Congenital Cytomegalovirus Infection, 3rd Edition

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 18

Special Issue Editor


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Guest Editor
President of the Non-Profit Association Mother-Infant Cytomegalovirus Infection (CMV-AMICI), Rome, Italy
Interests: primary cytomegalovirus infection; pregnancy; CMV screening; hyperimmune globulin; antiviral strategies
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Special Issue Information

Dear Colleagues,

The relevance of congenital cytomegalovirus (CMV) infection has been well known for more than 50 years. However, this virus is still a major cause of severe and permanent disabilities in children, mostly after primary maternal infection, and it is associated with severe neurological and hearing sequelae, which may appear during pregnancy, at birth, or years after birth. Hygienic measures can prevent CMV transmission, which mainly occurs following contact with children under 3 years of age when attending a nursery or daycare. In animal and human pregnancies, many studies have been conducted on the prevention of congenital CMV infection and disease using CMV-specific hyper immune globulin (HIG). A recent study has shown that high-dosage valaciclovir appears to be capable of lowering the rates of congenital infection and disease. The implementation of CMV screening can enable primary prevention via hygiene counseling, an improvement in the understanding and awareness of congenital CMV infection, and an increase in our knowledge on the potential efficacy of preventive or therapeutic HIG or valaciclovir administration.

Our aim in launching this Special Issue of Viruses is to compile the newest contributions on the prevention of congenital CMV infection and disease.

Prof. Dr. Giovanni Nigro
Guest Editor

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Keywords

  • primary cytomegalovirus infection
  • pregnancy
  • CMV screening
  • hyperimmune globulin
  • valaciclovir

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