Pharmacotherapy of Diseases Affecting Urinary Tract
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 1018
Special Issue Editor
Interests: natural products; bioactive compounds; kidney disease; hypertension; cardiovascular disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Diseases of the urinary tract are extremely varied, ranging from acute infections to chronic disorders that considerably debilitate patients' quality of life. Other common conditions include urinary tract infection (UTI), kidney stones, prostatic hyperplasia (PH), overactive bladder (OAB) and cystitis. These disorders collectively place a considerable burden on healthcare systems and require effective pharmacological interventions to manage symptoms, prevent complications, and improve outcomes.
Pharmacotherapy differs according to the condition, with the main treatments being antibiotics for UTIs and alpha-blockers and 5-alpha reductase inhibitors for PH. OAB is managed with anticholinergic drugs or beta-3 adrenergic agonists. On the other hand, chronic cystitis generally requires a multimodal approach using oral medications, intravesical therapies, and adjunctive treatments.
Despite these developments, several challenges persist. Antibiotic resistance has become a critical issue in the management of UTIs, with multidrug-resistant pathogens limiting treatment options. Similarly, many drugs used for chronic conditions like OAB and cystitis have limited efficacy and are associated with significant side effects, such as dry mouth, cognitive impairment, or gastrointestinal disturbances, which often lead to poor patient adherence. Current pharmacological options may not fully address the underlying pathophysiology of PH and urinary incontinence, leaving some patients with residual symptoms.
Finally, emerging research emphasizes the need for new therapeutic options. Thus, this Special Issue will summarize the advantages of using pharmacotherapy to respond to acquired resistance, reduce side effects, and further improve personalized treatments for urinary tract diseases.
Dr. Priscila de Souza
Guest Editor
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Keywords
- natural products
- plant extracts and isolated compounds
- synthesized compounds
- modified compounds
- drug repositioning
- kidney stone
- urolithiasis
- diuresis
- urinary tract
- urinary tract infection
- cystitis
- urethritis
- nephritis
- renal hypertension
- diabetic nephropathy
- nephrotoxicity
- renal failure
- urinary incontinence
- overactive bladder
- prostatitis
- prostatic hyperplasia
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