HIV and Aging
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 48
Special Issue Editor
Interests: aging in HIV; chronic inflammation and immune activation; hallmarks of aging; long-term complications of antiretroviral therapy; new models of care; strategies for healthy aging in HIV
Special Issue Information
Dear Colleagues,
With the remarkable success of antiretroviral therapy (ART), HIV infection has transformed from a rapidly fatal disease into a manageable chronic condition. As a result, people with HIV (PWH) are now living longer, leading to an increasing prevalence of age-related comorbidities and an accelerated aging phenotype. This demographic shift presents unique challenges in understanding the complex interplay between HIV, ART, and the aging process.
In this Special Issue, we aim to explore the latest advancements in research concerning HIV and aging. We will focus on, but are not limited to, the following areas:
- Mechanisms of accelerated and accentuated aging in PWH: Chronic inflammation, immune senescence, and other hallmarks of aging.
- Non-AIDS-defining comorbidities: Such as cardiovascular disease, metabolic disorders, renal dysfunction, neurocognitive impairment, tumors, and bone disease in the context of HIV and aging.
- The impact of ART on aging: Long-term toxicities, drug–drug interactions, and the optimization of ART regimens for older PLWH.
- Immunological changes with age in HIV infection: T-cell and B-cell dysfunction, altered vaccine responses, and chronic immune activation.
- Novel therapeutic strategies: Interventions to mitigate accelerated aging and age-related comorbidities in PLWH.
- Optimizing follow-up strategies: Tailoring clinical guidelines and monitoring protocols to address the unique health needs and increased complexity of older PLWH, including screening for age-associated comorbidities and geriatric syndromes.
- The role of multidisciplinary teams: Emphasizing the importance of collaborative efforts involving HIV specialists, geriatricians, cardiologists, and neurologists in providing comprehensive and holistic care for older individuals living with HIV.
We welcome original research articles, comprehensive review articles, and concise short communications that contribute to a deeper understanding of these critical issues.
Dr. Eugenia Negredo
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- HIV and aging
- accelerated and accentuated aging
- immune senescence
- inflammation
- comorbidities
- geriatric syndromes
- neurocognitive function
- functional status
- antiretroviral therapy
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