Multi-Omics Approaches for Gut Microbiota Research: Implications for Human Nutrition
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Microbiology".
Deadline for manuscript submissions: 16 January 2026
Special Issue Editors
Interests: gut microbiota; prebiotics; probiotics; dysbiosis; gut barrier
Special Issues, Collections and Topics in MDPI journals
Interests: inflammasome; nlrp3; cholangiocyte; gut–liver axis; clinical gastroenterology (division); after liver transplantation; pre-liver transplantation; chronic hepatitis; chronic liver disease; chronic inflammatory bowel disease
Special Issue Information
Dear Colleagues,
The human gut microbiota (GM) is a complex, dynamic and spatially diverse ecosystem—the largest in the body—consisting of a wide range of bacteria, viruses, fungi and protozoa that inhabit the gastrointestinal tract. These microorganisms interact with each other and the human host, maintaining a symbiotic relationship that is essential for homeostasis. Disruptions in its normal composition, known as “microbial dysbiosis”, result in imbalances in microbial diversity and function, which have been associated with various health conditions.
The advent of high-throughput platforms and advanced bioinformatic tools has significantly enhanced our understanding of the GM. The integration of multi-omics approaches, including genomics, metagenomics, transcriptomics, proteomics, and metabolomics, provides a comprehensive view of GM composition, functional potential, and metabolic interactions. These methodologies offer significant insights into the intricate relationships between the microbiota, host physiology, and nutrition. By integrating multi-omics techniques, researchers can uncover microbial diversity, gene expression patterns, protein functions, and metabolite production, leading to the identification of biomarkers and novel therapeutic targets. Additionally, these approaches help elucidate host–microbe interactions and the impact of dietary interventions on the GM.
This Special Issue highlights the latest applications of multi-omics strategies in GM research and their implications for human nutrition. Topics of interest include, but are not limited to, the following: multi-omics-driven precision nutrition, the dietary modulation of the gut microbiota through integrated omics approaches, the role of microbial metabolites in health and disease using multi-omics data, and the application of systems biology in microbiome research. By garnering interdisciplinary perspectives, this Special Issue aims to advance our understanding of the GM and its role in optimizing nutrition and health.
Dr. Georgia Saxami
Prof. Dr. Antonio Benedetti
Guest Editors
Manuscript Submission Information
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Keywords
- gut microbiota
- multi-omics
- metagenomics
- metabolomics
- host–microbiome interactions
- precision nutrition
- dietary interventions
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