Advances in Cardiac Arrest: Prognostic Performance and Management

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 566

Special Issue Editor


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Guest Editor
Department of Emergency Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA
Interests: cardiac arrest; resuscitation; emergency medicine; critical care medicine
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Special Issue Information

Dear Colleagues,

This Special Issue on “Advances in Cardiac Arrest: Prognostic Performance and Management” aims to serve as a seminal resource for medical professionals navigating the evolving landscape of cardiac arrest care. Despite advancements in resuscitative science, cardiac arrest continues to be a leading cause of mortality and morbidity around the world. This Special Issue seeks to address this critical gap by focusing on two pivotal aspects: prognostic performance and management strategies. It aims to elucidate the latest predictive models and biomarkers that can accurately forecast patient outcomes following resuscitation. Concurrently, this Special Issue will explore innovative management approaches, from pre-hospital interventions to advanced critical care techniques, that optimize patient survival and neurological function. By amalgamating cutting-edge research and expert opinions, this Special Issue endeavors to enhance clinical decision-making and set new benchmarks in cardiac arrest care. The target audience comprises basic researchers, resuscitation scientists, emergency physicians, intensivists, cardiologists, and other healthcare providers who are committed to elevating the standard of care in this life-threatening condition.

Dr. Kei Hayashida
Guest Editor

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Keywords

  • cardiac arrest
  • resuscitation
  • emergency medicine
  • critical care medicine

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Published Papers (1 paper)

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Research

16 pages, 4235 KiB  
Article
Feasibility of Xenogeneic Mitochondrial Transplantation in Neuronal Systems: An Exploratory Study
by Eriko Nakamura, Tomoaki Aoki, Cyrus E. Kuschner, Yusuke Endo, Jacob S. Kazmi, Tai Yin, Ryosuke Takegawa, Lance B. Becker and Kei Hayashida
Life 2025, 15(7), 998; https://doi.org/10.3390/life15070998 - 23 Jun 2025
Viewed by 291
Abstract
Mitochondrial transplantation (MTx) has emerged as a potential therapeutic approach for diseases associated with mitochondrial dysfunction, yet its scalability and cross-species feasibility remain underexplored. This study aimed to evaluate the dose-dependent uptake and molecular effects of xenogeneic mitochondrial transplantation (xeno-MTx) using rat-derived mitochondria [...] Read more.
Mitochondrial transplantation (MTx) has emerged as a potential therapeutic approach for diseases associated with mitochondrial dysfunction, yet its scalability and cross-species feasibility remain underexplored. This study aimed to evaluate the dose-dependent uptake and molecular effects of xenogeneic mitochondrial transplantation (xeno-MTx) using rat-derived mitochondria in mouse neuronal systems. HT-22 hippocampal neuronal cells and a murine model of cardiac arrest-induced global cerebral ischemia were used to assess mitochondrial uptake, gene expression, and mitochondrial DNA presence. Donor mitochondria were isolated from rat pectoralis muscle and labeled with MitoTracker dyes. Flow cytometry and confocal microscopy revealed a dose-dependent increase in donor mitochondrial uptake in vitro. Quantitative PCR demonstrated a corresponding increase in rat-specific mitochondrial DNA and upregulation of Mfn2 and Bak1, with no changes in other fusion, fission, or apoptotic genes. Inhibitor studies indicated that mitochondrial internalization may involve actin-dependent macropinocytosis and cholesterol-sensitive endocytic pathways. In vivo, rat mitochondrial DNA was detected in mouse brains post–xeno-MTx, confirming donor mitochondrial delivery to ischemic tissue. These findings support the feasibility of xeno-MTx and its dose-responsive biological effects in neuronal systems while underscoring the need for further research to determine long-term functional outcomes and clinical applicability. Full article
(This article belongs to the Special Issue Advances in Cardiac Arrest: Prognostic Performance and Management)
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