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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Oncogenic Infections and Cancer: Clinical Insights and Emerging Therapeutics

edited by G. Hossein Ashrafi and Mustafa Ozdogan

submission deadline 31 Dec 2025 | Viewed by 144 | Submission Open

Keywords: oncogenesis; viral oncology; bacterial oncogenesis; human papillomavirus (HPV); Epstein– Barr virus (EBV); Kaposi’ s sarcoma-associated herpesvirus (KSHV); hepatitis B virus (HBV); hepatitis C virus (HCV); human T-lymphotropic virus (HTLV-1); Helicobacter pylori; infection-driven cancers; molecular mechanisms; tumor microenvironment; immunotherapy; viral persistence; antiviral therapies; CRISPR-based treatments; cancer prevention; vaccine development; immune checkpoint inhibitors; diagnostic biomarkers; personalized medicine; translational oncology; therapeutic resistance; emerging therapeutics

(This special issue belongs to the Section Human Virology and Viral Diseases)

Picornavirus Evolution, Host Adaptation and Antiviral Strategies

edited by

Leyi Wang

submission deadline 31 Dec 2025 | Viewed by 140 | Submission Open

Keywords: virus evolution; new picornavirus; variant picornavirus; host adaptation; vaccine immunization; antiviral drugs

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Virus Infection Fate Regulation

edited by Andreas Meyerhans and

Gennady Bocharov

submission deadline 31 Dec 2025 | Viewed by 126 | Submission Open

Keywords: virus infection fate; dynamics; immune response; cellular response; regulation

(This special issue belongs to the Section General Virology)

Spotlight on Bocavirus and Other Parvoviruses, and Overlooked Respiratory Viruses

edited by

Suncanica Ljubin‐Sternak

and

Tatjana Vilibic-Cavlek

submission deadline 31 Dec 2025 | Viewed by 90 | Submission Open

Keywords: bocavirus; Parvovirus B19; canine parvovirus; porcine parvovirus; metapneumovirus; rhinovirus Planned Papers 1. Molecular detection of Porcine cytomegalovirus (PCMV) and Porcine parvovirus (PPV) in domestic pigs and wild boars from Croatia 2. Protoparvovirus carnivoran 1 outbreak in golden jackals in Croatia 3. Epidemiology of parvovirus B19 in Croatian childbearing-aged women: A ten-year seroprevalence study

(This special issue belongs to the Section Animal Viruses)

Innovative Drug Discovery for Emerging Viral Diseases, 2nd Edition

edited by Chaoping Chen

submission deadline 31 Dec 2025 | Viewed by 64 | Submission Open

Keywords: antivirals; drug discovery; high-throughput screen; SARS-CoV-2; influenza virus; RSV; zika; ebola virus; chikungunya virus; emerging/re-emerging RNA viral pathogens; host-directed therapies; immunomodulator

(This special issue belongs to the Section General Virology)

Antigenic Drift in Respiratory Viruses

edited by

Gabriel Gonzalez

submission deadline 31 Dec 2025 | Viewed by 63 | Submission Open

Keywords: respiratory viruses; virus diversity; viral recombination; reassortment; zoonotic viruses; wastewater pathogen surveillance; viral sequencing; virus evolutionary characterization; animal viruses

(This special issue belongs to the Section Human Virology and Viral Diseases)

Interferon-Stimulated Genes in Antiviral Immunity

edited by

Chen Liang

submission deadline 31 Dec 2025 | Viewed by 62 | Submission Open

Keywords: interferon-stimulated genes; ISGs; non-coding RNA; viral replication; deep learning tools

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Animal Virus Discovery and Genetic Diversity: 2nd Edition

edited by

Ryan Troyer

submission deadline 31 Dec 2025 | Viewed by 47 | Submission Open

Keywords: animal virus; evolution; genetic; diversity; richness; emerging viruses; virome; metagenomics; ecology; cross-species transmission; zoonotic

(This special issue belongs to the Section Animal Viruses)

Mechanisms of Ribozyviria Transmission in Animal and Vegetal Holobionts

edited by

Maurizia Rossana Brunetto

and Ferruccio Bonino

submission deadline 31 Dec 2025 | Viewed by 19 | Submission Open

Keywords: viroid-like RNAs; holobionts; RNA viruses; circular RNA genomes; satellite viruses; HBsAg (hepatitis b surface antigen)

(This special issue belongs to the Section General Virology)

Progress and Prospects in Oncolytic Virotherapy 2025

edited by

Arianna Calistri

and

Sandra Tuyaerts

submission deadline 15 Jan 2026 | Viewed by 151 | Submission Open

Keywords: oncovirotherapy; chemotherapy; preclinical studies; clinical trials; combinatory strategy; safety profile; therapeutic efficacy; immunotherapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Phage–Antibiotic Combination Therapy

edited by

Prasanth Manohar

submission deadline 20 Jan 2026 | Viewed by 529 | Submission Open

Keywords: bacteriophage; antibiotics; phage therapy; phage– antibiotic synergy; combination therapy; in vitro study; sub-lethal dose; emerging alternative; bacteria-killing

(This special issue belongs to the Section Bacterial Viruses)

Viral Infections in Hematopoietic Stem Cell Transplant and Cellular Therapy Recipients, 2nd Edition

edited by Sanjeet Singh Dadwal

submission deadline 30 Jan 2026 | Viewed by 29 | Submission Open

Keywords: HSCT; GVHD; HHV6; CMV; adenovirus; BK and JC virus (polyomaviruses); HIV

(This special issue belongs to the Section Human Virology and Viral Diseases)

Phage Cocktails: Promising Approaches Against Infections

edited by Jin Woo Jun

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5383 | Submission Open

Keywords: phage cocktail; phage therapy; prophylaxis; infectious diseases; veterinary medicine; agriculture; food industry; zoonoses

(This special issue belongs to the Section Bacterial Viruses)

Tick-Borne Viruses: Transmission and Surveillance, 2nd Edition

edited by

Anna Papa

submission deadline 31 Jan 2026 | 1 articles | Viewed by 3394 | Submission Open

Keywords: tick-borne viruses; transmissibility; vector competence; virulence; interactions; surveillance; discovery; replication; pathogenesis; vaccine development

(This special issue belongs to the Section Invertebrate Viruses)

Role of Lectins in Viral Infections and Antiviral Intervention

edited by Yuan Guo

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1511 | Submission Open

Keywords: lectin– glycan interaction; membrane fusion; immune evasion; multivalency; glycan conjugates; lectin constructs; antivirals

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Host Defense, Viruses and Cell Death Pathways

edited by

Pascale Krejbich-Trotot

submission deadline 31 Jan 2026 | 1 articles | Viewed by 725 | Submission Open

Keywords: virus– host; programmed cell death; apoptosis; necroptosis; pyroptosis; viral factors and cell death effector interplay; oncolytic

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

HIV and Drugs of Abuse, 4th Edition

edited by

Maria Cecilia Garibaldi Marcondes

and

Marcus Kaul

submission deadline 31 Jan 2026 | 1 articles | Viewed by 405 | Submission Open

Keywords: substance use disorders; HIV; HAND; methamphetamine

(This special issue belongs to the Section Human Virology and Viral Diseases)

Bornaviruses 2025: News, Gaps and Future Directions

edited by

Christiane E. Herden

submission deadline 31 Jan 2026 | Viewed by 288 | Submission Open

Keywords: bornaviruses; zoonotic; epidemiology; transmission; molecular infection mechanisms; pathogenesis; antiviral

(This special issue belongs to the Section Animal Viruses)

Long-Acting Antiretrovirals

edited by Camilla Muccini and Antonella Castagna

submission deadline 31 Jan 2026 | Viewed by 278 | Submission Open

Keywords: HIV infection; HIV prevention; long-acting; antiretroviral therapy; clinical studies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Dynamics in Aquatic Environments: Pathogens, Transmission and Impacts

edited by

Jesús L. Romalde

submission deadline 31 Jan 2026 | Viewed by 88 | Submission Open

Keywords: waterborne viruses; emerging pathogens; human and animal health; viral dynamics; viral ecology; bacteriophages; transmission

(This special issue belongs to the Section General Virology)

Emerging and Re-Emerging Plant Viruses and Vector Complexes: Advances in Characterization, Surveillance, and Mitigation

edited by

Judith K. Brown

and

Jiban Kumar Kundu

submission deadline 31 Jan 2026 | Viewed by 79 | Submission Open

Keywords: climate change and emerging/re-emerging virus threats; impact of virus evolution on the emerging/re-emerging virus diseases; innovative virus detection and surveillance methods; plant defense and virus resistance mechanisms responding to new outbreaks; plant defenses that respond to virus infection in lieu of extreme climate circumstances; plant virus diseases; plant– virus and/or plant– vector interactions; including tritrophic interactions; plant/crop resistance to viruses and/or arthropod vectors; strategies for management of viruses and vectors; virus– vector interactions; specific scenarios of emerging and reemerging viruses:; insect or mite-transmitted viruses of plants; seed-borne or seed-transmitted viruses of plants; soil-borne or soil-transmitted viruses; viruses infecting nursery crops and trees; water-borne or water-transmitted plant viruses

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Emerging Controversies and Advances in Neurovirology

edited by

Karolina Akinosoglou

submission deadline 31 Jan 2026 | 1 articles | Viewed by 78 | Submission Open

Keywords: neurovirology; viral encephalitis; persistent viral infection; neuroinflammation; viral latency; oncolytic viruses; brain tumors; neurodegeneration; SARS-CoV-2; long COVID; zoonotic viruses; neural organoids; microglia activation; virus– host interactions; viral neuropathogenesis; central nervous system infections; herpesviruses; immune-mediated neurodegeneration; viral reactivation; ethical issues in neurovirology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Bluetongue, Epizootic Haemorrhagic Disease, and Other Emerging Orbiviruses, 2nd Edition

edited by

Ludovic Martinelle

submission deadline 31 Jan 2026 | Viewed by 56 | Submission Open

Keywords: bluetongue; epizootic haemorrhagic disease; orbiviruses; African horse sickness; vector-borne diseases

(This special issue belongs to the Section Animal Viruses)

Congenital Cytomegalovirus Infection, 3rd Edition

edited by

Giovanni Nigro

submission deadline 31 Jan 2026 | Viewed by 39 | Submission Open

Keywords: primary cytomegalovirus infection; pregnancy; CMV screening; hyperimmune globulin; valaciclovir

(This special issue belongs to the Section Human Virology and Viral Diseases)

Antiviral Drugs and Biologics Targeting HIV: Drug Resistance to Newer Treatment and Pre-Exposure Prophylaxis (PrEP) Options 2.0

edited by

Bluma G. Brenner

submission deadline 31 Jan 2026 | Viewed by 34 | Submission Open

Keywords: HIV; antiretroviral therapy (ART); pre-exposure prophylaxis (PrEP); antiviral drugs; drug resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Baculovirus as Vaccine Vectors, RNA Interference Mediators, and Gene Delivery Vectors: 2nd Edition

edited by

Hung-Jen Liu

submission deadline 31 Jan 2026 | Viewed by 28 | Submission Open

Keywords: baculovirus; vaccine vectors; subunit vaccine; baculovirus display vectors; RNA interference mediators; gene delivery vectors

(This special issue belongs to the Section Invertebrate Viruses)

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus: 2nd Edition

edited by Tongqing An and Xingyang Cui

submission deadline 31 Jan 2026 | Viewed by 19 | Submission Open

Keywords: PRRSV; genetic evolution; replication regulation; immunological or pathogenic mechanism; vaccine development; prevention and control

(This special issue belongs to the Section Animal Viruses)

Viruses in the Reproductive Tract

edited by

Mimi Ghosh

Raina Nakova Fichorova

and Christina Farr

submission deadline 31 Jan 2026 | Viewed by 14 | Submission Open

Keywords: reproductive tract virome; viruses in pregnancy; virus infections and adverse fetal health; virus-associated malignancies of the reproductive tract; immune response to viruses of the reproductive tract; antiviral biomarkers; antiviral vaccines and drugs; hormonal regulation of virus infections

(This special issue belongs to the Section General Virology)

Rift Valley Fever Virus: New Insights into a One Health Archetype

edited by

Rebekah C. Kading

, Juliette Lewis and Brian H. Bird

submission deadline 31 Jan 2026 | Viewed by 7 | Submission Open

Keywords: One Health; emerging infectious diseases; mosquito; bunyavirus; arbovirus; medical entomology; medical countermeasures; livestock

(This special issue belongs to the Section Animal Viruses)

Insect-Specific Viruses and Biological Control of Arboviruses

edited by

Valéria Lima Carvalho

and

Carlos A.M. Carvalho

submission deadline 6 Feb 2026 | Viewed by 119 | Submission Open

Keywords: insect-specific virus; mosquito-specific virus; arbovirus; evolution; vaccine; biological control; interference

(This special issue belongs to the Section Invertebrate Viruses)

Infectious Disease Epidemiology: Current Updates and Perspectives

edited by

Agata Skrzat-Klapaczynska

and

Justyna Dominika Kowalska

submission deadline 10 Feb 2026 | Viewed by 9 | Submission Open

Keywords: infection prevention and control; infectious diseases epidemiology; public health; novel treatments

(This special issue belongs to the Section General Virology)

Pharmacology of Antiviral Drugs, 2nd Edition

edited by

David E. Martin

submission deadline 28 Feb 2026 | 1 articles | Viewed by 612 | Submission Open

Keywords: pharmacology; clinical pharmacology; antiviral therapy; antiviral prophylaxis; human viruses; animal viruses; pharmacokinetics; pharmacodynamics; drug resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Endogenous Retrovirus Proteins and Their Functions, 2nd Edition

edited by

Benoit Barbeau

submission deadline 28 Feb 2026 | Viewed by 401 | Submission Open

Keywords: endogenous retrovirus; ERV envelope protein; receptor; cell fusion; cancer; pre-eclampsia; obstetric disorder; diagnosis; evolutionary conservation; gene regulation

(This special issue belongs to the Section Human Virology and Viral Diseases)

Foot-and-Mouth Disease Virus

edited by

Satya Parida

and

Zhidong Zhang

submission deadline 28 Feb 2026 | Viewed by 57 | Submission Open

Keywords: foot-and-mouth disease; foot-and-mouth disease virus; hoof-and-mouth disease; FMD; FMD virus; foot-and-mouth disease vaccines

(This special issue belongs to the Section Animal Viruses)

HIV Accessory Proteins

edited by

Gail E. Fanucci

submission deadline 28 Feb 2026 | Viewed by 47 | Submission Open

Keywords: accessory proteins; cellular interactions; drug design; liquid– liquid phase separations; molecular condensate; HIV; novel accessory proteins from other viruses

(This special issue belongs to the Section General Virology)

Food-Associated and Foodborne Viruses: A Food Safety Concern or Tool?

edited by

Ningbo Liao

, Daofeng Liu and

Hao Yan

submission deadline 28 Feb 2026 | Viewed by 13 | Submission Open

Keywords: foodborne viruses; norovirus epidemiology; viral zoonoses; phage biocontrol; food viromics; virus detection technologies

(This special issue belongs to the Section General Virology)

Nuclear Architecture in Viral Infection

edited by Veronica Sanchez and Elizabeth White

submission deadline 28 Feb 2026 | Viewed by 4 | Submission Open

Keywords: nuclear architecture; viral transcription; viral replication; viral assembly

(This special issue belongs to the Section General Virology)

Chronic Infection by Oncogenic Viruses 2.0

edited by

Christophe Nicot

submission deadline 28 Feb 2026 | Viewed by 1 | Submission Open

Keywords: virus transmission; virus replication; virus pathogenesis; virus latency; virus– host interactions; antiviral immune responses; virus-induced cellular transformation; antiviral drugs and vaccines

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Mpox (Monkeypox): From Neglected Tropical Disease to Emerging Global Pathogen

edited by

David A. Schwartz

Robert Colebunders

and Patrick Katoto

submission deadline 1 Mar 2026 | 10 articles | Viewed by 18055 | Submission Open

Keywords: monkeypox; mpox; monkeypox virus; mpxv; poxvirus; Poxviridae; Africa; DR Congo; outbreak; epidemic; stillbirth; sexual transmission; vaccination; emerging infection

(This special issue belongs to the Section Human Virology and Viral Diseases)

Epidemiology, Pathogenesis and Immunity of Adenovirus

edited by Adriana Kajon and

Jay R. Radke

submission deadline 6 Mar 2026 | 3 articles | Viewed by 2050 | Submission Open

Keywords: human adenovirus; viral infection; pathogenesis; epidemiology; immune response; diagnosis; therapeutics; vaccine development

(This special issue belongs to the Section Human Virology and Viral Diseases)

Hepatitis Viral Infections, Pathogenesis and Therapeutics (2nd Edition)

edited by

Fan Zhu

submission deadline 31 Mar 2026 | Viewed by 128 | Submission Open

Keywords: hepatitis A virus (HAV); hepatitis B virus (HBV); hepatitis C virus (HCV); hepatitis D virus (HDV); hepatitis E virus (HEV); chronic liver disease; chronic hepatitis; liver cirrhosis; hepatocellular carcinoma (HCC); liver cancer; antiviral therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Tick-Borne Viruses 2026

edited by

Pat Nuttall

submission deadline 31 Mar 2026 | Viewed by 104 | Submission Open

Keywords: tick-borne viruses; vector-borne pathogens; virus– tick– host interactions; saliva-assisted transmission; tick exosomes; tick antiviral mechanisms; virus evolution; surveillance

(This special issue belongs to the Section General Virology)

Viral Non-Structural Proteins

edited by

Giuseppe Sautto

submission deadline 31 Mar 2026 | Viewed by 58 | Submission Open

Keywords: viral genome; non-structural proteins; virus replication; vaccines; viral therapeutics

(This special issue belongs to the Section General Virology)

Porcine Epidemic Diarrhea Virus (PEDV): A Persistent Threat to the Global Swine Industry

edited by

Ke Liu

submission deadline 31 Mar 2026 | Viewed by 40 | Submission Open

Keywords: porcine epidemic diarrhea virus; global epidemiology; economic loss; vaccines and drugs; molecular mechanism; transmission and pathogenic mechanisms

(This special issue belongs to the Section Animal Viruses)

HPV-Associated Cancers 2025

edited by Diane M. Harper

submission deadline 31 Mar 2026 | Viewed by 23 | Submission Open

Keywords: HPV; cervical cancer; head and neck cancer; penile cancer; cancer prevention; targeted therapy; cancer stem cells; molecular study; carcinogenesis; immunotherapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Japanese Encephalitis Virus and Other Closely Related Clinically Important Orthoflaviviruses—A Persistent Threat to Public and Animal Health

edited by

Ke Liu

submission deadline 31 Mar 2026 | Viewed by 15 | Submission Open

Keywords: Japanese encephalitis virus; mosquito-borne; orthoflaviviruses; public and animal health; transmission; infection; host

(This special issue belongs to the Section General Virology)

Advances in HSV

edited by Susmit Suvas and James Chodosh

submission deadline 31 Mar 2026 | Viewed by 2 | Submission Open

Keywords: HSV-1; HSV-2; latency; herpes epithelial keratitis; herpes stromal keratitis; HSV vaccine; herpes simplex encephalitis

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular Epidemiology, Evolution, and Dispersion of Flaviviruses (2nd Edition)

edited by

Marta Giovanetti

Fernanda De Bruycker Nogueira

Ana Maria Bispo De Filippis

and

Anne Paiva

submission deadline 30 Apr 2026 | 4 articles | Viewed by 9596 | Submission Open

Keywords: flavivirus; evolution; genomic epidemiology; phylodynamics; transmission

(This special issue belongs to the Section Animal Viruses)

Plant Virus Resistance—2nd Edition

edited by

Miguel A. Aranda

submission deadline 30 Apr 2026 | Viewed by 47 | Submission Open

Keywords: plant virus resistance mechanisms; resistance-breaking viral strains; genetic and molecular breeding; virus– host interactions; genome editing; virus susceptibility factors; plant virus ecology; plant virus host range

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Epidemiology of Zoonotic Virus Transmission: Pathways, Host Factors, and Public Health Strategies

edited by