Rodent-Borne Viruses 2025

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 2236

Special Issue Editors


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Guest Editor
Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro 21040-900, Brazil
Interests: hantavirus; rodent-borne diseases; hantavirus pulmonary syndrome
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro 21040-900, Brazil
Interests: arenavirus; rodent-borne diseases; viral hemorrhagic fevers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Rodents (order Rodentia) represent the most diverse and geographically widespread group of mammals, playing vital roles in the maintenance, evolution, and spread of many emerging viral infectious diseases. These animals are increasingly in contact with humans and domestic animals as a result of several factors, such as natural disasters, human interventions in natural environments, high population growth, and mass migrations, among others. Knowledge of the diversity and distribution of these mammals and the host–virus interactions is essential to understanding the ecology of zoonotic diseases and thereby preventing and controlling new outbreaks. A wide range of new rodent-associated viruses has been discovered in recent years, with or without zoonotic potential, including members of the Arenaviridae, Hantaviridae, and Poxviridae families.

This Special Issue aims to cover the whole spectrum of research focused on rodent-borne viruses, including eco-epidemiological studies; descriptions of new viruses; studies on virus–host interactions, co-infections, and involved viral and cellular factors; studies on the ecological processes involved in virus diversity and host adaptation; viral evolutionary aspects; and research on the spillover from infected rodent species to humans and animal models for studying rodent-borne viruses.

Dr. Renata Carvalho De Oliveira
Dr. Jorlan Fernandes
Guest Editors

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Keywords

  • rodent-borne viruses
  • hantaviridae
  • arenaviridae
  • poxviridae
  • zoonosis
  • virus ecology and evolution
  • virus–host interaction
  • virus discovery
  • animal model
  • rodents

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Published Papers (1 paper)

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Review

27 pages, 4146 KiB  
Review
The Hidden Threat: Rodent-Borne Viruses and Their Impact on Public Health
by Awad A. Shehata, Rokshana Parvin, Shadia Tasnim, Phelipe Magalhães Duarte, Alfonso J. Rodriguez-Morales and Shereen Basiouni
Viruses 2025, 17(6), 809; https://doi.org/10.3390/v17060809 - 2 Jun 2025
Viewed by 1821
Abstract
Rodents represent the most diverse order of mammals, comprising over 2200 species and nearly 42% of global mammalian biodiversity. They are major reservoirs of zoonotic pathogens, including viruses, bacteria, protozoa, and fungi, and are particularly effective at transmitting diseases, especially synanthropic species that [...] Read more.
Rodents represent the most diverse order of mammals, comprising over 2200 species and nearly 42% of global mammalian biodiversity. They are major reservoirs of zoonotic pathogens, including viruses, bacteria, protozoa, and fungi, and are particularly effective at transmitting diseases, especially synanthropic species that live in close proximity to humans. As of April 2025, approximately 15,205 rodent-associated viruses have been identified across 32 viral families. Among these, key zoonotic agents belong to the Arenaviridae, Hantaviridae, Picornaviridae, Coronaviridae, and Poxviridae families. Due to their adaptability to both urban and rural environments, rodents serve as efficient vectors across diverse ecological landscapes. Environmental and anthropogenic factors, such as climate change, urbanization, deforestation, and emerging pathogens, are increasingly linked to rising outbreaks of rodent-borne diseases. This review synthesizes current knowledge on rodent-borne viral zoonoses, focusing on their taxonomy, biology, host associations, transmission dynamics, clinical impact, and public health significance. It underscores the critical need for early detection, effective surveillance, and integrated control strategies. A multidisciplinary approach, including enhanced vector control, improved environmental sanitation, and targeted public education, is essential for mitigating the growing threat of rodent-borne zoonoses to global health. Full article
(This article belongs to the Special Issue Rodent-Borne Viruses 2025)
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