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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Evolutionary Challenges of RNA Viruses: Insights from SARS-CoV-2 Variants and Emerging Respiratory Diseases

edited by

Ahmed El-Shamy

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1048 | Submission Open

Keywords: RNA viruses; evolution; influenza; SARS-CoV2; COVID-19; respiratory diseases

(This special issue belongs to the Section General Virology)

Enveloped and Non-Enveloped Virus Assembly

edited by

Schuyler van Engelenburg

submission deadline 30 Nov 2025 | Viewed by 205 | Submission Open

Keywords: virus assembly; viral host factors; virus methodology; virus egress; membrane remodeling; cellular imaging; virus budding and release; protein-protein interactions; genome packaging; viral capsid; assembly inhibitors

(This special issue belongs to the Section Human Virology and Viral Diseases)

Peste Des Petits Ruminants (PPR): Progress and Efforts Toward 2030 Eradication

edited by

Satya Parida

and

Felix Njeumi

submission deadline 30 Nov 2025 | Viewed by 166 | Submission Open

Keywords: peste des petits ruminants virus (PPRV); PPR; PPR in sheep; goats; cattle; buffaloes; and wildlife; PPR vaccination strategy; diagnosis; surveillance; epidemiology; episystem; socioeconomics; transmission; pathogenesis; atypical hosts and wildlife hosts

(This special issue belongs to the Section Animal Viruses)

Cellular Mechanisms Regulating HIV Replication, 2nd Edition

edited by

Sergei Nekhai

submission deadline 30 Nov 2025 | Viewed by 118 | Submission Open

Keywords: HIV-1; HIV-1 replication; host factors

(This special issue belongs to the Section Human Virology and Viral Diseases)

Functional Structures in RNA Viruses

edited by Riccardo Delli Ponti,

Gian Gaetano Tartaglia

Andrea Vandelli

and Laura Broglia

submission deadline 30 Nov 2025 | Viewed by 70 | Submission Open

Keywords: RNA secondary structure; RNA viruses; machine learning; SHAPE; protein– RNA interactions

(This special issue belongs to the Section General Virology)

Virology Research in South Africa—from a Great Legacy to an Optimistic Future

edited by

Burtram C. Fielding

and

Ziyaad Valley-Omar

submission deadline 1 Dec 2025 | 9 articles | Viewed by 27291 | Submission Open

Keywords: SARS-CoV-2; other respiratory viruses; vaccines; HIV; antiviral resistance; zoonotic viruses; hepatitis viruses; enteric viruses; novel viruses/virus discovery

(This special issue belongs to the Section General Virology)

Structure-Based Antiviral Drugs and Vaccine Design

edited by

Shi-hua Xiang

and

Fengwei Bai

submission deadline 15 Dec 2025 | 3 articles | Viewed by 2977 | Submission Open

Keywords: antiviral; structure based; AI-powered; drug design; vaccine design

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Bioinformatics and Computational Approaches in Viral Genomics and Evolution 2025

edited by Camila Malta Romano, Mariana Severo Ramundo and Nilson Coimbra

submission deadline 16 Dec 2025 | 4 articles | Viewed by 3218 | Submission Open

Keywords: bioinformatics tools; genomic surveillance; viral evolution; computational genomics; host-pathogen interactions

(This special issue belongs to the Section General Virology)

Diversity and Coinfections of Plant or Fungal Viruses, 3rd Edition

edited by

Islam Hamim

Ken Komatsu

and

Hiromitsu Moriyama

submission deadline 20 Dec 2025 | 4 articles | Viewed by 5985 | Submission Open

Keywords: diagnosis; surveillance; molecular mechanism; viroid; subviral agents; mycoviruses; biological control; pesticide resistance; antiviral defense mechanism; population genetics; recombination; gene expressions; host range

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Swine Viruses: Immunology and Vaccinology

edited by

Yue Wang

and

Hongying Chen

submission deadline 20 Dec 2025 | 1 articles | Viewed by 352 | Submission Open

Keywords: swine virology; swine immunology; vaccine development; vaccinology; viral pathogenesis; vaccine design; disease prevention; swine health

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Virology in Italy 2025—9th National Congress of the Italian Society for Virology

edited by

Enzo Tramontano

Arnaldo Caruso

Massimiliano Galdiero

Luisa Rubino

and

Gabriele Vaccari

submission deadline 20 Dec 2025 | Viewed by 241 | Submission Open

Keywords: Italy; emerging viruses; viral subversion of host cell processes; viruses of microbes; antivirals; vaccines; emerging methods in virology; RNA in virus infection; plant viruses; antiviral innate immunity; animal viruses; mycoviruses

(This special issue belongs to the Section General Virology)

Understanding the Oncogenesis of Human Herpesviruses through Their Critical Comparisons

edited by Ya-Fang Chiu and Bill Sugden

submission deadline 30 Dec 2025 | 3 articles | Viewed by 6770 | Submission Open

(This special issue belongs to the Section Human Virology and Viral Diseases)

RSV Epidemiological Surveillance: 2nd Edition

edited by Emanuele Castagno and Irene Raffaldi

submission deadline 30 Dec 2025 | 4 articles | Viewed by 4645 | Submission Open

Keywords: respiratory syncytial virus (RSV); epidemiological surveillance; bronchiolitis; children; newborns; infants

(This special issue belongs to the Section Human Virology and Viral Diseases)

Immune Mechanisms Against Respiratory Viral Pathogens

edited by Telugu Akula Narasaraju and Sunil More

submission deadline 30 Dec 2025 | Viewed by 77 | Submission Open

Keywords: respiratory viral infections; innate and adaptive immunity; host– pathogen interactions; inflammatory response; therapeutic interventions

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

HIV Reservoirs, Latency, and the Factors Responsible

edited by Yuyang Tang and

Mudit Tyagi

submission deadline 31 Dec 2025 | 4 articles | Viewed by 19298 | Submission Open

Keywords: HIV; HIV latency; HIV persistence; HIV eradication; HIV cure; HIV vaccine

(This special issue belongs to the Section Human Virology and Viral Diseases)

Microscopy Methods for Virus Research

edited by Krishanu Ray

submission deadline 31 Dec 2025 | 7 articles | Viewed by 16472 | Submission Open

Keywords: viruses; fluorescence imaging; single-molecule imaging; super-resolution imaging; intra-vital imaging; electron microscopy; Cryo-EM; Cryo-ET

(This special issue belongs to the Section General Virology)

Viral Infections and Immune Dysregulation 2024–2025

edited by

Ester Ballana Guix

and

Ifeanyi Jude Ezeonwumelu

submission deadline 31 Dec 2025 | 6 articles | Viewed by 14411 | Submission Open

Keywords: immune responses; immune dysregulation; autoimmunity; viral infections; immunomodulation

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Controlling Zoonotic Viral Diseases from One Health Perspective 2025

edited by

Maureen T. Long

and Erika Schwarz-Collins

submission deadline 31 Dec 2025 | 5 articles | Viewed by 13386 | Submission Open

Keywords: one health; viral zoonoses; control; vaccine; surveillance; epidemiology

(This special issue belongs to the Section Animal Viruses)

H5N1 Influenza Viruses

edited by

Daniel R. Perez

submission deadline 31 Dec 2025 | 6 articles | Viewed by 8541 | Submission Open

Keywords: H5N1; avian influenza; genetic diversity; immune response; vaccines and antiviral therapies

(This special issue belongs to the Section Animal Viruses)

EBV and Disease: New Perspectives in the Post COVID-19 Era

edited by

Xiaoming Lyu

and Dengke Li

submission deadline 31 Dec 2025 | 6 articles | Viewed by 7334 | Submission Open

Keywords: EBV; reactivation and immune dysregulation; EBV-associated malignancies; autoimmune diseases; diagnostic and therapeutic

(This special issue belongs to the Section Human Virology and Viral Diseases)

Preparation for the Next Potential Pandemic—Chikungunya, Dengue, Zika and Other Viruses

edited by

Zoltan Vajo

submission deadline 31 Dec 2025 | 5 articles | Viewed by 7250 | Submission Open

Keywords: chikungunya; dengue; zika; next pandemic; epidemiology; pharmaceutics; immunology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular Biomarkers for Viral Infection

edited by

Paulina Niedźwiedzka-Rystwej

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5757 | Submission Open

Keywords: molecular biomarkers; viral infections

(This special issue belongs to the Section Animal Viruses)

Application of Genetically Engineered Plant Viruses

edited by

Tsung-Chi Chen

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5043 | Submission Open

Keywords: plant virus; infectious clone; viral vector; virus-induced gene silencing (VIGS); virus-like particles (VLPs); cross-protection

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Interplay Between Influenza Virus and Host Factors

edited by

Matloob Husain

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4329 | Submission Open

Keywords: influenza virus; host factors; proviral host factors; antiviral host factors; host adaptation; virus entry; virus assembly; virus release; innate antiviral response; interferon-stimulated genes; post-translational protein modifications

(This special issue belongs to the Section Animal Viruses)

Intra-patient Viral Evolution and Diversity

edited by Adam A. Capoferri and

Mary Kearney

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3794 | Submission Open

Keywords: intra-patient viral evolution; drug resistance; immune escape; co-evolution; virus persistence; virus evolution

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular Virus–Insect Interactions, 2nd Edition

edited by Li-Long Pan

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3706 | Submission Open

Keywords: plant virus-insect vector interactions; virus transmission; entomopathogenic virus-insect host interactions; insect-specific viruses; induction and suppression of immune responses

(This special issue belongs to the Section Invertebrate Viruses)

Surveillance, Transmission Dynamics, and Control of Zoonotic Viruses

edited by Dimitrios A. Chatzidimitriou,

Anna Papa

and Ilias Bouzalas

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3269 | Submission Open

Keywords: zoonosis; surveillance; epidemiology; diagnostics

(This special issue belongs to the Section Animal Viruses)

Emerging Microbes, Infections and Spillovers, 2nd Edition

edited by

Ravi Kant

Tarja Sironen

and

Maciej Grzybek

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2504 | Submission Open

Keywords: emerging infections; virus spillovers; microbes; cross-species transmission; virus evolution; viral disease; virus reservoirs; virus– host interaction; pathogenesis

(This special issue belongs to the Section Animal Viruses)

Human Hepatitis Viruses and Their Animal Homologues

edited by

Bo Wang

and

Xinglou Yang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2379 | Submission Open

Keywords: hepatitis viruses; animal virome; genetic diversity; genomic organization; ecology and evolution; molecular biology; molecular epidemiology; zoonotic potential

(This special issue belongs to the Section General Virology)

SARS-CoV-2, COVID-19 Pathologies, Long COVID, and Anti-COVID Vaccines

edited by

Jean-Marc Sabatier

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2220 | Submission Open

Keywords: SARS-CoV-2; COVID-19; long COVID; anti-COVID vaccines; spikeopathy; renin– angiotensin system

(This special issue belongs to the Section Coronaviruses)

Advancing Hepatitis Elimination: HBV, HDV, and HCV

edited by

Federico Garcia

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2076 | Submission Open

Keywords: hepatitis elimination; HBV; HCV; HDV

(This special issue belongs to the Section Human Virology and Viral Diseases)

Severe Fever with Thrombocytopenia Syndrome Virus 2025

edited by

Masayuki Saijo

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2075 | Submission Open

Keywords: SFTS; SFTSV; emerging viral infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Coronavirus Pathogenesis and Virus-Host Interaction

edited by

Hin Chu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1874 | Submission Open

Keywords: COVID-19; SARS-CoV-2; SARS-CoV-1; MERS-CoV; pathogenesis; virus– host interaction; virus entry; host factors; animal models; SARS-CoV-2 variants

(This special issue belongs to the Section General Virology)

Porcine Viruses 2025

edited by

Guoxin Li

Lingxue Yu

and

Jin Cui

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1861 | Submission Open

Keywords: epidemiology; pathogenesis; immune evasion; virus evolution; vaccine

(This special issue belongs to the Section Animal Viruses)

Lung Immunity to Viral Infections

edited by

Ana Paula Duarte De Souza

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1860 | Submission Open

Keywords: respiratory virus; lung immune response; vaccines to respiratory virus; microbiota and lung immune response; environmental factors and lung immune responses; virus– host interaction in the lung; immunotherapies to prevent or treat respiratory viral infection

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Antiviral Development for Emerging and Re-Emerging Viruses

edited by

Ming-Hon Hou

and

Shih-Chao Lin

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1698 | Submission Open

Keywords: protein– protein interaction; viral– host interaction; viral replication; antiviral; human viruses; emerging infections

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Harnessing AI and Machine Learning for Antiviral Development

edited by

X. Frank Zhang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1434 | Submission Open

Keywords: artificial intelligence; machine learning; antiviral therapies; personalized medicine; drug discovery; drug repurposing; drug resistance

(This special issue belongs to the Section General Virology)

Viral Strategies and Cellular Countermeasures That Regulate mRNA Access to the Translation Apparatus: 2nd Edition

edited by

Christopher Hellen

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1142 | Submission Open

Keywords: virus– host interactions; IRES elements; RNA structure; translation initiation; translational control; innate immune response; RNA modification

(This special issue belongs to the Section General Virology)

Virology and Immunology of Gene Therapy 2025

edited by Weidong Xiao and

Jianming Qiu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1036 | Submission Open

Keywords: gene therapy; viral vector; vaccine; immune responses; viruses; AAV; lentiviral vectors; neutralizing antibody

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Zika Virus and Congenital Zika Syndrome, 2nd Edition

edited by Marcos Vinicius da Silva Pone and Sheila Moura Pone

submission deadline 31 Dec 2025 | 1 articles | Viewed by 857 | Submission Open

Keywords: viral infections; Zika virus; congenital Zika syndrome

(This special issue belongs to the Section Human Virology and Viral Diseases)

Arboviruses and Climate, 2nd Edition

edited by José Lourenço and

Marta Giovanetti

submission deadline 31 Dec 2025 | 1 articles | Viewed by 814 | Submission Open

Keywords: arbovirus; climate; climate change; arthropods; vectors; epidemiology; evolution; ecology; public health

(This special issue belongs to the Section Invertebrate Viruses)

Current: Measles Outbreak, a Global Situation

edited by

S. Louise Cosby

submission deadline 31 Dec 2025 | 1 articles | Viewed by 794 | Submission Open

Keywords: measles; vaccination; surveillance; complications; outbreaks

(This special issue belongs to the Section Human Virology and Viral Diseases)

Animal Virus Discovery and Genetic Diversity: 2nd Edition

edited by

Ryan Troyer

submission deadline 31 Dec 2025 | 2 articles | Viewed by 753 | Submission Open

Keywords: animal virus; evolution; genetic; diversity; richness; emerging viruses; virome; metagenomics; ecology; cross-species transmission; zoonotic

(This special issue belongs to the Section Animal Viruses)

The Structure and Function of Flavivirus Genes and Proteins

edited by

Tadahisa Teramoto

and Kay Choi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 688 | Submission Open

Keywords: flavivirus; structural protein; non-structural protein; 5'UTR; 3'UTR

(This special issue belongs to the Section General Virology)

Virological and Immunological Factors Underlying HBV Functional Cure and HBV Reactivation

edited by

Valentina Svicher

submission deadline 31 Dec 2025 | Viewed by 607 | Submission Open

Keywords: HBV persistence; HBV functional cure; cccDNA; immunology of HBV; HBV reactivation; immune-escape mutations

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advancing Research of Anelloviruses, Second Edition

edited by

Fabrizio Maggi

and

Pietro Giorgio Spezia

submission deadline 31 Dec 2025 | Viewed by 374 | Submission Open

Keywords: TTV; TTMV; TTMDV; virome; viral species; immune system; orphan virus

(This special issue belongs to the Section Human Virology and Viral Diseases)

Virus Bioinformatics 2025

edited by

Manja Marz

and

Maria Fabisch

submission deadline 31 Dec 2025 | Viewed by 341 | Submission Open

Keywords: virus bioinformatics; software; viral metagenomics and ecology; virus– host interactions; viral diversity and evolution; virus identification

(This special issue belongs to the Section General Virology)

Phage Display in Cancer Diagnosis and Screening

edited by

Valery A. Petrenko

submission deadline 31 Dec 2025 | Viewed by 331 | Submission Open

Keywords: phage display; cancer; diagnosis; screening; prognosis and monitoring

(This special issue belongs to the Section Bacterial Viruses)

Virus Biosensing

edited by Guobin Mao

submission deadline 31 Dec 2025 | Viewed by 314 | Submission Open

Keywords: virus detection; molecular diagnosis; immunoassay; nucleic acid amplification; CRISPR-based detection; nucleic acid assembly; biosensor; point-of-care testing

(This special issue belongs to the Section General Virology)

RNA Viruses Replication and Innate Immunity

edited by

Griffith Parks

submission deadline 31 Dec 2025 | Viewed by 299 | Submission Open

Keywords: RNA virus replication and transcription; pathogen-associated molecular patterns; interferons; cytokines; signaling pathways

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

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