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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antigenic Drift in Respiratory Viruses

edited by

Gabriel Gonzalez

submission deadline 31 Dec 2025 | Viewed by 144 | Submission Open

Keywords: respiratory viruses; virus diversity; viral recombination; reassortment; zoonotic viruses; wastewater pathogen surveillance; viral sequencing; virus evolutionary characterization; animal viruses

(This special issue belongs to the Section Human Virology and Viral Diseases)

Mechanisms of Ribozyviria Transmission in Animal and Vegetal Holobionts

edited by

Maurizia Rossana Brunetto

and Ferruccio Bonino

submission deadline 31 Dec 2025 | Viewed by 121 | Submission Open

Keywords: viroid-like RNAs; holobionts; RNA viruses; circular RNA genomes; satellite viruses; HBsAg (hepatitis b surface antigen)

(This special issue belongs to the Section General Virology)

Innovative Drug Discovery for Emerging Viral Diseases, 2nd Edition

edited by Chaoping Chen

submission deadline 31 Dec 2025 | Viewed by 111 | Submission Open

Keywords: antivirals; drug discovery; high-throughput screen; SARS-CoV-2; influenza virus; RSV; zika; ebola virus; chikungunya virus; emerging/re-emerging RNA viral pathogens; host-directed therapies; immunomodulator

(This special issue belongs to the Section General Virology)

Arboviral Diseases in Livestock

edited by

Estelle Venter

and

Antoinette Van Schalkwyk

submission deadline 15 Jan 2026 | 2 articles | Viewed by 2882 | Submission Open

Keywords: arbovirus; epidemiology; diagnostics; vaccines

(This special issue belongs to the Section Animal Viruses)

Progress and Prospects in Oncolytic Virotherapy 2025

edited by

Arianna Calistri

and

Sandra Tuyaerts

submission deadline 15 Jan 2026 | Viewed by 526 | Submission Open

Keywords: oncovirotherapy; chemotherapy; preclinical studies; clinical trials; combinatory strategy; safety profile; therapeutic efficacy; immunotherapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Phage–Antibiotic Combination Therapy

edited by

Prasanth Manohar

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1693 | Submission Open

Keywords: bacteriophage; antibiotics; phage therapy; phage– antibiotic synergy; combination therapy; in vitro study; sub-lethal dose; emerging alternative; bacteria-killing

(This special issue belongs to the Section Bacterial Viruses)

Viral Infections in Hematopoietic Stem Cell Transplant and Cellular Therapy Recipients, 2nd Edition

edited by Sanjeet Singh Dadwal

submission deadline 30 Jan 2026 | Viewed by 122 | Submission Open

Keywords: HSCT; GVHD; HHV6; CMV; adenovirus; BK and JC virus (polyomaviruses); HIV

(This special issue belongs to the Section Human Virology and Viral Diseases)

Phage Cocktails: Promising Approaches Against Infections

edited by Jin Woo Jun

submission deadline 31 Jan 2026 | 3 articles | Viewed by 6817 | Submission Open

Keywords: phage cocktail; phage therapy; prophylaxis; infectious diseases; veterinary medicine; agriculture; food industry; zoonoses

(This special issue belongs to the Section Bacterial Viruses)

Tick-Borne Viruses: Transmission and Surveillance, 2nd Edition

edited by

Anna Papa

submission deadline 31 Jan 2026 | 3 articles | Viewed by 6082 | Submission Open

Keywords: tick-borne viruses; transmissibility; vector competence; virulence; interactions; surveillance; discovery; replication; pathogenesis; vaccine development

(This special issue belongs to the Section Invertebrate Viruses)

Plant Virus Spillovers

edited by

Steve Wylie

and

Nuredin Habili

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5965 | Submission Open

Keywords: spillover; emergence; replication; wild-plant virus; transmission; virus-cell interaction; vector

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

TMPRSS2 and Other Host Factors in Influenza Virus and Coronavirus Infections

edited by

Judy Wai Ping Yam

and Sze Keong Tey

submission deadline 31 Jan 2026 | 2 articles | Viewed by 5845 | Submission Open

Keywords: TMPRSS2; host factors; influenza virus; coronavirus; viral infection; treatment of viral diseases

(This special issue belongs to the Section Human Virology and Viral Diseases)

Novel Strategies to Identify and Eliminate Latent HIV Cells

edited by

Francesco Andrea Procopio

submission deadline 31 Jan 2026 | 1 articles | Viewed by 5585 | Submission Open

Keywords: HIV; HIV-1 infection; antiretroviral therapy (ART); HIV single cell analysis; HIV reservoir; HIV cure

(This special issue belongs to the Section Human Virology and Viral Diseases)

Intra-Patient Viral Evolution and Diversity

edited by Adam A. Capoferri and

Mary Kearney

submission deadline 31 Jan 2026 | 2 articles | Viewed by 4191 | Submission Open

Keywords: intra-patient viral evolution; drug resistance; immune escape; co-evolution; virus persistence; virus evolution

(This special issue belongs to the Section Human Virology and Viral Diseases)

Role of Lectins in Viral Infections and Antiviral Intervention

edited by Yuan Guo

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3198 | Submission Open

Keywords: lectin– glycan interaction; membrane fusion; immune evasion; multivalency; glycan conjugates; lectin constructs; antivirals

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

SARS-CoV-2 Neutralizing Antibodies, 3rd Edition

edited by Youchun Wang

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3104 | Submission Open

Keywords: SARS-CoV-2; neutralizing antibodies; neutralization assays; standards; monoclonal antibodies; vaccines; viral variants

(This special issue belongs to the Section Coronaviruses)

Translational Research in Virology

edited by

Kenneth Lundstrom

and

Alaa A. A. Aljabali

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2481 | Submission Open

Keywords: vaccines; antiviral drugs; monoclonal antibodies; viral vectors; self-amplifying RNA; clinical trials; translational medicine; proteomic analysis; antiviral resistance; bioinformatics; structural virology; immune escape mechanisms; viral evolution; diagnostic virology; high-throughput screening; nanotechnology in virology; viral assembly and disassembly; host-pathogen interactions; emerging viral infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

HIV and Drugs of Abuse, 4th Edition

edited by

Maria Cecilia Garibaldi Marcondes

and

Marcus Kaul

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2040 | Submission Open

Keywords: substance use disorders; HIV; HAND; methamphetamine

(This special issue belongs to the Section Human Virology and Viral Diseases)

Emerging and Re-Emerging Plant Viruses and Vector Complexes: Advances in Characterization, Surveillance, and Mitigation

edited by

Judith K. Brown

and

Jiban Kumar Kundu

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1869 | Submission Open

Keywords: climate change and emerging/re-emerging virus threats; impact of virus evolution on the emerging/re-emerging virus diseases; innovative virus detection and surveillance methods; plant defense and virus resistance mechanisms responding to new outbreaks; plant defenses that respond to virus infection in lieu of extreme climate circumstances; plant virus diseases; plant– virus and/or plant– vector interactions; including tritrophic interactions; plant/crop resistance to viruses and/or arthropod vectors; strategies for management of viruses and vectors; virus– vector interactions; specific scenarios of emerging and reemerging viruses:; insect or mite-transmitted viruses of plants; seed-borne or seed-transmitted viruses of plants; soil-borne or soil-transmitted viruses; viruses infecting nursery crops and trees; water-borne or water-transmitted plant viruses

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Long-Acting Antiretrovirals

edited by Camilla Muccini and Antonella Castagna

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1547 | Submission Open

Keywords: HIV infection; HIV prevention; long-acting; antiretroviral therapy; clinical studies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Rift Valley Fever Virus: New Insights into a One Health Archetype

edited by

Rebekah C. Kading

, Juliette Lewis and Brian H. Bird

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1254 | Submission Open

Keywords: One Health; emerging infectious diseases; mosquito; bunyavirus; arbovirus; medical entomology; medical countermeasures; livestock

(This special issue belongs to the Section Animal Viruses)

Host Defense, Viruses and Cell Death Pathways

edited by

Pascale Krejbich-Trotot

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1091 | Submission Open

Keywords: virus– host; programmed cell death; apoptosis; necroptosis; pyroptosis; viral factors and cell death effector interplay; oncolytic

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Emerging Controversies and Advances in Neurovirology

edited by

Karolina Akinosoglou

submission deadline 31 Jan 2026 | 1 articles | Viewed by 956 | Submission Open

Keywords: neurovirology; viral encephalitis; persistent viral infection; neuroinflammation; viral latency; oncolytic viruses; brain tumors; neurodegeneration; SARS-CoV-2; long COVID; zoonotic viruses; neural organoids; microglia activation; virus– host interactions; viral neuropathogenesis; central nervous system infections; herpesviruses; immune-mediated neurodegeneration; viral reactivation; ethical issues in neurovirology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viruses in the Reproductive Tract

edited by

Mimi Ghosh

Raina Nakova Fichorova

and Christina Farr

submission deadline 31 Jan 2026 | 1 articles | Viewed by 589 | Submission Open

Keywords: reproductive tract virome; viruses in pregnancy; virus infections and adverse fetal health; virus-associated malignancies of the reproductive tract; immune response to viruses of the reproductive tract; antiviral biomarkers; antiviral vaccines and drugs; hormonal regulation of virus infections

(This special issue belongs to the Section General Virology)

Bornaviruses 2025: News, Gaps and Future Directions

edited by

Christiane E. Herden

submission deadline 31 Jan 2026 | Viewed by 442 | Submission Open

Keywords: bornaviruses; zoonotic; epidemiology; transmission; molecular infection mechanisms; pathogenesis; antiviral

(This special issue belongs to the Section Animal Viruses)

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus: 2nd Edition

edited by Tongqing An and Xingyang Cui

submission deadline 31 Jan 2026 | Viewed by 201 | Submission Open

Keywords: PRRSV; genetic evolution; replication regulation; immunological or pathogenic mechanism; vaccine development; prevention and control

(This special issue belongs to the Section Animal Viruses)

Viral Dynamics in Aquatic Environments: Pathogens, Transmission and Impacts

edited by

Jesús L. Romalde

submission deadline 31 Jan 2026 | Viewed by 161 | Submission Open

Keywords: waterborne viruses; emerging pathogens; human and animal health; viral dynamics; viral ecology; bacteriophages; transmission

(This special issue belongs to the Section General Virology)

Bluetongue, Epizootic Haemorrhagic Disease, and Other Emerging Orbiviruses, 2nd Edition

edited by

Ludovic Martinelle

submission deadline 31 Jan 2026 | Viewed by 149 | Submission Open

Keywords: bluetongue; epizootic haemorrhagic disease; orbiviruses; African horse sickness; vector-borne diseases

(This special issue belongs to the Section Animal Viruses)

Congenital Cytomegalovirus Infection, 3rd Edition

edited by

Giovanni Nigro

submission deadline 31 Jan 2026 | Viewed by 144 | Submission Open

Keywords: primary cytomegalovirus infection; pregnancy; CMV screening; hyperimmune globulin; valaciclovir

(This special issue belongs to the Section Human Virology and Viral Diseases)

Cellular Immune Response to Hepatitis Viruses

edited by

Armando Andres Roca Suarez

submission deadline 31 Jan 2026 | Viewed by 142 | Submission Open

Keywords: viral hepatitis; viral/host interactions; immune response; immune evasion; immunopathogenesis; immunomodulatory therapy; pre-clinical models

(This special issue belongs to the Section Human Virology and Viral Diseases)

Antiviral Drugs and Biologics Targeting HIV: Drug Resistance to Newer Treatment and Pre-Exposure Prophylaxis (PrEP) Options: 2nd Edition

edited by

Bluma G. Brenner

submission deadline 31 Jan 2026 | Viewed by 104 | Submission Open

Keywords: HIV; antiretroviral therapy (ART); pre-exposure prophylaxis (PrEP); antiviral drugs; drug resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Baculovirus as Vaccine Vectors, RNA Interference Mediators, and Gene Delivery Vectors: 2nd Edition

edited by

Hung-Jen Liu

submission deadline 31 Jan 2026 | Viewed by 70 | Submission Open

Keywords: baculovirus; vaccine vectors; subunit vaccine; baculovirus display vectors; RNA interference mediators; gene delivery vectors

(This special issue belongs to the Section Invertebrate Viruses)

Insect-Specific Viruses and Biological Control of Arboviruses

edited by

Valéria Lima Carvalho

and

Carlos A.M. Carvalho

submission deadline 6 Feb 2026 | Viewed by 277 | Submission Open

Keywords: insect-specific virus; mosquito-specific virus; arbovirus; evolution; vaccine; biological control; interference

(This special issue belongs to the Section Invertebrate Viruses)

Infectious Disease Epidemiology: Current Updates and Perspectives

edited by

Agata Skrzat-Klapaczynska

and

Justyna Dominika Kowalska

submission deadline 10 Feb 2026 | Viewed by 110 | Submission Open

Keywords: infection prevention and control; infectious diseases epidemiology; public health; novel treatments

(This special issue belongs to the Section General Virology)

Role of Bacteriophage in Intestine Microbial Communities

edited by Yi Duan

submission deadline 15 Feb 2026 | 1 articles | Viewed by 839 | Submission Open

Keywords: bacteriophage; intestinal microbiome; virome; microbial homeostasis; phage therapy; gut ecology; intestinal dysbiosis; antimicrobial resistance; microbiome engineering; host– microbe interactions

(This special issue belongs to the Section Bacterial Viruses)

Evolution and Adaptation of Avian Viruses

edited by

Giovanni Franzo

and

Matteo Legnardi

submission deadline 28 Feb 2026 | 7 articles | Viewed by 11886 | Submission Open

Keywords: virus; poultry; evolution; genetics; diagnosis; host; epidemiology; control; vaccine

(This special issue belongs to the Section Animal Viruses)

PANoptosis in Viral Infection

edited by

Thirumala-Devi Kanneganti

submission deadline 28 Feb 2026 | 4 articles | Viewed by 11639 | Submission Open

Keywords: • Viruses• Inflammation• PANoptosis• PANoptosome

(This special issue belongs to the Section General Virology)

Viral Diseases of Domestic Animals

edited by

Scott P. Kenney

submission deadline 28 Feb 2026 | 6 articles | Viewed by 6473 | Submission Open

Keywords: viral diseases; emerging infections; domestic animals; epidemiology; pathogenesis

(This special issue belongs to the Section Animal Viruses)

Virus-Host Protein Interactions

edited by

Benoit Coulombe

submission deadline 28 Feb 2026 | 4 articles | Viewed by 4742 | Submission Open

Keywords: protein– protein interactions; antiviral drug discovery; protein target inhibitors

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Bovine Viral Diarrhea Viruses and Other Pestiviruses

edited by

Enrica Sozzi

submission deadline 28 Feb 2026 | 6 articles | Viewed by 4511 | Submission Open

Keywords: epidemiological survey; prevalence; seroprevalence; bovine viral diarrhoea; mucosal disease; neutralizing antibodies; taxonomy; antiviral drugs; vaccines; species and subgenotypes; wild animal

(This special issue belongs to the Section Animal Viruses)

Diversity and Evolution of Viruses in Ecosystem 2025

edited by

René Kallies

submission deadline 28 Feb 2026 | 3 articles | Viewed by 3798 | Submission Open

Keywords: environmental virology; viral metagenomics; viral metatranscriptomics; phage genomics; virus evolution and phylogeny

(This special issue belongs to the Section General Virology)

Bacteriophage Diversity, 2nd Edition

edited by Bert Ely

submission deadline 28 Feb 2026 | 3 articles | Viewed by 2451 | Submission Open

Keywords: bacteriophages phage; diversity genome; evolution; new genera; phage-host interactions

(This special issue belongs to the Section Bacterial Viruses)

Pharmacology of Antiviral Drugs, 2nd Edition

edited by

David E. Martin

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1007 | Submission Open

Keywords: pharmacology; clinical pharmacology; antiviral therapy; antiviral prophylaxis; human viruses; animal viruses; pharmacokinetics; pharmacodynamics; drug resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

One Health Approach: Tackling the Spillover of Zoonotic Viruses from Wildlife to Humans

edited by

Gilberto Sabino-Santos

Jamie Kristine Reaser

and

Kirk Douglas

submission deadline 28 Feb 2026 | Viewed by 720 | Submission Open

Keywords: One Health; spillover; viruses; emerging viruses

(This special issue belongs to the Section Animal Viruses)

Veterinary Virology: Unraveling Host–Pathogen Interactions for Animal Health

edited by

Muhammad Jasim Uddin

submission deadline 28 Feb 2026 | 1 articles | Viewed by 527 | Submission Open

Keywords: veterinary virology; host– pathogen interactions; viral replication and immune evasion; zoonotic viruses; One Health; vaccine and therapeutic development; molecular virology and genomics; emerging and re-emerging viral pathogens or diseases; animal health and welfare; high-throughput or deep sequencing; outbreak prevention and control; food security

(This special issue belongs to the Section Animal Viruses)

Synanthropy and Zoonotic Viral Spillover

edited by

João R. Mesquita

submission deadline 28 Feb 2026 | Viewed by 505 | Submission Open

Keywords: zoonoses; synanthropic interactions; virus; emergence; spillover

(This special issue belongs to the Section Animal Viruses)

Endogenous Retrovirus Proteins and Their Functions, 2nd Edition

edited by

Benoit Barbeau

submission deadline 28 Feb 2026 | Viewed by 452 | Submission Open

Keywords: endogenous retrovirus; ERV envelope protein; receptor; cell fusion; cancer; pre-eclampsia; obstetric disorder; diagnosis; evolutionary conservation; gene regulation

(This special issue belongs to the Section Human Virology and Viral Diseases)

Innovative Prophylactic and Therapeutics for the Treatment of Coronavirus Infection

edited by

Luis Martinez-Sobrido

and Jun-Gyu Park

submission deadline 28 Feb 2026 | Viewed by 279 | Submission Open

Keywords: prophylactic; therapeutics; SARS-CoV-2; viral variants; antivirals

(This special issue belongs to the Section Coronaviruses)

Foot-and-Mouth Disease Virus

edited by

Satya Parida

and

Zhidong Zhang

submission deadline 28 Feb 2026 | Viewed by 206 | Submission Open

Keywords: foot-and-mouth disease; foot-and-mouth disease virus; hoof-and-mouth disease; FMD; FMD virus; foot-and-mouth disease vaccines

(This special issue belongs to the Section Animal Viruses)

HIV Accessory Proteins

edited by

Gail E. Fanucci

submission deadline 28 Feb 2026 | Viewed by 108 | Submission Open

Keywords: accessory proteins; cellular interactions; drug design; liquid– liquid phase separations; molecular condensate; HIV; novel accessory proteins from other viruses

(This special issue belongs to the Section General Virology)

Host-Targeting Antivirals: From Mechanism to Intervention

edited by

Stephan Pleschka

submission deadline 28 Feb 2026 | Viewed by 105 | Submission Open

Keywords: host-targeting antivirals; host receptors; signaling pathways; metabolic networks; transcription factors; treatment; clinical intervention practice; preclinical data; intervention strategy design; mechanism

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

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