Special Issues

Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Viral Diseases of Sheep and Goats
edited by Ramsés Reina and Álex Gómez
submission deadline 30 Sep 2025 | 2 articles | Viewed by 1027 | Submission Open
Keywords: small ruminants; viral immunopathogenesis; infection; transmission; epidemiology; control strategies; vaccines
(This special issue belongs to the Section Animal Viruses)
Molecular Epidemiology of SARS-CoV-2, 4th Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 950 | Submission Open
Keywords: SARS-CoV-2; genomic monitoring; phylodynamic; molecular epidemiology
(This special issue belongs to the Section Coronaviruses)
Development of Diagnostics and Therapeutic Interventions for Viral Infections of the Central Nervous System
edited by Karin E. Peterson and Amanda E. Calvert
submission deadline 30 Sep 2025 | 1 articles | Viewed by 780 | Submission Open
Keywords: encephalitis; arbovirus; diagnosis; treatment; neurovirology; antibody therapeutics; agnostic therapeutics; point of care diagnostics; rapid diagnostics
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Advances in Understanding Viral Pathogenesis and Host Immune Responses to Arboviruses and Respiratory Viruses submission deadline 30 Sep 2025 | 1 articles | Viewed by 768 | Submission Open
Keywords: arboviruses; respiratory viruses; viral pathogenesis; host immune responses; innate immunity; adaptive immunity; viral immune evasion; cytokine storm; interferon response; viral replication; viral transmission; immunopathology; neutralizing antibodies; host– virus interactions
(This special issue belongs to the Section Animal Viruses)
Pathogenesis of Viral Infections
edited by
submission deadline 30 Sep 2025 | Viewed by 300 | Submission Open
Keywords: human and zoonotic viral diseases; viral pathogenesis; systems-level analyses; immune response; protein– protein interactions
(This special issue belongs to the Section General Virology)
Viral Strategies to Regulate Host Immunity or Signal Pathways 2nd Edition
edited by
submission deadline 30 Sep 2025 | Viewed by 213 | Submission Open
Keywords: virus– host interaction; viral immunity; viral pathogenesis; immune evasion; innate immunity; adaptive immunity; signal pathway
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Human Leukocyte Antigen (HLA) in Viral Infections
edited by Nicholas Borcherding
submission deadline 30 Sep 2025 | Viewed by 195 | Submission Open
Keywords: HLA; viral infection; immune response; T cells; antigen presentation; viral evasion; immunogenetics; polymorphism; disease susceptibility; vaccine development
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Therapeutic Interfering Particles (TIPs): A Promising Treatment for Viral Infections
edited by and Rebekah Honce
submission deadline 30 Sep 2025 | Viewed by 169 | Submission Open
Keywords: defective interfering particles; defective viral genomes; therapeutic interfering particles; DIPs; DVGs; TIPs
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Giant, Jumbo and Mega Phages
edited by
submission deadline 30 Sep 2025 | Viewed by 164 | Submission Open
Keywords: long-genome phage; giant phage; jumbo phage; mega phage; genomes; structure/assembly; infection strategies; ecology; evolution; applications
(This special issue belongs to the Section Bacterial Viruses)
Viral Pathogenesis and Novel Vaccines for Fish Viruses
edited by Vikram Vakharia
submission deadline 30 Sep 2025 | Viewed by 135 | Submission Open
Keywords: fish; RNA viruses; viral pathogenesis; virulence; reverse genetics; recombinant vaccines; oral vaccines
(This special issue belongs to the Section Animal Viruses)
Recent Advances in Anti-HCV, Anti-HBV and Anti-Flavivirus Agents, 2nd Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 122 | Submission Open
Keywords: medicinal chemistry of anti-HCV; anti-HBV and anti-flavivirus agents; synthesis; structure activity relationships (SAR); antiviral drug discovery; HBV; HCV; Dengue (DENV); Yellow Fever (YFV); West Nile (WNV); Zika (ZIKV); mechanism of action; drug targets; in silico studies
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Women in Virology 2025
edited by , , Priti Kumar and Ulrike Lange
submission deadline 1 Oct 2025 | 5 articles | Viewed by 11279 | Submission Open
Keywords: human; animal; and plant viruses; virus replication; pathogenesis; transmission; antivirals; antiviral resistance; drug discovery; vaccine development and evaluation; animal models; high-risk populations
(This special issue belongs to the Section General Virology)
15-Year Anniversary of Viruses submission deadline 1 Oct 2025 | 9 articles | Viewed by 7336 | Submission Open
Keywords: diversity; innovation; and impact of modern virology research; virology across all domains; Viruses  fifteenth year anniversary  
(This special issue belongs to the Section General Virology)
Viral Infection in Airway Epithelial Cells
edited by Camille Ehré and Raymond J. Pickles
submission deadline 1 Oct 2025 | 1 articles | Viewed by 1171 | Submission Open
Keywords: respiratory viral infections; airway epithelial cells; virus– host interactions; viral pathogenesis; immune responses; Influenza viruses; respiratory syncytial virus (rsv); coronaviruses; SARS-CoV-2; respiratory tract
(This special issue belongs to the Section Animal Viruses)
Conquering Antiviral Drug Resistance via Development of Novel Antivirals and New Testing Methods for Drug Resistance: From Bench to Bedside
edited by , and David Hillyard
submission deadline 15 Oct 2025 | Viewed by 350 | Submission Open
Keywords: antivirals; viral hepatitis; HIV; Mpox; influenza; enterovirus; chronic viral infections; acute viral infections; diagnosis; antiviral drug resistance; antiviral drug mutations; antiviral drug development; viral evolution; treatment
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Viral RNA and Its Interaction with the Host
edited by and Neva Caliskan
submission deadline 24 Oct 2025 | 2 articles | Viewed by 2973 | Submission Open
Keywords: virus life cycle; host-virus interactions; viral RNA; RNA structures; RNA binding proteins; translational control; RNA modifications; immune evasion; RNA localization
(This special issue belongs to the Section General Virology)
Pestivirus 2025
edited by and Christiane M. Riedel
submission deadline 30 Oct 2025 | 3 articles | Viewed by 1228 | Submission Open
Keywords: pestiviruses; classical swine fever virus; bovine viral diarrhea virus; BVDV-1; BVDV-2; CSF
(This special issue belongs to the Section Animal Viruses)
Mosquito-Borne Encephalitis Viruses submission deadline 31 Oct 2025 | 11 articles | Viewed by 17130 | Submission Open
Keywords: mosquito-borne arboviruses; encephalitic togaviruses; encephalitic flaviviruses; encephalitic bunyaviruses; mosquito vectors; laboratory diagnostics; one health approaches to arbovirus ecology; arbovirus surveillance; vaccines to encephalitic arboviruses
(This special issue belongs to the Section Human Virology and Viral Diseases)
Innate and Adaptive Immune Responses to Arbovirus Infections
edited by Manuela Sales Lima Nascimento, Paulo Marcos da Matta Guedes and
submission deadline 31 Oct 2025 | 2 articles | Viewed by 7039 | Submission Open
Keywords: arbovirus; innate immunity; adaptive immunity; immunotherapeutic; immunoprophylaxis; vaccines
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
HIV-1 Infection and Immunometabolism: Relevance to HIV Pathogenesis and Persistence 3.0
edited by
submission deadline 31 Oct 2025 | 3 articles | Viewed by 4535 | Submission Open
Keywords: immunometabolism; HIV-1; inflammation; immune activation; HIV pathogenesis; HIV latency; innate/adaptive immunity; metabolic diseases; non-AIDS-associated comorbidities
(This special issue belongs to the Section Human Virology and Viral Diseases)
Biotechnological Applications of Phage and Phage-Derived Proteins 2025
edited by
submission deadline 31 Oct 2025 | 2 articles | Viewed by 3999 | Submission Open
Keywords: bacteriophage; biotechnological applications; genetic engineering; antimicrobials; diagnostic
(This special issue belongs to the Section Bacterial Viruses)
Viruses Associated with Gastroenteritis submission deadline 31 Oct 2025 | 5 articles | Viewed by 3871 | Submission Open
Keywords: vaccines; therapeutic approaches; virus replication; molecular epidemiology; immune response; microbiome; diagnosis
(This special issue belongs to the Section Human Virology and Viral Diseases)
HIV Neurological Disorders: 2nd Edition
edited by
submission deadline 31 Oct 2025 | 2 articles | Viewed by 3434 | Submission Open
Keywords: neuroinflammation; chronic HIV inflammation; HIV reservoir; HIV proteins; HIV receptors; HIV models; drugs of abuse; AIDS dementia complex; HIV noninfectious comorbidities; HIV healthcare disparities; HIV neuropathology
(This special issue belongs to the Section Human Virology and Viral Diseases)
Viral Hemorrhagic Disease
edited by Joseph W. Golden and Aura R. Garrison
submission deadline 31 Oct 2025 | 3 articles | Viewed by 3041 | Submission Open
Keywords: host factors contributing to severe disease; immune correlates of protection; animal models; persistent infections; surveillance of hemorrhagic fever viruses; prophylactic and therapeutic development against hemorrhagic fever viruses
(This special issue belongs to the Section Animal Viruses)
Bunyaviruses 2025
edited by Natasha L. Tilston-Lunel, Kenneth A. Stapleford and Ryan F. Relich
submission deadline 31 Oct 2025 | 2 articles | Viewed by 1697 | Submission Open
Keywords: bunyaviruses; viral evolution; reassortment; vector biology; pathogenesis; animal models; vaccines and therapeutics
(This special issue belongs to the Section General Virology)
Advances in Research on HIV Drug Resistance and Other Determinants of Treatment Success: 3rd Edition
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1485 | Submission Open
Keywords: HIV; antiretroviral therapies; virological failure; HIV drug resistance; HIV reservoir; HIV viral subtype; predictors of virological failure
(This special issue belongs to the Section Human Virology and Viral Diseases)
Molecular Epidemiology of Re-Emerging Arboviruses: Genetics and Ecology Insights
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1295 | Submission Open
Keywords: arboviruses; climate change; epidemic– pandemic preparedness; genomic surveillance
(This special issue belongs to the Section Animal Viruses)
Current ART, Virologic Failure and Implications for HIV Drug Resistance, 2nd Edition
edited by Susan M. Schader
submission deadline 31 Oct 2025 | 1 articles | Viewed by 1093 | Submission Open
Keywords: antiretroviral therapy (ART); HIV; AIDS; drug resistance; low level viremia (LLV); very low level viremia (VLLV); virologic failure (VF); clinical failure; viral load (VL); viral suppression; long-acting injectables (LAI); pre-exposure prophylaxis (PrEP); first-line ART; second-line ART; target detected; target not detected (TND); viral blips; novel mechanisms of HIV drug resistance; acquired genotypic drug resistance; adherence; people living with HIV (PLWH); management of people living with HIV (PLWH); risk factors; genotype; phenotype; treatment efficacy
(This special issue belongs to the Section Human Virology and Viral Diseases)
Regulation of HIV-1 Transcription and Latency, 2nd Edition
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 676 | Submission Open
Keywords: HIV provirus; HIV latency; latency reversal; HIV transcription initiation; HIV transcription elongation; transcription factors; epigenetic silencing; posttranscriptional control of HIV gene expression; transcriptomic analysis of HIV infection; HIV reservoir
(This special issue belongs to the Section Human Virology and Viral Diseases)
Emerging and Re-emerging Infections: Impact on Substances of Human Origin (SoHO) submission deadline 31 Oct 2025 | Viewed by 492 | Submission Open
Keywords: substances of human origin (SoHO); infectious diseases; emerging and re-emerging infections; transmission risk
(This special issue belongs to the Section Human Virology and Viral Diseases)
Vaccines and Antiviral Drugs Against Viral Diseases in Domestic Animals
edited by
submission deadline 31 Oct 2025 | 1 articles | Viewed by 401 | Submission Open
Keywords: vaccines; antiviral drugs; domestic animals; virus
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
One Health Approach: Tackling the Spillover of Zoonotic Viruses from Wildlife to Humans
edited by Gilberto Sabino-Santos, and
submission deadline 31 Oct 2025 | Viewed by 369 | Submission Open
Keywords: One Health; spillover; viruses; emerging viruses
(This special issue belongs to the Section Animal Viruses)
Virus Infections and Host Metabolism 2025
edited by , and Liang Cui
submission deadline 31 Oct 2025 | Viewed by 348 | Submission Open
Keywords: host– virus interactions; host response to viruses; immunometabolism; viral pathogenesis; metabolic reprogramming; metabolome; metabolism; lipidomics
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
The Immunosocial Approach to Emerging and Re-Emerging Viral Infections submission deadline 31 Oct 2025 | Viewed by 302 | Submission Open
Keywords: viral infections; immunosocial approach; public health
(This special issue belongs to the Section General Virology)
Influenza Viruses in Wildlife 2025
edited by and Wendy Blay Puryear
submission deadline 31 Oct 2025 | Viewed by 167 | Submission Open
Keywords: avian influenza; wild birds; wildlife; influenza epidemiology; surveillance; HPAI
(This special issue belongs to the Section Animal Viruses)
Vesicular Stomatitis Virus (VSV) 2025
edited by Michael A. Whitt, , Luis L. Rodriguez and
submission deadline 31 Oct 2025 | Viewed by 158 | Submission Open
Keywords: pathogenesis; innate immune evasion; virus– vector interactions; virus– host interactions; epidemiology; entry; assembly; replication; transcription; vaccine; oncolytic
(This special issue belongs to the Section Animal Viruses)
Enteric Viruses in Environment and Humans: Identification, Surveillance and Control
edited by and Maria Inês Zanoli Sato
submission deadline 31 Oct 2025 | Viewed by 128 | Submission Open
Keywords: enteric viruses; wastewater-based epidemiology; human-based epidemiology; One Health
(This special issue belongs to the Section Human Virology and Viral Diseases)
2nd Edition: How to Adjust the Action Steps for Achieving the Global Hepatitis Virus (HBV/HCV/HDV) Elimination Targets?
edited by Ferruccio Bonino
submission deadline 31 Oct 2025 | Viewed by 118 | Submission Open
Keywords: antivirals; chronic viral hepatitis infections; HBV; HBV; functional cure; HCV; HCV vaccine; HDV; HDV-RNA; anti-HD
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Economically Important Viruses in African Crops
edited by James Peter Legg, Stephen Winter, and
submission deadline 31 Oct 2025 | Viewed by 113 | Submission Open
Keywords: economically important viruses; african crops; cassava; banana; potato; yams; beans; cowpeas; maize; cacao; tomatoes; peppers; rice yellow mottle virus; chili; okra
(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)
Multiscale Modeling and Forecasting of COVID-19 and Respiratory Virus Dynamics
edited by and Sunmi Lee
submission deadline 31 Oct 2025 | Viewed by 94 | Submission Open
Keywords: COVID-19 modeling; respiratory virus dynamics modeling; epidemic forecasting; parameter identifiability; multiscale transmission dynamics
(This special issue belongs to the Section General Virology)
Neurocognitive Dynamics and Biomarkers in HIV
edited by Mattia Trunfio and Carmela Pinnetti
submission deadline 1 Nov 2025 | 2 articles | Viewed by 1284 | Submission Open
Keywords: HIV infection; neurodegeneration; biomarkers; neuroinflammation; cognitive performance; mood; central nervous system
(This special issue belongs to the Section Human Virology and Viral Diseases)
Opportunistic Viral Infections, 3rd Edition
edited by
submission deadline 7 Nov 2025 | Viewed by 80 | Submission Open
Keywords: epidemiology of opportunistic viral infections; immunocompromised individuals (HIV/AIDS; transplants; tumors; chemotherapeutics; biotechnological drugs; etc.); advances in diagnosis; management and treatment of opportunistic viral infections; JC virus; HPV; CMV; EBV and other herpesvirus; human T-cell leukemia virus type 1 (HTLV-1); hepatitis B virus (HBV) and hepatitis C virus (HCV); polyomavirus; new Coronavirus including SARS-CoV-2; emerging viruses (arbovirus other zoonotic virus)
(This special issue belongs to the Section General Virology)
Host-Directed Antiviral Therapy
edited by and
submission deadline 15 Nov 2025 | Viewed by 358 | Submission Open
Keywords: host-directed antivirals; antiviral agents; drug resistance; host factors; viral– host interplay
(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)
Recent Advances on Arboviruses Pathogenesis and Evolution
edited by Mariana Sequetin Cunha
submission deadline 17 Nov 2025 | 2 articles | Viewed by 2189 | Submission Open
Keywords: virus outbreaks; phylogeny; virus evolution; pathology
(This special issue belongs to the Section Human Virology and Viral Diseases)
Emerging Concepts in SARS-CoV-2 Biology and Pathology, 3rd Edition
edited by
submission deadline 28 Nov 2025 | Viewed by 328 | Submission Open
Keywords: SARS-CoV-2; epidemiology; virology; therapeutics; zoonoses
(This special issue belongs to the Section Coronaviruses)
Advances in Plant Virus/Viroid Detection and Identification Methods, 2nd Edition
edited by Laura Tomassoli and
submission deadline 28 Nov 2025 | Viewed by 65 | Submission Open
Keywords: plant viruses and viroids diagnostics; high-throughput sequencing; bioinformatics; virus taxonomy; virus/viroid– plant– vector interactions; real-time PCR; digital droplet PCR; hyperspectral imaging; machine learning; artificial intelligence; biosensors
(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)
Molecular Mechanisms and Clinical Manifestations of Persistent Viral Infections
edited by and Simone La Frazia
submission deadline 30 Nov 2025 | 7 articles | Viewed by 21046 | Submission Open
Keywords: mammalian viruses; chronic infection; latent infection; pathogenetic mechanisms; molecular pathways; oncogenic processes; episomal genome; host-integrated genome; immunity; antiviral drugs; endogenous viral element
(This special issue belongs to the Section Human Virology and Viral Diseases)
Molecular Epidemiology, Evolution, and Transmission of Avian Influenza Viruses
edited by
submission deadline 30 Nov 2025 | 8 articles | Viewed by 15041 | Submission Open
Keywords: avian influenza viruses; highly pathogenic avian influenza viruses (HPAIs); molecular epidemiology; phylogeny; evolution; intra- and cross-species transmission
(This special issue belongs to the Section Animal Viruses)
Advances in Rabies Research 2024
edited by and Juan A. Montaño-Hirose
submission deadline 30 Nov 2025 | 4 articles | Viewed by 10453 | Submission Open
Keywords: rabies; zoonosis; vaccine; evolution; structural biology; viral replication; virus– host interaction; pathogenesis and immunity; clinical virology
(This special issue belongs to the Section General Virology)
Avian Reovirus
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4825 | Submission Open
Keywords: avian reovirus; pathogenesis; reassortment; virus evolution; vaccines
(This special issue belongs to the Section Animal Viruses)
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