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Advances in Endoscopy for the Diagnosis and Treatment of Gastrointestinal Diseases

A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 20 December 2026 | Viewed by 833

Editors


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Guest Editor
1. Gastroenterology and Gastrointestinal Endoscopy, IRCCS San Raffaele Institute, Via Olgettina 60, 20132 Milan, Italy
2. Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Via Olgettina 56, 20132 Milan, Italy
Interests: gastroenterology; digestive endoscopy; therapeutic endoscopy; luminal endoscopy

E-Mail
Guest Editor
1. Gastroenterology and Gastrointestinal Endoscopy, IRCCS San Raffaele Institute, Via Olgettina 60, 20132 Milan, Italy
2. Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Via Olgettina 56, 20132 Milan, Italy
Interests: gastroenterology; digestive endoscopy; therapeutic endoscopy; luminal endoscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The role of digestive endoscopy in modern gastroenterology continues to expand rapidly, driven by advances in both diagnostic and therapeutic techniques. Innovations in enhanced imaging, artificial intelligence (AI)-assisted lesion detection and characterization, and the refinement of advanced resection methods have significantly improved the identification and organ-sparing treatment of gastrointestinal neoplasia. At the same time, third-space endoscopy and interventional endoscopic ultrasound (EUS) have broadened the therapeutic reach of the endoscopist to conditions previously managed by surgery.

This Special Issue aims to explore the evolving role of endoscopy in addressing key clinical challenges across the full spectrum of gastrointestinal diseases. Topics of interest include: endoscopic management of early gastrointestinal neoplasia, advanced resection techniques, third-space endoscopy, diagnostic and therapeutic applications of EUS, endoscopic approach to pancreaticobiliary disease, management of post-surgical complications and luminal defects, and integration of AI and emerging technologies into clinical practice.

We invite researchers and clinicians to contribute original studies that advance current knowledge and highlight innovation in diagnostic and therapeutic gastrointestinal endoscopy.

We warmly welcome original retrospective and prospective clinical studies and comprehensive reviews, as well as expert contributions that demonstrate how recent endoscopic advances are reshaping the future of gastroenterological care and clinical practice.

Dr. Ernesto Fasulo
Dr. Francesco Vito Mandarino
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • gastrointestinal endoscopy
  • early gastrointestinal neoplasia
  • endoscopic imaging
  • endoscopic submucosal dissection (ESD)
  • per-oral endoscopic myotomy (POEM)
  • endoscopic full-thickness resection (EFTR)
  • pancreatic and biliary diseas-es
  • endoscopic ultrasound (EUS)
  • endoscopic retrograde cholangiopancreatography (ERCP)
  • small bowel pathology
  • video capsule endoscopy (VCE)
  • artificial intelligence (AI)

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Published Papers (1 paper)

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Review

12 pages, 1175 KB  
Review
A Conceptual Bi-Dimensional Risk Assessment Framework in Bleeding Peptic Ulcers
by Lodovica Langellotti, Flavio Tirelli, Francesca Mangiola, Valerio Pontecorvi, Rosario Landi, Elena Rodolfino, Roberto Iezzi, Helena Pelanda, Fausto Rosa and Sergio Alfieri
J. Clin. Med. 2026, 15(11), 4231; https://doi.org/10.3390/jcm15114231 - 30 May 2026
Viewed by 469
Abstract
Peptic ulcer disease remains one of the leading causes of non-variceal upper gastrointestinal bleeding. Despite advances in endoscopic therapy and pharmacological management, recurrent bleeding continues to represent a major cause of morbidity and mortality. Risk stratification is traditionally based on endoscopic stigmata according [...] Read more.
Peptic ulcer disease remains one of the leading causes of non-variceal upper gastrointestinal bleeding. Despite advances in endoscopic therapy and pharmacological management, recurrent bleeding continues to represent a major cause of morbidity and mortality. Risk stratification is traditionally based on endoscopic stigmata according to the Forrest classification; however, ulcers with similar endoscopic findings may exhibit markedly different clinical outcomes. Increasing evidence suggests that ulcer-related anatomical factors, including size, location, and depth of penetration, may influence the risk of severe or recurrent hemorrhage, particularly in cases involving adjacent arterial structures. In this conceptual, hypothesis-generating review, we propose a conceptual bi-dimensional framework integrating endoscopic and anatomical determinants of bleeding risk. This approach aims to improve patient stratification by identifying a subgroup at “very-high-risk” of recurrent bleeding, in whom standard endoscopic therapy alone may be insufficient. Although this framework is hypothesis-generating and not yet validated, it may provide a conceptual basis for future studies aimed at improving individualized management strategies, including early imaging assessment and consideration of transarterial embolization in selected high-risk patients. Full article
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