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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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HIV Accessory Proteins

edited by

Gail E. Fanucci

submission deadline 28 Feb 2026 | Viewed by 75 | Submission Open

Keywords: accessory proteins; cellular interactions; drug design; liquid– liquid phase separations; molecular condensate; HIV; novel accessory proteins from other viruses

(This special issue belongs to the Section General Virology)

Host-Targeting Antivirals: From Mechanism to Intervention

edited by

Stephan Pleschka

submission deadline 28 Feb 2026 | Viewed by 56 | Submission Open

Keywords: host-targeting antivirals; host receptors; signaling pathways; metabolic networks; transcription factors; treatment; clinical intervention practice; preclinical data; intervention strategy design; mechanism

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Food-Associated and Foodborne Viruses: A Food Safety Concern or Tool?

edited by

Ningbo Liao

, Daofeng Liu and

Hao Yan

submission deadline 28 Feb 2026 | Viewed by 46 | Submission Open

Keywords: foodborne viruses; norovirus epidemiology; viral zoonoses; phage biocontrol; food viromics; virus detection technologies

(This special issue belongs to the Section General Virology)

Chronic Infection by Oncogenic Viruses: 2nd Edition

edited by

Christophe Nicot

submission deadline 28 Feb 2026 | Viewed by 42 | Submission Open

Keywords: virus transmission; virus replication; virus pathogenesis; virus latency; virus– host interactions; antiviral immune responses; virus-induced cellular transformation; antiviral drugs and vaccines

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Functional RNAs in Virology

edited by

Michael T. Wolfinger

submission deadline 28 Feb 2026 | Viewed by 40 | Submission Open

Keywords: functional RNA elements; viral RNA structure; cis-acting RNA motifs; non-coding RNAs; RNA– protein interactions; RNA-based regulation; RNA virus biology; structured RNA; computational RNA analysis; virus bioinformatics

(This special issue belongs to the Section General Virology)

Veterinary Virology: Unraveling Host–Pathogen Interactions for Animal Health

edited by

Muhammad Jasim Uddin

submission deadline 28 Feb 2026 | Viewed by 35 | Submission Open

Keywords: veterinary virology; host– pathogen interactions; viral replication and immune evasion; zoonotic viruses; One Health; vaccine and therapeutic development; molecular virology and genomics; emerging and re-emerging viral pathogens or diseases; animal health and welfare; high-throughput or deep sequencing; outbreak prevention and control; food security

(This special issue belongs to the Section Animal Viruses)

Pathogenesis and Persistence in Flavivirus Infections: Mechanisms, Biomarkers, and Clinical Implications

edited by

Aleksandra Drelich

and

Barbara Judy

submission deadline 28 Feb 2026 | Viewed by 30 | Submission Open

Keywords: tropical infectious diseases; flaviviruses; co-infection; cross-reactivity; long-term sequelae; neurological symptoms; autoimmunity; pathogenesis; molecular virology; diagnosis; biomarkers

(This special issue belongs to the Section Human Virology and Viral Diseases)

Nuclear Architecture in Viral Infection

edited by Veronica Sanchez and Elizabeth White

submission deadline 28 Feb 2026 | Viewed by 30 | Submission Open

Keywords: nuclear architecture; viral transcription; viral replication; viral assembly

(This special issue belongs to the Section General Virology)

Viruses of Plant Pathogens and Pests

edited by Alexander V. Karasev

submission deadline 28 Feb 2026 | Viewed by 25 | Submission Open

Keywords: plant virus; virus diversity; transmission; genetic diversity; evolution; virus– host interactions

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Advancing Understanding of Filoviruses

edited by John Misasi and

Adam Hume

submission deadline 28 Feb 2026 | Viewed by 24 | Submission Open

Keywords: filoviruses; Ebola virus; Marburg virus; Sudan virus; Tai Forest virus; Bundibugyo virus; Reston virus; Lloviu virus; Bombali virus; Mengla virus; Dehong virus

(This special issue belongs to the Section Animal Viruses)

Mpox (Monkeypox): From Neglected Tropical Disease to Emerging Global Pathogen

edited by

David A. Schwartz

Robert Colebunders

and Patrick Katoto

submission deadline 1 Mar 2026 | 10 articles | Viewed by 19904 | Submission Open

Keywords: monkeypox; mpox; monkeypox virus; mpxv; poxvirus; Poxviridae; Africa; DR Congo; outbreak; epidemic; stillbirth; sexual transmission; vaccination; emerging infection

(This special issue belongs to the Section Human Virology and Viral Diseases)

Spumaretroviruses: Research and Applications

edited by

Arifa S. Khan

Marcelo A. Soares

Dirk Lindemann

, Martin Löchelt and Paul Lesbats

submission deadline 1 Mar 2026 | 2 articles | Viewed by 1481 | Submission Open

Keywords: ancient retroviruses; antivirals; complex retroviruses; endogenous elements; foamy viruses; foamy virus-host interactions; foamy virus prevalence; foamy virus vectors; immune responses; molecular biology and replication; natural infections; nonhuman primates and non-primates; restriction factors spumaretroviruses; structural biology; taxonomy; viral proteins; virus detection assays; zoonoses

(This special issue belongs to the Section Animal Viruses)

Nucleocytoviricota

edited by Natalya Yutin

submission deadline 1 Mar 2026 | Viewed by 28 | Submission Open

Keywords: Nucleocytoviricota; giant viruses; virophages; host– virus (-virophage) interactions; virion structure; viral ecology; diversity and classification; evolution of Nucleocytoviricota

(This special issue belongs to the Section General Virology)

Epidemiology, Pathogenesis and Immunity of Adenovirus

edited by Adriana Kajon and

Jay R. Radke

submission deadline 6 Mar 2026 | 3 articles | Viewed by 2652 | Submission Open

Keywords: human adenovirus; viral infection; pathogenesis; epidemiology; immune response; diagnosis; therapeutics; vaccine development

(This special issue belongs to the Section Human Virology and Viral Diseases)

Herpesviruses and Associated Diseases, 2nd Edition

edited by

Sherif T.S. Hassan

submission deadline 20 Mar 2026 | Viewed by 16 | Submission Open

Keywords: human herpesviruses; animal herpesviruses; viral latency and reactivation; immune evasion strategies; herpesvirus– host interactions; herpesvirus biology and pathogenesis; herpesvirus diagnosis; environmental factors; herpesvirus-associated diseases; prevention and treatment strategies; antiviral therapies; vaccine development

(This special issue belongs to the Section Human Virology and Viral Diseases)

Coronaviruses and Influenza Viruses: Evolution, Cross-Species Transmission, and Recombination

edited by

Maged Gomaa Hemida

submission deadline 31 Mar 2026 | 5 articles | Viewed by 6495 | Submission Open

Keywords: coronaviruses; influenza viruses; highly pathogenic influenza viruses; species jump; avian coronaviruses; porcine coronaviruses; vaccines; diagnostic assays; one health; virus/host interaction.

(This special issue belongs to the Section Coronaviruses)

Interferon Signaling in Viral Pathogenesis

edited by Lishan Su

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2425 | Submission Open

Keywords: type I interferons; virus replication; viral pathogenesis; autoimmune diseases; inflamation-induced cancer; immunotherapy

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Cascade of Care for HIV, Hepatitis and Sexually Transmitted Infections

edited by

Justyna Dominika Kowalska

submission deadline 31 Mar 2026 | 3 articles | Viewed by 1825 | Submission Open

Keywords: HIV; AIDS; cascade; linkage; HCV; HBV; sexually transmitted infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advancements in Immunotherapy for Human Papillomavirus

edited by Katharine A. Price

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1378 | Submission Open

Keywords: human papillomavirus; cancer screening; vaccination; treatment; head-and-neck cancer; oropharyngeal cancer

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Hepatitis Viral Infections, Pathogenesis and Therapeutics (2nd Edition)

edited by

Fan Zhu

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1054 | Submission Open

Keywords: hepatitis A virus (HAV); hepatitis B virus (HBV); hepatitis C virus (HCV); hepatitis D virus (HDV); hepatitis E virus (HEV); chronic liver disease; chronic hepatitis; liver cirrhosis; hepatocellular carcinoma (HCC); liver cancer; antiviral therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Novel Insights into Porcine Viral Diseases: Recombinant Strains and Immune Responses

edited by

Kegong Tian

and

Xiangdong Li

submission deadline 31 Mar 2026 | 1 articles | Viewed by 829 | Submission Open

Keywords: porcine viral diseases; epidemiology; pathogenesis; recombination; immune responses

(This special issue belongs to the Section Animal Viruses)

Tick-Borne Viruses 2026

edited by

Pat Nuttall

submission deadline 31 Mar 2026 | 1 articles | Viewed by 563 | Submission Open

Keywords: tick-borne viruses; vector-borne pathogens; virus– tick– host interactions; saliva-assisted transmission; tick exosomes; tick antiviral mechanisms; virus evolution; surveillance

(This special issue belongs to the Section General Virology)

Dengue, Zika and Yellow Fever Virus Replication

edited by

Rosa M. Del Angel

submission deadline 31 Mar 2026 | Viewed by 451 | Submission Open

Keywords: flavivirus; dengue; Zika; yellow fever; virus replication; virus entry; genome replication; host cell factors; replication structures

(This special issue belongs to the Section Invertebrate Viruses)

Viral Non-Structural Proteins

edited by

Giuseppe Sautto

submission deadline 31 Mar 2026 | Viewed by 106 | Submission Open

Keywords: viral genome; non-structural proteins; virus replication; vaccines; viral therapeutics

(This special issue belongs to the Section General Virology)

Porcine Epidemic Diarrhea Virus (PEDV): A Persistent Threat to the Global Swine Industry

edited by

Ke Liu

submission deadline 31 Mar 2026 | Viewed by 82 | Submission Open

Keywords: porcine epidemic diarrhea virus; global epidemiology; economic loss; vaccines and drugs; molecular mechanism; transmission and pathogenic mechanisms

(This special issue belongs to the Section Animal Viruses)

Chikungunya Virus in Viral Immunology and Vaccine Research

edited by Shuaiyao Lu and

Hongyu Chen

submission deadline 31 Mar 2026 | Viewed by 76 | Submission Open

Keywords: Chikungunya virus; viral immunology; CHIKV vaccine development; virus– host interactions; innate immunity; adaptive immunity; neutralizing antibodies; viral pathogenesis; vaccine platforms; antivirals; Alpha virus

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

HPV-Associated Cancers 2025

edited by Diane M. Harper

submission deadline 31 Mar 2026 | Viewed by 75 | Submission Open

Keywords: HPV; cervical cancer; head and neck cancer; penile cancer; cancer prevention; targeted therapy; cancer stem cells; molecular study; carcinogenesis; immunotherapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advances in HSV

edited by Susmit Suvas and James Chodosh

submission deadline 31 Mar 2026 | Viewed by 61 | Submission Open

Keywords: HSV-1; HSV-2; latency; herpes epithelial keratitis; herpes stromal keratitis; HSV vaccine; herpes simplex encephalitis

(This special issue belongs to the Section Human Virology and Viral Diseases)

Japanese Encephalitis Virus and Other Closely Related Clinically Important Orthoflaviviruses—A Persistent Threat to Public and Animal Health

edited by

Ke Liu

submission deadline 31 Mar 2026 | Viewed by 46 | Submission Open

Keywords: Japanese encephalitis virus; mosquito-borne; orthoflaviviruses; public and animal health; transmission; infection; host

(This special issue belongs to the Section General Virology)

Rabies Virus: Treatment and Prevention—2nd Edition

edited by

Paulo Eduardo Brandão

submission deadline 31 Mar 2026 | Viewed by 37 | Submission Open

Keywords: rabies; antiviral; treatment; prevention

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

New Findings in Animal Biosecurity Related to Viral Diseases

edited by

Claude Saegerman

and Jean-Pierre Vaillancourt

submission deadline 31 Mar 2026 | Viewed by 27 | Submission Open

Keywords: viruses; animal; biosecurity; evaluation; communication; needs; cost– benefit analysis; behaviour change

(This special issue belongs to the Section Animal Viruses)

Epidemiology, Risk Analysis, Detection and Management of Lumpy Skin Disease in Europe

edited by

Claude Saegerman

submission deadline 31 Mar 2026 | Viewed by 26 | Submission Open

Keywords: lumpy skin disease (LSD); lumpy skin disease virus (LSDV); vectors; pathogenesis; epidemiology; modelling; risk analysis; detection; management; cost– benefit analysis; Europe

(This special issue belongs to the Section Animal Viruses)

Bacteriophages and Biofilms 2026

edited by

Bartłomiej Grygorcewicz

submission deadline 31 Mar 2026 | Viewed by 15 | Submission Open

Keywords: bacteriophages; phage therapy; biofilms; phage– biofilm interaction; depolymerases; antibiofilm agents; phage engineering; phage resistance; combination therapy; microbial ecology

(This special issue belongs to the Section Bacterial Viruses)

HIV and Aging

edited by Eugenia Negredo

submission deadline 31 Mar 2026 | Viewed by 1 | Submission Open

Keywords: HIV and aging; accelerated and accentuated aging; immune senescence; inflammation; comorbidities; geriatric syndromes; neurocognitive function; functional status; antiretroviral therapy

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Molecular Epidemiology, Evolution, and Dispersion of Flaviviruses (2nd Edition)

edited by

Marta Giovanetti

Fernanda De Bruycker Nogueira

Ana Maria Bispo De Filippis

and

Anne Paiva

submission deadline 30 Apr 2026 | 5 articles | Viewed by 12055 | Submission Open

Keywords: flavivirus; evolution; genomic epidemiology; phylodynamics; transmission

(This special issue belongs to the Section Animal Viruses)

Viral Diseases of Major Crops

edited by Zaifeng Fan and Yan Shi

submission deadline 30 Apr 2026 | 2 articles | Viewed by 1431 | Submission Open

Keywords: viral infection; viral pathogenicity; virus movement; replication; RNA silencing suppressor; host response; host factors; molecular plant– virus– vector interactions

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Plant Virus Resistance—2nd Edition

edited by

Miguel A. Aranda

submission deadline 30 Apr 2026 | Viewed by 77 | Submission Open

Keywords: plant virus resistance mechanisms; resistance-breaking viral strains; genetic and molecular breeding; virus– host interactions; genome editing; virus susceptibility factors; plant virus ecology; plant virus host range

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Human T-Cell Leukemia Virus (HTLV) Infection and Treatment: 2nd Edition

edited by Cynthia A. Pise-Masison and Damian F. J. Purcell

submission deadline 30 Apr 2026 | Viewed by 68 | Submission Open

Keywords: HTLV; HTLV-associated myelopathy/tropical spastic paraparesis; adult T-cell leukemia/lymphoma; inflammation; neurodegeneration; therapeutics; infectious dermatitis; cancer; antiviral drugs

(This special issue belongs to the Section Human Virology and Viral Diseases)

Epidemiology of Zoonotic Virus Transmission: Pathways, Host Factors, and Public Health Strategies

edited by

Francisco José Nunes Antunes

and

Rita Cordeiro

submission deadline 30 Apr 2026 | Viewed by 58 | Submission Open

Keywords: zoonotic viruses; transmission pathways; host factors; public health strategies; one health

(This special issue belongs to the Section Animal Viruses)

Respiratory Syncytial Virus: Pathogenesis, Prevention and Treatment

edited by

Javier de Miguel-Díez

submission deadline 30 Apr 2026 | Viewed by 36 | Submission Open

Keywords: respiratory syncytial virus (RSV); RSV infection; pathogenesis; RSV prevention; RSV treatment; vaccines

(This special issue belongs to the Section Human Virology and Viral Diseases)

Plant Viral Pathogens: Innovations in Detection, Genetic Diversity, and Evolutionary Dynamics

edited by

Akhtar Ali

submission deadline 30 Apr 2026 | Viewed by 22 | Submission Open

Keywords: high-throughput sequencing; RT-PCR and qRT-PCR; genetic diversity; virus evolution; mutations; reassortment; recombination

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Virus-Associated Nephropathies

edited by Rajendra Bhimma and

Sudesh Hariparshad

submission deadline 30 Apr 2026 | Viewed by 14 | Submission Open

Keywords: viruses; kidney; nephropathy; immunosuppressed; pathogenesis; BK polyomavirus; COVID-19; HIV-associated nephropathy (HIVAN); diagnostic advances; antiviral therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Coxsackieviruses, Polioviruses and Associated Diseases (Second Edition)

edited by

Yong Zhang

and

Didier Hober

submission deadline 1 May 2026 | 10 articles | Viewed by 11525 | Submission Open

Keywords: coxsackievirus; HFMD; viral Meningitis; myocarditis; pericarditis; herpangina; poliovirus; poliomyelitis; acute flaccid paralysis; post-polio syndrome; pleurodynia (Bornholm disease)

(This special issue belongs to the Section Human Virology and Viral Diseases)

Control and Contributions of Transposable Elements: Implications for Development and Disease

edited by Suzanne B. Sandmeyer and Henry L. Levin

submission deadline 1 May 2026 | Viewed by 203 | Submission Open

Keywords: transposable elements; endogenous viruses; transcription factors; neurotransmission; aging

(This special issue belongs to the Section General Virology)

Viral Genetic Variability and Its Role in Assessing Infectious Diseases

edited by

Fabio Scarpa

and

Francesco Branda

submission deadline 6 May 2026 | Viewed by 160 | Submission Open

Keywords: viral genetic diversity; infectious diseases; viral evolution; host adaptation; next-generation sequencing; pathogenicity; immune evasion; viral surveillance; bioinformatics; genetic variability; phylogeny; phylodynamics

(This special issue belongs to the Section General Virology)

Influenza B Virus: From Infection to Prevention

edited by Saira Hussain

submission deadline 30 May 2026 | Viewed by 220 | Submission Open

Keywords: influenza B viruses; epidemiology; evolution; pathogenesis; immunity; vaccine; antivirals

(This special issue belongs to the Section Animal Viruses)

Roles of Macrophages in Viral Infections, 2nd Edition

edited by

Stefano Aquaro

submission deadline 31 May 2026 | 2 articles | Viewed by 1726 | Submission Open

Keywords: macrophage; microglia; Kupffer cells; viral infection; antiviral immunity; inflammatory cytokines; langerhans cell; antiviral drugs; viral pathogenesis

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Biosecurity and Plant Viruses: A Call to Action for a Sustainable Future

edited by

Yi Xu

and

Patricia Valle Pinheiro

submission deadline 31 May 2026 | 1 articles | Viewed by 1068 | Submission Open

Keywords: biosecurity; viral disease; sustainable agriculture; emerging plant viruses; quarantine regulations

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Animal Models in Emerging/Re-Emerging Infectious Diseases

edited by Dong Yang

submission deadline 31 May 2026 | 1 articles | Viewed by 883 | Submission Open

Keywords: emerging/re-emerging infectious diseases; animal models; pathogen– host interactions; pathogenesis; interventions; drugs; vaccines

(This special issue belongs to the Section Animal Viruses)

Emerging and Re-Emerging Viral Zoonoses

edited by

Lorena Jemeršić

and

Margarida Simões

submission deadline 31 May 2026 | 2 articles | Viewed by 880 | Submission Open

Keywords: epidemiology of emerging and re-emerging viral zoonoses; zoonotic spillover; viral evolution; animal reservoirs; zoonotic transmission; animals as sentinels of viral zoonoses and risk analyses; diagnostic novelties and early detection of viral threats; viral genomics and molecular epidemiology; viral pathogenesis; viral adaptation mechanisms; wildlife– human interface; monkeypox virus (mpxv); influenza viruses; nipah virus; ebola/marburg virus; hantavirus; crimea-congo virus; vaccine development; therapeutic and mitigation strategies; climate change; biodiversity loss and infectious diseases

(This special issue belongs to the Section Animal Viruses)

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