Research on Female Reproductive Health and Metabolism
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 31
Special Issue Editor
Special Issue Information
Dear Colleagues,
In recent decades, reproductive disorders have emerged as a major public health concern, particularly in women’s health. Globally, infertility is estimated to affect between 8 and 12% of reproductive-aged couples, and adverse pregnancy outcomes, including preterm delivery, low birth weight, hypertensive disorders and gestational diabetes, have been demonstrated to significantly impact human health in both the short and long term.
Metabolic and reproductive pathways are closely linked, and this relationship has been conserved throughout evolution. The integration of environmental, nutritional and hormonal signals with the hypothalamic–pituitary–gonadal axis is essential for both normal pubertal development and the maintenance of adult reproductive function. Although infertility has traditionally been associated with severe malnutrition and allostatic overload, the existence of a significant association between obesity and an increased risk of reproductive dysfunction is now recognized. Chronic inflammation, oxidative stress, lipotoxicity and altered levels of adipocytokines, such as leptin, are just some of the factors involved in this association.
This Special Issue will therefore present advances in understanding how metabolic dysfunction may impact female reproductive function and, conversely, how reproductive diseases may lead to metabolic changes, with the aim of improving our knowledge about female reproductive pathophysiology and its management in terms of both medical care and quality of life.
Dr. Alice Bongrani
Guest Editor
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Keywords
- female reproduction
- metabolism
- nutrition
- adipose tissue
- hypothalamus–pituitary–gonadal axis
- insulin resistance
- adipocytokines
- reproductive disorders
- PCOS
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