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Electroencephalography: Advances in Clinical Applications

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 20 November 2026 | Viewed by 1420

Editor


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Guest Editor
Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA
Interests: electroencephalography; clinical neurophysiology; epilepsy monitoring; machine learning for neural signal processing; sleep neurophysiology; computational neuroscience

Special Issue Information

Dear Colleagues,

Electroencephalography remains one of the most accessible and widely used neurophysiological tools in clinical practice. Yet, the translation of computational methods to bedside EEG interpretation has lagged behind other domains. At the same time, artificial intelligence and machine learning have transformed clinical decision-making in radiology, pathology, and cardiology, achieving diagnostic performance that rivals expert clinicians. This gap persists despite rapid advances in research settings, where modern architectures, including convolutional networks, autoencoders and transformers, have demonstrated strong performance on EEG decoding tasks. Key barriers include limited data standardization across clinical sites, poor model generalizability to unseen patients, and the absence of clear regulatory and validation pathways for modern, computer-assisted EEG tools.

This Special Issue welcomes original research articles and reviews that advance EEG-based diagnosis, prognosis, or treatment across neurological and psychiatric conditions. Particularly, it aims to bridge the gap between computational EEG research and clinical application. Contributions leveraging computational, machine learning and AI methods are of particular interest, though studies advancing traditional EEG methodology with demonstrated clinical impact are equally encouraged. We especially welcome work that benchmarks automated approaches against expert clinical interpretation or that addresses the challenges of deploying these tools in real-world clinical environments.

Topics of interest for publication include, but are not limited to, the following:

  • Automated EEG interpretation and clinical diagnosis;
  • Machine learning architectures for seizure detection, prediction, and classification;
  • Sleep EEG biomarkers for neurological and psychiatric conditions;
  • EEG-based assessment of consciousness in clinical populations;
  • Computational approaches to neurodegenerative disease detection;
  • Multimodal integration of EEG with neuroimaging, neurochemistry, or wearable biosensors;
  • Brain–computer interfaces for rehabilitation;
  • Signal processing and standardization pipelines for clinical EEG;
  • Benchmarking AI performance against expert clinical judgment.

Dr. Leonardo S. Barbosa
Guest Editor

Manuscript Submission Information

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Keywords

  • electroencephalography
  • clinical EEG
  • machine learning
  • deep learning
  • seizure detection
  • sleep EEG
  • brain–computer interface
  • neurodegenerative disease
  • consciousness assessment
  • automated diagnosis
  • multimodal neu-roimaging
  • human-AI benchmarking

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Published Papers (2 papers)

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86 pages, 1358 KB  
Systematic Review
Electrophysiological Correlates of Cognitive Dysfunction in Obsessive–Compulsive Disorder (OCD): A Systematic and Mechanistic Review of EEG, ERP, and QEEG Evidence
by James Chmiel and Aleksandra Kładna
J. Clin. Med. 2026, 15(15), 5994; https://doi.org/10.3390/jcm15155994 - 1 Aug 2026
Viewed by 132
Abstract
Background/Objectives: Obsessive–compulsive disorder (OCD) is associated not only with obsessions and compulsions, but also with cognitive dysfunction involving inhibitory control, cognitive flexibility, working memory, attention, decision-making, feedback learning, and performance monitoring. Electroencephalography (EEG), event-related potentials (ERPs), quantitative EEG, and time–frequency analyses provide temporally [...] Read more.
Background/Objectives: Obsessive–compulsive disorder (OCD) is associated not only with obsessions and compulsions, but also with cognitive dysfunction involving inhibitory control, cognitive flexibility, working memory, attention, decision-making, feedback learning, and performance monitoring. Electroencephalography (EEG), event-related potentials (ERPs), quantitative EEG, and time–frequency analyses provide temporally precise methods for examining how these cognitive abnormalities unfold during information processing. This review aimed to synthesise electrophysiological evidence on the neural correlates of cognitive dysfunction in OCD. Methods: A systematic literature search was conducted in PubMed/MEDLINE, Scopus, Web of Science Core Collection, Embase, PsycINFO, and Google Scholar from database inception to 30 May 2026. Eligible studies included patients with OCD and used EEG, qEEG, spectral EEG, EEG connectivity, or ERP methods in relation to cognitive performance, cognitive task demands, or cognitive dysfunction. Studies were grouped according to electrophysiological modality and ERP component. Because of methodological heterogeneity, findings were synthesised narratively and mechanistically rather than by meta-analysis. Methodological quality was assessed using ROBINS-I. Results: The search identified 1321 records, of which 42 studies met the inclusion criteria. Most studies used task-based ERP paradigms, while fewer examined resting-state EEG, qEEG, or oscillatory activity. The most consistent findings concerned altered performance monitoring and cognitive control, especially ERN, N2/N200, Pe, Pc, and P3/P300 abnormalities. ERN findings suggested excessive early error monitoring, whereas N2/N200 and P3/P300 findings indicated task-dependent abnormalities in inhibition, conflict processing, attentional allocation, stimulus evaluation, and context updating. Earlier components, including P50, N1/N100, P2/P200, and N450, suggested abnormalities in sensory gating, early attentional selection, stimulus evaluation, and interference control, particularly under emotionally salient or OCD-relevant conditions. FRN findings indicated altered feedback processing and reinforcement learning, while limited P600 evidence suggested inefficient working-memory preparation. Plain EEG and time–frequency studies further implicated abnormal theta, alpha, beta, and delta activity in monitoring, inhibition, arousal, and network efficiency. Conclusions: EEG-based evidence suggests that cognitive dysfunction in OCD reflects a dysregulated control system rather than a general reduction in cognitive ability. The disorder appears to involve excessive performance monitoring, abnormal sensory and attentional gating, inefficient inhibition, altered feedback evaluation, and reduced cognitive flexibility. However, the current evidence is limited by heterogeneity in samples, paradigms, EEG methodology, medication status, and statistical approaches. Future studies should use larger, well-characterised samples, standardised EEG/ERP paradigms, direct brain–behaviour analyses, and longitudinal designs to clarify whether electrophysiological abnormalities represent trait markers, state-dependent effects, compensatory mechanisms, or clinically useful predictors of cognitive dysfunction in OCD. Full article
(This article belongs to the Special Issue Electroencephalography: Advances in Clinical Applications)
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56 pages, 1061 KB  
Systematic Review
Multimodal EEG–MRI Neuroimaging in Schizophrenia—A Systematic and Mechanistic Review
by James Chmiel and Marta Kopańska
J. Clin. Med. 2026, 15(11), 4306; https://doi.org/10.3390/jcm15114306 - 2 Jun 2026
Viewed by 933
Abstract
Introduction: Schizophrenia is characterised by distributed abnormalities in electrophysiological dynamics and large-scale brain networks, yet unimodal EEG or MRI alone cannot fully explain how fast neural computations relate to spatially organised circuit dysfunction. Multimodal EEG–MRI approaches offer a bridge across temporal and [...] Read more.
Introduction: Schizophrenia is characterised by distributed abnormalities in electrophysiological dynamics and large-scale brain networks, yet unimodal EEG or MRI alone cannot fully explain how fast neural computations relate to spatially organised circuit dysfunction. Multimodal EEG–MRI approaches offer a bridge across temporal and anatomical scales by explicitly modelling cross-modal coupling. Methods: Following PRISMA 2020 guidance, we conducted a systematic, mechanistic review of human studies (adults ≥ 18 years) comparing schizophrenia-spectrum groups with healthy controls using EEG combined with at least one MRI modality (fMRI, structural MRI, and/or diffusion MRI) and explicit EEG–MRI integration (e.g., EEG-informed fMRI, joint ICA, mCCA/MCCA, coupled matrix–tensor factorisation, DCM-based fusion). Searches were performed in PubMed/MEDLINE, Embase, Web of Science, Scopus, PsycINFO, IEEE Xplore, ResearchGate, and Google Scholar for January 2000–December 2025, supplemented by citation tracking. Risk of bias was assessed with ROBINS-I, and due to heterogeneity, results were synthesised narratively by integration of families. Results: From 148 records, 23 studies met the inclusion criteria. Studies used mainly simultaneous EEG–fMRI at 3T and spanned resting-state designs and task paradigms dominated by auditory processing (oddball, MMN/N100–P200, ASSR/aeGBR), with additional work in affective context, working memory, semantic processing (N400), sensory gating, and pharmacologic challenge. Across tasks, the most reproducible multimodal signature was disrupted coupling between electrophysiological markers and the recruitment of large-scale networks, rather than isolated changes in EEG or fMRI metrics. Target detection/oddball paradigms converged on reduced late ERP responses (especially P300, sometimes N2) alongside reduced expression or loss of coupling to salience/ventral attention and control circuitry (including ACC/anterior insula/TPJ). Resting-state studies most consistently indicated altered “coupling rules” (frequency specificity, timing/lag structure, and directionality), including abnormalities detectable even when unimodal summaries were weak. Extended multimodal studies (adding sMRI/DTI and/or classification) suggested that combining modalities can improve discrimination, though performance was sensitive to sample size, demographic imbalance, and feature-selection/validation choices. Conclusions: Multimodal EEG–MRI studies support schizophrenia as a disorder involving persistent structural and circuit-level abnormalities whose functional expression varies dynamically across cognitive states and task demands. Future progress will depend on harmonised acquisition/artefact-control practices for simultaneous EEG–fMRI, larger and more diverse samples (including early/CHR and longitudinal designs), and cross-site replication of mechanistically interpretable coupling biomarkers. Full article
(This article belongs to the Special Issue Electroencephalography: Advances in Clinical Applications)
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