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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Advances in Rhinitis and Sinusitis: Diagnosis, Therapy and Multimorbidity Management
edited by , and Veronica Seccia
submission deadline 18 Dec 2026 | 2 articles | Viewed by 1330 | Submission Open
Keywords: allergy; asthma; biologics; chronic rhinosinusitis; chronic rhinosinusitis with nasal polyps; endoscopic sinus surgery; NSAID-ERD; olfaction; personalized treatment; precision medicine; quality of life; respiratory disease; rhinitis; sinusitis; type-2 inflammation
(This special issue belongs to the Section Otolaryngology)
Evidence-Based Diagnosis and Clinical Management of Low Back Pain submission deadline 20 Dec 2026 | 6 articles | Viewed by 13975 | Submission Open
Keywords: low back pain; classification systems; risk stratification; health services research; management strategies; timing and sequencing; prognosis; predictor; clinical decision making; primary care
(This special issue belongs to the Section Clinical Rehabilitation)
Scoliosis: Advances in Diagnosis and Management
edited by Michal Latalski
submission deadline 20 Dec 2026 | 8 articles | Viewed by 12931 | Submission Open
Keywords: scoliosis; adolescent idiopathic scoliosis; adult scoliosis; congenital scoliosis; neuromuscular scoliosis; diagnosis; imaging; treatment; surgery; bracing; rehabilitation; patient-reported outcomes; quality of life
(This special issue belongs to the Section Orthopedics)
Advances in Clinical Approaches to Breast Cancer Diagnosis and Treatment
edited by
submission deadline 20 Dec 2026 | 10 articles | Viewed by 12571 | Submission Open
Keywords: breast cancer; diagnosis; precision medicine; molecular profiling; targeted therapy; breast-conserving surgery; minimally invasive techniques; artificial intelligence; personalized medicine; radiation therapy
(This special issue belongs to the Section Oncology)
Spine Surgery: Current Practice and Future Directions
edited by Claudio Bernucci and Francesco Costa
submission deadline 20 Dec 2026 | 4 articles | Viewed by 9340 | Submission Open
Keywords: degenerative; spinal trauma; spine tumors; neurosurgery; spine surgery; spinal deformity; scoliosis; robotics surgery; spinal cord injury; clinical practices; regenerative therapies
(This special issue belongs to the Section Clinical Neurology)
Imaging and Surgery in Endometriosis—Recent Advances submission deadline 20 Dec 2026 | 3 articles | Viewed by 9125 | Submission Open
Keywords: robotic-assisted surgery; MR imaging; radiomics; transvaginal ultrasound; deep endometriosis; ovarian endometriosis; fluorescence-guided surgery; artificial intelligence; adhesions in endometriosis; infertility; classification systems
(This special issue belongs to the Section Obstetrics & Gynecology)
Imaging and Molecular Biomarkers: The New Approach to Degenerative Retinal Diseases submission deadline 20 Dec 2026 | 7 articles | Viewed by 9071 | Submission Open
Keywords: ophthalmology; degenerative retinal diseases; imaging biomarkers; multimodal imaging; OCT; OCT angiography; molecular biomarkers; precision medicine; translational ophthalmic research
(This special issue belongs to the Section Ophthalmology)
Autoimmune Diseases and Multisystem Inflammation: Pathophysiology and Therapeutic Strategies
edited by
submission deadline 20 Dec 2026 | 2 articles | Viewed by 8749 | Submission Open
Keywords: autoimmune diseases; cardiovascular diseases; cutaneous diseases; gastrointestinal diseases; pulmonary diseases; renal diseases; systemic manifestation; rheumatoid arthritis; systemic lupus erythematosus; vasculitis
(This special issue belongs to the Section Immunology & Rheumatology)
Updates on the Clinical Applications of Dental Restorative Materials
edited by
submission deadline 20 Dec 2026 | 3 articles | Viewed by 6707 | Submission Open
Keywords: restorative dentistry; restorations; adhesive dentistry; resin composites; ceramics; aesthetics; dental materials; direct restorations; indirect restorations; conservative dentistry; prosthetic dentistry; partial restorations; total restorations
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Clinical Rheumatology—2nd Edition
edited by
submission deadline 20 Dec 2026 | 5 articles | Viewed by 5515 | Submission Open
Keywords: rheumatoid arthritis; spondylarthritis; interventional; osteoporosis; complex regional pain syndrome
(This special issue belongs to the Section Immunology & Rheumatology)
Heart Failure Management Innovations, Evidence, and the Patient Perspective submission deadline 20 Dec 2026 | 9 articles | Viewed by 5156 | Submission Open
Keywords: Pharmacological advances across HFrEF, HFmrEF, and HFpEF;; SGLT2 inhibitors and emerging drug classes;; Devices, resynchronization therapy, and mechanical circulatory support;; Digital health, telemedicine, and remote monitoring;; AI and machine learning in HF diagnosis and prognosis;; Biomarkers and imaging for risk stratification;; Multidisciplinary and integrated care models;; HF in special populations;; Acute decompensated HF management;; Cardiac rehabilitation and exercise interventions.
(This special issue belongs to the Section Cardiology)
Physiotherapy in Clinical Practice: From Assessment to Rehabilitation submission deadline 20 Dec 2026 | 5 articles | Viewed by 4998 | Submission Open
Keywords: clinical assessment; rehabilitation; clinical practice; patient-centered care; physiotherapy innovation
(This special issue belongs to the Section Clinical Rehabilitation)
Current Perspectives and Innovations in Urogynecology
edited by
submission deadline 20 Dec 2026 | 3 articles | Viewed by 4598 | Submission Open
Keywords: urogynecology; pelvic organ prolapse; urinary incontinence; overactive bladder; pelvic floor surgery; reconstructive surgery; minimally invasive surgery; pelvic floor disorders; innovative surgical techniques; quality of life
(This special issue belongs to the Section Obstetrics & Gynecology)
New Perspectives in Maternal–Fetal Medicine
edited by Catalina de Paco-Matallana
submission deadline 20 Dec 2026 | 2 articles | Viewed by 4392 | Submission Open
Keywords: maternal–fetal medicine; prenatal diagnostics; fetal therapy; precision medicine; neonatal outcomes; maternal health
(This special issue belongs to the Section Obstetrics & Gynecology)
State of the Art in Cardiac Surgery: Progress, Challenges and Opportunities
edited by Tomasz Plonek and Sleiman Sebastian Aboul-Hassan
submission deadline 20 Dec 2026 | 3 articles | Viewed by 4306 | Submission Open
Keywords: aorta ascendens; minimally invasive surgery; aortic arch surgery; off pump coronary surgery; arterial grafts
(This special issue belongs to the Section Cardiology)
Advances and Innovations in Reconstructive Microsurgery: Techniques, Outcomes, and Future Directions
edited by Youn Hwan Kim
submission deadline 20 Dec 2026 | 7 articles | Viewed by 4141 | Submission Open
Keywords: microsurgery; free flap; perforator flap; supermicrosurgery; reconstructive surgery; lymphatic surgery; chimeric flap; flow-through flap; surgical innovation; functional outcomes
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Diagnosis and Treatment of Connective Tissue Diseases: A Clinician's Perspective: 2nd Edition
edited by , and Aleksandra Dańczak-Pazdrowska
submission deadline 20 Dec 2026 | 2 articles | Viewed by 3989 | Submission Open
Keywords: connective tissue diseases; lupus erythematosus; scleroderma; dermatomyositis; MCTD; clinical picture; spectrum of clinical symptoms; treatment; complications; clinical follow-up
(This special issue belongs to the Section Immunology & Rheumatology)
Acute Endocarditis: Clinical Advances in Diagnosis, Treatment, and Management
edited by
submission deadline 20 Dec 2026 | 2 articles | Viewed by 3822 | Submission Open
Keywords: acute endocarditis; disease natural history; surgical treatment; postoperative outcome; long term follow up
(This special issue belongs to the Section Cardiology)
Oral and Maxillofacial Surgery: Clinical Progress, Challenges and Opportunities
edited by Janet Hayes Southerland and Leslie Robin Halpern
submission deadline 20 Dec 2026 | 4 articles | Viewed by 3767 | Submission Open
Keywords: OMFS; surgery; research; innovation; interdisciplinary; cosmetic; pharmacology; cancer; repair; nerve; TMJ; rehabilitation; orthognathic; disorder; bleeding
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Children and Adolescent Mood Disorders: Risks and Treatment submission deadline 20 Dec 2026 | 2 articles | Viewed by 3625 | Submission Open
Keywords: emotional dysregulation; mood disorders; adolescence; anxiety; depression; addiction; psychotherapy; pharmacological treatments; prevention programs
(This special issue belongs to the Section Mental Health)
Novel Technologies to Assist Emergency Medical Care
edited by and Young Soon Cho
submission deadline 20 Dec 2026 | 3 articles | Viewed by 3479 | Submission Open
Keywords: emergency medical services; artificial intelligence in emergency medicine; telemedicine and remote patient monitoring; wearable health technologies; point-of-care diagnostics; automated decision support systems; robotics in emergency medicine; pre-hospital care innovations
(This special issue belongs to the Section Emergency Medicine)
Advances in Anterior Segment Surgery: Second Edition
edited by
submission deadline 20 Dec 2026 | 2 articles | Viewed by 3444 | Submission Open
Keywords: lenticule-based surgery; surface ablations; blended vision treatments with laser refractive surgery; corneal inlay procedures; presbyopia management with monovision laser vision correction; refractive lens exchange; premium presbyopia-correcting intraocular lens; refractive solutions for keratoconics; cataract surgery; corneal transplant; biometry
(This special issue belongs to the Section Ophthalmology)
Cardiovascular Disease in the Elderly: Cardiogeriatric Assessment, Prevention, Treatment Outcomes and Perspectives
edited by Georgia Vamvakou
submission deadline 20 Dec 2026 | 5 articles | Viewed by 3209 | Submission Open
Keywords: cardiovascular diseases; elderly patients; cardiogeriatric assessment; diagnosis and therapeutic planning; healthy aging; digital medicine
(This special issue belongs to the Section Cardiovascular Medicine)
Joint Repair and Replacement: Current Challenges and Opportunities
edited by Bartosz Gonera and Kacper Ruzik
submission deadline 20 Dec 2026 | 3 articles | Viewed by 3166 | Submission Open
Keywords: orthopedic biomechanics; knee injuries; joint replacement; anterior cruciate ligament; arthroscopy; sports medicine; prosthetic implants
(This special issue belongs to the Section Orthopedics)
Carotid Artery Disease (CAD) and Its Complications: A Comprehensive Update
edited by Yacob G. Tedla
submission deadline 20 Dec 2026 | 3 articles | Viewed by 2922 | Submission Open
Keywords: carotid artery disease; ischemic stroke; vascular dementia; transient ischemic attack; vascular imaging; carotid endarterectomy; carotid stent placement; risk stratification
(This special issue belongs to the Section Vascular Medicine)
Transcatheter Aortic Valve Implantation and Replacement: Prospects and Challenges—2nd Edition
edited by Konstantinos Toutouzas and
submission deadline 20 Dec 2026 | 4 articles | Viewed by 2806 | Submission Open
Keywords: TAVI; aortic stenosis; valve-in-valve; structural heart disease; TAVI-in-TAVI
(This special issue belongs to the Section Cardiology)
Clinical Advances in Risk Minimization Through Robot-Assisted Surgery
edited by Radko Komadina
submission deadline 20 Dec 2026 | 6 articles | Viewed by 2772 | Submission Open
Keywords: robot-assisted technology; robotic surgery; laparoscopic surgery; spinal surgery; robot-assisted gynecological operations; robot-assisted operations in urology; robot-assisted prostatectomy
(This special issue belongs to the Section General Surgery)
Applications of Artificial Intelligence in Cardiology: New Tools to Transform Care submission deadline 20 Dec 2026 | 1 articles | Viewed by 2585 | Submission Open
Keywords: artificial intelligence in cardiology; machine learning; deep learning; AI-driven ECG analysis; cardiovas-cular imaging and AI; predictive analytics in cardiology; mHealth and wearables; clinical decision support systems; ethics and AI in healthcare; digital health and remote monitoring
(This special issue belongs to the Section Cardiology)
Recent Advancements in Nuclear Medicine and Radiology: 2nd Edition
edited by Adriaan A. Lammertsma
submission deadline 20 Dec 2026 | 3 articles | Viewed by 2540 | Submission Open
Keywords: PET; SPECT; CT; MRI; AI; image analysis; kinetic analysis
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Advanced Applications of Magnetic Resonance Imaging (MRI) in Clinical Diagnosis
edited by Francescamaria Donati
submission deadline 20 Dec 2026 | 4 articles | Viewed by 2515 | Submission Open
Keywords: magnetic resonance imaging (MRI); clinical diagnosis; high-field MRI; diffusion-weighted imaging (DWI); perfusion MRI (pMRI); artificial intelligence in imaging; diagnostic imaging; early disease detection; disease monitoring; treatment planning
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Clinical Cardiac Rehabilitation: Integrating Multidimensional Approaches for Enhanced Cardiovascular Health
edited by
submission deadline 20 Dec 2026 | 2 articles | Viewed by 2417 | Submission Open
Keywords: cardiac rehabilitation; multidimensional approach; integrating approach; cardiovascular health; primary and secondary prevention
(This special issue belongs to the Section Clinical Rehabilitation)
State-of-the-Art Advances in Bloodstream Infections submission deadline 20 Dec 2026 | 2 articles | Viewed by 2295 | Submission Open
Keywords: bloodstream infections; sepsis; antimicrobial resistance; rapid diagnostics; metagenomics; antimicrobial treatment; antimicrobial stewardship; artificial intelligence; precision medicine
(This special issue belongs to the Section Infectious Diseases)
The New Era of Urological Surgery: Technology-Enhanced Clinical Outcomes submission deadline 20 Dec 2026 | 1 articles | Viewed by 2052 | Submission Open
Keywords: urology; surgery; robotic surgery; artificial intelligence; urological cancer
(This special issue belongs to the Section Nephrology & Urology)
Clinical Applications of Artificial Intelligence and Machine Learning in Diagnosis and Therapy
edited by Christian Salvatore, Valentina Chiappa and Gennaro D’Anna
submission deadline 20 Dec 2026 | 4 articles | Viewed by 1998 | Submission Open
Keywords: artificial intelligence in clinical medicine; machine learning in clinical medicine; medical imaging analysis; digital biomarkers; explainable artificial intelligence (XAI); precision medicine; human–AI interaction in healthcare
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Atrial Fibrillation and Heart Failure: Diagnosis, Risk Stratification, and Clinical Management
edited by Christian Grebmer
submission deadline 20 Dec 2026 | 2 articles | Viewed by 1861 | Submission Open
Keywords: atrial fibrillation; heart failure; clinical management; risk stratification; anticoagulation; catheter ablation; guide-line-directed therapy; clinical outcomes
(This special issue belongs to the Section Cardiology)
Pharmacotherapy of Mental Diseases: Latest Developments submission deadline 20 Dec 2026 | 2 articles | Viewed by 1821 | Submission Open
Keywords: brain stimulation; mental health; novel intervention; pharmacotherapy; psychotherapy; quality of life; psychologi-cal well-being; treatment personalization in mental diseases
(This special issue belongs to the Section Mental Health)
Advances in Spinal Deformity: Current Challenges and Future Directions
edited by and Sam Yeol Chang
submission deadline 20 Dec 2026 | 4 articles | Viewed by 1769 | Submission Open
Keywords: spinal deformity; adult spinal deformity; pediatric scoliosis; minimally invasive spine surgery; navigation and robotics; spinal alignment; surgical outcomes
(This special issue belongs to the Section Orthopedics)
Perioperative Management in Thoracic Surgery: Current Advances and Future Perspectives submission deadline 20 Dec 2026 | 1 articles | Viewed by 1664 | Submission Open
Keywords: thoracic surgery; perioperative care; ERAS; minimally invasive surgery; interventional pulmonology; preoperative assessment; postoperative management; surgical outcomes; multidisciplinary approach; technology in surgery
(This special issue belongs to the Section Respiratory Medicine)
New Insights into Regional Anesthesia and Pain Management submission deadline 20 Dec 2026 | 3 articles | Viewed by 1554 | Submission Open
Keywords: regional anesthesia; pain management; ultrasound-guided techniques; erector spinae plane block; pericapsular nerve group (PENG) block; interfascial plane blocks; multimodal analgesia; opioid-sparing analgesia; postoperative pain; inflammatory response; enhanced recovery after surgery (ERAS); pediatric anesthesia; geriatric anesthesia; orthopedic anesthesia; randomized controlled trials
(This special issue belongs to the Section Anesthesiology)
Advancements in Diagnosing, Management and Treatment of Gynecologic Oncology submission deadline 20 Dec 2026 | 3 articles | Viewed by 1547 | Submission Open
Keywords: gynecologic oncology; ovarian cancer; endometrial cancer; cervical cancer; breast cancer; peritoneal metastasis; biomarkers; cytoreductive surgery; HIPEC; targeted therapy; immunotherapy; artificial intelligence
(This special issue belongs to the Section Obstetrics & Gynecology)
Advancing Personalized and Precision Medicine with Large Language Models
edited by
submission deadline 20 Dec 2026 | 2 articles | Viewed by 1420 | Submission Open
Keywords: large language models; precision medicine; clinical decision support; electronic health records; phenotyping; multimodal data integration; explainable artificial intelligence; clinical summarization; biomedical data interpretation; digital health
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Innovations in Infertility Treatment and Assisted Reproductive Technologies (ARTs)
edited by Diana Alecsandru
submission deadline 20 Dec 2026 | 1 articles | Viewed by 1224 | Submission Open
Keywords: infertility; assisted reproductive technology (ARTs); fertility preservation; in vitro fertilization (IVF); reproductive endocrinology
(This special issue belongs to the Section Obstetrics & Gynecology)
Advances in Laparoscopic, Robotic, and Minimally Invasive Gastrointestinal Surgery submission deadline 20 Dec 2026 | 2 articles | Viewed by 1219 | Submission Open
Keywords: minimally invasive surgery; laparoscopy; robotic surgery; gastrointestinal surgery; surgical innovation; patient outcomes; enhanced recovery; clinical research
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Beyond Full Weight-Bearing Alone: Innovative, Individualized and Holistic Rehabilitation in Geriatric Orthopedic Trauma submission deadline 20 Dec 2026 | Viewed by 1128 | Submission Open
Keywords: geriatric trauma; orthogeriatrics; rehabilitation; weight-bearing; partial weight-bearing; full weight-bearing; fracture healing; frailty; sarcopenia; mobilization; tele-rehabilitation; digital health; wearable sensors; biofeedback; exoskeleton; robotics; neuromuscular electrical stimulation; multimodal rehabilitation; individualized care; postoperative aftercare
(This special issue belongs to the Section Clinical Rehabilitation)
Schizophrenia and Psychotic Disorders: Clinical Updates submission deadline 20 Dec 2026 | 1 articles | Viewed by 1059 | Submission Open
Keywords: schizophrenia spectrum disorder; mobile health apps; antipsychotics; repetitive transcranial magnetic stimulation; artificial intelligence; machine learning; augmented reality; neuroimaging; treatment resistance; quality of life; comorbidities
(This special issue belongs to the Section Mental Health)
Clinical Diagnosis and Treatment of Demyelinating Diseases
edited by and John S. Tzartos
submission deadline 20 Dec 2026 | 1 articles | Viewed by 1041 | Submission Open
Keywords: demyelinating diseases of the CNS; demyelinating diseases of the PNS; multiple sclerosis; neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); clinical diagnosis; biomarkers; therapeutics
(This special issue belongs to the Section Clinical Neurology)
Moving Forward to New Trends in Pulmonary Diseases: 2nd Edition submission deadline 20 Dec 2026 | 1 articles | Viewed by 858 | Submission Open
Keywords: pulmonary tuberculosis; chronic obstructive airway diseases; bronchiectasis; COVID-19; sleep apnea; ultrasound; lung cancer; pulmonary rehabilitation
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Obstructive Sleep Apnea submission deadline 20 Dec 2026 | 1 articles | Viewed by 824 | Submission Open
Keywords: obstructive sleep apnea; sleep apnea syndromes; precision medicine; treatment outcome; diagnosis
(This special issue belongs to the Section Respiratory Medicine)
Advances in Endoscopy for the Diagnosis and Treatment of Gastrointestinal Diseases submission deadline 20 Dec 2026 | 1 articles | Viewed by 799 | Submission Open
Keywords: gastrointestinal endoscopy; early gastrointestinal neoplasia; endoscopic imaging; endoscopic submucosal dissection (ESD); per-oral endoscopic myotomy (POEM); endoscopic full-thickness resection (EFTR); pancreatic and biliary diseas-es; endoscopic ultrasound (EUS); endoscopic retrograde cholangiopancreatography (ERCP); small bowel pathology; video capsule endoscopy (VCE); artificial intelligence (AI)
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Critical Care Cardiology
edited by Marc-Olivier Fischer
submission deadline 20 Dec 2026 | 1 articles | Viewed by 790 | Submission Open
Keywords: antiplatelets drugs; arrhythmia ablations; cardiology; catecholamines; sodium-glucose cotransporter type 2 inhibitors; critical care; cardiogenic shock; echocardiography; ECLS; ECMO; inotropic drugs; vasopressors drugs
(This special issue belongs to the Section Intensive Care)
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