Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Plants: Emerging Bio-Manufacturing Chassis for Bioactive Molecules
edited by
submission deadline 15 Sep 2026 | Viewed by 352 | Submission Open
Keywords: plant biotechnology; metabolic engineering; secondary metabolite; recombinant proteins; synthetic biology; biopharmaceuticals; plant cell culture; molecular farming
(This special issue belongs to the Section Plant Science)
Sleep-Disordered Breathing: Cardiovascular Vulnerability
edited by Ravi S. Aysola
submission deadline 15 Sep 2026 | Viewed by 268 | Submission Open
Keywords: sleep-disordered breathing; obstructive sleep apnea; cardiovascular disease; autonomic nervous system; ventilatory control; intermittent hypoxia; cardiopulmonary coupling; hypertension
(This special issue belongs to the Section Medical Research)
Bioactive Natural Products: From Exploration to Therapeutic Potential submission deadline 16 Sep 2026 | 6 articles | Viewed by 4041 | Submission Open
Keywords: secondary metabolites; in vivo/in vitro biological activity; structural elucidation; molecular modeling studies; natural pigment
(This special issue belongs to the Section Pharmaceutical Science)
Immune Reset and Renal Recovery: Novel Insights into Kidney Inflammation and Repair
edited by Mohanraj Sadasivam
submission deadline 17 Sep 2026 | Viewed by 699 | Submission Open
Keywords: renal immunopathology; immune reset; CAR-T-cell therapy; B-cell depletion; mRNA therapies; autoimmune kidney disease; lupus nephritis; T-cell tolerance; kidney inflammation; renal regeneration
(This special issue belongs to the Section Medical Research)
Advances in 5-Aminolevulinic Acid Applications in Medical and Healthcare
edited by Motowo Nakajima, Walter Stummer and Shun-ichiro Ogura
submission deadline 18 Sep 2026 | 9 articles | Viewed by 21152 | Submission Open
Keywords: 5-aminolevulinic acid (5-ALA); heme; protoporphyrin IX; photodynamic diagnosis; fluorescence guided surgery; photodynamic therapy; cancer metastasis; reactive oxygen species (ROS); oxide radical; heme oxygenase 1 (HO-1); NF-E2-related factor 2 (Nrf2); anti-inflammation; mitochondrial disease; diabetes; infectious disease; malaria; COVID-19
(This special issue belongs to the Section Pharmaceutical Science)
Gynecology Update: Modern Diagnostic Approaches and Innovative Therapies
edited by Szabolcs Várbíró, , Richárd Tóth and Balázs Lintner
submission deadline 20 Sep 2026 | 7 articles | Viewed by 10099 | Submission Open
Keywords: gynecologic oncology; endocrinology; reproductive medicine; fertility preservation; prevention; women’s health innovation; quality of life; personalized therapy
(This special issue belongs to the Section Medical Research)
Prebiotic RNA: From Autocatalysis and Chirality to Functional Evolution
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 1751 | Submission Open
Keywords: RNA; origin of life; replication; autocatalysis; chirality; ribozymes; metabolism
(This special issue belongs to the Section Origins of Life)
Translational Neuro-Oncology: Molecular Insights, Bioinformatics, and Technological Innovations
edited by Felix Mircea Brehar
submission deadline 20 Sep 2026 | Viewed by 491 | Submission Open
Keywords: translational neuro-oncology; central nervous system tumors; molecular and cellular mechanisms; multi-omics and biomarkers; bioinformatics and systems biology; artificial intelligence in medicine; radiomics and radiogenomics; precision neurosurgery; experimental and clinical research; therapeutic innovation in neuro-oncology
(This special issue belongs to the Section Physiology and Pathology)
Mucosal Immunity and Immune Memory: The New Frontier in Vaccination and Immunopathology
edited by
submission deadline 20 Sep 2026 | Viewed by 447 | Submission Open
Keywords: mucosal immunity; hybrid immunity; next-generation vaccines; artificial intelligence; neo-adjuvants; clinical trial; case studies
(This special issue belongs to the Section Medical Research)
Imaging and Analysis of Microbial Motility: From Single Cells to Communities
edited by
submission deadline 20 Sep 2026 | Viewed by 296 | Submission Open
Keywords: motility; cell tracking; biofilm; swimming; swarming; Archaea; flagella
(This special issue belongs to the Section Microbiology)
Microbiome Engineering for Sustainable Pest Control Under Climate Change
edited by Abdul Basit and
submission deadline 20 Sep 2026 | Viewed by 285 | Submission Open
Keywords: microbiome engineering; climate-smart pest management; systems biology; One Health; sustainable agriculture; microbial ecology; plant resilience; climate change; beneficial microbes; evolutionary biology; environmental sustainability; agricultural ecosystems; microbial communities
(This special issue belongs to the Section Microbiology)
Liver Disease: Pathogenesis, Diagnosis, and Treatments
edited by Hsien-Hui Chung
submission deadline 25 Sep 2026 | 6 articles | Viewed by 9923 | Submission Open
Keywords: alcoholic hepatitis; artificial intelligence; biomarkers; clinical trials; gut–liver axis; liver cancer; metabolic dysfunction-associated steatohepatitis; molecular targets; pharmacotherapeutic mechanisms; therapeutic strategies
(This special issue belongs to the Section Medical Research)
Plant Life: Integrating Multi-Omic Approaches from Molecules to Environment
edited by and Fang He
submission deadline 25 Sep 2026 | 6 articles | Viewed by 5866 | Submission Open
Keywords: plant physiology; multi-omics integration; ionomics; genomics; transcriptomics; metabolomics; proteomics; epigenetics; single-cell analysis; environmental stress; molecular mechanisms; systems biology
(This special issue belongs to the Section Plant Science)
Mitochondrial and Endoplasmic Reticulum Dynamics in Cellular Stress Responses
edited by , Xing Duan and
submission deadline 25 Sep 2026 | 2 articles | Viewed by 2771 | Submission Open
Keywords: mitochondria; endoplasmic reticulum; MAMs; cellular responses; physiopathology; homeostasis; cross-talk; stress; signaling; regulation
(This special issue belongs to the Section Physiology and Pathology)
Spotlight on Veterinary Pathology and Toxicology
edited by and Mario Darius Codreanu
submission deadline 25 Sep 2026 | 3 articles | Viewed by 2071 | Submission Open
Keywords: veterinary pathology; toxicology; advanced diagnostic techniques; pathogenesis; public health
(This special issue belongs to the Section Animal Science)
From Physiology and Pathology Research to Clinical Insights in Gastrointestinal Disorders
edited by , and Ana Lascu
submission deadline 30 Sep 2026 | 6 articles | Viewed by 23212 | Submission Open
Keywords: cellular signaling; inflammation; oxidative stress; cellular death and proliferation; motility, digestion and absorption; vascular patterns; gut microbiota
(This special issue belongs to the Section Physiology and Pathology)
Advances in Bioprinting, Tissue Engineering, and Regenerative Medicine
edited by
submission deadline 30 Sep 2026 | 4 articles | Viewed by 16937 | Submission Open
Keywords: model tissues; scaffolds; biocompatible materials; biodegradable materials; tissue-on-a-chip; organoids
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Feature Papers in Synthetic Biology and Systems Biology 2026
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 8933 | Submission Open
Keywords: design and construction of synthetic biological systems; innovations in the creation of synthetic organisms, genetic circuits, and biomolecular devices; bottom-up synthetic biology; cell-free synthetic biology; tissue engineering and organoids; bioorthogonal parts, devices, systems; microcompartmentalized systems with soft or hard interfaces; theoretical considerations about synthetic biology; synthetic biology intersection with systems chemistry and bioorganic chemistry; computational modeling and simulation of biological processes; advances in computational tools and models that enhance our understanding of biological processes and systems; metabolic engineering and synthetic pathways; development of novel approaches for the production of biofuels, pharmaceuticals, and other valuable compounds; synthetic biology for approaching evolutionary problems; artificial evolution and in vitro evolution; optogenetics and related techniques; gene editing technologies, applications, and developments; education in synthetic and systems biology; cutting-edge techniques and applications of CRISPR and other gene editing tools; systems biology approaches to understanding complex biological networks; mathematical aspects of systems biology approaches; artificial photosynthesis; applications of synthetic biology in medicine, agriculture, and industry; practical applications of synthetic and systems biology in various sectors, including healthcare, agriculture, and industrial biotechnology; ethical, legal, and social implications of synthetic and systems biology; exploration of the broader implications of advancements in synthetic and systems biology, including ethical considerations and regulatory challenges and social implications
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
Genetics, Breeding and Reproduction of Honeybees: Second Edition
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 8564 | Submission Open
Keywords: phenomics; genetics; genomics; functional genomics; metabolomics; functional genes identification; genetics editing; genome selection; genetic evaluation; hybrid breeding; egg-laying; honey production; queen breeding; varroa resistance
(This special issue belongs to the Section Animal Science)
Advances in Personalized Management in Orthopedics and Traumatology submission deadline 30 Sep 2026 | 4 articles | Viewed by 7302 | Submission Open
Keywords: personalized orthopedics; hip replacement; knee replacement; patient-specific treatment; clinical outcomes
(This special issue belongs to the Section Medical Research)
Advances in Plant Biotechnology and Molecular Breeding
edited by Serik Eliby, Nikolai Borisjuk and
submission deadline 30 Sep 2026 | 5 articles | Viewed by 6805 | Submission Open
Keywords: doubled haploidy; genetic engineering; genome editing; genomics; marker-assisted selection; molecular breeding; molecular markers; plant biotechnology
(This special issue belongs to the Section Plant Science)
Natural Products and Modern Drug Discovery: Emerging Strategies Targeting Cancer- and Disease-Related Molecular Mechanisms
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 5816 | Submission Open
Keywords: natural products; phytochemicals; drug discovery; bioactivity profiling; pharmacophore modeling; synthetic biology; cancer therapy; microbial metabolites
(This special issue belongs to the Section Medical Research)
Advances in the Rehabilitation of Stroke
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 5355 | Submission Open
Keywords: stroke; acute stroke; chronic stroke; post-acute stroke; functional recovery; rehabilitation
(This special issue belongs to the Section Medical Research)
Prebiotic Chemistry: The Molecular Origins of Life
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 5002 | Submission Open
Keywords: astrobiology; astrochemistry; biochemistry; computational modelling; geochemistry; metabolic pathways; lipid formation; peptide synthesis; photochemistry; radiation chemistry; RNA world; self-assembly; systems chemistry
(This special issue belongs to the Section Origins of Life)
Ocular Diseases: Mechanisms, Diagnostics, and Emerging Therapeutic Strategies
edited by Joanna Dolar-Szczasny
submission deadline 30 Sep 2026 | 4 articles | Viewed by 4438 | Submission Open
Keywords: molecular mechanisms of eye disease; oxidative stress and inflammation; neurodegeneration in vision; ocular biomarkers; pharmacological therapies; gene therapy; stem cell and regenerative approaches; precision/personalized ophthalmology
(This special issue belongs to the Section Medical Research)
Advances in Imaging for Female Patients: Breast and Gynecological Diagnostics
edited by Silvia Gigli, Emanuele David and Giacomo Bonito
submission deadline 30 Sep 2026 | 2 articles | Viewed by 4191 | Submission Open
Keywords: breast cancer; breast screening; gynecological cancer; mammography; CEM; ultrasound; MRI; PET/TC; radiomics; artificial intelligence
(This special issue belongs to the Section Medical Research)
Pathophysiology, Diagnosis, and Treatments of Intestinal Diseases—2nd Edition
edited by Amosy Ephreim M’Koma
submission deadline 30 Sep 2026 | 4 articles | Viewed by 3836 | Submission Open
Keywords: gastrointestinal disease/disorders; pathophysiology; diagnostics and treatment
(This special issue belongs to the Section Physiology and Pathology)
Research Updates in Hematology
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 3610 | Submission Open
Keywords: antiphospholipid syndrome; complement; endothelium; hemoglobinopathies; hemophilia; leukemias; lymphomas; multiple myeloma; pediatric hematology; thrombosis
(This special issue belongs to the Section Physiology and Pathology)
Advanced Research in Plant–Pathogen Interactions
edited by and
submission deadline 30 Sep 2026 | 5 articles | Viewed by 3477 | Submission Open
Keywords: plant-pathogen interaction; plant immunity; pathogen effectors; host defense mechanisms; autophagy; noncoding RNA; small peptides; molecular plant pathology; crop disease resistance
(This special issue belongs to the Section Plant Science)
Nutrition–Physiology Interactions in Aquatic Species
edited by , and
submission deadline 30 Sep 2026 | 2 articles | Viewed by 3153 | Submission Open
Keywords: aquatic animal nutrition; fish physiology; sustainable aquaculture; alternative lipid sources; alternative protein sources; gut–microbiota interactions
(This special issue belongs to the Section Animal Science)
Microbial Biotechnology and Biomanufacturing submission deadline 30 Sep 2026 | 3 articles | Viewed by 2986 | Submission Open
Keywords: synthetic biology tools; microbial biomanufacturing; future foods; bulk chemicals; plant natural products
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
Microvascular Research: Advances and Perspectives submission deadline 30 Sep 2026 | 2 articles | Viewed by 2796 | Submission Open
Keywords: microvasculature; microvascular dysfunction; systemic diseases; pathophysiology; cardiovascular diseases; hypertension; therapeutic advances
(This special issue belongs to the Section Medical Research)
The Oral-Systemic Link in Chronic Mucosal Diseases
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 2491 | Submission Open
Keywords: oral diseases; general diseases; biomarkers
(This special issue belongs to the Section Medical Research)
Agroforestry Systems and Global Change: Carbon and Nitrogen Cycling Regulation, Ecosystem Functions, and Sustainable Development
edited by , Xintong Xu and Xi Yuan
submission deadline 30 Sep 2026 | 3 articles | Viewed by 2103 | Submission Open
Keywords: carbon and nitrogen cycling; plant–microbe–soil interactions; plant-ecology
(This special issue belongs to the Section Biodiversity, Ecology and Evolution)
Neurorehabilitation: Technology-Driven Recovery and Functional Rewiring
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2054 | Submission Open
Keywords: cognitive-motor recovery; neuroplasticity; multidimensional assessment; post-stroke rehabilitation
(This special issue belongs to the Section Medical Research)
Biochemical Modulators in Chronic Diseases: The Antioxidant/Anti-Inflammatory Interdependence—2nd Edition
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1916 | Submission Open
Keywords: oxidative stress; inflammation; redox modulator; anti-inflammatory agents; chronic diseases; antioxidant paradox; reactive oxygen species
(This special issue belongs to the Section Pharmaceutical Science)
Pathology, Diagnosis, and Treatment of Cardiomyopathies submission deadline 30 Sep 2026 | 2 articles | Viewed by 1889 | Submission Open
Keywords: cardiomyopathies; pathogenetic mechanisms; diagnoses
(This special issue belongs to the Section Medical Research)
Women's Health and Well-Being: A Focus on Obstetrics and Gynecologic Medicine
edited by Luca Roncati
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1791 | Submission Open
Keywords: women’s health; gynecology; gynecopathology; preventive gynecological oncology; senology; breast cancer; cervical cancer; sexually transmitted infections; human papillomavirus; autoimmune diseases
(This special issue belongs to the Section Medical Research)
Molecular Underpinnings of Cancer: Pathways to Targeted Therapy submission deadline 30 Sep 2026 | 1 articles | Viewed by 1650 | Submission Open
Keywords: signaling pathways; tumor microenvironment; cancer metabolism; biomarkers; drug resistance; precision medicine; targeted therapy
(This special issue belongs to the Section Medical Research)
The Biological Impacts of Fetal Alcohol Exposure
edited by Kelly J. Huffman
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1548 | Submission Open
Keywords: fetal alcohol spectrum disorders; fetal alcohol syndrome; brain development; behavioral development; prenatal exposure
(This special issue belongs to the Section Reproductive and Developmental Biology)
Latest Research Updates on Laparoscopy
edited by Niculae N. Iordache and Claudiu-Octavian Ungureanu
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1527 | Submission Open
Keywords: laparoscopy; minimally invasive surgery; surgical innovation; imaging and navigation; artificial intelligence in surgery; surgical outcomes; clinical advancements
(This special issue belongs to the Section Medical Research)
Biomaterials for Antimicrobial Applications submission deadline 30 Sep 2026 | 1 articles | Viewed by 1473 | Submission Open
Keywords: antimicrobial biomaterials; translational materials; antifouling and antibiofilm surfaces; antimicrobial coatings; controlled release; diagnostic materials; implant surfaces; infection-resistant implants; wound healing and tissue engineering
(This special issue belongs to the Section Microbiology)
Gender Medicine in Dermatology, Rheumatology and Immunology
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1107 | Submission Open
Keywords: gender medicine; sex and gender differences; immune-mediated diseases; autoimmunity and inflammation; dermatology; rheumatology; immunology
(This special issue belongs to the Section Medical Research)
Updates in Human Disease Genetic Research submission deadline 30 Sep 2026 | 1 articles | Viewed by 1004 | Submission Open
Keywords: gene discovery; cancer biomarker discovery; GWAS; genetic testing; personalized therapy; genotype–phenotype correlations
(This special issue belongs to the Section Genomics and Proteomics)
Parasite Detection, Control Strategies and Risk Factors Related to Reproductive Health in Livestock submission deadline 30 Sep 2026 | Viewed by 854 | Submission Open
Keywords: livestock; parasite control; reproductive health; management
(This special issue belongs to the Section Animal Science)
New Challenges in Fracture Management
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 802 | Submission Open
Keywords: fracture; extremity trauma; orthopedic trauma; orthopedics
(This special issue belongs to the Section Medical Research)
New Insights into Skin Health and Disease
edited by and Mark G. Lebwohl
submission deadline 30 Sep 2026 | 1 articles | Viewed by 724 | Submission Open
Keywords: skin health; inflammatory skin diseases; immune regulation; autoimmune skin disorders; skin cancer; targeted therapies; translational dermatology; long-term disease management
(This special issue belongs to the Section Medical Research)
Genetic Regulation of Natural Product Biosynthesis in Medicinal Plants
edited by and Lin Cheng
submission deadline 30 Sep 2026 | 1 articles | Viewed by 708 | Submission Open
Keywords: medicinal plants; natural products; biosynthesis; genetic regulation; transcription factors; multi-omics; metabolic engineering; specialized metabolism
(This special issue belongs to the Section Plant Science)
Wearable Biosensor Methodologies for Disease Diagnosis and Health Monitoring
edited by
submission deadline 30 Sep 2026 | Viewed by 470 | Submission Open
Keywords: brain–computer interface (BCI); electroencephalogram (EEG); machine learning; biomedical signal processing; brain computer interface; health monitoring
(This special issue belongs to the Section Medical Research)
Cognitive and Imaging Mechanisms in Neurological Disorders
edited by Foteini Christidi, and
submission deadline 30 Sep 2026 | Viewed by 400 | Submission Open
Keywords: neurological disorders; cognitive dysfunction; neuropsychological assessment; neuroimaging; structural MRI; functional MRI; multimodal neuroimaing; biomarkers; machine learning in neurology; neurorehabilitation
(This special issue belongs to the Section Medical Research)
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