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30th Anniversary of Molecules—Recent Advances in Organic Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 574

Special Issue Editors


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Guest Editor
Dipartimento di Chimica e Biologia, Università di Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy
Interests: synthetic methodologies; asymmetric catalysis; total synthesis; heterocycles; biologically active compounds
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Dipartimento Di Chimica e Biologia “A. Zambelli”, Università degli Studi di Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy
Interests: heterocyclic chemistry; polysaccharides; total synthesis of bioactive compounds

Special Issue Information

Dear Colleagues,

In 2025, we will be celebrating the 30th anniversary of Molecules. Molecules has carved out a notable space in the literature on chemistry, with an impact factor of 4.2 (2023) and a 5-year impact factor of 4.6 (2023). Our sincerest thanks go to our readers, authors, anonymous peer reviewers, editors, and all the people who have joined forces to work on the journal over the years. We would never have achieved this without your help.

To mark this important milestone, a Special Issue entitled “30th Anniversary of Molecules—Recent Advances in Organic Chemistry” is being launched. This Special Issue will include communications, full papers, and high-quality review papers from the field of organic chemistry.

We invite and encourage all research groups in the various areas of organic chemistry to make a contribution to this important and celebratory Special Issue.

Dr. Maria G. P. M. S. Neves
Dr. Antonio Massa
Dr. Antonia Di Mola
Dr. Nuno M. M. Moura
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organic synthesis
  • organic chemistry research
  • theoretical study
  • reaction mechanisms
  • catalysis

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Published Papers (1 paper)

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Research

12 pages, 1502 KiB  
Article
General Synthesis of 2-Substituted Benzoxazoles Based on Tf2O-Promoted Electrophilic Activation of Tertiary Amides
by Hongchen Li, Xingyong Wang, Fujun Zhao, Lu Wang and Songbao Fu
Molecules 2025, 30(7), 1510; https://doi.org/10.3390/molecules30071510 - 28 Mar 2025
Viewed by 204
Abstract
We report a method for the synthesis of 2-substituted benzoxazoles from tertiary amides and 2-aminophenols in the presence of triflic anhydride (Tf2O) and 2-Fluoropyridine (2-F-Pyr). The cascade reaction involves the activation of the amide carbonyl group by Tf2O, nucleophilic [...] Read more.
We report a method for the synthesis of 2-substituted benzoxazoles from tertiary amides and 2-aminophenols in the presence of triflic anhydride (Tf2O) and 2-Fluoropyridine (2-F-Pyr). The cascade reaction involves the activation of the amide carbonyl group by Tf2O, nucleophilic addition, intramolecular cyclization, and elimination. Furthermore, we explore the scope of this method by varying both the amide and 2-aminophenol substrates, highlighting its versatility in the synthesis of a wide range of functionalized benzoxazole derivatives. Full article
(This article belongs to the Special Issue 30th Anniversary of Molecules—Recent Advances in Organic Chemistry)
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