Live-Attenuated Bacterial Vaccines for the Prevention of Multiresistant Infections

Dear Colleagues, 

Bacterial infections remain a major cause of mortality, with antimicrobial resistance being a contributing factor. At present, we are observing the continuous emergence of human infections caused by multidrug-resistant (MDR) bacteria. As a consequence, existing antibiotics have become less effective. Along with the increasing complexity in the development of new compounds, the effective treatment of bacterial infections is being seriously compromised. In order to address the impact of antimicrobial resistance, a multi-pronged approach will be needed, with priority given to accelerating the research and development of preventive vaccines. Whole-cell vaccines that comprise weakened versions of a bacterial pathogen are a promising strategy considering that they are able to elicit strong, effective and durable immune responses. 

This Special Issue aims to provide advances in vaccines against both Gram-positive and Gram-negative pathogens, with the focus on those bacteria in which antimicrobial resistance/MDR is becoming increasingly common. Research topics may include (i) novel strategies for attenuating bacteria and/or the rational construction of live-attenuated strains, (ii) routes for safer administration and toxicity evaluation, (iii) vaccination-induced immune responses, and (iv) vaccine efficacy in relevant murine models of infection. Research papers, short communications, and reviews related to these topics are welcome for this Special Issue.

Dr. Patricia García
Dr. Miriam Moscoso
Guest Editors

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