Porcine Virus–Host Interactions: Entry, Tropism, Immune Evasion and Control

Dear Colleagues,

Porcine viruses impose substantial health and economic burdens on swine production and raise important One Health considerations. This Special Issue, ‘Porcine Virus–Host Interactions: Entry, Tropism, Immune Evasion and Control,’ invites studies that elucidate how porcine viruses attach and enter cells, establish tissue and cell tropism, subvert cellular machinery, evade innate and adaptive immunity, and how swine viral infections can be controlled through vaccination, antivirals, immunomodulation, and management strategies.

We encourage diverse approaches across molecular and cellular virology, structural biology, immunology, multi-omics (genomics, transcriptomics, proteomics, lipidomics, glycomics), single-cell and spatial analyses, CRISPR and other functional-genomics screens, organoid/air–liquid interface and ex vivo systems, in vivo challenge studies, epidemiology, and modeling. Advanced imaging—including live-cell, super-resolution, EM/CLEM, and in situ mapping—is also welcome as a complementary approach to dissect entry, replication, assembly, egress, and virus-induced organelles. Submissions may address major swine pathogens (e.g., PRRSV, IAV-S, ASFV, PEDV/PDCoV, PCV2/3, CSFV, PRV) and related zoonotic interfaces.

Topics of interest include (non-exhaustive) the following:

• Receptors/co-receptors, endocytosis, membrane fusion, uncoating, and entry routes
• Determinants of tissue/cell tropism and within-host spread.
• Immune evasion (e.g., interferon antagonism, PRR signaling, antigenic variation) and host restriction factors.
• Systems virology and network biology; single-cell/spatial readouts and within-host dynamics.
• Imaging of entry/replication/assembly/egress and virus-induced organelles/viral factories.
• Vaccines (including mucosal and DIVA concepts), antivirals, monoclonals, and host-directed therapies.
• Diagnostics, surveillance, outbreak investigation, and integrated control strategies.

We welcome Original Research Articles, Reviews, Communications/Brief Reports, and Technical Notes. All submissions will undergo single-blind peer review; please consult Viruses “Instructions for Authors” for details.

Prof. Dr. Levon Abrahamyan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.