Drug-Induced and Herbal Hepatotoxicity and Methods of Its Prevention: 2nd Edition
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 94
Special Issue Editors
Interests: pharmacology and toxicology; oxidative stress; drug-induced organ injuries; prevention of organ damage
Special Issues, Collections and Topics in MDPI journals
Interests: medicine; ischemia/reperfusion injury; pharmacology; hypertension; diabetes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The liver is an important organ, regulating many physiological digestive functions. It plays a crucial role in xenobiotics metabolism, detoxification, and clearance. Therefore, the liver is one of the main targets of drug toxicity. Many endogenous and exogenous substances are metabolized in the liver and may be harmful to this organ, causing acute or chronic liver injury.
Prescription-only medicines or over-the-counter drugs may cause liver function disturbances and liver tissue damage through a variety of mechanisms. The use of herbal formulations and dietary supplements, sometimes obtained from unknown sources, has gradually increased from year to year worldwide. Although both postulated and well-established benefits of such formulations have been reported, their liver toxicity and interactions sometimes present a lack of evidence, highlighting an essential field of research. Although the mechanism of drug-induced liver toxicity is now better described, many newly recognized intracellular pathways are considered important in hepatotoxicity, which opens new possibilities for the successful prevention and treatment of hepatotoxicity.
We invite authors to submit research articles and reviews on drug- or herb-induced hepatotoxicity. Papers focusing on the currently available methods of hepatotoxicity prevention and the interactions that lead to liver damage or dysfunction are also welcome.
Dr. Anna Merwid-Ląd
Dr. Malgorzata Trocha
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- drug-induced hepatotoxicity
- herbal hepatotoxicity
- hepatotoxic interactions
- acute and chronic liver damage
- pathomechanisms of liver injury
- oxidative stress
- inflammation
- apoptosis and necrosis
- fibrosis
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