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Electroencephalography: Advances in Clinical Applications

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 20 November 2026 | Viewed by 97

Special Issue Editor


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Guest Editor
Fralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA
Interests: electroencephalography; clinical neurophysiology; epilepsy monitoring; machine learning for neural signal processing; sleep neurophysiology; computational neuroscience

Special Issue Information

Dear Colleagues,

Electroencephalography remains one of the most accessible and widely used neurophysiological tools in clinical practice. Yet, the translation of computational methods to bedside EEG interpretation has lagged behind other domains. At the same time, artificial intelligence and machine learning have transformed clinical decision-making in radiology, pathology, and cardiology, achieving diagnostic performance that rivals expert clinicians. This gap persists despite rapid advances in research settings, where modern architectures, including convolutional networks, autoencoders and transformers, have demonstrated strong performance on EEG decoding tasks. Key barriers include limited data standardization across clinical sites, poor model generalizability to unseen patients, and the absence of clear regulatory and validation pathways for modern, computer-assisted EEG tools.

This Special Issue welcomes original research articles and reviews that advance EEG-based diagnosis, prognosis, or treatment across neurological and psychiatric conditions. Particularly, it aims to bridge the gap between computational EEG research and clinical application. Contributions leveraging computational, machine learning and AI methods are of particular interest, though studies advancing traditional EEG methodology with demonstrated clinical impact are equally encouraged. We especially welcome work that benchmarks automated approaches against expert clinical interpretation or that addresses the challenges of deploying these tools in real-world clinical environments.

Topics of interest for publication include, but are not limited to, the following:

  • Automated EEG interpretation and clinical diagnosis;
  • Machine learning architectures for seizure detection, prediction, and classification;
  • Sleep EEG biomarkers for neurological and psychiatric conditions;
  • EEG-based assessment of consciousness in clinical populations;
  • Computational approaches to neurodegenerative disease detection;
  • Multimodal integration of EEG with neuroimaging, neurochemistry, or wearable biosensors;
  • Brain–computer interfaces for rehabilitation;
  • Signal processing and standardization pipelines for clinical EEG;
  • Benchmarking AI performance against expert clinical judgment.

Dr. Leonardo S. Barbosa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electroencephalography
  • clinical EEG
  • machine learning
  • deep learning
  • seizure detection
  • sleep EEG
  • brain–computer interface
  • neurodegenerative disease
  • consciousness assessment
  • automated diagnosis
  • multimodal neu-roimaging
  • human-AI benchmarking

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Published Papers

This special issue is now open for submission.
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