The Latest Advancements in Solid Organ Transplantation
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "General Surgery".
Deadline for manuscript submissions: 20 November 2026 | Viewed by 161
Special Issue Editor
Interests: innovation in transplantation; patient safety–donors and recipients; immunological risk stratification and rejection mitigation solid organ transplantation; robotic transplant surgery; living donor transplantation; indocyanine green fluorescence imaging; delayed graft function; mixed chimerism; tolerance induction; bone marrow trans-plantation; islet autotransplantation; total pancreatectomy; artificial intelligence; machine learning; kidney trans-plantation; liver transplantation; immunosuppression
Special Issue Information
Dear Colleagues,
Solid organ transplantation has undergone transformative advances over the past decade, driven by innovations in surgical technique, immunological understanding and emerging technologies. This Special Issue aims to provide a comprehensive overview of these developments, highlighting both established practices and pioneering approaches that are reshaping the field.
Robotic-assisted surgery has revolutionized both donor nephrectomy and recipient transplantation. Recent milestones include the first fully robotic liver transplant using deceased and living donors, with multicenter data demonstrating superior outcomes including reduced surgical site infections and shorter hospital stays. The learning curve for robotic donor hepatectomy stabilizes at approximately 9–17 cases, making this approach increasingly accessible to high-volume transplant centers.
Intraoperative imaging using indocyanine green (ICG) fluorescence has emerged as a valuable tool for real-time assessment of graft perfusion. Quantitative ICG fluorescence angiography now enables objective prediction of delayed graft function, replacing subjective visual inspection with reproducible metrics. Importantly, recent scoping reviews confirm the safety of ICG in patients with chronic kidney disease and transplant recipients.
Most significant are perhaps advances in tolerance induction through combined bone marrow and solid organ transplantation. Phase 3 multicenter trials have demonstrated that mixed chimerism protocols can achieve immunosuppression-free graft survival in over 75% of HLA-matched living related kidney transplant recipients, with no graft-versus-host disease observed. These findings represent a paradigm shift toward donor-specific tolerance without lifelong immunosuppression.
Total pancreatectomy with islet autotransplantation (TPIAT) has become an established treatment for refractory chronic pancreatitis, with over 90% of patients experiencing significant pain reduction and 30-40% achieving insulin independence. Artificial intelligence applications are expanding across all phases of transplantation, from donor–recipient matching optimization to personalized immunosuppression protocols and long-term outcome prediction.
This Special Issue invites original research and reviews addressing these themes, with particular emphasis on translational advances that bridge laboratory innovations with clinical practice.
Dr. Eviatar Nesher
Guest Editor
Manuscript Submission Information
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Keywords
- solid organ transplantation
- robotic transplant surgery
- living donor transplantation
- indocyanine green fluorescence imaging
- delayed graft function
- mixed chimerism
- tolerance induction
- bone marrow transplantation
- islet autotransplantation
- total pancreatectomy
- artificial intelligence
- machine learning
- kidney transplantation
- liver transplantation
- immunosuppression
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