Clinical Challenges in Endocrine Oncology

Dear Colleagues,

Endocrine oncology encompasses a wide spectrum of tumors arising from hormone-secreting glands, presenting unique diagnostic, prognostic, and therapeutic challenges. This Special Issue focuses on recent advances and persistent hurdles in the clinical management of neuroendocrine tumors, thyroid cancer, adrenal tumors, pituitary neoplasms, and other rare endocrine malignancies. We aim to compile research that bridges molecular insights with practical clinical applications, addressing areas such as biomarker development, imaging innovations, personalized treatment strategies, and management of treatment-related complications. Imaging is essential in endocrine oncology, enabling accurate diagnosis, staging, and therapy planning. Conventional techniques combined with molecular imaging, such as PET and SPECT, improve tumor characterization, guide personalized treatments, and support follow-up.

We welcome original research articles, systematic reviews, and clinical studies that explore:

• Novel diagnostic and prognostic biomarkers;
• Advances in targeted and immunotherapies;
• Surgical and non-surgical treatment optimization;
• Management of metastatic and refractory disease.

This issue will serve as a timely resource for endocrinologists, oncologists, surgeons, and researchers dedicated to improving outcomes in endocrine cancer care.

Dr. Francesco Dondi
Guest Editor

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