New Insights into Pneumonia Pathophysiology—from Lung Fibrosis to Coagulation Disorders

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 114

Special Issue Editor


E-Mail Website
Guest Editor
1. Faculty of Medicine, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania
2. National Institute for Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania
Interests: pathophysiology; infectious diseases; lung diseases; HIV

Special Issue Information

Dear Colleagues,

Pneumonia remains a major global health burden, with significant morbidity and mortality despite advances in antimicrobial therapy and supportive care. Recently, research has highlighted that pneumonia is not merely an acute infectious disease but a complex inflammatory condition with far-reaching systemic consequences. This Special Issue, “New Insights into Pneumonia Pathophysiology—from Lung Fibrosis to Coagulation Disorders, aims to explore the multifaceted biological mechanisms underlying pneumonia. The pathophysiological interplay between immune dysregulation, endothelial dysfunction, and thromboinflammatory responses offers new perspectives for diagnostic biomarkers and targeted therapies. Seeking cutting-edge research on cellular and molecular mechanisms, clinical imaging, disease management, and translational models, this Special Issue encourages the submission of contributions that enhance our understanding of pneumonia and its associated complications. We welcome original research and comprehensive reviews that elucidate specific pathways or propose innovative approaches to prevention, diagnosis, and treatment. This Special Issue hopes to foster interdisciplinary dialogue and accelerate the integration of emerging pathophysiological insights into clinical practice.

Dr. Mihai Lazar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pneumonia pathophysiology
  • lung fibrosis
  • coagulation disorders
  • thromboinflammation
  • immune dysregulation
  • diagnostic biomarkers
  • translational medicine

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

24 pages, 1624 KB  
Article
Pancreatic Injury in Severe SARS-CoV-2 Infection: A Retrospective Study Across Three Pandemic Waves
by Mihai Lazar, Cristina Emilia Chitu and Ecaterina Constanta Barbu
Life 2025, 15(9), 1439; https://doi.org/10.3390/life15091439 (registering DOI) - 14 Sep 2025
Abstract
Acute pancreatitis (AP) has emerged as a notable complication in patients with COVID-19, yet the interplay between viral infection, systemic inflammation, and pancreatic injury remains incompletely understood. This study aimed to evaluatethe characteristics and risk factors of APin patients with severe COVID-19 pneumonia. [...] Read more.
Acute pancreatitis (AP) has emerged as a notable complication in patients with COVID-19, yet the interplay between viral infection, systemic inflammation, and pancreatic injury remains incompletely understood. This study aimed to evaluatethe characteristics and risk factors of APin patients with severe COVID-19 pneumonia. We conducted a retrospective, single-center analysis of 405 hospitalized COVID-19 patients with and without AP. Laboratory markers, including CRP, ESR, fibrinogen, LDH, D-dimers, WBC, neutrophils, serum potassium, and serum glucose, alongside imaging and clinical parameters, were analyzed for associations with AP occurrence. Our results indicate that elevated inflammatory and coagulation markers, leukocytosis with neutrophilia, hyperglycemia, hypokalemia, and more severe pulmonary involvement were significantly associated with AP in COVID-19. LDH and inflammatory markers demonstrated particularly strong predictive value, while D-dimers and lung injury severity also contributed to risk stratification. These findings suggest that systemic inflammation, endothelial dysfunction, immunothrombosis, and metabolic impairments converge to increase pancreatic vulnerability in COVID-19 patients. Early recognition of these risk factors may guide monitoring and therapeutic interventions, although prospective validation is needed. Full article
Show Figures

Figure 1

Back to TopTop