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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Antiviral Drugs and Biologics Targeting HIV: Drug Resistance to Newer Treatment and Pre-Exposure Prophylaxis (PrEP) Options: 2nd Edition

edited by

Bluma G. Brenner

submission deadline 31 Jul 2026 | Viewed by 337 | Submission Open

Keywords: HIV; antiretroviral therapy (ART); pre-exposure prophylaxis (PrEP); antiviral drugs; drug resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Intrinsic Immunity vs. Viral Antagonism: Which One Bites the Dust?

edited by

Akatsuki Saito

and

Kenzo Tokunaga

submission deadline 31 Jul 2026 | Viewed by 330 | Submission Open

Keywords: host restriction factors; viral antagonists; replication cycle; interferon-inducible pathways; ubiquitination; membrane trafficking

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Phage: Biocontrol and Biosafety

edited by Ran Wang and Tao He

submission deadline 31 Jul 2026 | Viewed by 324 | Submission Open

Keywords: phage– host interaction; biocontrol and biosafety; antimicrobial resistance; pharmacokinetics/pharmacodynamics of phage; phage and immunity; phage safety assessment; regulatory frameworks

(This special issue belongs to the Section Bacterial Viruses)

Advances in the Dynamics of Viral Structures

edited by

Nese Kurt-Yilmaz

and Celia A. Schiffer

submission deadline 31 Jul 2026 | Viewed by 239 | Submission Open

Keywords: virus structure; conformational dynamics; molecular interactions; viral proteins; antiviral drug design; protein structure; functional dynamics; molecular simulations; biophysical spectroscopy; crystallography; cryo-EM; NMR

(This special issue belongs to the Section General Virology)

Viral Regulation of Cell Death and Stress Responses

edited by

Jiann-Ruey Hong

submission deadline 31 Jul 2026 | Viewed by 235 | Submission Open

Keywords: virus; cell death; stress response; viral gene; viral controlling; viral therapy

(This special issue belongs to the Section General Virology)

Phages in the Battle Against Antimicrobial Resistance

edited by

Bożena Nejman-Faleńczyk

submission deadline 31 Jul 2026 | Viewed by 234 | Submission Open

Keywords: antimicrobial resistance (AMR); multidrug-resistant bacteria (MDR); non-antibiotic strategies; phage therapy; phage characteristics

(This special issue belongs to the Section Bacterial Viruses)

The 13th Wisc-e-sota Symposium

edited by

Louis M. Mansky

and

Paul F. Lambert

submission deadline 31 Jul 2026 | Viewed by 216 | Submission Open

Keywords: HIV; retrovirus; adeno-associated virus; Epstein– Barr virus; pichinde virus; porcine reproductive and respiratory syndrome virus

(This special issue belongs to the Section General Virology)

The Role of Adjuvants in Viral Vaccines and Vaccination

edited by

Zoltan Vajo

submission deadline 31 Jul 2026 | Viewed by 195 | Submission Open

Keywords: aluminum hydroxide; oil-in-water emulsion adjuvants; TLR agonists; combination adjuvants

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Immune Modulation by Human Cytomegalovirus: 2nd Edition

edited by

Davide Abate

submission deadline 1 Aug 2026 | Viewed by 255 | Submission Open

Keywords: human cytomegalovirus (CMV); molecular and cellular mechanisms; cell-intrinsic immunity; adaptive immunity; innate immunity

(This special issue belongs to the Section Human Virology and Viral Diseases)

Control and Contributions of Transposable Elements: Implications for Development and Disease

edited by Suzanne B. Sandmeyer and Henry L. Levin

submission deadline 14 Aug 2026 | Viewed by 2516 | Submission Open

Keywords: transposable elements; endogenous viruses; transcription factors; neurotransmission; aging

(This special issue belongs to the Section General Virology)

Infectious Disease Epidemiology: Current Updates and Perspectives

edited by

Agata Skrzat-Klapaczynska

and

Justyna Dominika Kowalska

submission deadline 15 Aug 2026 | Viewed by 380 | Submission Open

Keywords: infection prevention and control; infectious diseases epidemiology; public health; novel treatments

(This special issue belongs to the Section General Virology)

Rift Valley Fever Virus: New Insights into a One Health Archetype

edited by

Rebekah C. Kading

, Juliette Lewis and Brian H. Bird

submission deadline 16 Aug 2026 | 3 articles | Viewed by 5650 | Submission Open

Keywords: One Health; emerging infectious diseases; mosquito; bunyavirus; arbovirus; medical entomology; medical countermeasures; livestock

(This special issue belongs to the Section Animal Viruses)

Spotlight on Bocavirus and Other Parvoviruses, and Overlooked Respiratory Viruses

edited by

Suncanica Ljubin‐Sternak

and

Tatjana Vilibic-Cavlek

submission deadline 30 Aug 2026 | 3 articles | Viewed by 3312 | Submission Open

Keywords: bocavirus; Parvovirus B19; canine parvovirus; porcine parvovirus; metapneumovirus; rhinovirus Planned Papers 1. Molecular detection of Porcine cytomegalovirus (PCMV) and Porcine parvovirus (PPV) in domestic pigs and wild boars from Croatia 2. Protoparvovirus carnivoran 1 outbreak in golden jackals in Croatia 3. Epidemiology of parvovirus B19 in Croatian childbearing-aged women: A ten-year seroprevalence study

(This special issue belongs to the Section Animal Viruses)

Avian Viral Pathogenesis and Host Interactions

edited by Ping Wei and Xiumiao He

submission deadline 30 Aug 2026 | 1 articles | Viewed by 1232 | Submission Open

Keywords: avian virus; molecular mechanisms; epidemiology and evolution; molecular biology; pathogenesis; virus– host interaction; diagnostic; vaccine

(This special issue belongs to the Section Animal Viruses)

Porcine Epidemic Diarrhea Virus (PEDV): A Persistent Threat to the Global Swine Industry

edited by

Ke Liu

submission deadline 31 Aug 2026 | 4 articles | Viewed by 6482 | Submission Open

Keywords: porcine epidemic diarrhea virus; global epidemiology; economic loss; vaccines and drugs; molecular mechanism; transmission and pathogenic mechanisms

(This special issue belongs to the Section Animal Viruses)

Long-Acting Antiretrovirals

edited by Camilla Muccini and Antonella Castagna

submission deadline 31 Aug 2026 | 3 articles | Viewed by 5522 | Submission Open

Keywords: HIV infection; HIV prevention; long-acting; antiretroviral therapy; clinical studies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Polyomavirus

edited by

Sunnie R. Thompson

and Patrick S. Moore

submission deadline 31 Aug 2026 | 3 articles | Viewed by 4213 | Submission Open

Keywords: virus– host interactions; viral life cycle; viral replication; pathogenesis; phylogeny; structure; transcription; packaging; trafficking; persistence; re-arrangements; gene regulation; reactivation; miRNA; viral immune evasion; vaccines

(This special issue belongs to the Section Animal Viruses)

2nd Edition: How to Adjust the Action Steps for Achieving the Global Hepatitis Virus (HBV/HCV/HDV) Elimination Targets?

edited by Ferruccio Bonino

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2594 | Submission Open

Keywords: antivirals; chronic viral hepatitis infections; HBV; HBV; functional cure; HCV; HCV vaccine; HDV; HDV-RNA; anti-HD

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

CRISPR Applications in Plant Virology

edited by

Jian Wu

submission deadline 31 Aug 2026 | Viewed by 2123 | Submission Open

Keywords: CRISPR/Cas9; plant virology; virus resistance; genome editing; plant breeding; viral evolution; CRISPR applications; host– virus interactions; crop protection; genome modification

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Arboviruses and Climate, 2nd Edition

edited by José Lourenço and

Marta Giovanetti

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1953 | Submission Open

Keywords: arbovirus; climate; climate change; arthropods; vectors; epidemiology; evolution; ecology; public health

(This special issue belongs to the Section Invertebrate Viruses)

Japanese Encephalitis Virus and Other Closely Related Clinically Important Orthoflaviviruses—a Persistent Threat to Public and Animal Health

edited by

Ke Liu

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1856 | Submission Open

Keywords: Japanese encephalitis virus; mosquito-borne; orthoflaviviruses; public and animal health; transmission; infection; host

(This special issue belongs to the Section General Virology)

Advancing Understanding of Filoviruses

edited by John Misasi and

Adam Hume

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1735 | Submission Open

Keywords: filoviruses; Ebola virus; Marburg virus; Sudan virus; Tai Forest virus; Bundibugyo virus; Reston virus; Lloviu virus; Bombali virus; Mengla virus; Dehong virus

(This special issue belongs to the Section Animal Viruses)

Hepatitis Viruses: Detection, Diagnosis and Treatment

edited by

Daryl Lau

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1684 | Submission Open

Keywords: molecular virology; virus– host interactions; epidemiology; novel biomarkers and therapy; HBV; HCV; HDV

(This special issue belongs to the Section Human Virology and Viral Diseases)

Contribution of the Host Cell Integrated Stress Response (ISR) to Immunopathogenesis of Human RNA Viral Infections

edited by

Qiyi Tang

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1560 | Submission Open

Keywords: RNA viruses; immunopathogenesis; unfolded protein response; organelle stress; innate immunity

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Pathogenesis and Persistence in Flavivirus Infections: Mechanisms, Biomarkers, and Clinical Implications

edited by

Aleksandra Drelich

and

Barbara Judy

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1404 | Submission Open

Keywords: tropical infectious diseases; flaviviruses; co-infection; cross-reactivity; long-term sequelae; neurological symptoms; autoimmunity; pathogenesis; molecular virology; diagnosis; biomarkers

(This special issue belongs to the Section Human Virology and Viral Diseases)

Insights into Feline Viruses: Molecular, Structural, Pathogenic, and Clinical Aspects

edited by

Barbara Di Martino

submission deadline 31 Aug 2026 | 1 articles | Viewed by 974 | Submission Open

Keywords: cats; feline viruses; emerging viruses; molecular virology; pathogenesis; clinical virology; molecular and serological diagnostics; metagenomics; therapeutic and control strategies; One Health

(This special issue belongs to the Section Animal Viruses)

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus: 2nd Edition

edited by Tongqing An and Xingyang Cui

submission deadline 31 Aug 2026 | Viewed by 531 | Submission Open

Keywords: PRRSV; genetic evolution; replication regulation; immunological or pathogenic mechanism; vaccine development; prevention and control

(This special issue belongs to the Section Animal Viruses)

Rotaviruses and Rotavirus Vaccines: 2nd Edition

edited by

Lijuan Yuan

and

Viviana Parreño

submission deadline 31 Aug 2026 | Viewed by 393 | Submission Open

Keywords: rotaviruses; molecular biology; reverse genetics; molecular epidemiology; vaccine development; human intestinal organoid models

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Therapeutic Antibodies in HIV

edited by

Pradeep Uchil

and

Jonathan Richard

submission deadline 31 Aug 2026 | Viewed by 277 | Submission Open

Keywords: HIV-1; therapeutic antibodies; Fc-effector functions; broadly neutralizing antibodies; non-neutralizing antibodies; CD4 mimetics; Env conformation; antibody-based CAR T cells; epitope location; ADCC; ADCP; antibody engineering; HIV-1 reservoir clearance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Gene Therapy in the Fight Against Viral Infections and Related Diseases: Innovations, Challenges and Future Perspectives

edited by

Michele Lai

and

Alessandro De Carli

submission deadline 31 Aug 2026 | Viewed by 259 | Submission Open

Keywords: gene therapy; viral infections; gene delivery systems; viral vectors; non-viral vectors; gene editing; CRISPR/Cas systems; antiviral therapy vector engineering; targeted delivery; tissue-specific targeting; host– pathogen interactions; CAR-T

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Extracellular Vesicles in Viral Pathogenesis and Therapy

edited by

Fatah Kashanchi

and

Shilpa Buch

submission deadline 31 Aug 2026 | Viewed by 247 | Submission Open

Keywords: extracellular vesicles; viral infection; host– pathogen interaction; intercellular communication; immune evasion

(This special issue belongs to the Section General Virology)

Virus-Mediated Genome Editing in Plants

edited by

Jeanmarie Verchot

submission deadline 31 Aug 2026 | Viewed by 240 | Submission Open

Keywords: genetic vectors; viral vectors; gene editing; genetically modified plants; genetically modified insects; CRISPR-Cas systems

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Baculovirus as Vaccine Vectors, RNA Interference Mediators, and Gene Delivery Vectors: 2nd Edition

edited by

Hung-Jen Liu

submission deadline 31 Aug 2026 | Viewed by 238 | Submission Open

Keywords: baculovirus; vaccine vectors; subunit vaccine; baculovirus display vectors; RNA interference mediators; gene delivery vectors

(This special issue belongs to the Section Invertebrate Viruses)

Hepatitis Viruses in Pathogenesis: Chronic Infection to Hepatocellular Carcinoma

edited by

Giraud Guillaume

submission deadline 31 Aug 2026 | Viewed by 214 | Submission Open

Keywords: hepatocellular carcinoma; chronic infection; viral hepatitis; liver pathogenesis; biomarkers

(This special issue belongs to the Section Human Virology and Viral Diseases)

Virus Discovery: Innovative Approaches to Detection and Characterization of Emerging Viruses

edited by

Steve Wylie

submission deadline 31 Aug 2026 | Viewed by 213 | Submission Open

Keywords: virus detection; virus assay; emerging viruses; virus threats; cryptic viruses

(This special issue belongs to the Section General Virology)

Seed-Borne and Seed-Transmitted Virus

edited by Qinsheng Gu

submission deadline 31 Aug 2026 | Viewed by 205 | Submission Open

Keywords: seed-borne virus; seed-transmitted virus; management; detection

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Mosquito-Borne Encephalitis Viruses: 2nd Edition

edited by

Megan Lloyd

and

Allison Imrie

submission deadline 31 Aug 2026 | Viewed by 187 | Submission Open

Keywords: mosquito-borne arboviruses; encephalitic togaviruses; encephalitic flaviviruses; encephalitic bunyaviruses; mosquito vectors; laboratory diagnostics; one health approaches to arbovirus ecology; arbovirus surveillance; vaccines to encephalitic arboviruses

(This special issue belongs to the Section Human Virology and Viral Diseases)

Mechanisms of Herpesvirus Resistance

edited by

Graciela Andrei

submission deadline 1 Sep 2026 | 3 articles | Viewed by 7382 | Submission Open

Keywords: human herpesviruses; cytomegalovirus; drug resistance; antiviral agents; immunocompromised host; novel anti-herpesvirus therapies; DNA polymerase; terminase

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Hepatitis B Virus—Mechanisms of Persistence and Progress Towards a Cure

edited by

Qiong Zhao

and

Yongzhen Liu

submission deadline 16 Sep 2026 | Viewed by 244 | Submission Open

Keywords: hepatitis B virus (HBV); animal models; viral– host interactions; immune responses; pathogenesis; antivirals; HBV persistence

(This special issue belongs to the Section Human Virology and Viral Diseases)

Coronaviruses Pathogenesis, Immunity, and Antivirals (2nd Edition)

edited by

Wentao Li

and Fei Yu

submission deadline 30 Sep 2026 | 10 articles | Viewed by 19975 | Submission Open

Keywords: coronavirus; pathogenesis; molecular; vaccines; evolution; immunity; antivirals

(This special issue belongs to the Section Coronaviruses)

Viral Diseases of Domestic Animals

edited by

Scott P. Kenney

submission deadline 30 Sep 2026 | 6 articles | Viewed by 12896 | Submission Open

Keywords: viral diseases; emerging infections; domestic animals; epidemiology; pathogenesis

(This special issue belongs to the Section Animal Viruses)

Viruses in the Reproductive Tract

edited by

Mimi Ghosh

Raina Nakova Fichorova

and Christina Farr

submission deadline 30 Sep 2026 | 6 articles | Viewed by 5950 | Submission Open

Keywords: reproductive tract virome; viruses in pregnancy; virus infections and adverse fetal health; virus-associated malignancies of the reproductive tract; immune response to viruses of the reproductive tract; antiviral biomarkers; antiviral vaccines and drugs; hormonal regulation of virus infections

(This special issue belongs to the Section General Virology)

Pestivirus 2026

edited by

Benjamin J. Lamp

and Christiane M. Riedel

submission deadline 30 Sep 2026 | 3 articles | Viewed by 4898 | Submission Open

Keywords: pestiviruses; classical swine fever virus; bovine viral diarrhea virus; BVDV-1; BVDV-2; CSF

(This special issue belongs to the Section Animal Viruses)

Wastewater-Based Epidemiology and Viral Surveillance

edited by

Elisabetta Carraro

Cristina Pignata

and

Silvia Bonetta

submission deadline 30 Sep 2026 | 5 articles | Viewed by 4355 | Submission Open

Keywords: wastewater‐based epidemiology; WBE; viral surveillance; virus shedding; sewage; viral dynamics

(This special issue belongs to the Section Human Virology and Viral Diseases)

Antigenic Drift in Respiratory Viruses

edited by

Gabriel Gonzalez

submission deadline 30 Sep 2026 | 3 articles | Viewed by 3882 | Submission Open

Keywords: respiratory viruses; virus diversity; viral recombination; reassortment; zoonotic viruses; wastewater pathogen surveillance; viral sequencing; virus evolutionary characterization; animal viruses

(This special issue belongs to the Section Human Virology and Viral Diseases)

The Structure and Function of Flavivirus Genes and Proteins

edited by

Tadahisa Teramoto

and Kay Choi

submission deadline 30 Sep 2026 | 3 articles | Viewed by 3840 | Submission Open

Keywords: flavivirus; structural protein; non-structural protein; 5'UTR; 3'UTR

(This special issue belongs to the Section General Virology)

Progress and Prospects in Oncolytic Virotherapy 2025–2026

edited by

Arianna Calistri

and

Sandra Tuyaerts

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3735 | Submission Open

Keywords: oncovirotherapy; chemotherapy; preclinical studies; clinical trials; combinatory strategy; safety profile; therapeutic efficacy; immunotherapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Cross-Pathogen Insights into Infectious Diseases: From Biomarkers to Burden and Therapeutic Strategies of Viral Pathogens

edited by

Karolina Akinosoglou

submission deadline 30 Sep 2026 | 4 articles | Viewed by 3649 | Submission Open

Keywords: cross-pathogen perspective; biomarkers; viral sepsis; therapeutic landscape

(This special issue belongs to the Section General Virology)

Nucleocytoviricota

edited by Natalya Yutin

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3490 | Submission Open

Keywords: Nucleocytoviricota; giant viruses; virophages; host– virus (-virophage) interactions; virion structure; viral ecology; diversity and classification; evolution of Nucleocytoviricota

(This special issue belongs to the Section General Virology)

Herpesviruses and Associated Diseases, 2nd Edition

edited by

Sherif T.S. Hassan

submission deadline 30 Sep 2026 | 2 articles | Viewed by 3119 | Submission Open

Keywords: human herpesviruses; animal herpesviruses; viral latency and reactivation; immune evasion strategies; herpesvirus– host interactions; herpesvirus biology and pathogenesis; herpesvirus diagnosis; environmental factors; herpesvirus-associated diseases; prevention and treatment strategies; antiviral therapies; vaccine development

(This special issue belongs to the Section Human Virology and Viral Diseases)

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