Nutrition and Treatment Guidelines of Atopic Eczema
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 4388
Special Issue Editor
Interests: dermatology; eczema; lifestyle; diet
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex pathophysiology that underlies a wide spectrum of clinical phenotypes. Diet has long been understood to have an intricate association with atopic dermatitis, although much remains unelucidated. Th2 cell-mediated immunity, skin barrier dysfunction with dysbiosis and consequent impairment of immune tolerance likely underlie the pathogenesis of coincident atopic dermatitis and food allergy. There is a wide range of possible skin reactions to food, complicating the diagnosis and understanding of food allergies. Many patients, parents, and providers incorrectly suspect diet as causative of atopic dermatitis symptoms and many have tried elimination diets. This frequently leads to the inaccurate labeling of food allergies, contributing to a dangerous spiral of inappropriate testing, referrals, and dietary changes, while neglecting established atopic dermatitis treatment essentials. A novel promising therapeutic target for AD is the microbiota. Numerous studies have highlighted the involvement of the skin and gut microbiota in the pathogenesis of AD. Multiple oral supplements with prebiotics, probiotics, postbiotics, and synbiotics have demonstrated promising efficacy in both AD prevention and treatment. In addition to regulatory approval for the IL-4Ra inhibitor dupilumab, the anti-IL-13 inhibitor tralokinumab and the JAK1/2 inhibitor baricitinib in Europe, there are now more than 70 new compounds in development.
Dr. Ilaria Proietti
Guest Editor
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Keywords
- diet
- microbiota
- dupilumab
- tralokinumab
- baricitinib
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