocomial outbreaks in neonatal or pediatric wards, and relevant studies of novel prophylactic and therapeutic intervention strategies. We welcome all paper formats, including short and regular original articles and reviews.

Prof. Dr. Adriana Kajon
Prof. Dr. Glen R. Nemerow
Guest Editors

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Keywords

  • epidemiology
  • pediatric
  • transplant recipients
  • antivirals
  • outbreak
  • acute respiratory illness
  • gastroenteritis

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Published Papers (1 paper)

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Research

15 pages, 898 KB  
Article
A Pediatric Case of Rapidly Progressing Disseminated Human Adenovirus C1 Infection with Multiorgan Failure and Evidence of Intra-Host Variation
by William Otto, Lindsey Rickerman, Maria Deza Leon, Felicia Scaggs Huang, Krithivasan Sankaranarayanan, Christopher Dandoy, Daryl M. Lamson and Adriana E. Kajon
Viruses 2026, 18(6), 607; https://doi.org/10.3390/v18060607 - 26 May 2026
Viewed by 1007
Abstract
A strain of human adenovirus type C1 was isolated from multiple anatomical compartments in a pediatric patient with late-onset Pompe disease. Over a period of 23 days from the appearance of fever and respiratory symptoms until death, disease progression was rapid with severe [...] Read more.
A strain of human adenovirus type C1 was isolated from multiple anatomical compartments in a pediatric patient with late-onset Pompe disease. Over a period of 23 days from the appearance of fever and respiratory symptoms until death, disease progression was rapid with severe disseminated disease and complications that included respiratory distress, liver failure, cardiac dysfunction, and hemophagocytic lymphohistiocytosis. Detected viral DNAemia peaked at log10 9.52 copies/mL on the last hospitalization day. Next-generation whole-genome sequencing with depth > 2700 reads/position identified the virus as closely related to the prototype strain Adenoid 71 isolated in the US in 1953, and to strains circulating worldwide in recent years. Sequence data analysis revealed the presence of intra-host single nucleotide variants (iSNV) at low frequency in the isolates recovered from a nasopharyngeal swab, blood, urine, and stool specimens obtained during the last three days of life and from lung, liver, and kidney tissue obtained at autopsy. Evidence of iSNVs was found in only three coding regions (E1A, DNA polymerase, and pVII). Different variant combinations were found in different anatomical compartments. The contribution of intrahost genetic diversity to HAdV-associated disease development and progression warrants investigation. Full article
(This article belongs to the Special Issue Human Adenovirus (HAdV) Infection in Children)
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