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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neuropathic Pain: From Prevention to Diagnosis and Management
edited by Enrico Martin
submission deadline 10 Oct 2026 | 2 articles | Viewed by 5558 | Submission Open
Keywords: neuropathic pain; clinical research; TMR; RPNI; preclinical studies; QoL; PROMS; translational medicine; pain mechanisms
(This special issue belongs to the Section Clinical Neurology)
New Insights into Clinical Application of Embolization Techniques
edited by and Yan Epelboym
submission deadline 10 Oct 2026 | 3 articles | Viewed by 4090 | Submission Open
Keywords: embolization; interventional radiology; musculoskeletal embolization; uterine artery embolization; prostate artery embolization; vascular malformations; catheter-directed therapy
(This special issue belongs to the Section Vascular Medicine)
Current Trends and Future Challenges in Coronary Artery Disease
edited by Federica Agnello
submission deadline 10 Oct 2026 | 2 articles | Viewed by 1605 | Submission Open
Keywords: coronary artery disease; cardiovascular prevention; coronary computed tomography angiography (CCTA); CT-derived fractional flow reserve (FFR-CT); intracoronary imaging; residual risk; functional assessment; artificial intelligence in cardiology; percutaneous coronary intervention
(This special issue belongs to the Section Cardiology)
Treatment Strategies in Congenital Heart Disease: Current Practices and Future Directions
edited by Anastasia Schleiger, Julia Moosmann and
submission deadline 10 Oct 2026 | 2 articles | Viewed by 1504 | Submission Open
Keywords: congenital heart disease; transcatheter management of congenital heart defects; surgical strategies for congenital heart defects; medical heart failure treatment; mechanical circulatory support; hybrid procedures; pulmonary hypertension; heart teams; multidisciplinary management; quality of life
(This special issue belongs to the Section Cardiology)
Clinical Advances and Insights in Cardiovascular Imaging
edited by Maurizio Cusmà Piccione
submission deadline 10 Oct 2026 | 2 articles | Viewed by 877 | Submission Open
Keywords: cardiovascular imaging; multimodality imaging; cardiac magnetic resonance; cardiac computed tomography; advanced echocardiography
(This special issue belongs to the Section Cardiovascular Medicine)
Biomarkers in Peripheral Artery Disease
edited by Ben Li
submission deadline 10 Oct 2026 | 1 articles | Viewed by 697 | Submission Open
Keywords: vascular diseases; biomarkers; diagnosis; prognosis; risk stratification; vascular inflammation; endothelial dysfunc-tion; aneurysmal degeneration; imaging biomarkers; precision medicine
(This special issue belongs to the Section Vascular Medicine)
The Evolution of Knee Surgery: The Role of Robotics and Personalization
edited by
submission deadline 10 Oct 2026 | 1 articles | Viewed by 624 | Submission Open
Keywords: robotic knee surgery; robot-assisted knee arthroplasty; personalized knee replacement; personalized alignment; total knee arthroplasty
(This special issue belongs to the Section Orthopedics)
Application of Artificial Intelligence in Cardiology submission deadline 13 Oct 2026 | 9 articles | Viewed by 14934 | Submission Open
Keywords: artificial intelligence; cardiology; clinical practice; valvular heart disease; arrhythmias; device therapy; machine learning
(This special issue belongs to the Section Cardiology)
Innovations in Parkinson’s Disease
edited by
submission deadline 15 Oct 2026 | 5 articles | Viewed by 8046 | Submission Open
Keywords: Parkinson’s disease; parkinsonism; patient-reported outcomes; wearable technology; disease-modifying therapies; non-pharmacological therapies; care delivery; models of care
(This special issue belongs to the Section Clinical Neurology)
Clinical Diagnostics and Therapeutic Advances in Pregnancy Complications submission deadline 15 Oct 2026 | 5 articles | Viewed by 7568 | Submission Open
Keywords: prenatal diagnosis; pre-eclampsia; gestational diabetes; pregnancy complications; preterm labor; congenital mal-formations; prenatal genetic testing
(This special issue belongs to the Section Obstetrics & Gynecology)
Pharmacotherapy and Patient Care in Rheumatoid Arthritis
edited by
submission deadline 15 Oct 2026 | 2 articles | Viewed by 6590 | Submission Open
Keywords: rheumatoid arthritis; pharmacotherapy; patient care; biomarkers; treatment outcomes
(This special issue belongs to the Section Immunology & Rheumatology)
Retinal Dystrophies—Structure and Function Relationship submission deadline 15 Oct 2026 | 3 articles | Viewed by 4022 | Submission Open
Keywords: retinal dystrophies; structural changes; functional impairment; in retinal degenerative diseases; retinitis pigmentosa
(This special issue belongs to the Section Ophthalmology)
Orthopedic Surgery: Latest Advances and Future Prospects—2nd Edition
edited by Andrea Marinozzi and
submission deadline 15 Oct 2026 | 4 articles | Viewed by 3429 | Submission Open
Keywords: custom-made; regenerative; prosthetic; noninvasive surgery; robotic surgery; percutaneous surgery; minimally invasive surgery
(This special issue belongs to the Section Orthopedics)
Prenatal Diagnosis and Intervention: Shaping the Future of Maternal–Fetal Medicine submission deadline 15 Oct 2026 | 4 articles | Viewed by 3201 | Submission Open
Keywords: diabetes in pregnancy; hypertension in pregnancy; cholestasis in pregnancy; endocrine disorder in pregnancy; sepsis in pregnancy
(This special issue belongs to the Section Obstetrics & Gynecology)
Transjugular Intrahepatic Portosystemic Shunt: Challenges and Perspectives—2nd Edition
edited by , Stefania Gioia and
submission deadline 15 Oct 2026 | 2 articles | Viewed by 2170 | Submission Open
Keywords: hepatic encephalopathy; spontaneous portal-systemic shunts; transjugular intrahepatic portosystemic shunt; cirrhosis; portal hypertension; sarcopenia; myosteatosis; gastrointestinal bleeding; ascites; non cirrhotic portal hypertension
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in Liver Transplantation and Organ Perfusion
edited by Franziska A. Meister
submission deadline 15 Oct 2026 | 4 articles | Viewed by 1836 | Submission Open
Keywords: liver transplantation; extended criteria donors; ischemia–reperfusion injury; graft dysfunction; organ preservation; machine perfusion; normothermic perfusion; hypothermic perfusion; transplant outcomes
(This special issue belongs to the Section General Surgery)
Clinical Challenges in Endocrine Oncology
edited by
submission deadline 15 Oct 2026 | 2 articles | Viewed by 1248 | Submission Open
Keywords: neuroendocrine tumors; thyroid cancer; adrenocortical carcinoma; pituitary adenoma; multiple endocrine neoplasia (MEN); hormone-secreting tumors
(This special issue belongs to the Section Endocrinology & Metabolism)
Contemporary Challenges and Advances in Pulmonary Embolism
edited by Roy Beigel, Shlomi Matetzky and Fernando Chernomordik
submission deadline 15 Oct 2026 | 1 articles | Viewed by 1125 | Submission Open
Keywords: pulmonary embolism; treatment; coagulation; venous thrombosis; thrombolysis; anticoagulation; risk stratification; PERT; CTEPH
(This special issue belongs to the Section Respiratory Medicine)
Comprehensive Approaches in Gastrointestinal Oncology: Focus on Colorectal, Gastric, and Pancreatic Cancer Treatment submission deadline 15 Oct 2026 | 1 articles | Viewed by 835 | Submission Open
Keywords: colorectal cancer; gastric cancer; pancreatic cancer; biological staging; clinical staging; early tumors; locally advanced tumors; oligometastatic tumor; neoadjuvant approach; chemotherapy; radiotherapy; immunotherapy; radical surgery; conservative treatment; targeted therapy
(This special issue belongs to the Section Oncology)
Cardiac Surgery: Current Clinical Challenges and New Perspectives
edited by Sadeq Ali-Hasan-Al-Saegh and
submission deadline 15 Oct 2026 | 2 articles | Viewed by 611 | Submission Open
Keywords: cardiac surgery; surgical challenges; innovations in cardiology; minimally invasive techniques; robotic-assisted surgery; artificial intelligence in cardiac surgery; postoperative management; quality improvement in cardiac surgery
(This special issue belongs to the Section Cardiology)
Clinical and Surgical Treatment for Orthopedic Trauma
edited by Mihnea Ioan Gabriel Popa
submission deadline 15 Oct 2026 | Viewed by 305 | Submission Open
Keywords: orthopedic surgery; orthopedic trauma; trauma surgery; musculoskeletal oncology; musculoskeletal biomaterials; infection management; complication management
(This special issue belongs to the Section Orthopedics)
Urologic Disorders: Advances in Diagnosis and Therapy
edited by Carmen Gonzalez-Enguita and
submission deadline 15 Oct 2026 | Viewed by 270 | Submission Open
Keywords: prostatic hyperplasia; urinary incontinence; urothelial carcinoma; minimally invasive surgery; kidney stone; urinary tract infection
(This special issue belongs to the Section Nephrology & Urology)
Advances in Coronary Heart Disease: From Diagnosis to Long-Term Care
edited by and Cristian Leva
submission deadline 15 Oct 2026 | Viewed by 241 | Submission Open
Keywords: coronary heart disease; myocardial ischemia; percutaneous coronary intervention; coronary artery bypass surgery; left ventricular reconstruction; coronary diagnostic; coronary microvascular dysfunction; personalized medicine
(This special issue belongs to the Section Cardiology)
Clinical Management of Pemphigus
edited by
submission deadline 15 Oct 2026 | Viewed by 235 | Submission Open
Keywords: pemphigus; pemphigus IgA; paraneoplastic pemphigus; cell–cell contact proteins and diagnostic procedures; novel therapies
(This special issue belongs to the Section Dermatology)
Otolaryngologic Clinical Findings and Management Across the Spectrum of Idiopathic Intracranial Hypertension
edited by Bülent Mamikoǧlu
submission deadline 15 Oct 2026 | Viewed by 213 | Submission Open
Keywords: idiopathic intracranial hypertension; intracranial pressure dysregulation; pulsatile tinnitus; venous sinus stenosis; CSF–inner ear coupling; vestibular migraine; dizziness and vertigo; aural fullness; glymphatic system; Chiari malformation; otologic manifestations of IIH; endovascular treatment; acetazolamide therapy
(This special issue belongs to the Section Otolaryngology)
Current Challenges and Innovations in Spine Deformity: Biomechanics, Imaging and AI-Driven Analysis
edited by Dong-Ho Kang
submission deadline 16 Oct 2026 | 4 articles | Viewed by 4457 | Submission Open
Keywords: spinal deformity; cervical deformity; biomechanics; postural alignment; sagittal imbalance; medical imaging; radiographic analysis; artificial intelligence; machine learning; deep learning; phenotyping; computer-assisted diagnosis; predictive modeling; surgical planning
(This special issue belongs to the Section Orthopedics)
Haemodialysis and Peritoneal Dialysis: Current Clinical Practices and Innovations
edited by
submission deadline 16 Oct 2026 | 1 articles | Viewed by 936 | Submission Open
Keywords: haemodialysis; peritoneal dialysis; end-stage kidney disease; chronic kidney disease; nephrology
(This special issue belongs to the Section Nephrology & Urology)
Contemporary Treatment of Complement-Mediated Diseases
edited by and Danko Milošević
submission deadline 16 Oct 2026 | Viewed by 262 | Submission Open
Keywords: complement-mediated diseases; complement activation; atypical hemolytic uremic syndrome; C3 glomerulopathy; thrombotic microangiopathy; complement inhibitors; kidney transplantation; antibody-mediated rejection; complement dysregulation; genetic testing; kidney failure; dialysis; kidney transplantation; kidney allograft rejection
(This special issue belongs to the Section Nephrology & Urology)
Advances and Clinical Updates in the Gastrointestinal and Abdominal Diseases
edited by Elissavet Anestiadou, Savvas Symeonidis and Ioannis Mantzoros
submission deadline 19 Oct 2026 | 1 articles | Viewed by 646 | Submission Open
Keywords: gastrointestinal surgery; minimally invasive surgery; enhanced recovery; digestive oncology; inflammatory bowel disease; abdominal wall reconstruction; biomaterials; perioperative management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Acute Ischemic Stroke Management Strategies
edited by
submission deadline 20 Oct 2026 | 9 articles | Viewed by 15683 | Submission Open
Keywords: mechanical thrombectomy; leptomeningeal collateral circulation; neuroprotection; reperfusion injury; ischemic penumbra
(This special issue belongs to the Section Clinical Neurology)
Clinical Management of Pediatric Heart Diseases
edited by
submission deadline 20 Oct 2026 | 11 articles | Viewed by 12214 | Submission Open
Keywords: pediatric heart diseases; children; pediatric cardiology; congenital heart disease; clinical management; congenital heart surgery; outcome
(This special issue belongs to the Section Clinical Pediatrics)
Chronic Disease Management and Rehabilitation in Older Adults
edited by
submission deadline 20 Oct 2026 | 7 articles | Viewed by 11560 | Submission Open
Keywords: chronic disease; older adults; geriatric rehabilitation; holistic physiotherapy; physical activity; health outcomes; elderly people; geriatric care; health promotion
(This special issue belongs to the Section Geriatric Medicine)
Clinical Challenges and Innovations in Cochlear Implantation and Hearing Rehabilitation
edited by
submission deadline 20 Oct 2026 | 10 articles | Viewed by 10373 | Submission Open
Keywords: cochlear implant outcomes; clinical efficiency; barriers to care; cochlear implant surgery; cochlear implant referral; cochlear implant evaluation; cochlear implant candidacy; rehabilitation; rehabilitation strategies; quality of life
(This special issue belongs to the Section Otolaryngology)
Acute Myeloid Leukemia: Latest Advances in Diagnostics, Therapeutic Strategies and Clinical Management: 2nd Edition
edited by Michael D. Diamantidis
submission deadline 20 Oct 2026 | 5 articles | Viewed by 10198 | Submission Open
Keywords: ELN; ICC and WHO 2022 AML classifications; molecular AML diagnostics; AML biology; measurable residual disease (MRD); novel targeted AML therapies; AML immunotherapies; hematopoietic stem cell transplantation (HSCT)
(This special issue belongs to the Section Hematology)
Clinical Management of Patients with Heart Failure: 3rd Edition
edited by
submission deadline 20 Oct 2026 | 10 articles | Viewed by 9288 | Submission Open
Keywords: acute heart failure; chronic heart failure; treatment options; management of heart failure; lifestyle changes; diagnosis of heart failure
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Update on Thoracic Trauma
edited by
submission deadline 20 Oct 2026 | 6 articles | Viewed by 8504 | Submission Open
Keywords: flail chest; isolated sternal fractures; manubrio-sternal dislocation; pneumothorax; hemothorax; thoracic aortic injury; heart and pulmonary vessels lesion; intercostal artery injury; diaphragm rupture; thoracoabdominal hernia; chylothorax; esophageal perforation
(This special issue belongs to the Section Respiratory Medicine)
Application of Echocardiography in the Diagnosis and Management of Cardiac Diseases
edited by and
submission deadline 20 Oct 2026 | 5 articles | Viewed by 8354 | Submission Open
Keywords: echocardiography; cardiac diseases; 3D echo; stress; myocardial strain; intracardiac; subclinical cardiac disease
(This special issue belongs to the Section Cardiology)
Clinical Management of Corneal Diseases
edited by Hyeck Soo Son
submission deadline 20 Oct 2026 | 3 articles | Viewed by 7730 | Submission Open
Keywords: corneal diseases; keratoconus; corneal dystrophy; corneal ectasia; corneal transplantation; DMEK; DSAEK; kerato-prosthesis; crosslinking; ICRS; CAIRS; Bowman layer transplantation; treatment outcomes; clinical management
(This special issue belongs to the Section Ophthalmology)
Recent Developments in Hearing and Balance Disorders: 2nd Edition submission deadline 20 Oct 2026 | 4 articles | Viewed by 7450 | Submission Open
Keywords: ear; otology; audiology; hearing disorders; deafness; hearing loss; autoimmunity; ENT; inflammation; vertigo; imbalance
(This special issue belongs to the Section Otolaryngology)
Advances in Maternal Fetal Medicine
edited by and Anna Franca Cavaliere
submission deadline 20 Oct 2026 | 4 articles | Viewed by 6873 | Submission Open
Keywords: drugs use during pregnancy; fetal treatment; pregnancy complications; infectious diseases; neonatal poor adaptation syndrome
(This special issue belongs to the Section Obstetrics & Gynecology)
Novel Insights into Clinical Diagnosis and Management of Degenerative Cervical Myelopathy
edited by , Francesco Costa and Filippo Maria Polli
submission deadline 20 Oct 2026 | 4 articles | Viewed by 6004 | Submission Open
Keywords: degenerative cervical myelopathy (DCM); cervical spondylotic myelopathy (CSM); cervical spinal stenosis; cervical cord compression; MRI of the cervical spine; cervical spine surgery; physical therapy; rehabilitation; ossification of the posterior longitudinal ligament (OPLL); cervical deformity (e.g., kyphosis and lordosis); patient-reported out-comes; surgical outcome prediction
(This special issue belongs to the Section Clinical Neurology)
Pediatric Dentistry: Real-World Clinical Insights submission deadline 20 Oct 2026 | 4 articles | Viewed by 5471 | Submission Open
Keywords: pediatric dentistry; minimally invasive dentistry; new technologies; biomaterials; innovative management approaches; caries management; pulp management; dental trauma; molar incisor hypomineralization; public health services research; epidemiological research; translational research
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Insights and Emerging Techniques in Interventional Cardiology
edited by
submission deadline 20 Oct 2026 | 1 articles | Viewed by 5071 | Submission Open
Keywords: percutaneous coronary intervention; coronary imaging; intravascular ultrasound; IVUS; computed tomography; optical coherence tomography; OCT; chronic total occlusions; drug-coated balloons; bifurcations; calcified coronary lesions; rotational atherectomy; intravascular lithotripsy; acute coronary syndromes; chronic coronary syndromes
(This special issue belongs to the Section Cardiology)
Recent Developments in Gynecological Endocrinology: 2nd Edition submission deadline 20 Oct 2026 | 2 articles | Viewed by 4968 | Submission Open
Keywords: amenorrhea; puberty; PCOS; premature ovarian insufficiency; endometriosis; infertility; pregnancy; hormones; menopause
(This special issue belongs to the Section Obstetrics & Gynecology)
Skin Cancer: Prevention, Diagnosis, Quality of Life and Treatment Outcomes
edited by Athanassios A. Kyrgidis and
submission deadline 20 Oct 2026 | 5 articles | Viewed by 4875 | Submission Open
Keywords: skin cancer; melanoma; squamous cell carcinoma; basal cell carcinoma; clinical biomarkers; dermoscopy; quality of life
(This special issue belongs to the Section Dermatology)
Heart Failure: Treatment and Clinical Perspectives
edited by Geza Halasz, Domenico Gabrielli and Francesco Grigioni
submission deadline 20 Oct 2026 | 6 articles | Viewed by 4849 | Submission Open
Keywords: heart failure; chronic heart failure; acute heart failure; treatment; cardiac imaging; diagnostics; patient outcomes; prognosis
(This special issue belongs to the Section Cardiology)
Intrarenal Surgery for Kidney Stones and Other Kidney Diseases
edited by Razvan Multescu
submission deadline 20 Oct 2026 | 4 articles | Viewed by 4833 | Submission Open
Keywords: intrarenal surgery; flexible ureteroscopy; percutaneous nephrolithotomy (PCNL); Mini-PCNL; thulium laser; ureteral access sheaths; flexible and navigable suction (FANS); upper urinary tract urothelial tumors
(This special issue belongs to the Section Nephrology & Urology)
New Insights into Retinal Diseases
edited by Fabio Scarinci and Giulio Pocobelli
submission deadline 20 Oct 2026 | 5 articles | Viewed by 4362 | Submission Open
Keywords: optical coherence tomography; optical coherence tomography angiography; vitreoretinal diseases; retinal imaging analysis; biomarkers; segmentation; retinal ischemia; retinal blood flow; choroidal blood flow
(This special issue belongs to the Section Ophthalmology)
Clinical Implications of Pupil Function: Optical Quality, Visual Performance, and Neurological Biomarkers
edited by Pablo De Gracia and Héctor E. Soriano Baron
submission deadline 20 Oct 2026 | 1 articles | Viewed by 4246 | Submission Open
Keywords: pupil function; visual performance; intraocular lens (IOL) optimization; pupillometry diagnostics; neuro-ophthalmic biomarkers
(This special issue belongs to the Section Ophthalmology)
Recent Advances in Endocrine Surgery—2nd Edition
edited by
submission deadline 20 Oct 2026 | 2 articles | Viewed by 4193 | Submission Open
Keywords: endocrine surgery; thyroid; thyroid cancer; parathyroid; parathyroidectomy; adrenal glands; disorders of hepatobiliary and gastrointestinal tract
(This special issue belongs to the Section General Surgery)
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