Advances in Vascular Health and Metabolism

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 30 May 2025 | Viewed by 712

Special Issue Editor


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Guest Editor
Department of Basic Medical Sciences, Western University of Health Sciences, 309 E. Second Street, HEC 2264, Pomona, CA 91766, USA
Interests: cardiovascular research; adipogenesis; cardiometabolic diseases

Special Issue Information

Dear Colleagues,

The link between metabolism and cardiovascular physiology has been evident for a long time. Both metabolic and cardiovascular diseases have experienced continuous increases in incidence and prevalence in recent years. The increase in unhealthy dietary habits has led to an increase in overweight and obesity to the point where obesity is considered an epidemic by the WHO. The worldwide prevalence of obesity more than doubled between 1990 and 2022.

Obesity and overweight are associated with an increased risk of adverse cardiovascular events and diseases, and the increase of overweight and obesity rates during childhood makes negative outcomes in adulthood more likely.

The magnitude of these issues and their severe effects on the life expectancy and quality of life of those affected have led many researchers to focus their efforts on them in recent years. While getting billions of people to change their lifestyle habits in order to prevent these issues would be an impossible task, better understanding the mechanisms underlying the connection between metabolic disorders and vascular pathologies would improve the quality of treatment of the affected people and can have a potential effect in reducing the pathologies derived from or linked to overweight and obesity, including vascular issues.

This issue aims to inquire further about the mechanisms linking metabolic and vascular health and to include the most updated knowledge in cardiometabolic diseases.

Dr. Ana Blazquez-Medela
Guest Editor

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Keywords

  • cardiovascular
  • cardiometabolic disease
  • adipogenesis
  • atherosclerosis
  • obesity
  • overweight
  • peripheral artery disease

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Published Papers (1 paper)

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Review

16 pages, 238 KiB  
Review
The Role of Resistin in Macrovascular and Microvascular Complications of Type 2 Diabetes
by Africa Samantha Reynoso-Roa, Susan Andrea Gutiérrez-Rubio, Ezequiel Magallón-Gastélum, Trinidad García-Iglesias, Daniel Osmar Suárez-Rico and Teresa Arcelia García-Cobián
Life 2025, 15(4), 585; https://doi.org/10.3390/life15040585 - 2 Apr 2025
Viewed by 414
Abstract
Resistin is an adipokine produced in adipose tissue with pro-inflammatory properties, whose elevation has been associated with insulin resistance and diabetes. Over the past years, significant research has explored the pathophysiological mechanisms involving resistin, utilizing various in vitro and in vivo models. Additionally, [...] Read more.
Resistin is an adipokine produced in adipose tissue with pro-inflammatory properties, whose elevation has been associated with insulin resistance and diabetes. Over the past years, significant research has explored the pathophysiological mechanisms involving resistin, utilizing various in vitro and in vivo models. Additionally, numerous clinical studies have aimed to establish a correlation between resistin and the development and progression of macrovascular and microvascular complications in type 2 diabetes. This narrative review summarizes in vitro, in vivo, and human studies published in English since the discovery of resistin in 2001 to the present, examining the role of this adipokine in the pathophysiology of macrovascular and microvascular complications in in vivo and in vitro T2D models, as well as the clinical evidence supporting its use as a biochemical marker in patients with these conditions. The results exhibit considerable heterogeneity and appear to be dependent on the experimental model or population studied. While experimental evidence supports resistin’s involvement at the cellular and molecular levels in the pathogenesis of these complications, current clinical evidence remains insufficient to justify its use as a biochemical marker for either diagnosis or prognosis. Therefore, further well-designed studies are required to elucidate resistin’s potential role in the clinical setting. Full article
(This article belongs to the Special Issue Advances in Vascular Health and Metabolism)
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