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Back to Nature: Pharmacological Activities of Phytochemicals Isolated from Medicinal Plants

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 October 2025

Special Issue Editors

Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
Interests: oral drug absorption; intestinal permeability; drug solubility; drug dissolution; biopharmaceutics classification system (BCS); drug delivery and targeting
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Guest Editor Assistant
Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel
Interests: properties of medicinal plants (antiviral, antimicrobial, anti-inflammatory and so on); isolation, purification, and identification of active compounds from medicinal plants

Special Issue Information

Dear Colleagues,

Numerous scientific studies in recent decades have indicated that medicinal plants can serve as a promising source for pharmacologically active phytochemicals, combating various diseases. In recent years, a large number of phytochemicals, including polyphenols (flavonoids, phenolic acids, lignans, tannins, stilbenes, and coumarins), terpenes, carotenoids, saponins, alkaloids, thiophenes, different sugars, fatty oils, resins, phytosterols, proteins, peptides, and many others, have exhibited noteworthy anticancer, antibacterial, anti-inflammatory, and countless other therapeutic actions, with significant potential to make it to the market as drug/drug-like substances. This Special Issue aims to provide verified data on the pharmacological activities of phytochemicals isolated from medicinal plants of the world flora. We welcome submissions of review and research articles describing, but not limited to, significant anti-inflammatory, antidiabetic, neuroprotective, anticancer, antioxidative, antimicrobial, antiviral, and antifungal activities of phytochemicals isolated from medicinal plants. Given that the medical and scientific communities have become increasingly interested in using phytochemicals isolated from medicinal plants for therapeutic purposes, we cordially invite clinicians, pharmacologists, and researchers to submit their scientific work to this Special Issue.

Dr. Arik Dahan
Guest Editor

Dr. Ludmila Yarmolinsky
Guest Editor Assistant

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Keywords

  • medicinal plant
  • pharmacological activity
  • phytochemical
  • disease
  • drug
  • therapeutic
  • polyphenol
  • terpene
  • carotenoid
  • saponin
  • alkaloid
  • thiophene
  • sugar
  • fatty oil
  • resin
  • phytosterol
  • protein
  • peptide
  • anti-inflammatory
  • antidiabetic
  • neuroprotective
  • anticancer
  • antioxidative
  • antimicrobial
  • antiviral
  • antifungal

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Published Papers (1 paper)

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Research

15 pages, 3839 KiB  
Article
Therapeutic Potential of Ficus benjamina: Phytochemical Identification and Investigation of Antimicrobial, Anticancer, Pro-Wound-Healing, and Anti-Inflammatory Properties
by Arik Dahan, Ludmila Yarmolinsky, Arie Budovsky, Boris Khalfin and Shimon Ben-Shabat
Molecules 2025, 30(9), 1961; https://doi.org/10.3390/molecules30091961 - 28 Apr 2025
Abstract
Ficus benjamina is a common park tree, with previous reports of some medicinal properties. In this work, we identified and explored phytochemicals from F. benjamina for potential antimicrobial, pro-wound-healing, anti-inflammatory, and effect on cancer cell lines’ proliferation, both experimentally and bioinformatically. Gas chromatography/mass [...] Read more.
Ficus benjamina is a common park tree, with previous reports of some medicinal properties. In this work, we identified and explored phytochemicals from F. benjamina for potential antimicrobial, pro-wound-healing, anti-inflammatory, and effect on cancer cell lines’ proliferation, both experimentally and bioinformatically. Gas chromatography/mass spectrometry (GC/MS) analysis was performed to identify the volatile compounds. The nonvolatile active components of the extract were identified by HPLC and LC-ESI-MS. We found that some drug-resistant microorganisms (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Serratia marcescens, and Salmonella enteritidis) were inhibited by the extract, the 80% fraction, and all the identified flavonoids except quercetin 3-O-rutinoside. Furthermore, the extract and above-mentioned compound also inhibited the growth of biofilm-producing bacterium. The extract and 80% fraction were very potent (p < 0.001) at inducing death of MCF7 and U87 cancer cell cultures and were more effective in that than the chemotherapeutic agent doxorubicin which served as a positive control. Additionally, the extract of F. benjamina, the 80% fraction, and selected phytochemicals had pronounced pro-wound-healing properties. Finally, the extracts, the 80% fraction, caffeic acid, kaempferol 3-O-rutinoside, and kaempferol 3-O-robinobioside significantly inhibited the secretion of pro-inflammatory cytokines, IL-6 and IL-8 (p < 0.001). In conclusion, this comprehensive research revealed convincing and promising indications of significant therapeutic potential of a F. benjamina extract and its active phytochemicals. Full article
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