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30th Anniversary of Molecules—Recent Advances in Medicinal Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 1423

Special Issue Editors


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Guest Editor
Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain
Interests: multitarget anti-Alzheimer agents; hybrid compounds; cholinesterase inhibitors; amyloid anti-aggregating compounds; BACE-1 inhibitors; antiprotozoan compounds
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of BioMolecular Sciences, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA
Interests: computational medicinal chemistry; cannabinoid receptors; drug discovery; quantum chemistry; allosteric modulators; protein modeling; quantitative structure–activity relationships; glycoscience
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The year 2026 commemorates the 30th anniversary of Molecules. Molecules has carved out a notable space in the field, with an Impact Factor of 4.6 (2024). The growth of Molecules has only been possible because authors, reviewers, editors, and all people working in some way for the journal have joined their efforts for years. Thank you for your confidence and your enthusiasm.

In order to mark that important milestone, we have launched a Special Issue titled “30th Anniversary of Molecules—Recent Advances in Medicinal Chemistry”, with the aim of encouraging authors to publish their cutting-edge research in our Medicinal Chemistry Section. We cordially encourage all research groups worldwide to contribute a research article reporting outstanding new results or an up-to-date, comprehensive review, highlighting one of the latest developments in medicinal chemistry.

Contributions to this Special Issue may focus on any area of medicinal chemistry, with those dealing with new drug modalities, such as proximity-inducing drugs, photoswitchable agents, antibody–drug conjugates, RNA-targeting compounds, modulation of epigenetic targets, covalent modifiers, etc., being especially welcome.

Prof. Dr. Diego Muñoz-Torrero
Prof. Dr. Robert J. Doerksen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • medicinal chemistry
  • drug discovery and development
  • lead compounds
  • proximity-inducing drugs
  • photopharmacology
  • covalent modifiers
  • antibody-drug conjugates
  • epigenetic modulators

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Published Papers (1 paper)

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Review

25 pages, 2112 KB  
Review
Small-Molecule Modulation of the Circadian Clock in Cancer and Aging
by Ashraf N. Abdo and Moustafa Gabr
Molecules 2026, 31(9), 1543; https://doi.org/10.3390/molecules31091543 - 6 May 2026
Viewed by 725
Abstract
Circadian rhythms are ~24 h cycles regulated by an internal molecular clock. Disruption of this timing system has been implicated in numerous diseases, including the advancement of cancers and declines in function associated with aging. In recent years, scientists have identified various small [...] Read more.
Circadian rhythms are ~24 h cycles regulated by an internal molecular clock. Disruption of this timing system has been implicated in numerous diseases, including the advancement of cancers and declines in function associated with aging. In recent years, scientists have identified various small molecules that can modulate core circadian clock proteins and pathways, providing potential therapeutic strategies to correct circadian dysfunction. This review presents a thorough overview of circadian clock mechanisms and highlights known small-molecule modulators. We describe how these compounds were discovered (through high-throughput screening and rational design) and categorize them based on their molecular targets. This review also summarizes key findings in cancer models, where clock-modulating compounds affect tumor metabolism, cell proliferation, and responsiveness to treatments, as well as in aging models, where strengthening circadian function may enhance metabolic health and longevity. Additionally, we cover clinical and preclinical studies involving these molecules and address challenges such as off-target effects and the complex nature of clock regulation. Finally, we outline future directions, emphasizing the development of new chronotherapeutics and the incorporation of circadian modulation into interventions for cancer and aging. Full article
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