Integrated Management of Cardiorenal Metabolic Syndrome: From Obesity to Chronic Kidney Disease
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Endocrinology & Metabolism".
Deadline for manuscript submissions: 20 November 2026 | Viewed by 162
Special Issue Editor
Interests: type 2 diabetes; obesity; metabolic surgery; precision diabetology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiorenal metabolic (CRM) syndrome represents a pathophysiological continuum linking obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease, metabolic-associated liver disease, and chronic kidney disease (CKD). These conditions share common mechanisms—including adipose tissue dysfunction, chronic low-grade inflammation, insulin resistance, and neurohormonal activation—and frequently coexist, amplifying morbidity and mortality. Recent conceptual frameworks emphasize the need to move beyond a fragmented, disease-centered approach toward an integrated and early management strategy.
The adipocentric model provides a useful clinical perspective by identifying dysfunctional adipose tissue as a central driver of cardiometabolic and renal risk. Pathological expansion of visceral and ectopic fat promotes lipotoxicity, systemic inflammation, β-cell dysfunction, hypertension, and atherogenic dyslipidemia, ultimately contributing to cardiovascular and renal damage. Early identification of individuals at risk, stage-based risk stratification, and timely intervention are therefore essential to modify the natural history of CRM syndrome.
Management strategies should prioritize the treatment of obesity as a chronic causal disease and aim to reduce ectopic adiposity while protecting cardiovascular and renal function. Lifestyle interventions—including adherence to a Mediterranean dietary pattern and regular physical activity—remain foundational. Pharmacological therapies with proven cardiometabolic benefits, such as GLP-1 receptor agonists, SGLT2 inhibitors, lipid-lowering drugs, anti-hypertensive drugs, and finerenone, together with metabolic bariatric surgery in selected patients, provide additional therapeutic opportunities.
An integrated, preventive, and longitudinal approach is essential to reduce the burden of CRM disease and improve long-term outcomes.
Dr. Juan José Gorgojo-Martínez
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cardiorenal metabolic syndrome
- adipose tissue dysfunction
- Insulin resistance
- ectopic adiposity
- cardiometabolic therapies
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
