Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Gynecological Endocrinology: From Physiological Mechanisms to Clinical Practice: 2nd Edition
edited by Ralitsa Robeva
submission deadline 27 May 2026 | Viewed by 378
Keywords: PCOS; hypothalamic amenorrhea; congenital adrenal hyperplasia; hypogonadotropic hypogonadism; premature ovarian insufficiency (POI)
(This special issue belongs to the Section Physiology and Pathology)
Metabolic Health: The Interplay Between NAFLD, MAFLD, MASLD and Cardiovascular Disease
edited by and Monika Różycka-Kosmalska
submission deadline 28 May 2026 | 8 articles | Viewed by 17587 | Submission Open
Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic-dysfunction-associated fatty liver disease (MAFLD); metabolic-dysfunction-associated steatotic liver disease (MASLD); cardiovascular disease (CVD); cardiac arrhythmias; structural heart disease; coronary artery disease; hypertension
(This special issue belongs to the Section Medical Research)
Advances in Pulmonology: Transforming Diagnosis and Treatment of Lung Diseases submission deadline 28 May 2026 | 9 articles | Viewed by 10326 | Submission Open
Keywords: biomarkers in lung diseases; sleep disorders; chronic obstructive diseases; interstitial lung diseases; thoracic surgery
(This special issue belongs to the Section Medical Research)
Diagnosis and Treatment of Orthopedic Diseases: Advancing Arthroscopy submission deadline 28 May 2026 | 2 articles | Viewed by 4011 | Submission Open
Keywords: arthroscopy; knee; hip; shoulder; arthroscopic surgery
(This special issue belongs to the Section Medical Research)
Microglia, Behavior, and Sex Differences: Neuroimmune Mechanisms in Development and Disease
edited by Irene García Domínguez and Elena Aguado-Domínguez
submission deadline 28 May 2026 | Viewed by 336 | Submission Open
Keywords: microglia; neuroinflammation; sex differences; neurodevelopment; behavior; neuroimmune mechanisms; brain disorders
(This special issue belongs to the Section Physiology and Pathology)
The 15th Anniversary of Life—Alternatives to RNA World
edited by and Amit Kahana
submission deadline 29 May 2026 | 1 articles | Viewed by 2193 | Submission Open
Keywords: supramolecular; lipid; assembly; protocell; compositional; information; spontaneous; catalytic; network; reproduction; species; Darwinian; evolution; origin; life
(This special issue belongs to the Section Origin of Life)
The Role of Natural Products in Disease Treatment submission deadline 30 May 2026 | 1 articles | Viewed by 1877 | Submission Open
Keywords: natural products; bioactive compounds; functional foods and nutraceuticals; disease prevention and treatment
(This special issue belongs to the Section Plant Science)
Musculoskeletal Disorders: Integrative Insights into Pathophysiology, Therapeutic Strategies, and Rehabilitation
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 1451 | Submission Open
Keywords: musculoskeletal disorders; high-resolution imaging; biomarkers; ultrasound-guided therapy; regenerative medicine; personalized rehabilitation; wearable sensors; translational musculoskeletal research
(This special issue belongs to the Section Medical Research)
Current Approaches and Future Directions in the Treatment of Gynecologic Tumors: Molecular Biology, Diagnostic Advancements and Targeted Therapeutic Strategies—2nd Edition submission deadline 30 May 2026 | 1 articles | Viewed by 1401 | Submission Open
Keywords: gynecologic tumors; cervical cancer; ovarian cancer; endometrial cancer; vulvar cancer; vaginal cancer; gestational trophoblastic disease; molecular mechanisms; diagnostic advancements; novel therapies
(This special issue belongs to the Section Medical Research)
New Mechanisms and Insights into Insect Silk Gland Biology and Silk Production
edited by Wenliang Qian
submission deadline 30 May 2026 | Viewed by 291 | Submission Open
Keywords: silk gland morphogenesis; liquid-to-solid phase transition; biomimetic microfluidic spinning; silk gland multi-omics; silk protein evolutionary adaptations; CRISPR
(This special issue belongs to the Section Animal Science)
Advances in Skin-Related Disease: Pathogenesis and Novel Therapeutic Strategies submission deadline 31 May 2026 | 5 articles | Viewed by 19892 | Submission Open
Keywords: skin pathologies; skin cancer; eczema; acne; psoriasis; skin microbiome
(This special issue belongs to the Section Physiology and Pathology)
Prognosis and Management of Dry Eye Disease submission deadline 31 May 2026 | 3 articles | Viewed by 11220 | Submission Open
Keywords: dry eye disease; dry eye epidemiology; dry eye management; dry eye natural course; meibomian gland dysfunction; evaporative dry eye; aqueous deficiency dry eye; artificial tear substitutes; tear film lipid layer; meibomian glands
(This special issue belongs to the Section Medical Research)
Physiological, Pathological, and Clinical Effects of Exercise Training and Physical Activity
edited by Chia-Huei Lin
submission deadline 31 May 2026 | 7 articles | Viewed by 5586 | Submission Open
Keywords: exercise training; physical activity; individualized exercise prescription; physiological adaptation; chronic disease prevention; cardiovascular fitness; musculoskeletal health; neuroplasticity; metabolic syndrome; inflammation and immunity; stroke recovery; physical activity monitoring; mental health and exercise; cognitive function; aging and physical activity; sedentary behavior; physical function outcomes; patient-reported outcomes; clinical trial
(This special issue belongs to the Section Physiology and Pathology)
New Insights into Pediatric Rheumatic and Autoimmune Diseases
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 5333 | Submission Open
Keywords: arthritis; juvenile; autoimmune diseases; biomarkers; diagnostic imaging; juvenile dermatomyositis; lupus erythematosus; systemic; pediatric rheumatology; vasculitis
(This special issue belongs to the Section Medical Research)
Current and Future Perspectives of Takotsubo Syndrome
edited by Luca Arcari
submission deadline 31 May 2026 | 2 articles | Viewed by 4691 | Submission Open
Keywords: takotsubo syndrome; heart failure; microvascular dysfunction; inflammation; myocardial edema; heart– brain axis; echocardiography; cardiac magnetic resonance; computed tomography; nuclear imaging
(This special issue belongs to the Section Physiology and Pathology)
Recent Advances in Lymphomas
edited by Magdalena Witkowska
submission deadline 31 May 2026 | 4 articles | Viewed by 4380 | Submission Open
Keywords: lymphoma; cellular therapy; epigenetics; immunotherapy; targeted therapies
(This special issue belongs to the Section Medical Research)
Advances in Wildlife Behavior and Biodiversity submission deadline 31 May 2026 | 2 articles | Viewed by 2507 | Submission Open
Keywords: behavioral abnormalities; the ability to exhibit natural behavior; reduced genetic diversity; habitat loss; extinction of species; species rehousing; coexistence
(This special issue belongs to the Section Diversity and Ecology)
New Developments in Mycology submission deadline 31 May 2026 | 2 articles | Viewed by 2159 | Submission Open
Keywords: fungal diversity; population genetics; phylogeography; mycorrhizae; biotechnology
(This special issue belongs to the Section Microbiology)
Innovative Cardiovascular Interventions: From Imaging to Precision Therapies submission deadline 31 May 2026 | 1 articles | Viewed by 1895 | Submission Open
Keywords: cardiovascular diseases (CVDs); diagnostic imaging; minimally invasive interventions; precision medicine; 3D/4D imaging; gene therapy; cell-based therapies
(This special issue belongs to the Section Physiology and Pathology)
Harmful Algal Bloom Risk: Mechanisms, Prediction, Impacts and Mitigation
edited by Lixia Shang
submission deadline 31 May 2026 | 1 articles | Viewed by 1453 | Submission Open
Keywords: harmful algal blooms; marine risk; bloom mechanisms; prediction models; mitigation strategies; ecosystem impact
(This special issue belongs to the Section Diversity and Ecology)
New Screening Methods for Diagnosis of Cardiovascular Diseases
edited by , Ruxandra Maria Ilie-Mihai and Damaris Cristina Gheorghe
submission deadline 31 May 2026 | 1 articles | Viewed by 972 | Submission Open
Keywords: cardiovascular diseases; biomarkers; screening methods; sensor; spectroscopic methods; chromatographic methods
(This special issue belongs to the Section Medical Research)
Objective Tools to Aid the Diagnosis and Treatment of Neurodevelopmental Disorders
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 948 | Submission Open
Keywords: intervertion training  ; eye tracker  ; dyslexia  ; postural sways  ; reading  ; ASD  ; ADHD  ; attention  ; emotion
(This special issue belongs to the Section Medical Research)
Comorbidities of Migraine: Clinical and Research Perspectives
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 866 | Submission Open
Keywords: migraine; pain; headache; comorbidities; internal medicine; complex disorders
(This special issue belongs to the Section Medical Research)
Hybrid Molecules in Drug Discovery: From Antidiabetic Agents to Anticancer Therapeutics
edited by Jatinder Singh and Shreyosree Chatterjee
submission deadline 31 May 2026 | Viewed by 482 | Submission Open
Keywords: hybrid molecules; drug discovery; antidiabetic; oncology; structure— activity relationships
(This special issue belongs to the Section Pharmaceutical Science)
Biofluid Mechanics and Medical Diagnostic Simulations submission deadline 31 May 2026 | Viewed by 415 | Submission Open
Keywords: biofluid mechanics; computational modeling; medical diagnostics; fluid-structure interaction; patient-specific modeling
(This special issue belongs to the Section Medical Research)
Understanding Early Dysmetabolism in Adolescents: Bridging Research, Mechanisms and Clinical Management
edited by Anna Di Sessa
submission deadline 31 May 2026 | Viewed by 300 | Submission Open
Keywords: dysmetabolism; biomarkers; intervention; prevention; early diagnosis; strategies; children; adolescents
(This special issue belongs to the Section Physiology and Pathology)
Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Disorders
edited by Giovanni Tomasello
submission deadline 31 May 2026 | Viewed by 210 | Submission Open
Keywords: gut dysbiosis; gastrointestinal; probiotics; inflammatory bowel diseases
(This special issue belongs to the Section Microbiology)
Agri-Food Waste Extracts: Structural and Functional Characterization
edited by
submission deadline 12 Jun 2026 | 1 articles | Viewed by 2255 | Submission Open
Keywords: agri-food waste; extracts; extraction techniques; chemical characterization; bioactivity; cytotoxicity and cytocompatibility; isolation of bioactive molecules
(This special issue belongs to the Section Plant Science)
Ultrasound and Anatomical Studies
edited by , Ingrid Moller and
submission deadline 15 Jun 2026 | 1 articles | Viewed by 644 | Submission Open
Keywords: ultrasound techniques; musculoskeletal system; human anatomy; medicine specialties; clinical students; ultrasound teaching
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Epigenetics, Microbiota, and Food—Shaping Immune Health and Longevity
edited by
submission deadline 18 Jun 2026 | 3 articles | Viewed by 11891 | Submission Open
Keywords: epigenetics; nutrigenomics; aging; microRNA; DNA methylation; diet; nutrients; microbiota; longevity; natural components
(This special issue belongs to the Section Physiology and Pathology)
Advances in Research on Motor Deficits Caused by Neurological Disorders: From Mechanism to Treatment
edited by and Hans Hultborn
submission deadline 18 Jun 2026 | 3 articles | Viewed by 8667 | Submission Open
Keywords: neurological disorders; neurodegenerative diseases; brain injury; spinal cord injury; stroke; cerebral palsy; peripheral nerve injury; paralysis; spasticity; contracture; muscle weakness; postural asymmetry; gate pattern changes; uncontrolled movements
(This special issue belongs to the Section Medical Research)
Dive into Myopia
edited by
submission deadline 19 Jun 2026 | 4 articles | Viewed by 9839 | Submission Open
Keywords: myopia; hyperopia; myopia control; axial length; axial length retardation; axial length elongation; myopia complications; refraction measurement; atropine; rebound effect; orthokeratology; missight; defocus incorporated multiple segments (DIMSs); highly aspherical lenslets (HALs); red light; repeated low-level red light (RLRL) therapy; enhance myopia control; customized myopia control; peripheral refraction; peripheral myopia; refractive surgery; PRK; LASIK; smile; contact lens; spectacles
(This special issue belongs to the Section Medical Research)
Lipid Metabolism Pathways: From Life to Disease
edited by
submission deadline 19 Jun 2026 | 2 articles | Viewed by 8563 | Submission Open
Keywords: lipid metabolism; lipid signaling; apoptosis; ferroptosis; autophagy; membrane dynamics; fatty acid oxidation; obesity
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
An Integrated Approach on Diagnosis and Treatment of Cerebral Veins and Intracranial Dural Sinuses Thrombosis (CVT)
edited by and
submission deadline 20 Jun 2026 | 1 articles | Viewed by 535 | Submission Open
Keywords: cerebral veins and intracranial dural sinuses thrombosis (CVT); thrombophilia; intracranial hypertension; non-enhanced computer tomography (NECT) of the head; computer tomography venography (CTV); magnetic resonance imaging (MRI) of the head; magnetic resonance venography (MRV); anticoagulation
(This special issue belongs to the Section Medical Research)
Advances in Knee Biomechanics—2nd Edition
edited by Jason Shearn
submission deadline 22 Jun 2026 | Viewed by 237 | Submission Open
Keywords: knee; tendon; ligament; injury; repair; healing; biomechanics; advanced techniques
(This special issue belongs to the Section Physiology and Pathology)
Reconstruction of Bone Defects submission deadline 23 Jun 2026 | 10 articles | Viewed by 14842 | Submission Open
Keywords: bone and fracture biomechanics; bone healing; critical size bone defects; fracture non-union; inflammation; joint arthroplasty and fracture osteosynthesis; implant designs; materials proprieties; patient selection; primary and revision settings
(This special issue belongs to the Section Medical Research)
Recent Advances in Vascular Biology and Chronic Kidney Disease (CKD)
edited by
submission deadline 26 Jun 2026 | 2 articles | Viewed by 9848 | Submission Open
Keywords: chronic kidney disease; vascular dysfunction; endothelial cells
(This special issue belongs to the Section Medical Research)
Advances in Anesthesia and Critical Care
edited by
submission deadline 26 Jun 2026 | 5 articles | Viewed by 9787 | Submission Open
Keywords: anesthesia; intensive care training; updates in anesthesia; machine learning
(This special issue belongs to the Section Medical Research)
Advances in Dryland Agriculture Science
edited by and Hangyu Dong
submission deadline 26 Jun 2026 | 3 articles | Viewed by 5438 | Submission Open
Keywords: dry farming; climate smart agriculture; soil and water protection; conservation tillage; intercropping; crop rotation; saving irrigation
(This special issue belongs to the Section Plant Science)
Feature Papers in Medical Research: 4th Edition
edited by
submission deadline 26 Jun 2026 | 6 articles | Viewed by 4917 | Submission Open
Keywords: dermatological research; cancer research; cardiovascular research; general medicine; gastroenterological research; hematological research; immunological research; infectious diseases research; metabolism and endocrinology; nervous system research; nursing; pediatrics; pulmonary research; psychiatric research; rehabilitation; renal and urinary research; reproductive research and women's health; rheumatological research; skeletal and muscular research; vision research
(This special issue belongs to the Section Medical Research)
Advanced Technologies and Clinical Practice of Cancer Radiotherapy
edited by
submission deadline 26 Jun 2026 | 1 articles | Viewed by 1239 | Submission Open
Keywords: proton therapy; BNCT; in vivo dose verification in radiotherapy; accelerators for radiation therapy; simulation of radiotherapies
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Innovations in Thoracic Medicine: Advancements and Challenges—2nd Edition
edited by Paolo Scanagatta
submission deadline 26 Jun 2026 | 1 articles | Viewed by 1135 | Submission Open
Keywords: thoracic medicine; lung cancer; artificial intelligence (AI); minimally invasive intervention; thoracic anesthesia; clinical innovation; technological advances
(This special issue belongs to the Section Medical Research)
Application of Mass Spectrometry-Based Multi-Omics in Biomedical Research submission deadline 26 Jun 2026 | 1 articles | Viewed by 747 | Submission Open
Keywords: mass spectrometry; multi-omics; proteomics; metabolomics; lipidomics; mass spectrometry imaging (MSI); biomarker discovery; translational research
(This special issue belongs to the Section Medical Research)
Harnessing Mitochondrial Rewiring for Cancer Therapy: Novel Strategies in the Era of Precision Medicine
edited by and Maria Sideridou
submission deadline 26 Jun 2026 | Viewed by 296 | Submission Open
Keywords: Oxidative stress; Metabolic rewiring; Carcinogenesis; DNA repair; Cancer therapy; Heteroplasmy
(This special issue belongs to the Section Physiology and Pathology)
Leveraging the Power of Enzymes in Biotechnological Applications
edited by
submission deadline 28 Jun 2026 | Viewed by 619 | Submission Open
Keywords: enzyme; 3D structure; function/activity; enzyme engineering; beneficial variants; industrial application
Effects of Exercise and Functional Interventions on Musculoskeletal Health
edited by
submission deadline 30 Jun 2026 | 10 articles | Viewed by 28457 | Submission Open
Keywords: musculoskeletal health; exercise; physical function; joint stability; fall prevention; rehabilitation science
(This special issue belongs to the Section Medical Research)
2nd Edition—Featured Papers on the Origins of Life
edited by James R. Lyons
submission deadline 30 Jun 2026 | 7 articles | Viewed by 26840 | Submission Open
Keywords: astrobiology; astrochemistry; planetary science; prebiotic chemistry; chirality; chemical evolution; protocells; synthetic biology; complex systems
(This special issue belongs to the Section Origin of Life)
Recent Advances in Physiotherapy for Musculoskeletal Disorders submission deadline 30 Jun 2026 | 6 articles | Viewed by 21711 | Submission Open
Keywords: musculoskeletal rehabilitation; emerging technologies; virtual reality; artificial intelligence; inflammatory genetics; physiotherapy; sports medicine; functional recovery
(This special issue belongs to the Section Physiology and Pathology)
The Emerging Role of Microbiota in Health and Diseases
edited by Edyta Juszczuk-Kubiak and Katarzyna Góralska
submission deadline 30 Jun 2026 | 7 articles | Viewed by 21269 | Submission Open
Keywords: microbiota; eubiosis; dysbiosis; microbiota– host interaction; microbiota– gut– brain axis; microbiome; bacteria– fungi interactions; microbiota modification; holobiont; cross-feeding; microbiota related diseases; microbiota functions
(This special issue belongs to the Section Microbiology)
Common and Novel Markers of Inflammation and Tissue Damage in Various Pathological Conditions—2nd Edition submission deadline 30 Jun 2026 | 9 articles | Viewed by 14846 | Submission Open
Keywords: body fluids; cytokines; damage-associated molecular patterns (DAMPs); inflammatory response; injury; markers of inflammation and tissue damage; metalloproteinases; novel markers; pathological conditions; proteasome; tissue damage; tissue repair processes; various diseases
(This special issue belongs to the Section Physiology and Pathology)
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