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30th Anniversary of Molecules—Recent Advances in Analytical Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 1187

Special Issue Editors


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Guest Editor
Department of Agriculture, Oecotrophology and Landscape Development, Anhalt University of Applied Sciences, Strenzfelder Allee 28, 06406 Bernburg, Germany
Interests: plant hormones; plant nutrition; responses of primary and secondary plant metabolism to plant nutrition; orphan crops; analytical methods including HPLC, UHPLC, GC, mass spectrometry, optical spectroscopy, electrophoresis, and quantitative PCR; separation and analysis of chiral molecules; enzyme assays; inhibitors
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Guest Editor
REQUIMTE/LAQV, ISEP, Polytechnic of Porto, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal
Interests: (bio)sensors; application of functional nanostructured materials; green technologies; new methodologies for (electro)analysis; environmental chemistry; monitoring/biomonitoring
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
LAQV/REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
Interests: trace element in health and disease; trace element analysis—development and validation of analytical procedures; food, environmental, pharmaceutical, forensic, and clinical/toxicological applications; atomic spectroscopy and elemental mass spectrometry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As we mark the 30th anniversary of Molecules, we are delighted to announce the launch of a Special Issue titled “30th Anniversary of Molecules—Recent Advances in Analytical Chemistry”.

Over the past three decades, Molecules has evolved into a pivotal platform for sharing groundbreaking scientific research. We extend our heartfelt thanks to our readers, authors, peer reviewers, and editorial team. Your unwavering support and active collaboration have been instrumental in reaching this significant milestone. This Special Issue aims to showcase the latest advances and innovations across the spectrum of analytical chemistry. We invite you to submit high-quality articles or reviews that focus on the innovation, evaluation, and application of analytical methods or techniques. We anticipate contributions from experts across all disciplines of analytical chemistry. Thank you for being a part of our journey.

Prof. Dr. Wilfried Rozhon
Prof. Dr. Simone Morais
Prof. Dr. Agostinho Almeida
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chromatography and advanced mass spectrometry
  • atomic spectroscopy and elemental mass spectrometry
  • molecular spectroscopy
  • miniaturization of analytical instruments
  • ohmics
  • nanomaterials and sensors
  • automation and high-throughput screening
  • single-cell analysis
  • non-invasive analysis/techniques
  • green analytical chemistry

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Published Papers (1 paper)

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Research

15 pages, 1287 KiB  
Article
Potency Analysis of Semi-Synthetic Cannabinoids in Vaping Oils Using Liquid Chromatography Diode Array Detector with Electrospray Ionization Time-of-Flight Mass Spectrometry for Confirmation of Analyte Identity
by Shaozhong Zhang, Md Mahmud Alam, Brent D. Chandler, Jocelyn P. Lanorio, Caitlin Deskins and Liguo Song
Molecules 2025, 30(12), 2597; https://doi.org/10.3390/molecules30122597 - 15 Jun 2025
Viewed by 942
Abstract
Since the 2018 Farm Bill legalized hemp, semi-synthetic cannabinoids, typically derived from hemp-extracted CBD, have been marketed as offering a “legal high”, raising concerns about consumer safety, labeling, and regulation. Consequently, the potency analysis of these compounds has become increasingly important. To address [...] Read more.
Since the 2018 Farm Bill legalized hemp, semi-synthetic cannabinoids, typically derived from hemp-extracted CBD, have been marketed as offering a “legal high”, raising concerns about consumer safety, labeling, and regulation. Consequently, the potency analysis of these compounds has become increasingly important. To address this need, an LC-DAD method was developed for the quantification of seventeen cannabinoids, selected based on the synthetic pathways of semi-synthetic cannabinoids. These included naturally occurring compounds, semi-synthetic derivatives, and byproducts (CBC, CBD, CBDV, CBG, CBN, CBN-O-acetate, CBT, 9(R)-HHC, 9(S)-HHC, 9(R)-HHC-O-acetate, 9(S)-HHC-O-acetate, Δ8-THC, Δ9-THC, Δ9,11-THC, Δ8-THC-O-acetate, Δ9-THC-O-acetate, and Δ9-THCV), using abnormal CBD as an internal standard. The method was validated according to ISO 17025 guidelines, demonstrating a linear calibration range from 0.1 to 50 µg/mL. The method was further applied to the potency analysis of one Δ8-THC, two THC-O-acetate, two HHC, and one HHC-O-acetate vaping oil sample. Using an innovative method to recover the contents of vaping cartridges, cannabinoids were extracted using methanol, diluted to a concentration of 50 µg/mL, and analyzed using the validated LC-DAD method, which provided a quantifiable range of 0.1 to 100% (w/w). Method specificity was evaluated using ESI/TOFMS and showed minimal interference, despite the presence of other isomers of the semi-synthetic cannabinoids in the samples. Full article
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