Dietary and Nutritional Interventions in Epilepsy

Dear Colleagues,

Nearly one third of people worldwide living with epilepsy do not achieve adequate seizure control with medication alone. This therapeutic gap has sustained and intensified interest in dietary interventions. Once considered a niche strategy, the ketogenic diet and its variants are now endorsed by international guidelines for drug-resistant epilepsy. The last several decades have brought about significant advances in understanding their mechanisms, spanning metabolic, neuroinflammatory, mitochondrial, and gut microbiome pathways. Improved formulations and monitoring protocols have also made these therapies more tolerable and accessible than ever before. This Special Issue will bring together original clinical and basic research, reviews, and clinical perspectives on dietary therapies for epilepsy, examining mechanisms, comparative efficacy, implementation challenges across the lifespan, and questions of patient access. We hope it will serve as a valuable resource for clinicians, researchers, and dietitians alike. We invite the submission of articles that describe advances in the dietary treatment of epilepsy.

Prof. Dr. Timothy A. Simeone
Guest Editor

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