Zika Virus and Congenital Zika Syndrome, 2nd Edition

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 525

Special Issue Editors


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Guest Editor
National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz Foundation (IFF-Fiocruz), Rio de Janeiro 22250-020, BR, Brazil
Interests: Zika virus; congenital Zika syndrome; congenital infections

E-Mail Website
Guest Editor
National Institute of Women, Children and Adolescents Health Fernandes Figueira, Oswaldo Cruz Foundation (IFF-Fiocruz), Rio de Janeiro 22250-020, BR, Brazil
Interests: dengue; Zika virus; congenital Zika syndrome
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Special Issue Information

Dear Colleagues,

Zika virus (ZIKV) infection became a global public health concern when a sudden increase in cases of microcephaly and other congenital anomalies was reported during an epidemic in Brazil from 2015 to 2016, and has triggered intensive research into many areas related to their transmission dynamics, pathogenesis, and description of the specific pattern of birth defects. Research over the past few years has explored many aspects of congenital Zika syndrome; however, our current understanding of the range of adverse impacts of intrauterine ZIKV infection, the disease’s natural history, and outcomes in children is still limited.

In this Special Issue, we welcome a wide range of articles, including original research, short communications, and reviews related to all aspects of Zika virus infection and congenital Zika syndrome. Specifically, we encourage investigations related to epidemiology, viral transmission, pathogenesis, molecular pathology, clinical presentation, and improvements in diagnostics, outcomes, and vaccine development, although other relevant topics are also welcome.

We look forward to receiving your contributions to this Special Issue.

Dr. Marcos Vinicius da Silva Pone
Dr. Sheila Moura Pone
Guest Editors

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Keywords

  • viral infections
  • Zika virus
  • congenital Zika syndrome

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Published Papers (1 paper)

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Research

28 pages, 4081 KiB  
Article
Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model
by Hannah K. Jaeger, Jessica L. Smith, Christopher J. Parkins, Nicole N. Haese, Craig N. Kreklywich, Michael Denton, Caralyn S. Labriola, Michael K. Axthelm, Aaron Barber-Axthelm, Kim Chun, Tonya Swanson, Rahul J. D’Mello, Terry K. Morgan, Duncan R. Smith, Jamie O. Lo, Alec J. Hirsch, Victoria H. J. Roberts and Daniel N. Streblow
Viruses 2025, 17(6), 762; https://doi.org/10.3390/v17060762 - 27 May 2025
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Abstract
Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due [...] Read more.
Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due to villous damage and uterine vasculitis in a nonhuman primate model. To investigate whether this type of damage occurs with endemically circulating strains in Thailand, we investigated a CZS case isolate, MU1-2017 (ZIKV-TH), in pregnant rhesus macaques. Pregnant animals (n = 3 per group) were infected subcutaneously with either ZIKV-PR or ZIKV-TH at ~50 days gestation (GD) and monitored for 40 days post-infection (GD90). Similar courses of viremia and immune activation were observed for both viruses when compared to uninfected controls. In addition, both viruses induced changes to the placental architecture, including spiral artery remodeling and the development of infarctions. Similar levels of viral RNA were detected at necropsy in maternal and fetal tissues. Overall, our results show that the ZIKV-TH strain MU1-2017 behaves similarly to the ZIKV-PR strain, and, importantly, provide evidence of in-utero infection with an additional contemporary strain of ZIKV. Full article
(This article belongs to the Special Issue Zika Virus and Congenital Zika Syndrome, 2nd Edition)
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