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Life
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Human Infertility and Reproductive Endocrinology: 2nd Edition
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Human Infertility and Reproductive Endocrinology: 2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Reproductive and Developmental Biology".

Deadline for manuscript submissions: 30 May 2025 | Viewed by 3139

Special Issue Editor

Dr. Giuseppe Grande

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Guest Editor
Unit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy.
Interests: reproductive endocrinology; male infertility; andrology; hypogonadism; proteomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The second volume of this Special Issue follows on from the success of the first. We invite you to publish your research in this edition of “Human Infertility and Reproductive Endocrinology” (https://www.mdpi.com/journal/life/special_issues/6R8KIXVW2L).

Infertility is a common clinical problem, affecting 13% to 15% of couples worldwide. In addition, infertility is considered a public problem, not only affecting couples’ lives, but also healthcare services and the social environment. The male factor is solely responsible for about 20% of infertile couples and contributory to another 30–40%. The female factor is responsible, solely or associated with the male factor, for about 50% of the cases.

This Special Issue will focus on human fertility and infertility, both at the molecular and clinical levels, including the hormonal regulation of male and female fertility, diagnosis and treatment of diseases causing infertility, and the clinical management of infertile couples.

Dr. Giuseppe Grande
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • infertility
  • reproduction
  • reproductive endocrinology
  • male infertility
  • female infertility

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

14 pages, 2200 KiB  
Article
CD56-Positive NK Cells and CD138-Positive Plasma Cells in Basal Decidua of Term Placentas in Singleton Pregnancies After Assisted Reproductive Technology Treatment of Endometriosis-Related Infertility
by Stipe Dumancic, Marinela Bakotin Jakovac, Marko Drazen Mimica, Sandra Zekic Tomas and Jelena Marusic
Life 2025, 15(2), 240; https://doi.org/10.3390/life15020240 - 5 Feb 2025
Viewed by 999
Abstract
A eutopic endometrium in endometriosis shows altered immune responses, including abnormalities of NK cells and expression of plasma cells, related to reproductive issues. This study investigated the counts of CD56-positive NK cells and CD138-positive plasma cells in the basal decidua of term placentas [...] Read more.
A eutopic endometrium in endometriosis shows altered immune responses, including abnormalities of NK cells and expression of plasma cells, related to reproductive issues. This study investigated the counts of CD56-positive NK cells and CD138-positive plasma cells in the basal decidua of term placentas in singleton pregnancies after endometriosis-related infertility conceived by assisted reproductive technology (ART). This single-center, case-control study involved immunohistochemical analysis of CD56-positive NK cells and CD138-positive plasma cells in basal decidua using primary monoclonal mouse antibodies, followed by secondary antibodies using a standardized protocol. CD56 and CD138 immunohistochemically positive cells were reported as the total cell count for each studied antibody expressed per 1 mm2 of basal decidua (Olympus BX46 and Olympus Image Analyzer). Placental samples containing basal decidua from 36 participants with endometriosis-related infertility who conceived by ART, 31 participants with male factor infertility who conceived by ART and 40 healthy controls were included. Endometriosis decidua showed the lowest median count of CD56-positive NK cells (11.5 / mm2, p = 0.039) in BD compared to male factor group (25 / mm2) and healthy controls (24.5 / mm2). No differences were found for CD138-positive plasma cells counts between study groups. Basal decidua in pregnancies after endometriosis-related infertility showed reduced total count of CD56-positive NK cells, without differences in the CD138-positive plasma cell counts compared to control groups. Future studies should investigate how changes in NK cells throughout pregnancy affect the development of perinatal complications and placental pathologies in women with endometriosis, which could uncover potential diagnostic and therapeutic targets. Full article
(This article belongs to the Special Issue Human Infertility and Reproductive Endocrinology: 2nd Edition)
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13 pages, 255 KiB  
Article
Retrospective Analysis of Effective Management Strategies for Primary Amenorrhea of Reproductive Age in Saudi Arabia
by Hanadi Bakhsh
Life 2024, 14(6), 772; https://doi.org/10.3390/life14060772 - 17 Jun 2024
Viewed by 1573
Abstract
Primary amenorrhea, the absence of menstruation by age 15, can have significant implications for reproductive health and overall well-being. This retrospective study aimed to evaluate the effectiveness of various management strategies for primary amenorrhea among women of reproductive age in Saudi Arabia. Medical [...] Read more.
Primary amenorrhea, the absence of menstruation by age 15, can have significant implications for reproductive health and overall well-being. This retrospective study aimed to evaluate the effectiveness of various management strategies for primary amenorrhea among women of reproductive age in Saudi Arabia. Medical records of 63 eligible patients from 2018 to 2023 were analyzed, assessing diagnostic methods, treatment modalities, and associated outcomes. The findings revealed that hormonal therapy was the most commonly employed management strategy (50.0%) and demonstrated the highest rate of achieving menstrual regularity (62.5%). Surgical interventions were utilized in 28.1% of cases, with a 50.0% rate of symptom resolution. Lifestyle modifications were less frequent (21.9%) but showed a moderate rate of symptom resolution (35.7%). Logistic regression analysis identified age, underlying etiology, and management strategy as significant predictors of treatment success. Subgroup analyses highlighted the efficacy of hormonal therapy and lifestyle modifications for genetic etiologies, while surgical interventions were more effective for anatomical causes. The study underscores the importance of a comprehensive diagnostic approach and personalized treatment plans tailored to individual patient characteristics. Despite limitations, the findings contribute to the understanding of optimal management strategies for primary amenorrhea and emphasize the need for multidisciplinary collaboration in addressing this complex condition. Full article
(This article belongs to the Special Issue Human Infertility and Reproductive Endocrinology: 2nd Edition)
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