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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hip Surgery: Recent Clinical Advances
edited by Sujith Konan
submission deadline 20 Dec 2026 | 1 articles | Viewed by 675 | Submission Open
Keywords: total hip replacement; revision hip replacement; bearing surfaces; instability; dislocation; fixation of hip implants; large heads; dual mobility; aces in hip surgery
(This special issue belongs to the Section Orthopedics)
Advanced Strategy for Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome (OSAS)—Second Edition
edited by
submission deadline 20 Dec 2026 | 1 articles | Viewed by 654 | Submission Open
Keywords: obstructive sleep apnea syndrome; diagnosis; obesity; treatment; CPAP; comorbidities; cardiovascular risk
(This special issue belongs to the Section Respiratory Medicine)
Chronic Kidney Disease: Treatment, Nutritional Intervention and Renal Transplantation
edited by Hülya Taşkapan
submission deadline 20 Dec 2026 | 1 articles | Viewed by 598 | Submission Open
Keywords: chronic kidney disease; renal insufficiency; nutritional therapy; dietary intervention; CKD management; treatment strategies; nephrology; dialysis; kidney transplantation
(This special issue belongs to the Section Nephrology & Urology)
Exploring Cardiomyopathy: Comprehensive Guide to Causes, Symptoms and Care
edited by
submission deadline 20 Dec 2026 | Viewed by 580 | Submission Open
Keywords: cardiomyopathy; heart failure; genetics; hypertrophic cardiomyopathy; dilated cardiomyopathy; left ventricular noncompaction; pediatric cardiomyopathies; cardiac imaging
(This special issue belongs to the Section Cardiology)
Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: 4th Edition
edited by and Panagiota Christia
submission deadline 20 Dec 2026 | 1 articles | Viewed by 576 | Submission Open
Keywords: echocardiography; cardiovascular magnetic resonance imaging; cardiovascular computed tomography imaging; nuclear cardiology imaging; stress test with imaging; multimodality cardiovascular imaging; cardiomyopathy; coronary artery disease; microvascular disease; valvular heart disease
(This special issue belongs to the Section Cardiology)
Kidney Cancer: From Diagnostic to Therapy—2nd Edition
edited by Devin N. Patel, Ithaar H. Derweesh and
submission deadline 20 Dec 2026 | 2 articles | Viewed by 574 | Submission Open
Keywords: biomarkers; clinical practice patterns; diagnosis; kidney cancer; metastasis; renal cell carcinoma; renal mass; staging; systemic therapy; surveillance
(This special issue belongs to the Section Nephrology & Urology)
Artificial Intelligence in Craniofacial Surgery: An Emerging Challenge submission deadline 20 Dec 2026 | 1 articles | Viewed by 574 | Submission Open
Keywords: artificial intelligence; craniofacial surgery; surgical simulation; machine learning; deep learning; predictive modeling; 3D reconstruction; intraoperative guidance; patient-specific planning; clinical validation; surgical innovation; precision medicine
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Liver Failure: Current Status and Future Opportunities
edited by
submission deadline 20 Dec 2026 | Viewed by 510 | Submission Open
Keywords: acute liver failure; acute-on-chronic liver failure; portal hypertension; hepatic encephalopathy; pathogenesis; management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Vulnerability and Resilience in the Perinatal Period: Focus on Maternal and Paternal Mental Health
edited by
submission deadline 20 Dec 2026 | 1 articles | Viewed by 507 | Submission Open
Keywords: perinatal mental health; maternal mental health; paternal mental health; resilience; perinatal wellbeing; dyadic processes; parent–infant relationship; perinatal affective disorders; perinatal psychiatry
(This special issue belongs to the Section Mental Health)
Surgical Treatment of Urinary System Cancers
edited by Roderick K. Clark and Matthew G. Kaag
submission deadline 20 Dec 2026 | 1 articles | Viewed by 484 | Submission Open
Keywords: urologic oncology; multimodal cancer treatment; perioperative management; oncologic outcomes; surgical innovation; minimally invasive surgery
(This special issue belongs to the Section Nephrology & Urology)
Pulmonary Embolism and Pulmonary Hypertension: From Diagnosis to Treatment
edited by Remigiusz Kazimierczyk
submission deadline 20 Dec 2026 | 1 articles | Viewed by 467 | Submission Open
Keywords: pulmonary hypertension; pulmonary embolism; CTEPH; PET/MRI; catheter-directed therapies
(This special issue belongs to the Section Cardiology)
Surgical Management of Vascular Diseases: Challenges and Innovations in the 21st Century
edited by Reinhardt T. Grundmann
submission deadline 20 Dec 2026 | Viewed by 385 | Submission Open
Keywords: abdominal aortic aneurysm; carotid stenosis; peripheral vascular disease; endovascular therapy; open surgery; vascular disease and cancer outcomes; clinical trial; meta-analysis; surgical innovation
(This special issue belongs to the Section Cardiovascular Medicine)
The Association Between Cancer and Cardiovascular Diseases: Insights After a Quarter of the Century
edited by Tomer Ziv-Baran and Elena Izkhakov
submission deadline 20 Dec 2026 | Viewed by 379 | Submission Open
Keywords: cancer survivors; cardiovascular disease; cardio-oncology; chemotherapy; radiation therapy; immunotherapy; multidisciplinary approach
(This special issue belongs to the Section Epidemiology & Public Health)
Skin Cancer: From Diagnosis to Personalized Treatment
edited by
submission deadline 20 Dec 2026 | Viewed by 375 | Submission Open
Keywords: immunotherapy; neoadjuvant; melanoma; cutaneous sarcoma; merkel cel tumor; risk assessment; combination therapy; surgery
(This special issue belongs to the Section Dermatology)
Transcatheter Strategies for Mitral and Tricuspid Valve Treatment
edited by , Magdalena Erlebach and Marco Gennari
submission deadline 20 Dec 2026 | 1 articles | Viewed by 342 | Submission Open
Keywords: TEER; tricuspid valve; mitral valve; remodeling; durability
(This special issue belongs to the Section Cardiology)
Advances in Orthopedic Trauma Surgery: From Surgical Techniques to Patient Outcomes submission deadline 20 Dec 2026 | Viewed by 333 | Submission Open
Keywords: trauma; fractures; clinical outcome; surgical techniques; complications; innovation; patient management
(This special issue belongs to the Section Orthopedics)
Clinical Advances in Cardio-Obstetrics on Labor and Delivery
edited by Diana S. Wolfe
submission deadline 20 Dec 2026 | Viewed by 324 | Submission Open
Keywords: cardio-obstetrics; maternal medicine; high risk pregnancy; perinatology; cardiology
(This special issue belongs to the Section Obstetrics & Gynecology)
Artificial Intelligence in Orthopedics: Current Advancements and Future Perspectives
edited by Koroush Kabir
submission deadline 20 Dec 2026 | Viewed by 301 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; orthopedics; trauma surgery; spinal surgery; arthroplasty; clin-ical guidelines
(This special issue belongs to the Section Orthopedics)
Clinical Management and Advances in Hereditary Hemorrhagic Telangiectasia
edited by Hanny Al-Samkari
submission deadline 20 Dec 2026 | Viewed by 301 | Submission Open
Keywords: hereditary hemorrhagic telangiectasia; epistaxis; gastrointestinal bleeding; women’s health; arteriovenous mal-formation; AVM; anemia; iron deficiency; vasculopathy; angiogenesis; novel therapy
(This special issue belongs to the Section Hematology)
Cardiogenic Shock: Multidisciplinary Approaches in Acute Cardiac Care submission deadline 20 Dec 2026 | Viewed by 291 | Submission Open
Keywords: cardiogenic shock; acute cardiac care; emergency department; intensive care unit; acute coronary syndromes; shock team; mechanical circulatory support; ECMO; hemodynamic monitoring
(This special issue belongs to the Section Emergency Medicine)
Current Treatments for Mitral Valve Regurgitation and Aortic Valve Stenosis submission deadline 20 Dec 2026 | Viewed by 271 | Submission Open
Keywords: mitral and aortic valve disease; transcatheter valve intervention; cardiac surgery; minimally invasive cardiac surgery; valve disease management
(This special issue belongs to the Section Cardiology)
Transdiagnostic Insights to Eating Disorders: Bridging Cognitive Processes and Clinical Outcomes
edited by and Patrizia Todisco
submission deadline 20 Dec 2026 | Viewed by 268 | Submission Open
Keywords: eating disorders; cognitive processes; emotional regulation; social cognition; neurocognitive functioning; interoception; body representation; clinical outcomes; psychopathology
(This special issue belongs to the Section Mental Health)
Recent Advances in Inflammatory and Infectious Skin Diseases (Third Edition) submission deadline 20 Dec 2026 | Viewed by 249 | Submission Open
Keywords: atopic dermatitis; eczematous diseases; inflammatory skin diseases; chronic skin diseases; human herpesvirus; roseola syphilitica; psoriasis; bacterial infections and mycoses; sexually transmitted diseases, bacterial; sexually transmitted diseases, viral; Papillomavirus infections
(This special issue belongs to the Section Dermatology)
Advancing Autism Care: Early Diagnosis and Care Pathways for Autistic Children
edited by Laura Maria Fatta
submission deadline 20 Dec 2026 | Viewed by 221 | Submission Open
Keywords: early diagnosis; developmental outcomes; integrated care pathways; real-world clinical care; care coordination; evidence-based interventions; family support systems
(This special issue belongs to the Section Mental Health)
Transforming the Diagnosis and Management of Retinal Diseases: Integrating Imaging, Modeling, and Digital Innovation submission deadline 20 Dec 2026 | Viewed by 209 | Submission Open
Keywords: retinal diseases; choroidal diseases; multimodal imaging; optical coherence tomography; OCT angiography; adaptive optics; artificial intelligence; imaging biomarkers; predictive modelling; precision medicine; digital ophthalmology; clinical management
(This special issue belongs to the Section Ophthalmology)
Clinical Updates in Treating Orthopaedic Deformities of the Foot submission deadline 20 Dec 2026 | Viewed by 202 | Submission Open
Keywords: foot deformity; hallux valgus; progressive collapsing foot deformities; ankle arthroplasty; minimally invasive surgery; diabetic foot; trauma; reconstructive surgery; clinical outcomes
(This special issue belongs to the Section Orthopedics)
Shoulder and Elbow Surgery: Clinical Updates and Digital Transformation submission deadline 20 Dec 2026 | Viewed by 200 | Submission Open
Keywords: shoulder surgery; elbow surgery; digitalization; patient pathway; clinical decision support systems; artificial intelligence; machine learning; radiological imaging; 3D planning; navigation; robotics; augmented reality; PROMs; wearables; big data; registries; outcome prediction; digital twins; large language models (LLMs); digital health; personalized medicine
(This special issue belongs to the Section Orthopedics)
Modern Diagnosis and Management of Coronary Artery Disease
edited by
submission deadline 20 Dec 2026 | Viewed by 195 | Submission Open
Keywords: coronary artery disease; myocardial revascularization; percutaneous coronary intervention; cardiac surgery; coronary artery bypass graft; intravascular ultrasound; fractional flow reserve; instantaneous wave-free ratio; angiogenesis
(This special issue belongs to the Section Cardiology)
Rethinking Renal Pathways: Recent Advances in Diagnosis, Vascular Access, and Targeted Therapy in Chronic Kidney Disease (CKD)
edited by Alina Ramona Potra, Ina Maria Kacsò and
submission deadline 20 Dec 2026 | Viewed by 190 | Submission Open
Keywords: chronic kidney disease; biomarkers in kidney disease; precision nephrology; artificial intelligence in nephrology; vascular access for dialysis; targeted therapies in CKD; malnutrition and protein-energy wasting in CKD; renal fibrosis and disease progression; translational nephrology research
(This special issue belongs to the Section Nephrology & Urology)
Atrial Fibrillation Rhythm Management: Outcomes, Innovations, and Future Directions: 2nd Edition
edited by Roberto Scacciavillani and Gemma Pelargonio
submission deadline 20 Dec 2026 | Viewed by 187 | Submission Open
Keywords: atrial fibrillation; catheter ablation; radiofrequency; cryoablation; pulsed field ablation; cardioneuroablation; left bundle branch area pacing
(This special issue belongs to the Section Cardiology)
Thoracic Organ Transplantation: From Diagnosis to Long-Term Outcomes
edited by Sławomir Zeglen
submission deadline 20 Dec 2026 | Viewed by 187 | Submission Open
Keywords: lung transplantation; heart transplantation; thoracic organ transplantation; transplantation candidate evaluation; transplant out-comes; immunosuppressive therapy; graft dysfunction; chronic lung allograft dysfunction (CLAD); artificial intelligence in preopera-tive medicine; physical activity in transplant candidates and recipients
(This special issue belongs to the Section General Surgery)
Sexually Transmitted Infections as a Challenge of Modern Society: Old Problems and Modern Solutions—2nd Edition
edited by Mauro Zaccarelli and
submission deadline 20 Dec 2026 | Viewed by 180 | Submission Open
Keywords: sexually transmitted infections (STIs); human papilloma virus (HPV); syphilis; gonorrhea; chlamydia trachomatis; HIV infection; PrEP; chemsex; doxycicline prophylaxis; gonococcal resistance
(This special issue belongs to the Section Infectious Diseases)
Cutting-Edge Advances in Valvular Heart Diseases: Novel Repair & Replacement Strategies submission deadline 20 Dec 2026 | Viewed by 173 | Submission Open
Keywords: valvular heart disease; echocardiography; transcatheter edge-to-edge repair; transcatheter aortic valve implantation; transcatheter mitral valve replacement; transcatheter tricuspid valve replacement; artificial intelligence; cardiac imaging; valvular heart surgery
(This special issue belongs to the Section Cardiology)
Innovative Therapeutic Strategies for Retinal Diseases
edited by Akihiro Ohira
submission deadline 20 Dec 2026 | Viewed by 172 | Submission Open
Keywords: retinal diseases; innovative therapies; clinical research; drug delivery; imaging biomarkers; real-world evidence; clinical application
(This special issue belongs to the Section Ophthalmology)
Laser Techniques in Prostate Treatment Innovations
edited by Matteo Vittori and Valerio Iacovelli
submission deadline 20 Dec 2026 | Viewed by 169 | Submission Open
Keywords: benign prostatic obstruction; laser prostate surgery; endoscopic enucleation; minimally invasive urology; surgical innovation
(This special issue belongs to the Section Nephrology & Urology)
Clinical Challenges in Abdominal Infections Management: Dynamic Source Control and Adaptive Antibiotic Therapy submission deadline 20 Dec 2026 | Viewed by 165 | Submission Open
Keywords: abdominal infections; source control failure; re-operation; antibiotic de-escalation; short-course antibiotic therapy; procalcitonin; multidrug-resistant organisms; enterococci; candida; empirical therapy
(This special issue belongs to the Section Infectious Diseases)
Hearing Rehabilitation Through Implantable Devices and Cochlear Implants
edited by Mario Sanna
submission deadline 20 Dec 2026 | Viewed by 148 | Submission Open
Keywords: cochlear implant; implantable devices; hearing rehabilitation; otoneurosurgery; middle ear surgery; otoneurological rehabilitation; schwannoma; cochlear ossification; difficult cases
(This special issue belongs to the Section Otolaryngology)
Prostate Cancer: Clinical Progress, Challenges and Opportunities
edited by Giulio Francesco Reale, and
submission deadline 20 Dec 2026 | Viewed by 133 | Submission Open
Keywords: prostate cancer; robotic surgery; Fusion Biopsy; PET-PSMA; radical prostatectomy; nerve sparing surgery; artificial intelligence
(This special issue belongs to the Section Nephrology & Urology)
Robotic Surgery in Urology: Current Advances and Future Perspectives
edited by
submission deadline 22 Dec 2026 | 1 articles | Viewed by 748 | Submission Open
Keywords: augmented reality; augmented sensations; artificial intelligence; single-port; reconstructive surgery; oncological surgery; image-guided surgery
(This special issue belongs to the Section Nephrology & Urology)
Biostatistics in Real-World Clinical Research: From Big Data to Clinical Decision-Making
edited by and Chul-Ho Oak
submission deadline 22 Dec 2026 | Viewed by 223 | Submission Open
Keywords: clinical biostatistics; epidemiology; real-world data; population-based cohort; survival analysis; clinical prediction models; prognostic modeling; risk stratification; translational clinical research; quantitative clinical data analysis
(This special issue belongs to the Section Clinical Research Methods)
Managements of Venous Thromboembolism submission deadline 24 Dec 2026 | 6 articles | Viewed by 8338 | Submission Open
Keywords: venous thromboembolism; deep vein thrombosis; pulmonary embolism; anticoagulation therapy; direct oral anticoagulants; risk stratification; bleeding risk; artificial intelligence; personalized medicine
(This special issue belongs to the Section Vascular Medicine)
Recent Research Progress in Pediatric Orthopedic Surgery
edited by and Madeleine Willegger
submission deadline 25 Dec 2026 | 7 articles | Viewed by 17209 | Submission Open
Keywords: pediatric orthopedics; deformity correction; pediatric hip; pediatric trauma; basic research in pediatric orthopedics; clubfoot; pediatric foot and ankle deformities; pediatric hand
(This special issue belongs to the Section Clinical Pediatrics)
Oral and Maxillofacial Surgery: Current Advances and Future Directions
edited by Iwona Niedzielska
submission deadline 25 Dec 2026 | 5 articles | Viewed by 15122 | Submission Open
Keywords: oral and maxillofacial surgery; reconstructive surgery; periodontitis; dental implants; maxillofacial deformities
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Interstitial Lung Diseases: New Treatments and Future Directions
edited by Justyna Fijołek
submission deadline 25 Dec 2026 | 3 articles | Viewed by 11743 | Submission Open
Keywords: Interstitial Lung Disease (ILD); pulmonary fibrosis; orphan lung disease; AAV-ILD; occupational ILD; rheumatic lung disease; treatment strategies; emerging therapies; precision medicine; future directions
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Radiation Therapy for Cancers submission deadline 25 Dec 2026 | 7 articles | Viewed by 9946 | Submission Open
Keywords: radiation oncology; radiotherapy; cancer radiotherapy; cancer radiation therapy; radiobiology; predictive and prognostic biomarkers; cancer treatment; heavy ions radiation oncology; protontherapy; cancer biolology
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Anesthesia and Intensive Care in Orthopedic and Trauma Surgery
edited by Liliana Mirea, Răzvan Ene and Cristian Cobilinschi
submission deadline 25 Dec 2026 | 2 articles | Viewed by 8166 | Submission Open
Keywords: opioid sparing analgetic technique; pain management; perioperative medicine; perioperative cognitive disfunction; delirium
(This special issue belongs to the Section Intensive Care)
New Insights into Skin Tumors: From Pathogenesis to Therapy
edited by Loredana Ungureanu and Simona C. Şenilǎ
submission deadline 25 Dec 2026 | 4 articles | Viewed by 7660 | Submission Open
Keywords: skin tumors; pathogenesis; diagnosis; personalized medicine; therapeutic strategies; dermato-oncology
(This special issue belongs to the Section Dermatology)
Advances and Innovations in Hand Surgery
edited by , Jason Wink and Anthony Archual
submission deadline 25 Dec 2026 | 5 articles | Viewed by 5612 | Submission Open
Keywords: hand surgery; peripheral nerve surgery; shared decision making; microsurgery; arthritis; compression neuropathy; carpal tunnel; cubital tunnel
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Advances in Diagnostic and Surgical Treatment in Lung Cancer and Related Pulmonary Disorders
edited by Natalia Motas and Veronica Manolache
submission deadline 25 Dec 2026 | 3 articles | Viewed by 4096 | Submission Open
Keywords: lung cancer; minimally invasive thoracic surgery (MITS); video-assisted thoracoscopic surgery (VATS); robot-assisted thoracic surgery (RATS); interventional pneumology; bronchoscopy; endobronchial ultrasound (EBUS); artificial intelligence (AI); lung nodule
(This special issue belongs to the Section Respiratory Medicine)
Current and Emerging Treatment Options in Colorectal Cancer
edited by Michael Osseis
submission deadline 25 Dec 2026 | 3 articles | Viewed by 3725 | Submission Open
Keywords: colorectal cancer (CRC); emerging treatment options; targeted therapies; new surgical technologies; precision medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
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