Immune Reset and Renal Recovery: Novel Insights into Kidney Inflammation and Repair
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: 13 March 2026 | Viewed by 4
Special Issue Editor
Interests: renal immunopathology; autoimmune kidney disease; kidney inflammation; renal regeneration
Special Issue Information
Dear Colleagues,
Chronic and autoimmune kidney diseases remain a major global health challenge, often driven by complex immune-mediated mechanisms that lead to persistent inflammation, progressive tissue damage, and organ dysfunction. Traditional immunosuppressive therapies, while effective for some, are frequently associated with relapse, systemic toxicity, and incomplete remission.
Recent advances in immunology and regenerative medicine are ushering in a new era of targeted and transformative therapies—aimed not just at suppressing disease activity but at resetting immune tolerance and promoting renal recovery. This Special Issue focuses on the latest breakthroughs in the understanding and treatment of renal immune disorders through precision immunomodulation, cellular therapies, and tissue repair mechanisms.
We welcome original research, reviews, and perspectives that explore the following topics:
- Cell-based immunotherapies (e.g., CAR-T, regulatory T-cell therapy) in autoimmune kidney diseases;
- B-cell- and plasma cell-targetingstrategies for lupus nephritis, vasculitis, and membranous nephropathy;
- In vivo immune reset technologies, including lipid nanoparticle (LNP) delivery and mRNA-based tolerance induction;
- Molecular mechanisms of renal inflammation, including cytokine networks, complement pathways, and innate immune activation;
- Tissue-level insights from single-cell and spatial omics in inflamed or fibrotic kidneys;
- Biomarkers of immune activity, disease progression, and therapeutic response;
- Regenerative strategies that support renal tissue repair and fibrosis reversal;
- Clinical trial updates and translational models for novel immunotherapies in nephrology.
This Special Issue aims to bridge cutting-edge immunology with renal pathology and clinical practice, providing a platform for interdisciplinary collaboration and shaping future approaches to managing complex kidney diseases.
Dr. Mohanraj Sadasivam
Guest Editor
Manuscript Submission Information
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Keywords
- renal immunopathology
- immune reset
- CAR-T-cell therapy
- B-cell depletion
- mRNA therapies
- autoimmune kidney disease
- lupus nephritis
- T-cell tolerance
- kidney inflammation
- renal regeneration
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