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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Drug Discovery Based on Non-Mammalian Models
edited by
submission deadline 30 Dec 2026 | Viewed by 110 | Submission Open
Keywords: disease models; drug discovery; zebrafish; drosophila melanogaster; caenorhabditis elegans
(This special issue belongs to the Section Medicinal Chemistry)
30th Anniversary of Molecules—Recent Advances in Organic Chemistry
edited by , Antonia Di Mola and
submission deadline 31 Dec 2026 | 22 articles | Viewed by 34022 | Submission Open
Keywords: organic synthesis; organic chemistry research; theoretical study; reaction mechanisms; catalysis
(This special issue belongs to the Section Organic Chemistry)
30th Anniversary of Molecules—Recent Advances in Chemical Biology submission deadline 31 Dec 2026 | 13 articles | Viewed by 28077 | Submission Open
Keywords: bioorthogonal chemistry; peptides; nucleic acids; proteins; analytical methods; chemical inhibitors; chemical probe; ubiquitination; structure-activity relationship
(This special issue belongs to the Section Chemical Biology)
30th Anniversary of Molecules: Recent Advances and the Next in Macromolecular Chemistry submission deadline 31 Dec 2026 | 10 articles | Viewed by 27510 | Submission Open
Keywords: macromolecular chemistry; synthetic polymers; natural polymers; polymerization mechanisms and kinetics; supramolecular self-assembly; biological macromolecules
(This special issue belongs to the Section Macromolecular Chemistry)
30th Anniversary of Molecules—Recent Advances in Food Chemistry
edited by and Marta Coelho
submission deadline 31 Dec 2026 | 22 articles | Viewed by 24453 | Submission Open
Keywords: functional foods; nutraceuticals; bioactive compounds; analytical techniques; by-products; food chemistry
(This special issue belongs to the Section Food Chemistry)
Featured Review Papers in Food Chemistry—2nd Edition
edited by
submission deadline 31 Dec 2026 | 7 articles | Viewed by 22397 | Submission Open
Keywords: food analysis; food additives; food supplements; functional foods; physicochemical properties; agro-food wastes recycling; bioaccessibility and bioavailability; food stability; food security
(This special issue belongs to the Section Food Chemistry)
Advances in Coordination Chemistry, 3rd Edition
edited by Juan Niclós-Gutiérrez and
submission deadline 31 Dec 2026 | 8 articles | Viewed by 20544 | Submission Open
Keywords: synthesis strategies for novel coordination compounds; coordination compounds with tailor-made ligands for specific applications; coordination compounds with multitopic ligands; single-crystal XRD structures and dimensionality of metal complexes; metal–organic frameworks and their applications; molecular recognition in mixed ligand–metal complexes at the molecular and/or supra-molecular levels; model metal complexes from the bioinorganic frontier of biological chemistry; DFT and other theoretical approaches for inter-ligand interactions in metal complexes
(This special issue belongs to the Section Inorganic Chemistry)
Biologically Active Molecules: Extraction Strategies, Therapeutic Potential and Biomedical Perspective
edited by
submission deadline 31 Dec 2026 | 10 articles | Viewed by 19182 | Submission Open
Keywords: natural bioactive components; extraction techniques; therapeutic and biomedical profiling
(This special issue belongs to the Section Medicinal Chemistry)
Review Papers in Analytical Chemistry, 2nd Edition
edited by
submission deadline 31 Dec 2026 | 4 articles | Viewed by 18315 | Submission Open
Keywords: analytical chemistry; analytical spectroscopy; environmental sciences; medical science; forensic science; cultural heritage; food analysis
(This special issue belongs to the Section Analytical Chemistry)
30th Anniversary of Molecules—Recent Advances in Inorganic Chemistry submission deadline 31 Dec 2026 | 10 articles | Viewed by 16233 | Submission Open
Keywords: inorganic chemistry; coordination chemistry; solid-state chemistry; nanomaterials; organometallics; transition and main group metal chemistry; catalysis; bioinorganic chemistry
(This special issue belongs to the Section Inorganic Chemistry)
The 30th Anniversary of Molecules—Recent Advances in Natural Products Chemistry submission deadline 31 Dec 2026 | 8 articles | Viewed by 14305 | Submission Open
Keywords: natural compounds; bioactive molecules; drug discovery; pharmacological activity; formulations, drug delivery systems; food applications and additives; cosmetic applications; synthesis
(This special issue belongs to the Section Natural Products Chemistry)
30th Anniversary of Molecules—Recent Advances in Analytical Chemistry submission deadline 31 Dec 2026 | 7 articles | Viewed by 11495 | Submission Open
Keywords: chromatography and advanced mass spectrometry; atomic spectroscopy and elemental mass spectrometry; molecular spectroscopy; miniaturization of analytical instruments; ohmics; nanomaterials and sensors; automation and high-throughput screening; single-cell analysis; non-invasive analysis/techniques; green analytical chemistry
(This special issue belongs to the Section Analytical Chemistry)
Advances and Opportunities of Natural Products in Drug Discovery submission deadline 31 Dec 2026 | 9 articles | Viewed by 10173 | Submission Open
Keywords: natural products; drug discovery; pharmacological activity; biological activity; new compounds
(This special issue belongs to the Section Natural Products Chemistry)
30th Anniversary of Molecules—Recent Advances in Bioorganic Chemistry submission deadline 31 Dec 2026 | 9 articles | Viewed by 9968 | Submission Open
Keywords: bioorganic chemistry; chemoenzymatic synthesis; biocatalysis; biomimetic synthesis; biomolecular interactions; functional biomolecules; molecular recognition
(This special issue belongs to the Section Bioorganic Chemistry)
Modern Trends and Solutions in Analytical Chemistry in Poland
edited by
submission deadline 31 Dec 2026 | 9 articles | Viewed by 9613 | Submission Open
Keywords: analytical and physical chemistry; separation sciences; chromatographic methods and related techniques (HPLC, SPE, SFC, GC, CZE, UPLC, GC × GC, and others); sample preparation and extraction techniques (SPE, QuEChERS/d-SPE, SPME, SBSE, HFLPME, DLLME, FUSLE, and others); detection techniques (DAD, FLD, MS, MS/MS, and others); spectrometry; bioanalytics; proteomics, metabolomics, and lipidomics; nanotechnology; environmental sciences; natural product chemistry (isolation, identification and quantification of bioactive compounds, and in vitro and then in vivo investigations on their biological activity); food analysis and food safety; xenobiotics analysis in environmental, biological, and food samples; chemometrics and statistical analysis
(This special issue belongs to the Section Analytical Chemistry)
Chemical Analysis of Pollutant in the Environment submission deadline 31 Dec 2026 | 5 articles | Viewed by 8809 | Submission Open
Keywords: inorganic and organic pollutants; persistent organic pollutants; heavy metals; nano- and microplastics; chemical methods; instrumental methods; validation
(This special issue belongs to the Section Green Chemistry)
Back to Nature: Pharmacological Activities of Phytochemicals Isolated from Medicinal Plants
edited by and Ludmila Yarmolinsky
submission deadline 31 Dec 2026 | 8 articles | Viewed by 8748 | Submission Open
Keywords: medicinal plant; pharmacological activity; phytochemical; disease; drug; therapeutic; polyphenol; terpene; carotenoid; saponin; alkaloid; thiophene; sugar; fatty oil; resin; phytosterol; protein; peptide; anti-inflammatory; antidiabetic; neuroprotective; anticancer; antioxidative; antimicrobial; antiviral; antifungal
(This special issue belongs to the Section Natural Products Chemistry)
Innovative Approaches to Sustainable Wastewater Treatment—Recent Developments in Hazardous Pollutants Removal submission deadline 31 Dec 2026 | 7 articles | Viewed by 8530 | Submission Open
Keywords: wastewater treatment; industrial wastewater; physical methods; chemical methods; biological methods; emerging micropollution; dyes; heavy metals; removal; (bio)sorbent; ion exchange resin
(This special issue belongs to the Section Green Chemistry)
Advance in Radiochemistry, 2nd Edition
edited by
submission deadline 31 Dec 2026 | 6 articles | Viewed by 8355 | Submission Open
Keywords: radiochemistry; radionuclide (radioisotopes); radiolabeling; radiopharmaceutical (radiotracer); nuclear medicine; theranostics (diagnostics and therapeutics); molecular imaging
(This special issue belongs to the Section Medicinal Chemistry)
Chromatography—The Ultimate Analytical Tool, 3rd Edition submission deadline 31 Dec 2026 | 6 articles | Viewed by 8035 | Submission Open
Keywords: chromatography; high-performance liquid chromatography; ultra-high-performance liquid chromatography; gas chromatography; two-dimensional gas chromatography; two-dimensional liquid chromatography; paper chromatography; liquid chromatography; preparative chromatography; supercritical fluid chromatography; thin-layer chromatography
(This special issue belongs to the Section Analytical Chemistry)
Recent Advances in Porous Materials, 2nd Edition
edited by
submission deadline 31 Dec 2026 | 5 articles | Viewed by 7894 | Submission Open
Keywords: porous carbon; adsorption; catalysis; supercapacitor; biomass; energy storage; zeolite; fuel cell; molecular sieves; metal–organic frameworks; porous metal oxide; mesoporous silicon; macroporous resin; aerogel; separation; porous composites; covalent organic frameworks
(This special issue belongs to the Section Materials Chemistry)
30th Anniversary of Molecules: Recent Advances in Photochemistry submission deadline 31 Dec 2026 | 6 articles | Viewed by 7811 | Submission Open
Keywords: organic photochemistry synthetic photochemistry; photocatalysis; photofunctionalization; photobiology; medicinal photochemistry; computational photochemistry; photoelectrochemistry; solar energy conversion; condensed and gas phase photochemistry; polymer photochemistry; supramolecular photochemistry; photochromism; luminescent sensors; photochemistry for environmental remediation
(This special issue belongs to the Section Photochemistry)
Novel Neuroprotective Agents: Design, Synthesis, and Biological Evaluation submission deadline 31 Dec 2026 | 3 articles | Viewed by 7665 | Submission Open
Keywords: neurodegenerative diseases; heterocyclic compounds; rational design; enzyme inhibitors; structure–activity relationship; structural characterization
(This special issue belongs to the Section Medicinal Chemistry)
30th Anniversary of Molecules—Recent Advances in Electrochemistry submission deadline 31 Dec 2026 | 9 articles | Viewed by 7528 | Submission Open
Keywords: electrochemical science; energy conversion; charge transfer; voltammetry; magnetoelectrochemistry/spin; redox chemistry
(This special issue belongs to the Section Electrochemistry)
30th Anniversary of Molecules—Recent Developments in Biobased Polymers submission deadline 31 Dec 2026 | 5 articles | Viewed by 7398 | Submission Open
Keywords: biobased polymers; sustainability; biodegradability; polymer recycling; polymer composites; polymer processing; green chemistry
(This special issue belongs to the Section Materials Chemistry)
Bee Product Chemistry: Identification and Characterization of Natural Compounds, 2nd Edition
edited by
submission deadline 31 Dec 2026 | 5 articles | Viewed by 6927 | Submission Open
Keywords: honey; wax; bee pollen; venom; propolis; royal jelly; bee larvae
(This special issue belongs to the Section Natural Products Chemistry)
Recent Advances in Transition Metal Catalysis, 2nd Edition
edited by Dingyi Wang
submission deadline 31 Dec 2026 | 4 articles | Viewed by 6385 | Submission Open
Keywords: transition metal catalysis; photocatalysis; electrosynthesis; organic synthesis; asymmetric synthesis; C-H functionalization; C-C functionalization; C-X functionalization
(This special issue belongs to the Section Organic Chemistry)
30th Anniversary of the MOF Concept
edited by and
submission deadline 31 Dec 2026 | 4 articles | Viewed by 6237 | Submission Open
Keywords: metal–organic frameworks; gas storage and separation; catalysis; drug delivery; sensing and detection; energy applications
(This special issue belongs to the Section Organometallic Chemistry)
30th Anniversary of Molecules: Recent Advances in Organometallic Chemistry
edited by
submission deadline 31 Dec 2026 | 5 articles | Viewed by 6175 | Submission Open
Keywords: metal–organic framework; organometallic compounds; coordination assembly; metal–organic cluster; metal–organic cage; supramolecular chemistry
(This special issue belongs to the Section Organometallic Chemistry)
Advanced Materials for Photocatalytic and Photoelectrocatalytic Water-Splitting submission deadline 31 Dec 2026 | 2 articles | Viewed by 5567 | Submission Open
Keywords: photocatalysis; photoelectrocatalysis; water splitting; bandgap engineering; semiconductor materials; visible-light-driven catalysis
(This special issue belongs to the Section Materials Chemistry)
Quantum-Chemical Studies for Superspecies—in Celebration of Professor Jean-François Gal’s 80th Birthday
edited by
submission deadline 31 Dec 2026 | 6 articles | Viewed by 5201 | Submission Open
Keywords: structure of superspecies; neutral, ionic, and/or radical forms; isomerism; electron delocalization; energetic parameters of electron transfer; thermochemistry of proton transfer; quantum-chemical studies
Optimization of Process Methodology for Specialty and Fine Chemicals
edited by and Łukasz Lamch
submission deadline 31 Dec 2026 | 5 articles | Viewed by 4254 | Submission Open
Keywords: process optimization; specialty and fine chemicals; process intensification; numerical and statistical optimization; design of experiments; green and sustainable chemistry; chemical engineering; data driven and model-based process design
(This special issue belongs to the Section Green Chemistry)
Novel Nanomaterials for Photocatalysis submission deadline 31 Dec 2026 | 4 articles | Viewed by 4172 | Submission Open
Keywords: photocatalyst synthesis; band gap engineering; enhanced light absorption; clean energy; advanced oxidation/reduction processes; self-cleaning coatings; photocatalysis reaction mechanisms; artificial photosynthesis
(This special issue belongs to the Section Photochemistry)
Bioactive Peptides: Isolation, Identification and Application submission deadline 31 Dec 2026 | 1 articles | Viewed by 4040 | Submission Open
Keywords: peptides; proteins; hydrolysis; bioavailability; application; biological activity; food technology
(This special issue belongs to the Section Food Chemistry)
Applications of Agro-Industrial By-Products in Health and Beauty: Innovative Strategies and Applications submission deadline 31 Dec 2026 | 6 articles | Viewed by 3959 | Submission Open
Keywords: valorization of by-products; bioactive compounds; extraction technologies; delivery systems (micro/nano-carriers); health and skin applications
(This special issue belongs to the Section Food Chemistry)
Advances in Trace Element Analysis: Techniques and Applications
edited by
submission deadline 31 Dec 2026 | 4 articles | Viewed by 3847 | Submission Open
Keywords: trace element analysis; speciation techniques; environmental monitoring; atomic spectrometry; mass spectrometry; chromatography; bioavailability; environmental impact
(This special issue belongs to the Section Analytical Chemistry)
Bioactive Compounds Encapsulation System: Design and Applications
edited by and
submission deadline 31 Dec 2026 | 2 articles | Viewed by 3759 | Submission Open
Keywords: bioactive compounds; encapsulation; nanocarriers; bioavailability; targeted delivery; drug delivery; functional foods
(This special issue belongs to the Section Food Chemistry)
30th Anniversary of Molecules—Recent Advances in Physical Chemistry
edited by
submission deadline 31 Dec 2026 | 7 articles | Viewed by 3668 | Submission Open
Keywords: physical chemistry; dynamics and kinetics; thermodynamics; quantum chemistry; spectroscopy
(This special issue belongs to the Section Physical Chemistry)
Analytical Methods for Food and Environmental Pollutants: Current and Future Perspectives, 2nd Edition submission deadline 31 Dec 2026 | 5 articles | Viewed by 3662 | Submission Open
Keywords: emerging pollutants; food samples; environmental samples; sampling; sample preparation; analytical instrumentation; chemometric tools
(This special issue belongs to the Section Analytical Chemistry)
Interactions of Plant-Derived Foods and Medicines with the Gut Microbiome submission deadline 31 Dec 2026 | 5 articles | Viewed by 3514 | Submission Open
Keywords: anti-inflammatory effect; antimicrobial activity; fermented foods; gut metabolism; gut microbiota; herbal product; immunomodulatory effect; microbiome therapy; phytochemical; plant-based diet; postbiotics; prebiotic effect; probiotic microorganisms
30th Anniversary of Molecules—Recent Advances in Medicinal Chemistry submission deadline 31 Dec 2026 | 3 articles | Viewed by 3132 | Submission Open
Keywords: medicinal chemistry; drug discovery and development; lead compounds; proximity-inducing drugs; photopharmacology; covalent modifiers; antibody-drug conjugates; epigenetic modulators
(This special issue belongs to the Section Medicinal Chemistry)
Plant Bioactive Compounds in Pharmaceuticals, 2nd Edition submission deadline 31 Dec 2026 | 2 articles | Viewed by 2964 | Submission Open
Keywords: bioactive compounds; medicinal plant; phytocomplexes; cell cultures
(This special issue belongs to the Section Natural Products Chemistry)
Heterocyclic Molecules in Drug Discovery submission deadline 31 Dec 2026 | 2 articles | Viewed by 2921 | Submission Open
Keywords: organic synthesis of bioactive heterocyclic compounds; structural analysis of heterocycles; biological activity of heterocycles; ADME properties of heterocycles; in silico analysis and experimental analysis of heterocyclic molecules
(This special issue belongs to the Section Medicinal Chemistry)
Secondary Metabolites from Natural Products: Extraction, Isolation and Biological Activities, 2nd Edition submission deadline 31 Dec 2026 | 4 articles | Viewed by 2800 | Submission Open
Keywords: natural products; secondary metabolites; analytical techniques application; extraction and separation; chemical composition; phytochemistry; isolation and structure elucidation; secondary metabolites; antimicrobial activity; antioxidant activity; anticancer activity
(This special issue belongs to the Section Natural Products Chemistry)
Photo- and Sonodynamic Antimicrobial and Anticancer Compounds submission deadline 31 Dec 2026 | 2 articles | Viewed by 2616 | Submission Open
Keywords: photosensitizers; sonosensitizers; photodynamic treatment; sonodynamic treatment; antimicrobials; anticancer treatment
(This special issue belongs to the Section Medicinal Chemistry)
Featured Reviews in Chemical Biology 2026
edited by and
submission deadline 31 Dec 2026 | 2 articles | Viewed by 2561 | Submission Open
Keywords: chemical biology; chemical probes; phenotypic screening; target identification/validation; bioactive metabolites; signaling molecules; drug discovery; enzymology; synthetic biology
(This special issue belongs to the Section Chemical Biology)
Organometallic Compounds: Design, Synthesis and Application: 2nd Edition
edited by
submission deadline 31 Dec 2026 | 2 articles | Viewed by 2436 | Submission Open
Keywords: organometallic compounds; design and synthesis; transition metal complexes; catalysis; metal coordination; catalytic applications; mechanisms; organic–inorganic hybrid compounds
(This special issue belongs to the Section Organometallic Chemistry)
Immunomodulatory and Anti-Inflammatory Activities of Natural Compounds with Adaptogenic Potential
edited by Daniel Załuski and
submission deadline 31 Dec 2026 | 2 articles | Viewed by 2397 | Submission Open
Keywords: adaptogens; immunomodulation; inflammation; phytochemicals; herbal medicine; cytokines; oxidative stress
(This special issue belongs to the Section Medicinal Chemistry)
Functional Molecules as Novel Cosmetic Ingredients, 2nd Edition
edited by Jing Wang and
submission deadline 31 Dec 2026 | 1 articles | Viewed by 2275 | Submission Open
Keywords: synthetic molecules; plant extracts; natural compounds; biotech-derived molecules; natural-derived molecules; fermentation-derived ingredients; biological activity; cosmetics; encapsulation and delivery technologies of ingredients; skin-care; hair-care
(This special issue belongs to the Section Applied Chemistry)
Metal–Halide Perovskites for Solar Cell and LED Materials
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 2272 | Submission Open
Keywords: hybrid halide perovskite solar cell materials; perovskite light-emitting diode materials; optical properties; luminescence; material property characterization; thin solid films; crystal formation
(This special issue belongs to the Section Materials Chemistry)
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