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Advanced Strategy for Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome (OSAS)—Second Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".

Deadline for manuscript submissions: 20 December 2026 | Viewed by 519

Editor


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Guest Editor
Institute of Internal Medicine “A. Murri”, Department of Precision and Regenerative Medicine and Ionian Area, Università Degli studi di Bari Aldo Moro, Bari, Italy
Interests: obstructive sleep apnea (OSA); respiratory diseases; COPD; noninvasive ventilation; pulmonary fibrosis; lung function; smoking; pollution
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Special Issue Information

Dear Colleagues,

Following the success of our inaugural Special Issue, “Advanced Strategy for Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome (OSAS)” (https://www.mdpi.com/journal/jcm/special_issues/W32CO47RI3), we are pleased to announce the launch of “Advanced Strategy for Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome (OSAS)—Second Edition”.

Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by the collapse of the pharynx during sleep, as well as recurrent episodes of upper airway obstruction during sleep, leading to intermittent hypoxia and sleep fragmentation. Partial arousals occur frequently throughout sleep, resulting in relative sleep deprivation and daytime fatigue. If left untreated, OSAS can have significant adverse effects on an individual's health and quality of life. Therefore, it has been increasingly recognized as a major health issue.

For this Special Issue, entitled “Advanced Strategy for Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome (OSAS)—Second Edition”, we continue to welcome contributions on the topic of OSAS. We invite original research papers based on original data, as well as review articles. All manuscripts will be subjected to a standard peer review process, in line with the journal’s procedures and policies.

We warmly welcome your submissions!

Dr. Pierluigi Carratù
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obstructive sleep apnea syndrome
  • diagnosis
  • obesity
  • treatment
  • CPAP
  • comorbidities
  • cardiovascular risk

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Published Papers (1 paper)

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Research

17 pages, 1591 KB  
Article
Reduced Serum Pannexin-1 Levels in Obstructive Sleep Apnea and Their Association with Nocturnal Hypoxemic Burden
by Esma Tuğba Canlı, Önder Öztürk, Hilal Türkmen Kaya, Fevziye Burcu Şirin, Doğukan Gümüşcan, Tutku Aydın and Adnan Karaibrahimoğlu
J. Clin. Med. 2026, 15(11), 4299; https://doi.org/10.3390/jcm15114299 - 2 Jun 2026
Viewed by 345
Abstract
Background: Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder characterized by recurrent episodes of intermittent hypoxia and systemic inflammation. Pannexin-1 (Panx1) is a transmembrane channel involved in ATP release and purinergic signaling and has been implicated in hypoxia-related inflammatory responses. [...] Read more.
Background: Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder characterized by recurrent episodes of intermittent hypoxia and systemic inflammation. Pannexin-1 (Panx1) is a transmembrane channel involved in ATP release and purinergic signaling and has been implicated in hypoxia-related inflammatory responses. However, the clinical relevance of circulating Panx1 levels in patients with OSA remains poorly understood. This study aimed to evaluate serum Panx1 concentrations in patients with OSA and to investigate their association with nocturnal hypoxemic burden. Methods: In this cross-sectional study, 40 patients with obstructive sleep apnea (OSA) and 40 control subjects underwent overnight polysomnography for diagnostic evaluation. Serum Panx1 concentrations were measured using an enzyme-linked immunosorbent assay (ELISA). Logistic regression models were constructed to evaluate the association between Panx1 and OSA status while adjusting for clinical covariates. In addition, a propensity score–matched sensitivity analysis based on age, sex, and body mass index was performed to further assess potential confounding. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic performance of Panx1 alone and in combination with clinical variables. Results: Serum Panx1 levels were significantly lower in patients with OSA than in controls (4.27 ± 2.66 vs. 6.24 ± 4.75 ng/mL, p = 0.013). Although Panx1 was not an independent predictor of OSA after adjustment for age, sex, and body mass index, its integration with clinical variables significantly improved diagnostic discrimination. The area under the receiver operating characteristic curve increased from 0.662 for Panx1 alone to 0.858 in the fully adjusted model. Sensitivity analyses attenuated the observed association after matching for major baseline characteristics, suggesting a potential contribution of demographic and anthropometric factors. In addition, Panx1 concentrations were inversely correlated with markers of nocturnal hypoxemic burden, particularly the cumulative time spent with oxygen saturation below 90% (T90). Conclusions: Lower serum Panx1 concentrations were associated with OSA status and nocturnal hypoxemic burden. While Panx1 alone demonstrated modest discriminatory ability, its integration with established clinical factors improved diagnostic performance. These findings suggest that Panx1 may represent a biologically plausible adjunct biomarker reflecting hypoxic burden and may contribute to multi-parameter approaches for OSA risk assessment; however, further validation in larger matched cohorts is warranted. Full article
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