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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Optimizing Outcomes in Pancreato-Biliary Care: Integrating Technology, Technique, and Personalized Approaches
edited by
submission deadline 20 Mar 2027 | Viewed by 326 | Submission Open
Keywords: pancreato-biliary care; pancreatic diseases; biliary diseases; hepato-pancreato-biliary (HPB) surgery; interventional endoscopy; interventional radiology; minimally invasive surgery; EUS-guided procedures; ERCP; personalized care/personalized medicine; multidisciplinary care; clinical outcomes; robotics and AI in PB care
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Gastrointestinal Surgery: New Insights into Tumor Metabolism and Translational Oncology
edited by Konstantinos Romanidis
submission deadline 20 Mar 2027 | 1 articles | Viewed by 274 | Submission Open
Keywords: gastrointestinal cancer; tumor metabolism; translational oncology; surgical oncology; metabolic profiling; artificial intelligence
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Contactless Magnetocardiography and Related Novel Methods for Non-Invasive Experimental and Clinical Functional Imaging of Normal and Abnormal Cardiac Electrophysiology submission deadline 20 Mar 2027 | Viewed by 267 | Submission Open
Keywords: magnetocardiography; non-invasive functional imaging of cardiac electrophysiology; arrhythmogenic mechanisms; atrial fibrillation; magnetoionography; antiarrhythmic drugs; artificial intelligence
(This special issue belongs to the Section Cardiology)
Head and Neck Surgery: Immunotherapy’s Role in Shaping Treatment Paradigms
edited by
submission deadline 20 Mar 2027 | Viewed by 260 | Submission Open
Keywords: head and neck surgery; otorhinolaryngology; ENT; transoral surgery; laryngeal surgery; laryngeal carcinoma; sinonasal surgery; oral cancer; oropharyngeal cancer; laryngectomy; immunotherapy; head and neck cancer; cutaneous cancer
(This special issue belongs to the Section Otolaryngology)
Game-Changing Advances in Minimally Invasive Spine Surgery
edited by Rouzbeh Motiei-Langroudi
submission deadline 20 Mar 2027 | Viewed by 258 | Submission Open
Keywords: minimally invasive spine surgery (MISS); technological innovation; navigation systems/robotic-assisted; endoscopic techniques; artificial intelligence/machine learning
(This special issue belongs to the Section Clinical Neurology)
Advances in Mental Health: All Ages and Multidisciplinary Clinical Perspectives
edited by Clara González-Sanguino and
submission deadline 20 Mar 2027 | Viewed by 201 | Submission Open
Keywords: stigma; discrimination; mental health; clinical psychology; depression and anxiety
(This special issue belongs to the Section Mental Health)
Clinical Physical Therapy: Current Advances and Future Challenges submission deadline 20 Mar 2027 | Viewed by 163 | Submission Open
Keywords: clinical physical therapy; chronic musculoskeletal disorders; chronic pain management; manual therapy; mind–body medicine; biopsychosocial model; autoimmune diseases; fatigue syndromes; bottom-up and top-down regulation; neurophysiological mechanisms
(This special issue belongs to the Section Clinical Rehabilitation)
Psychosis Across Disciplines: Emerging Perspectives in Neuroscience, Psychiatry, and Therapy
edited by Inmaculada Peñuelas-Calvo, Roberto Rodríguez-Jiménez and
submission deadline 20 Mar 2027 | Viewed by 155 | Submission Open
Keywords: psychosis; lifespan; neuroimaging; psychotherapy; prevention
(This special issue belongs to the Section Mental Health)
Advancing Precision Care in Neuropathic Pain: From Biomarkers to Neuromodulation to Artificial Intelligence
edited by Saurabh Kataria and
submission deadline 20 Mar 2027 | Viewed by 152 | Submission Open
Keywords: neuropathic pain; precision medicine; neuromodulation; spinal cord stimulation; peripheral nerve stimulation; ul-trasound-guided interventions; pain phenotyping; personalized therapeutics; opioid alternatives
(This special issue belongs to the Section Clinical Neurology)
Therapies for Heart Failure: Clinical Updates and Perspectives: 2nd Edition
edited by Cristina Tudoran, Stela Iurciuc and
submission deadline 20 Mar 2027 | Viewed by 148 | Submission Open
Keywords: mechanisms of heart failure; new therapies for heart failure; chronic and acute heart failure; new approaches to managing heart failure patients; special populations; clinical outcome
(This special issue belongs to the Section Cardiology)
Clinical Updates in Type 2 Diabetes and Related Complications
edited by
submission deadline 20 Mar 2027 | Viewed by 147 | Submission Open
Keywords: type 2 diabetes; chronic complications; microvascular disease; macrovascular disease; treatment
(This special issue belongs to the Section Endocrinology & Metabolism)
Clinical Challenges and Advances in Hepatobiliary and Pancreatic Surgery submission deadline 20 Mar 2027 | Viewed by 142 | Submission Open
Keywords: pancreatic cancer; pancreatic cancer surgery; neoadjuvant chemotherapy; perioperative management; surgical approaches
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Recent Advances in Clinical Perspectives on the Diagnosis and Treatment of Endometriosis
edited by Paweł Basta and
submission deadline 20 Mar 2027 | Viewed by 141 | Submission Open
Keywords: endometriosis; deep endometriosis; endometrioma; infertility; laparoscopy; minimally invasive techniques; biomarkers; pain; pelvic pain; adenomyosis; adhesions; dysmenorrhea; dyspareunia
(This special issue belongs to the Section Obstetrics & Gynecology)
The State of the Art in Robotic Thoracic Surgery: Innovation, Complexity and Outcomes
edited by Michael Zervos
submission deadline 20 Mar 2027 | Viewed by 137 | Submission Open
Keywords: thoracic surgery; robotic surgery; single-port robotic surgery; robotic-assisted thoracic surgery; minimally invasive surgery; lung cancer
(This special issue belongs to the Section General Surgery)
Developmental Transfusion Biology in Neonatal–Perinatal Medicine
edited by Thomas G. Brune
submission deadline 20 Mar 2027 | Viewed by 104 | Submission Open
Keywords: neonatal transfusion; preterm infants; fetal hemoglobin; cord blood; delayed cord clamping; oxygen transport; developmental hematology
(This special issue belongs to the Section Clinical Pediatrics)
Dentistry and Oral Surgery: Current Status and Future Prospects, 2nd Edition submission deadline 20 Mar 2027 | Viewed by 88 | Submission Open
Keywords: dentistry; oral surgery; dental implantology; prosthodontics; restorative dentistry; periodontology; digital dentistry; computer-guided surgery; artificial intelligence
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Neuro-Oncology: Diagnostics and Treatment
edited by and Derek A. Wainwright
submission deadline 20 Mar 2027 | Viewed by 83 | Submission Open
Keywords: glioblastoma; glioma; meningioma; brain metastases; blood–brain barrier
(This special issue belongs to the Section Clinical Neurology)
Diagnostic and Interventional Radiology: Advances in Treatment of Small Tumors
edited by Carolina Lanza
submission deadline 20 Mar 2027 | Viewed by 72 | Submission Open
Keywords: interventional radiology; MRI; contrast-enhanced ultrasound; CT; liver; kidney; lung; prostate; breast; multimodal imaging; diagnostic imaging; tumor
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Sarcopenia: Prevention and Treatment Options
edited by Steven Phu
submission deadline 21 Mar 2027 | 3 articles | Viewed by 1739 | Submission Open
Keywords: sarcopenia; skeletal muscle; ageing; falls; frailty; exercise; rehabilitation; nutrition
(This special issue belongs to the Section Geriatric Medicine)
Clinical Research on Robot-Assisted Thoracic Surgery and Lung Surgery
edited by Marco Scarci
submission deadline 21 Mar 2027 | 1 articles | Viewed by 935 | Submission Open
Keywords: robot-assisted thoracic surgery; robotic lung surgery; minimally invasive surgery; lobectomy; segmentectomy; thoracic oncology; surgical outcomes; learning curve; clinical research; robotic technology
(This special issue belongs to the Section General Surgery)
Macular Diseases: From Diagnosis to Treatment
edited by
submission deadline 22 Mar 2027 | 3 articles | Viewed by 2862 | Submission Open
Keywords: age-related macular degeneration; retinal vascular diseases; intraocular tumours; retinal imaging; OCT; OCT angiography; anti-VEGF; laser therapy; macular surgery; gene therapy; biomarkers; progression; intravitreal injections; biomarkers
(This special issue belongs to the Section Ophthalmology)
Psychological Affliction in Pregnancy, Delivery and Postpartum Period: A Multidisciplinary Approach submission deadline 24 Mar 2027 | 4 articles | Viewed by 2800 | Submission Open
Keywords: maternal mental health; pregnancy; postpartum depression; perinatal anxiety; midwifery; multidisciplinary care
(This special issue belongs to the Section Mental Health)
Rewriting Metastatic Colorectal Cancer Management: Innovative Frontiers in Clinical Diagnosis and Personalized Oncology submission deadline 24 Mar 2027 | Viewed by 396 | Submission Open
Keywords: molecular profiling; liquid biopsy; targeted therapy; immunotherapy; biomarkers treatment; sequencing; tumor heterogeneity; personalized medicine
(This special issue belongs to the Section Oncology)
Emergency Surgery: Clinical Updates and Key Insights
edited by
submission deadline 24 Mar 2027 | Viewed by 129 | Submission Open
Keywords: minimally invasive emergency surgery; biomarkers; point-of-care imaging (POCI); frailty assessment; surgical decision-making; risk stratification; damage control surgery; enhanced recovery (ERAS); patient outcomes; multidisciplinary care
(This special issue belongs to the Section Emergency Medicine)
Obstructive Sleep Apnea: Advances in Clinical Diagnosis and Management
edited by
submission deadline 25 Mar 2027 | 7 articles | Viewed by 7809 | Submission Open
Keywords: obstructive sleep apnea; sleep disorder breathing; central apnea; apnea–hypopnea index; precision medicine
(This special issue belongs to the Section Respiratory Medicine)
Thoracic Surgery: Updates and New Trends
edited by
submission deadline 25 Mar 2027 | 5 articles | Viewed by 7398 | Submission Open
Keywords: minimally invasive surgery; new technology; diagnosis; bronchoscopy; robotic system; artificial intelligence
(This special issue belongs to the Section Respiratory Medicine)
Update on Acute Severe Respiratory Infections: 2nd Edition submission deadline 25 Mar 2027 | 6 articles | Viewed by 6201 | Submission Open
Keywords: acute severe respiratory infection (ASRI); acute respiratory distress syndrome (ARDS); severe pneumonia; sepsis; ICU; viral respiratory infection; COVID-19; bacterial co-infection; diagnostic technology; treatment strategy; mechanical ventilation; extracorporeal membrane oxygenation (ECMO); antibiotics; non-antibiotics; pulmonary rehabilitation
(This special issue belongs to the Section Respiratory Medicine)
Sleep Disorders: Current Research and Future Directions—Second Edition
edited by Martina Vendrame
submission deadline 25 Mar 2027 | 6 articles | Viewed by 5568 | Submission Open
Keywords: obstructive sleep apnea; parasomnia; idiopathic hypersomnia; periodic limb movement disorder; periodic limb move-ment of sleep
(This special issue belongs to the Section Clinical Neurology)
Aortic Diseases: Modern Strategies in Diagnosis, Management, and Prevention of Complications
edited by , Tilo Kölbel and José Ignacio F. Torrealba
submission deadline 25 Mar 2027 | 7 articles | Viewed by 4850 | Submission Open
Keywords: aortic aneurysm; aortic dissection; genetic aortic disease; acute aortic syndromes; endovascular repair; complica-tions; outcomes
(This special issue belongs to the Section Vascular Medicine)
Clinical Advances in Prenatal Diagnosis and Fetal Therapy
edited by
submission deadline 25 Mar 2027 | 3 articles | Viewed by 4121 | Submission Open
Keywords: prenatal diagnosis; fetal therapy; genetic screening; non-invasive testing; fetal surgery; imaging technologies; high-risk pregnancies; in utero treatments; stem cell therapies; clinical innovations
(This special issue belongs to the Section Obstetrics & Gynecology)
Applications of Artificial Intelligence and Digital Therapeutics in Clinical Medicine: 2nd Edition
edited by
submission deadline 25 Mar 2027 | 3 articles | Viewed by 4109 | Submission Open
Keywords: artificial intelligence; biometric sensors; deep learning; digital therapies; Internet of Things; machine learning; virtual reality; augmented reality
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Obesity in the 2020s and Beyond: A Multidisciplinary Overview
edited by
submission deadline 25 Mar 2027 | 2 articles | Viewed by 3556 | Submission Open
Keywords: obesity; anti-obesity pharmacotherapy; clinical pharmacology; pharmacovigilance; cardiometabolic diseases
(This special issue belongs to the Section Pharmacology)
Endoscopic Management of Pancreaticobiliary Diseases
edited by
submission deadline 25 Mar 2027 | 4 articles | Viewed by 2989 | Submission Open
Keywords: pancreaticobiliary endoscopy; endoscopic ultrasound (EUS); endoscopic retrograde cholangiopancreatography (ERCP); biliary drainage; gallbladder drainage; lumen-opposing metal stents; cholangioscopy; pancreatoscopy; confocal laser endomicroscopy; pancreatic cysts; molecular diagnostics; lithotripsy (electrohydraulic and laser); radiofrequency ablation (RFA); photodynamic therapy (PDT); pancreatic and biliary tumors; interventional endoscopy; altered anatomy access; diagnostic and therapeutic endoscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Strategies for Preventing Healthcare-Associated Infections submission deadline 25 Mar 2027 | 3 articles | Viewed by 2886 | Submission Open
Keywords: healthcare-associated infections; multidrug resistance; prevention; screening scales; polymicrobial infections; oppor-tunistic infections; sepsis
(This special issue belongs to the Section Infectious Diseases)
New Advances in Hip and Knee Reconstructive Surgery: 2nd Edition
edited by Senthil Sambandam
submission deadline 25 Mar 2027 | 2 articles | Viewed by 1846 | Submission Open
Keywords: knee; hip; joint arthroplasty; minimally invasive surgery; revision arthroplasty; periprosthetic joint infection; muscle injury; joint alignment; surgical advances; osteotomy; fracture; robotic-assisted surgery; perioperative optimization; telerehabilitation; aseptic loosening
(This special issue belongs to the Section Orthopedics)
Segmentectomy and Lobectomy in Early-Stage Lung Cancer Management
edited by Yujin Kudo
submission deadline 25 Mar 2027 | 1 articles | Viewed by 1214 | Submission Open
Keywords: lung cancer; segmentectomy; lobectomy; thoracic surgery; early-stage NSCLC; oncologic outcomes; pulmonary function; surgical planning
(This special issue belongs to the Section Respiratory Medicine)
Exercise for Healthy Aging: Clinical Physiology, Functional Outcomes, and Implications for Clinical Practice submission deadline 25 Mar 2027 | 1 articles | Viewed by 993 | Submission Open
Keywords: exercise; healthy aging; functional independence; mitochondrial adaptations; physical activity interventions; neuromuscular function; cardiorespiratory fitness; metabolic health; biomarkers of aging
(This special issue belongs to the Section Sports Medicine)
Innovations in Elbow and Shoulder Surgery: Techniques, Outcomes, and Rehabilitation
edited by Andrea Celli
submission deadline 25 Mar 2027 | Viewed by 458 | Submission Open
Keywords: orthopedic; elbow surgery; shoulder surgery; infection; nonunion; malunion; ligaments injuries; tendon injuries; el-bow and shoulder replacement; arthroscopy
(This special issue belongs to the Section Orthopedics)
Integrated Assessment and Management of Heart Failure Syndromes
edited by Damiano Magrì and Emiliano Fiori
submission deadline 25 Mar 2027 | Viewed by 324 | Submission Open
Keywords: heart failure; functional capacity; multimodality assessment; advanced imaging; coronary and structural interventions; device therapies
(This special issue belongs to the Section Cardiology)
Advances in Cardiac Electrophysiology: Mechanisms of Arrhythmias and Ablation Technologies
edited by , Valeria Rella and Emanuele Curti
submission deadline 25 Mar 2027 | Viewed by 214 | Submission Open
Keywords: cardiac arrhythmias; cardiac electrophysiology; arrhythmias pathophysiology; arrhythmia mechanisms; catheter ablation; electro-anatomical mapping; mapping techniques; pacing maneuvers; pulsed field ablation; radiofrequency; autonomic modulation; cardioneuroablation; imaging; hybrid ablation; clinical outcomes
(This special issue belongs to the Section Cardiology)
Minimally Invasive Approaches in Hand Surgery: Optimizing Outcomes and Minimizing Complications
edited by
submission deadline 25 Mar 2027 | Viewed by 174 | Submission Open
Keywords: percutaneous technique; ultrasound-guided procedures; arthroscopic management; robotic surgery in the hand and upper extremity; hand surgery
(This special issue belongs to the Section Orthopedics)
Advanced and Personalized Drug Delivery Systems: From Formulation Science to Clinical Application
edited by
submission deadline 25 Mar 2027 | Viewed by 166 | Submission Open
Keywords: drug delivery systems; nanoparticles; lipid-based carriers; transdermal delivery; controlled release; bioavailability; pharmaceutical nanotechnology; personalized medicine; polymeric carriers; targeted therapy; in vitro–in vivo cor-relation; pharmaceutical compounding; stimuli-responsive drug delivery; clinical pharmacokinetics; innovative dosage forms
(This special issue belongs to the Section Pharmacology)
Insights into Infectious Disease Epidemiology, Management and Impact on Public Health
edited by Krystyna Dobrowolska, and
submission deadline 25 Mar 2027 | Viewed by 146 | Submission Open
Keywords: infectious disease; viral infections; bacterial infections; epidemiology; public health
(This special issue belongs to the Section Epidemiology & Public Health)
Current Updates and Advances in Hemodialysis—2nd Edition
edited by Edita Žiginskienė
submission deadline 25 Mar 2027 | Viewed by 106 | Submission Open
Keywords: kidney replacement therapy; hemodialysis; hemodiafiltration; vascular access; dialysis membranes; dialysis complications; dialysis adequacy; outcomes
(This special issue belongs to the Section Nephrology & Urology)
Robotic Pancreatic Surgery: Innovation, Outcomes, and Future Directions
edited by , Dimitrios Dimitroulis and
submission deadline 25 Mar 2027 | Viewed by 81 | Submission Open
Keywords: robotic surgery; pancreatic surgery; Whipple; distal pancreatectomy; spleen preserving; pylorus preserving; pan-creaticoduodenectomy; enucleation; POPF; delayed gastric emptying
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Hypertrophic Cardiomyopathy: Diagnosis and Management
edited by Muhammad Fuad Jan and Abdul Jamil Tajik
submission deadline 25 Mar 2027 | Viewed by 37 | Submission Open
Keywords: hypertrophic cardiomyopathy; genetics; heart failure; sudden death; echocardiography
(This special issue belongs to the Section Cardiology)
Retinal Diseases: Innovations in Diagnosis, Imaging, and Treatment
edited by and Hakan Kaymak
submission deadline 25 Mar 2027 | Viewed by 5 | Submission Open
Keywords: retinal diseases; biomarkers; spectral-domain optical coherence tomography; vitreoretinal surgery; retinal laser therapy
(This special issue belongs to the Section Ophthalmology)
The Future Direction of Medical Imaging in Hepato-Bilio-Pancreatic Oncology: Challenges and Opportunities
edited by
submission deadline 26 Mar 2027 | 2 articles | Viewed by 2146 | Submission Open
Keywords: MRI; CT; molecular imaging; radiomics; imaging; radiogenomics; precision medicine; outcome prediction; cholangiocarcinoma; pancreatic cancer; imaging biomarkers; treatment response
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Pulmonary Hypertension: Clinical Perspectives
edited by and Maria Wieteska-Miłek
submission deadline 27 Mar 2027 | Viewed by 228 | Submission Open
Keywords: pulmonary hypertension (PH); pulmonary arterial hypertension (PAH); chronic thromboembolic pulmonary hypertension (CTEPH); chronic thromboembolic pulmonary disease; pulmonary embolism; diagnosis; treatment; quality of life; physical activity; prognostic factors; nonpharmacological treatment
(This special issue belongs to the Section Respiratory Medicine)
Neuromuscular Diseases and Musculoskeletal Disorders
edited by
submission deadline 28 Mar 2027 | 5 articles | Viewed by 7864 | Submission Open
Keywords: neuromuscular diseases; osteoporosis; fractures; muscle weakness; muscle intolerance; shoulder dysfunction; myopathy; physiotherapy; rehabilitation
(This special issue belongs to the Section Clinical Neurology)
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