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Viruses
Special Issues
Coronavirus Pathogenesis and Virus-Host Interaction
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Coronavirus Pathogenesis and Virus-Host Interaction

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1449

Special Issue Editor

Dr. Hin Chu

E-Mail Website
Guest Editor
State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong
Interests: viral pathogenesis; virus-host interactions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Seven coronaviruses have been identified to infect humans. SARS-CoV-1, MERS-CoV, and SARS-CoV-2 are highly pathogenic coronaviruses that may result in severe pneumonia and cause lethal outcomes. In contrast, HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1 are recognized as common cold coronaviruses that have been circulating in humans. Exposure to these common cold coronaviruses, in general, results in mild upper-respiratory tract infections. Recently, Hu-PDCoV and CCoV-HuPn-2018 were reported in humans but their virological characteristics remain largely unknown. The frequent coronavirus spillover to humans indicates an alarming possibility of the emergence of future zoonotic coronaviruses. Despite global efforts on coronavirus research, multiple aspects of the mechanism of coronavirus pathogenesis and virus–host interaction remain largely unexplained or unsolved. (1) What are the underlying mechanisms of the differential pathogenicity of coronaviruses? (2) Are there additional host factors that facilitate coronavirus infection or replication? (3) Are there better vaccines or therapeutic strategies to better prevent and/or treat coronaviruses? (4) Are there lessons that we can learn from COVID-19 that better prepare us for the next coronavirus pandemic?

This Special Issue invites all types of manuscripts including reviews, research articles, and short communications. Through this collection of articles, we hope that we can advance our knowledge on coronaviruses so that we can better prepare for the next coronavirus pandemic together.

Dr. Hin Chu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • COVID-19
  • SARS-CoV-2
  • SARS-CoV-1
  • MERS-CoV
  • pathogenesis
  • virus–host interaction
  • virus entry
  • host factors
  • animal models
  • SARS-CoV-2 variants

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Published Papers (1 paper)

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Review

23 pages, 704 KiB  
Review
Animal Models for Human-Pathogenic Coronavirus and Animal Coronavirus Research
by Fenglian Xiao, Jincheng Hu, Minsheng Xu, Di Wang, Xiaoyan Shen, Hua Zhang, Jie Miao, Haodong Cai, Jihui Wang, Yaqing Liu, Shan Xiao and Longchao Zhu
Viruses 2025, 17(1), 100; https://doi.org/10.3390/v17010100 - 14 Jan 2025
Viewed by 1276
Abstract
Coronavirus epidemics have posed a serious threat to both human and animal health. To combat emerging infectious diseases caused by coronaviruses, various animal infection models have been developed and applied in research, including non-human primate models, ferret models, hamster models, mouse models, and [...] Read more.
Coronavirus epidemics have posed a serious threat to both human and animal health. To combat emerging infectious diseases caused by coronaviruses, various animal infection models have been developed and applied in research, including non-human primate models, ferret models, hamster models, mouse models, and others. Moreover, new approaches have been utilized to develop animal models that are more susceptible to infection. These approaches include using viral delivery methods to induce the expression of viral receptors in mouse tissues and employing gene-editing techniques to create genetically modified mice. This has led to the successful establishment of infection models for multiple coronaviruses, significantly advancing related research. In contrast, livestock and pets that can be infected by animal coronaviruses provide valuable insights when used as infection models, enabling the collection of accurate clinical data through the analysis of post-infection pathological features. However, despite the potential insights, there is a paucity of research data pertaining to these infection models. In this review, we provide a detailed overview of recent progress in the development of animal models for coronaviruses that cause diseases in both humans and animals and suggest ways in which animal models can be adapted to further enhance their value in research. Full article
(This article belongs to the Special Issue Coronavirus Pathogenesis and Virus-Host Interaction)
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