Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.7
3.5
Journals
Viruses
Special Issues
Zika Virus and Congenital Zika Syndrome, 2nd Edition
share announcement

Zika Virus and Congenital Zika Syndrome, 2nd Edition

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 2137

Special Issue Editors

Dr. Marcos Vinicius da Silva Pone

E-Mail Website
Guest Editor
National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz Foundation (IFF-Fiocruz), Rio de Janeiro 22250-020, BR, Brazil
Interests: Zika virus; congenital Zika syndrome; congenital infections
Dr. Sheila Moura Pone

E-Mail Website
Guest Editor
National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz Foundation (IFF-Fiocruz), Rio de Janeiro 22250-020, BR, Brazil
Interests: dengue; Zika virus; congenital Zika syndrome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Zika virus (ZIKV) infection became a global public health concern when a sudden increase in cases of microcephaly and other congenital anomalies was reported during an epidemic in Brazil from 2015 to 2016, and has triggered intensive research into many areas related to their transmission dynamics, pathogenesis, and description of the specific pattern of birth defects. Research over the past few years has explored many aspects of congenital Zika syndrome; however, our current understanding of the range of adverse impacts of intrauterine ZIKV infection, the disease’s natural history, and outcomes in children is still limited.

In this Special Issue, we welcome a wide range of articles, including original research, short communications, and reviews related to all aspects of Zika virus infection and congenital Zika syndrome. Specifically, we encourage investigations related to epidemiology, viral transmission, pathogenesis, molecular pathology, clinical presentation, and improvements in diagnostics, outcomes, and vaccine development, although other relevant topics are also welcome.

We look forward to receiving your contributions to this Special Issue.

Dr. Marcos Vinicius da Silva Pone
Dr. Sheila Moura Pone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • viral infections
  • Zika virus
  • congenital Zika syndrome

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 708 KB  
Article
Long-Term Nutritional Deficits and Growth Patterns in Children with Congenital Zika Virus Syndrome: Evidence from a Brazilian Cohort
by Carolina Santos Souza Tavares, Raquel Souza Marques, Janiele de Sá Ferreira, Marcela Barros Barbosa de Oliveira, Monique Carla da Silva Reis and Paulo Ricardo Martins-Filho
Viruses 2025, 17(9), 1239; https://doi.org/10.3390/v17091239 - 14 Sep 2025
Viewed by 752
Abstract
Children with Congenital Zika Virus Syndrome (CZVS) experience severe neurological and nutritional impairments. Although immediate clinical consequences are well-documented, long-term anthropometric and nutritional outcomes remain poorly understood. This study assessed longitudinal anthropometric and nutritional outcomes in children affected by CZVS. A cohort of [...] Read more.
Children with Congenital Zika Virus Syndrome (CZVS) experience severe neurological and nutritional impairments. Although immediate clinical consequences are well-documented, long-term anthropometric and nutritional outcomes remain poorly understood. This study assessed longitudinal anthropometric and nutritional outcomes in children affected by CZVS. A cohort of 38 children aged ≥ 5 years diagnosed with CZVS was followed at a reference center in Northeast Brazil. Anthropometric measures (weight, height, BMI, head circumference) were collected using standardized methods, including digital scales and anthropometric tape measures. Growth was analyzed using WHO Anthro and WHO Anthro Plus software (version 3.2.2). Dietary intake was evaluated through two 24 h recalls and analyzed with NutWIN 2.5 software. Nutritional status was classified using WHO growth standards, and associations between dietary intake and BMI were statistically examined. Children showed significant linear growth improvement (p = 0.007) without corresponding weight gain, leading to worsening BMI classifications (p = 0.017). Dietary evaluations revealed limited dietary diversity, frequent intake of ultra-processed foods, inadequate fruit consumption, and widespread insufficiencies in caloric and micronutrient intake (zinc, calcium, iron, vitamin D). Low carbohydrate intake was significantly associated with inadequate BMI (p = 0.030). Multidisciplinary nutritional interventions addressing medical, dietary, educational, and socioeconomic factors are essential for improving health outcomes in children with CZVS. Full article
(This article belongs to the Special Issue Zika Virus and Congenital Zika Syndrome, 2nd Edition)
►▼ Show Figures

Figure 1

28 pages, 4081 KB  
Article
Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model
by Hannah K. Jaeger, Jessica L. Smith, Christopher J. Parkins, Nicole N. Haese, Craig N. Kreklywich, Michael Denton, Caralyn S. Labriola, Michael K. Axthelm, Aaron Barber-Axthelm, Kim Chun, Tonya Swanson, Rahul J. D’Mello, Terry K. Morgan, Duncan R. Smith, Jamie O. Lo, Alec J. Hirsch, Victoria H. J. Roberts and Daniel N. Streblow
Viruses 2025, 17(6), 762; https://doi.org/10.3390/v17060762 - 27 May 2025
Viewed by 1116
Abstract
Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due [...] Read more.
Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due to villous damage and uterine vasculitis in a nonhuman primate model. To investigate whether this type of damage occurs with endemically circulating strains in Thailand, we investigated a CZS case isolate, MU1-2017 (ZIKV-TH), in pregnant rhesus macaques. Pregnant animals (n = 3 per group) were infected subcutaneously with either ZIKV-PR or ZIKV-TH at ~50 days gestation (GD) and monitored for 40 days post-infection (GD90). Similar courses of viremia and immune activation were observed for both viruses when compared to uninfected controls. In addition, both viruses induced changes to the placental architecture, including spiral artery remodeling and the development of infarctions. Similar levels of viral RNA were detected at necropsy in maternal and fetal tissues. Overall, our results show that the ZIKV-TH strain MU1-2017 behaves similarly to the ZIKV-PR strain, and, importantly, provide evidence of in-utero infection with an additional contemporary strain of ZIKV. Full article
(This article belongs to the Special Issue Zika Virus and Congenital Zika Syndrome, 2nd Edition)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop