Nuclear Architecture in Viral Infection
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 14
Special Issue Editors
Interests: human cytomegalovirus
Special Issue Information
Dear Colleagues,
Viruses have evolved extraordinary mechanisms to hijack cellular processes and create environments that enable virus replication. From utilizing the cell’s transcriptional and translational machinery to remodeling membranes and organelles to use as platforms for viral assembly, viruses have devised strategies to co-opt various components of the cell, including the nucleus. Our understanding of nuclear structure has expanded beyond the simple model consisting of the chromatin, lamina, nuclear pores, and nuclear membrane; we now know that the nucleus is a highly dynamic organelle that also contains distinct, functionally specialized substructures maintained by liquid–liquid phase separation (LLPS) and a nucleoskeleton that responds to extracellular cues and effects changes in gene expression. Viruses that replicate in the nucleus must manipulate its architecture, which can act as both a scaffold and a barrier to the production of viral progeny. In addition, viruses that replicate in the cytoplasm can target subnuclear structures, such as PML bodies and nucleoli, to counter innate defenses and DNA damage responses, respectively.
This Special Issue will focus on the interactions between viruses and nuclear architecture and how they can promote viral transcription, replication, and assembly or facilitate the persistence of the viral genome during latency.
Dr. Veronica Sanchez
Dr. Elizabeth White
Guest Editors
Manuscript Submission Information
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Keywords
- nuclear architecture
- viral transcription
- viral replication
- viral assembly
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