Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Early Prebiotic Reaction Networks
edited by Olga Taran and Paul J. Bracher
submission deadline 31 Dec 2025 | Viewed by 383 | Submission Open
Keywords: thioesters; autocatalytic reactions; redox cycling; chemical fossils; TCA cycle analogues
(This special issue belongs to the Section Origin of Life)
Sustainable Agroforestry: Molecular Strategies for Integrated Pest and Disease Management
edited by Gothandapani Sellamuthu and Kanakachari Mogilicherla
submission deadline 31 Dec 2025 | Viewed by 318 | Submission Open
Keywords: sustainable agroforestry; integrated pest management; genomics; transcriptomics; CRISPR technology; RNAi; plant– microbe interactions; biopesticides
(This special issue belongs to the Section Plant Science)
Plant Adaptation Mechanisms to Abiotic Stresses
edited by Sunchung Park and Ezekiel Ahn
submission deadline 31 Dec 2025 | Viewed by 306 | Submission Open
Keywords: abiotic stress; plant adaptation mechanisms; cold; heat; drought; salinity; flooding; waterlogging; transcription factors
(This special issue belongs to the Section Plant Science)
Origin of Life in Chemically Complex Messy Environments: 3rd Edition submission deadline 31 Dec 2025 | Viewed by 278 | Submission Open
Keywords: origin of life; complex chemical systems  ; prebiotic chemistry  ; prebiotic metabolisms  ; chemical evolution  ; prebiotic catalysts
(This special issue belongs to the Section Origin of Life)
Coagulation and Its Disorders: Diagnostics, Therapeutics, and Clinical Management submission deadline 31 Dec 2025 | Viewed by 270 | Submission Open
Keywords: coagulation; bleeding disorders; disseminated intravascular coagulation; fibrinolysis; new diagnostic tools and treatment; inflammation and coagulation disorders; thrombosis; platelet disorders; coagulation alterations induced by hepatic and metabolic disorders; drug-induced coagulation alterations
Understanding Brain Disorders Through EEG and AI submission deadline 31 Dec 2025 | Viewed by 267 | Submission Open
Keywords: EEG; ADHD; Alzheimer’ s; Parkinson’ s; neurological disorders; machine learning; deep learning
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Artificial Intelligence in Cardiovascular Diseases: Research, Technology and Clinical Practice
edited by
submission deadline 31 Dec 2025 | Viewed by 266 | Submission Open
Keywords: cardiovascular disease; artificial intelligence; atherosclerosis; atrial fibrillation; cardiomyopathy
(This special issue belongs to the Section Medical Research)
Non-Conventional Approaches in Modern Biological Analysis and Medical Diagnostics submission deadline 31 Dec 2025 | Viewed by 233 | Submission Open
Keywords: biological samples; non-conventional analytical techniques; life science; diagnostics; proteins
Recent Advances in Left Ventricular Unloading Therapy
edited by Mehmet Oezkur
submission deadline 31 Dec 2025 | Viewed by 144 | Submission Open
Keywords: left ventricular unloading therapy; cardiovascular medicine; heart failure; acute myocardial infarction
(This special issue belongs to the Section Medical Research)
Research on Female Reproductive Health and Metabolism
edited by
submission deadline 31 Dec 2025 | Viewed by 137 | Submission Open
Keywords: female reproduction; metabolism; nutrition; adipose tissue; hypothalamus– pituitary– gonadal axis; insulin resistance; adipocytokines; reproductive disorders; PCOS
(This special issue belongs to the Section Physiology and Pathology)
Biochemical Modulators in Chronic Diseases: The Antioxidant/Anti-Inflammatory Interdependence—2nd Edition
edited by
submission deadline 31 Dec 2025 | Viewed by 107 | Submission Open
Keywords: oxidative stress; inflammation; redox modulator; anti-inflammatory agents; chronic diseases; antioxidant paradox; reactive oxygen species
(This special issue belongs to the Section Pharmaceutical Science)
Human Infertility and Reproductive Endocrinology: 2nd Edition
edited by
submission deadline 6 Jan 2026 | 3 articles | Viewed by 6958 | Submission Open
Keywords: infertility; reproduction; reproductive endocrinology; male infertility; female infertility
(This special issue belongs to the Section Reproductive and Developmental Biology)
Brain Barrier Research: Mechanisms, Function, Regulation, and Therapeutic Medicine submission deadline 9 Jan 2026 | Viewed by 310 | Submission Open
Keywords: brain barriers; brain homeostasis; neurodegeneration; neuroinflammation; brain drug delivery
(This special issue belongs to the Section Physiology and Pathology)
Novel Biomaterial-Based Fertilizing Products and Bio-Fertilizers for Sustainable Agricultural Production: 2nd Edition submission deadline 9 Jan 2026 | Viewed by 260 | Submission Open
Keywords: biomaterials and bio-nanomaterials; bio-based hydrogels and polymers; lignocellulosic biomass and its derivatives; sustainable agriculture; biodegradability; stimuli-responsive fertilizer delivery; controlled-release fertilizers; bio-synthesis processes and characterization; control/sustained fertilizer release mechanisms; bio-fertilizers; plant growth-promoting microbes; fertilizers’ use efficiency; plant physiology; productivity; and quality
(This special issue belongs to the Section Plant Science)
Blood Rheology: Insights & Innovations
edited by Nadia Antonova
submission deadline 15 Jan 2026 | 4 articles | Viewed by 8848 | Submission Open
Keywords: hemorheology  ; microfluidics  ; blood viscosity  ; mechanobiology  ; cellular mechanics
(This special issue belongs to the Section Medical Research)
Research Progress in Kidney Diseases
edited by Ane Claudia Fernandes Nunes
submission deadline 15 Jan 2026 | 5 articles | Viewed by 7987 | Submission Open
Keywords: chronic kidney disease; acute kidney injury; hemodialysis; nephrology; renal failure; hypertension; diabetes; molecular genetics
(This special issue belongs to the Section Physiology and Pathology)
Innovations in Dairy Cattle Health and Nutrition Management
edited by Rasa Želvytė and Ingrida Monkevičienė
submission deadline 15 Jan 2026 | 4 articles | Viewed by 4327 | Submission Open
Keywords: innovations; dairy cattle; health; nutrition; rumen; metabolism; biomarkers
(This special issue belongs to the Section Animal Science)
Aspects of the Biology of Populations in Northern Africa and the Middle East
edited by and Shomarka Keita
submission deadline 15 Jan 2026 | Viewed by 304 | Submission Open
Keywords: biodiversity in the Middle East; biodiversity in  Northern Africa; population genetics in the Middle East; ecology in the Middle East; ecology in  Northern Africa; skeletal variation in the Middle East; skeletal variation in  Northern Africa; dental variation in the Middle East; dental variation in  Northern Africa
New Insights into Allergic Eye Diseases submission deadline 16 Jan 2026 | 2 articles | Viewed by 23278 | Submission Open
Keywords: allergy; IgE; IL-4; IL-5; IL-13; TNF-alpha; mast cells; eosinophils; Th1 cells; Th2 cells; therapeutics; immunopathogenesis; immunopathology; conjunctivitis; keratoconjunctivitis
(This special issue belongs to the Section Medical Research)
Multi-Omics Approaches for Gut Microbiota Research: Implications for Human Nutrition
edited by and Antonio Benedetti
submission deadline 16 Jan 2026 | Viewed by 769 | Submission Open
Keywords: gut microbiota; multi-omics; metagenomics; metabolomics; host– microbiome interactions; precision nutrition; dietary interventions
(This special issue belongs to the Section Microbiology)
Advances in Bioprinting, Tissue Engineering, and Regenerative Medicine
edited by
submission deadline 18 Jan 2026 | 3 articles | Viewed by 10829 | Submission Open
Keywords: model tissues; scaffolds; biocompatible materials; biodegradable materials; tissue-on-a-chip; organoids
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Advances in Vascular Health and Metabolism
edited by Ana Blazquez-Medela
submission deadline 18 Jan 2026 | 4 articles | Viewed by 4927 | Submission Open
Keywords: cardiovascular; cardiometabolic disease; adipogenesis; atherosclerosis; obesity; overweight; peripheral artery disease
(This special issue belongs to the Section Medical Research)
Knee Bracing in Human Movement: Biomechanics, Artificial Intelligence, and Optimization
edited by and Liangliang Xiang
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1563 | Submission Open
Keywords: knee bracing; sports biomechanics; neuromechanical mechanisms; gait analysis; functional movement adaptation; AI in orthotics; AI for brace performance; musculoskeletal modeling; finite element simulation; real-time monitoring of knees; human-in-the-loop control; robotic exoskeleton integration; human– machine interaction; rehabilitation or injury prevention
(This special issue belongs to the Section Medical Research)
Nutritional Supplements and Cardiovascular Function in Athletes and Sedentary People submission deadline 23 Jan 2026 | 6 articles | Viewed by 20520 | Submission Open
Keywords: athletes; sedentary; eating habits; nutrition; endothelium; microcirculation; vascular function; nutritional supplements; oxidative stress; antioxidants; NRF2-signaling pathway; functional food; cardiovascular function; prevention; physical activity
(This special issue belongs to the Section Medical Research)
Physical Medicine and Rehabilitation: Trends and Applications—4th Edition submission deadline 30 Jan 2026 | 5 articles | Viewed by 10296 | Submission Open
Keywords: clinical physical medicine and rehabilitation; neurorehabilitation; cardiopulmonary rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; geriatric rehabilitation; cancer rehabilitation; musculoskeletal pain management; physical therapy; occupational therapy; speech and swallowing therapy
(This special issue belongs to the Section Epidemiology)
Microbial Diversity and Function in Aquatic Environments
edited by Xianglong Chen and
submission deadline 30 Jan 2026 | 3 articles | Viewed by 6109 | Submission Open
Keywords: aquatic environment; microbial diversity and function; element biogeochemical cycle; interaction between microorganisms and aquatic environments; metaomic approaches
(This special issue belongs to the Section Microbiology)
Advancing Nanotechnology in Cancer Theranostics
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 2837 | Submission Open
Keywords: nanotechnology; cancer; nanoscale materials; nanoparticles; diagnostic accuracy; therapeutic efficacy; metastasis detection and prediction; targeted drug delivery; personalized cancer therapy
(This special issue belongs to the Section Medical Research)
3D Imaging and Facial Reconstruction
edited by Marios Papadakis
submission deadline 30 Jan 2026 | 1 articles | Viewed by 1857 | Submission Open
Keywords: 3D imaging; facial plastic surgery; reconstructive surgery; virtual surgical planning; custom implants; preoperative planning; intraoperative navigation
(This special issue belongs to the Section Medical Research)
Nutrition–Physiology Interactions in Aquatic Species
edited by , and
submission deadline 30 Jan 2026 | 2 articles | Viewed by 1681 | Submission Open
Keywords: aquatic animal nutrition; fish physiology; sustainable aquaculture; alternative lipid sources; alternative protein sources; gut– microbiota interactions
(This special issue belongs to the Section Animal Science)
Metabolic Research in Animal Nutrition submission deadline 30 Jan 2026 | Viewed by 606 | Submission Open
Keywords: nutrition; supplementation; microbiota; obesity; metabolic syndrome; metabolic disorders and diseases; hormonal factors; development and metabolism; metabolomics; nutrigenomics
(This special issue belongs to the Section Animal Science)
Targeting Hormonal Regulation in Prostate Cancer
edited by Marília Figueira
submission deadline 30 Jan 2026 | Viewed by 368 | Submission Open
Keywords: prostate cancer; castrate resistant prostate cancer (CRPC); metastatic prostate cancer; estrogens; estrogen receptors; drug resistance
(This special issue belongs to the Section Medical Research)
Ion Channels and Neurological Disease: 2nd Edition
edited by and Marzia Martina
submission deadline 31 Jan 2026 | 9 articles | Viewed by 29009 | Submission Open
Keywords: ion channels; neurological diseases; neurodegeneration; pain; cellular and animal models; neuronal excitability; neuronal activity; synaptic transmission; structural and functional correlates; computational modeling; pathophysiology and pathogenesis; channelopathies; altered currents; neuropharmacology and ethnopharmacology; drug screening; delivery; and targeting; pharmacological treatments; molecular therapeutic options; neuroprotection
(This special issue belongs to the Section Pharmaceutical Science)
New Advances in Neuroimaging and Brain Functions: 2nd Edition submission deadline 31 Jan 2026 | 4 articles | Viewed by 27775 | Submission Open
Keywords: neuroimaging; brain functions; neurological diseases; humanities and social sciences; noninvasive methods; AI deep learning
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Pain and Therapy: Historical Perspectives and Future Directions submission deadline 31 Jan 2026 | 8 articles | Viewed by 17819 | Submission Open
Keywords: pain; nociceptive pain; neuropathic pain; neoplastic pain; pain physiology; pain treatment
(This special issue belongs to the Section Medical Research)
Pancreatic Cancer: Long Survivals
edited by Francesco Leonardi and
submission deadline 31 Jan 2026 | 2 articles | Viewed by 11669 | Submission Open
Keywords: pancreatic cancer; long survival; outcome; pancreatic adenocarcinoma; long-term survival; surgical resection; chemotherapy; NGS
(This special issue belongs to the Section Physiology and Pathology)
Etiology, Prediction and Prognosis of Ischemic Stroke
edited by , and Jiang Li
submission deadline 31 Jan 2026 | 3 articles | Viewed by 10683 | Submission Open
Keywords: ischemic stroke; recurrent stroke; etiology; machine learning; artificial intelligence; subtyping; prediction; prognosis; genetic risk factors; lifestyle factors; environmental factors; biomarkers; cerebrovascular diseases; prevention; treatment strategies
(This special issue belongs to the Section Physiology and Pathology)
Microbiome–Gut–Brain Connections: New Windows into Health and Disease
edited by and Qi Su
submission deadline 31 Jan 2026 | 4 articles | Viewed by 7974 | Submission Open
Keywords: gut microbes; gut– brain axis; neuroscience
(This special issue belongs to the Section Microbiology)
Prevention, Diagnosis, and Treatment of Gestational Diseases
edited by
submission deadline 31 Jan 2026 | 4 articles | Viewed by 5469 | Submission Open
Keywords: gestational diseases; gestational diabetes; preeclampsia; pregnancy complications
(This special issue belongs to the Section Medical Research)
Recent Advances in Valve Therapy: Clinical and Molecular Perspectives
edited by , Konstantinos Toutouzas and Constantina Aggeli
submission deadline 31 Jan 2026 | 2 articles | Viewed by 4159 | Submission Open
Keywords: transcatheter aortic valve implantation (TAVI); valve-in-valve; long-term outcomes; aortic stenosis; molecular mechanisms in valve disease; structural heart disease
(This special issue belongs to the Section Medical Research)
Exploring the Mechanisms of the Effects of Microplastics and Nanomaterials on Biological Physiological Functions
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 3297 | Submission Open
Keywords: microplastics; nanomaterials; environmental toxicology; oxidative stress; physiological function
(This special issue belongs to the Section Physiology and Pathology)
Natural Products and Modern Drug Discovery: Emerging Strategies Targeting Cancer- and Disease-Related Molecular Mechanisms
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 3113 | Submission Open
Keywords: natural products; phytochemicals; drug discovery; bioactivity profiling; pharmacophore modeling; synthetic biology; cancer therapy; microbial metabolites
(This special issue belongs to the Section Medical Research)
Advances in the Rehabilitation of Stroke
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 3077 | Submission Open
Keywords: stroke; acute stroke; chronic stroke; post-acute stroke; functional recovery; rehabilitation
(This special issue belongs to the Section Medical Research)
Liver Disease: Pathogenesis, Diagnosis, and Treatments
edited by Hsien-Hui Chung
submission deadline 31 Jan 2026 | 2 articles | Viewed by 2586 | Submission Open
Keywords: alcoholic hepatitis; artificial intelligence; biomarkers; clinical trials; gut– liver axis; liver cancer; metabolic dysfunction-associated steatohepatitis; molecular targets; pharmacotherapeutic mechanisms; therapeutic strategies
(This special issue belongs to the Section Medical Research)
Advances in Cardiac Arrest: Prognostic Performance and Management
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1931 | Submission Open
Keywords: cardiac arrest; resuscitation; emergency medicine; critical care medicine
(This special issue belongs to the Section Medical Research)
Pig Microbiota Metabolism and Intestinal Health
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1755 | Submission Open
Keywords: pig microbiota; metabolism; intestinal health; gut microbiome; functional genomics; microbiome-host interactions; animal nutrition; disease resistance; gut barrier function; omics technologies; immune function; antibiotic reduction; feed efficiency; pathogen control; gastrointestinal health
(This special issue belongs to the Section Animal Science)
Intracerebral Hemorrhage: Advances and Perspectives
edited by Ane Claudia Fernandes Nunes
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1596 | Submission Open
Keywords: intracerebral hemorrhage; microangiopathic disease; cerebral microhemorrhages blood– brain barrier; small vessel disease
(This special issue belongs to the Section Physiology and Pathology)
Plant–Soil Interactions Under Global Change
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1543 | Submission Open
Keywords: plant– soil interactions; biodiversity; ecosystem; agroecosystem; natural ecosystem; sustainable development
(This special issue belongs to the Section Plant Science)
New Insights into Pneumonia Pathophysiology—from Lung Fibrosis to Coagulation Disorders
edited by Mihai Lazar
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1382 | Submission Open
Keywords: pneumonia pathophysiology; lung fibrosis; coagulation disorders; thromboinflammation; immune dysregulation; diagnostic biomarkers; translational medicine
(This special issue belongs to the Section Physiology and Pathology)
Brain Health for All Ages: Leave No One Behind
edited by and Dilani Wijeratne
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1009 | Submission Open
Keywords: brain health; neurology; neurological syndromes
(This special issue belongs to the Section Medical Research)
Advances in Emergency and Critical Care Medicine
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 994 | Submission Open
Keywords: emergency medicine; critical care; trauma; infectious diseases; elderly
(This special issue belongs to the Section Medical Research)
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