Special Issue "Immune Regulation by Vitamin D"
A special issue of Nutrients (ISSN 2072-6643).
Deadline for manuscript submissions: closed (31 March 2015) | Viewed by 133155
Interests: cellular immunology, cytokines and inflammation; intracellular signalling and leukocyte function; immunomodulation by fatty acids, their metabolites and other bioactive nutrients
Special Issues, Collections and Topics in MDPI journals
Interests: T cells, autoimmunity, infection, gastrointestinal tract
An entirely new facet of vitamin D effects, distinct from its action on homeostasis and bone metabolism, is increasingly being appreciated. These non-classical effects of vitamin D have now been acknowledged as important components of vitamin D physiology. The fact that the active form of vitamin D, 1,25-dihydroxyvitamin D3, is a regulator of immune responses has been recently discovered. The effects of vitamin D on both the innate and adaptive immune responses has reached a new horizon with the realisation that the intracrine metabolism of vitamin D in immune cells may be a control point in immunity to infection and in chronic inflammatory disease. Because such non-classical effects of vitamin D have now been accepted, coupled with the fact that vitamin D insufficiency is presently a global health issue even in developed countries, new interest has been raised concerning disease development. In addition, present research efforts will provide the molecular rationale for intervention studies designed to test vitamin D as a chemo-preventative strategy for clinical management of autoimmune diseases.
Prof. Dr. Antonio Ferrante
Prof. Dr. Margherita T. Cantorna
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- vitamin D and 1,25D3
- infection and immunity
- autoimmunity, inflammation
- dendritic cells
- T cells
- vitamin D
- innate immunity
- adaptive immunity