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Photo- and Sonodynamic Antimicrobial and Anticancer Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 1976

Special Issue Editors


E-Mail Website
Guest Editor
Department of Chemical Engineering, Biotechnology and Materials, Ariel University, Ariel 4070000, Israel
Interests: photo- and sonodynamic antimicrobial treatment; development of biodiesel production
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Chemical Engineering and Biotechnology, Ariel University, Ariel 4070000, Israel
Interests: photo- and sonodynamic antimicrobial treatment; waste-to-energy field; wastewater treatment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The problem of multidrug resistance in the treatment of infections and cancer cells has become one of the acute problems in medicine and community life. One of the alternatives to drugs, which cause resistance, is using photo- and sonosensitizers, which, according to the mechanism of their action, are not involved directly in the destruction of pathogenic cells but cause the production of reactive oxygen species or other free radicals, which are responsible for the eradication of microbial and cancer cells. Using photosensitizers demands illumination of the treated site by visible light and, for this reason, is mostly appropriate for superficial treatment, although chemiluminescent light can be applied instead of an external light source, thus enabling the use of photosensitizers for the treatment of internal infections. Sonosensitizers, which need ultrasound for excitation, can be applied in the dark, and this fact makes them suitable for application in the internal organs. Moreover, ultrasound can be focused on the site to be treated, thus enabling the excitation of sonosensitizers only in the needed region and decreasing any possible adverse effects of the treatment on normal cells.

Both photo- and sonosensitizers can be applied alone or in combination with other drugs. To increase the selectivity of the treatment, photo- and sonosensitizers can be conjugated with biomolecules, such as antibodies, lectins, or others, to make the drug delivery more specific.

This Special Issue aims to elucidate the latest advances in the field of photo- and sonodynamic treatment of pathogenic microorganisms, including bacteria and fungi, and cancer cells. We welcome high-quality reviews and research articles to be published in the current Special Issue. The topics of the Special Issue include, but are not limited to, the following fields:

  • Photodynamic antibacterial, antifungal, and anticancer treatment;
  • Sonodynamic antibacterial, antifungal, and anticancer treatment;
  • Combined photo- and sonodynamic antimicrobial and anticancer treatment;
  • Targeted photo- and sonodynamic antimicrobial and anticancer treatment.

Prof. Dr. Marina Nisnevitch
Dr. Faina Nakonechny
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photosensitizers
  • sonosensitizers
  • photodynamic treatment
  • sonodynamic treatment
  • antimicrobials
  • anticancer treatment

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Published Papers (2 papers)

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Research

26 pages, 5701 KB  
Article
Iodinated Near-Infrared Dyes as Effective Photosensitizers for the Photodynamic Eradication of Amphotericin B-Resistant Candida Pathogens
by Chen Damti, Andrii Bazylevich, Amartya Sanyal, Olga Semenova, Arjun Prakash, Iryna Hovor, Bat Chen R. Lubin, Leonid Patsenker and Gary Gellerman
Molecules 2025, 30(23), 4652; https://doi.org/10.3390/molecules30234652 - 4 Dec 2025
Cited by 1 | Viewed by 867
Abstract
Amphotericin: B (AmpB)-resistant Candida (C.) species, such as C. parapsilosis, are among the most common causes of invasive fungal infections, posing significant challenges in hospital settings. Although AmpB is considered the first-line treatment owing to its broad-spectrum [...] Read more.
Amphotericin: B (AmpB)-resistant Candida (C.) species, such as C. parapsilosis, are among the most common causes of invasive fungal infections, posing significant challenges in hospital settings. Although AmpB is considered the first-line treatment owing to its broad-spectrum fungicidal activity, its use is hampered by severe side effects and the emergence of acquired resistance, particularly in C. parapsilosis, which exhibits reduced susceptibility to polyene, azole, and echinocandin-based antifungal drugs. Here, we present findings on photodynamic therapy (PDT) that targets the opportunistic fungal pathogens C. parapsilosis and C. albicans via the use of photosensitizers from the iodocyanine and newly developed iodinated Methylene blue families. These compounds contain heavy iodine atoms that increase the production of reactive oxygen species (ROS), the agents responsible for oxidative cellular damage, via the heavy-atom effect, which promotes intersystem crossing (ISC) and triplet-state formation. A strong antifungal effect was observed against AmpB-resistant C. parapsilosis, indicating a correlation between the quantum yield of ROS generation and the photosensitizing efficacy under near-infrared (NIR) light irradiation. The combination of efficient cellular uptake and enhanced ROS generation positions iodinated photosensitizers as promising candidates for the treatment of drug-resistant Candida strains. Full article
(This article belongs to the Special Issue Photo- and Sonodynamic Antimicrobial and Anticancer Compounds)
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13 pages, 1502 KB  
Article
The “Irradiance Effect” Plays a Crucial Role in the Photosensitization of Escherichia coli by Blue Light
by Fabrizio Bolognese, Nataliia Emashova, Valerio Baldelli, Paolo Landini and Viviana Teresa Orlandi
Molecules 2025, 30(23), 4515; https://doi.org/10.3390/molecules30234515 - 22 Nov 2025
Cited by 1 | Viewed by 646
Abstract
Antimicrobial Blue Light (aBL) can be used to control the growth of pathogens in several applicative fields, from sanitization of inert surfaces to human skin treatment and from industry to food. Though the mechanism of action is still unknown, it has been hypothesized [...] Read more.
Antimicrobial Blue Light (aBL) can be used to control the growth of pathogens in several applicative fields, from sanitization of inert surfaces to human skin treatment and from industry to food. Though the mechanism of action is still unknown, it has been hypothesized that specific wavelengths can activate potential endogenous photosensitizers in microbial cytoplasm and/or envelope. In turn, this photooxidative stress could induce inactivation of macromolecules resulting in bacterial killing. In this work, we investigated the effect of radiometric parameters of light at 410 nm on Escherichia coli K-12 MG1655, a strain rather tolerant to blue light irradiation. Interestingly, by changing the radiometric parameters of aBL protocol, different rates of killing were observed. Irradiation at 100 J/cm2 caused a variable antimicrobial effect depending on the irradiance values. We observed an “irradiance effect”: namely, at higher irradiance values, the inhibitory effect is reduced. On the other hand, at increasing fluences the bactericidal rate increases. In addition, the shift from continuous to pulsed light could enhance the antimicrobial activity of protocols using higher irradiance values. Taken together, these results underline the importance of defining radiometric parameters to ensure the efficacy of aBL treatments and emphasize the importance of further research into the aBL mechanism. Full article
(This article belongs to the Special Issue Photo- and Sonodynamic Antimicrobial and Anticancer Compounds)
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