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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Placental Dysfunction and Cardiovascular Maternal Risk-Timing Assessment and Postpartum Challenges
edited by , Anca Huniadi and
submission deadline 8 Dec 2026 | Viewed by 327 | Submission Open
Keywords: cardiovascular risk; pre-eclampsia; fetal growth restriction; placental dysfunction; cardiac function; biomarkers
(This special issue belongs to the Section Obstetrics & Gynecology)
The Role of Cardiac Rehabilitation After Myocardial Infarction, Coronary Artery Bypass Surgery, and in Other Cardiac Diseases
edited by
submission deadline 10 Dec 2026 | 4 articles | Viewed by 13833 | Submission Open
Keywords: cardiac rehabilitation; coronary artery disease; myocardial infarction; coronary artery bypass surgery; heart failure; ventricular assist device; heart transplantation; cardiomyopathies; cardiac remodeling; illness perception; treatment adherence; gender difference; biomarkers; endothelial function
(This special issue belongs to the Section Cardiology)
Regional Anesthesia and Pain Management: Mastering Clinical Art for Optimal Patient Satisfaction
edited by
submission deadline 10 Dec 2026 | 8 articles | Viewed by 12010 | Submission Open
Keywords: regional anesthesia; pain management; ultrasound-guided nerve blocks; fascial plane blocks; multimodal analgesia; postoperative analgesia; chronic pain management; opioid-sparing strategies; non-opioid analgesics; patient satisfaction; anesthesia techniques; perioperative care; pain interventions; nerve block techniques; clinical outcomes
(This special issue belongs to the Section Anesthesiology)
Obstructive Sleep Apnea: Advances and Challenges in Diagnosis, Phenotyping, and Clinical Impact
edited by , Muna Irfan and Andrew Namen
submission deadline 10 Dec 2026 | 3 articles | Viewed by 4849 | Submission Open
Keywords: obstructive sleep apnea; sleep diagnostics; screening tools; pulse oximetry; polysomnography; home sleep apnea testing; diagnostic accuracy; phenotyping; cardiometabolic comorbidity; neuropsychiatric outcomes; sleep -disordered breathing; real-world implementation
(This special issue belongs to the Section Respiratory Medicine)
New Clinical Advances in Pediatric Asthma
edited by
submission deadline 10 Dec 2026 | 4 articles | Viewed by 4848 | Submission Open
Keywords: pediatric asthma; clinical management; treatment advances; diagnostic advances; biologic therapy; inhaled steroids; control of asthma; exacerbation prevention; quality of life
(This special issue belongs to the Section Clinical Pediatrics)
Prevention and Management of Sexual Dysfunction submission deadline 10 Dec 2026 | 3 articles | Viewed by 3282 | Submission Open
Keywords: sexual health; sexual dysfunction; reproductive health; general sexuology; sexological care
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Translational Immunology in Clinical Medicine: From Preclinical Insights to Therapeutic Impact
edited by
submission deadline 10 Dec 2026 | 2 articles | Viewed by 2526 | Submission Open
Keywords: translational immunology; autoimmune disease; autoinflammatory disease; immune-mediated diseases; oncology; preclinical models; immune efficacy and safety; mechanism of action; immunotoxicity assessment
(This special issue belongs to the Section Immunology & Rheumatology)
Breaking Barriers in Respiratory Conditions: From Clinical Pathophysiology to Treatment Across the Spectrum of Severity
edited by
submission deadline 10 Dec 2026 | 1 articles | Viewed by 1319 | Submission Open
Keywords: pulmonary rehabilitation; skeletal muscle; exercise physiology; exercise intolerance; physical activity; respiratory conditions
(This special issue belongs to the Section Respiratory Medicine)
Clinical Rehabilitation and Management of Chronic Musculoskeletal Pain Conditions
edited by
submission deadline 10 Dec 2026 | 2 articles | Viewed by 921 | Submission Open
Keywords: reproducibility of results; rehabilitation; physical therapy; artificial intelligence; machine learning; musculoskeletal system; treatment outcome
(This special issue belongs to the Section Clinical Rehabilitation)
The Current Trend in the Management of Bruxism and Temporomandibular Disorders, 2nd Edition submission deadline 10 Dec 2026 | 1 articles | Viewed by 742 | Submission Open
Keywords: bruxism; temporomandibular disorders (TMDs); dental health; treatment modalities; diagnosis; clinical interventions
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advances in Cosmetic Dermatology: From Health to Aesthetics and Restoring Confidence
edited by
submission deadline 10 Dec 2026 | 1 articles | Viewed by 697 | Submission Open
Keywords: aesthetic dermatology; cosmetic dermatology; energy-based devices; dermal fillers; botulinum toxin; biostimulators; skin rejuvenation; regenerative medicine; scar treatment; hair disorders; pigmentary disorders
(This special issue belongs to the Section Dermatology)
Cesarean Section Versus Vaginal Delivery submission deadline 10 Dec 2026 | Viewed by 577 | Submission Open
Keywords: cesarean section; vaginal delivery; birth outcomes; birth complications; delivery mode; labor process; obstetric care; trial of labor after cesarean (TOLAC); intrapartum care; obstetric decision-making
(This special issue belongs to the Section Obstetrics & Gynecology)
Contemporary Advances in Esophageal and Upper Gastrointestinal Surgery
edited by and Carlo Castoro
submission deadline 10 Dec 2026 | Viewed by 569 | Submission Open
Keywords: esophageal surgery; gastric surgery; upper gastrointestinal cancer; minimally invasive surgery; robotic surgery; artificial intelligence; radiomics; neoadjuvant therapy; surgical quality assessment; fluorescence-guided surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Optimizing Management of Advanced Ovarian Cancer: From Cytoreduction to Targeted Treatment
edited by Dimitrios Zouzoulas and Dimitrios Tsolakidis
submission deadline 10 Dec 2026 | Viewed by 215 | Submission Open
Keywords: ovarian cancer; cytoreduction; HIPEC; targeted therapies; post-operative complications
(This special issue belongs to the Section Obstetrics & Gynecology)
Hospital-Acquired Infections: Epidemiology, Prevention, Treatment, and Organizational and Clinical Challenges
edited by and Jarosław Drobnik
submission deadline 10 Dec 2026 | Viewed by 143 | Submission Open
Keywords: hospital-acquired infections; healthcare-associated infections; nosocomial infections; epidemiology; infection prevention and control; antimicrobial resistance; antimicrobial stewardship; patient safety
(This special issue belongs to the Section Epidemiology & Public Health)
Updates in Gynecologic Surgery
edited by and Giulio Sozzi
submission deadline 13 Dec 2026 | Viewed by 249 | Submission Open
Keywords: gynecologic surgery; minimally invasive surgery (MIS); robotic-assisted surgery; vNOTES; endometriosis; pelvic organ prolapses
(This special issue belongs to the Section Obstetrics & Gynecology)
Diagnosis and Treatment Strategies for Endometriosis: Evidence and Practice
edited by and Carlo Alviggi
submission deadline 14 Dec 2026 | Viewed by 170 | Submission Open
Keywords: endometriosis; ultrasound; fertility preservation; ovarian stimulation; cryopreservation
(This special issue belongs to the Section Obstetrics & Gynecology)
Current Trends and Future Prospects in Autoantibodies in Liver Diseases
edited by Takashi Himoto
submission deadline 15 Dec 2026 | 3 articles | Viewed by 10501 | Submission Open
Keywords: liver-specific autoantibodies; non-organ-specific autoantibodies; autoimmune liver disease; diagnosis; disease activity; treatment outcome; prognosis; virus-induced autoimmunity; drug-induced autoimmunity
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Root Canal Treatment and Healing Outcomes: Clinical Application of Endodontic Biomaterials and Postoperative Management submission deadline 15 Dec 2026 | 5 articles | Viewed by 4915 | Submission Open
Keywords: root canal treatment; healing outcomes; endodontic biomaterials; bioceramic sealers; postoperative management; clinical evidence; periapical healing; post operative pain; dentistry
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Advances in Cancer Imaging submission deadline 15 Dec 2026 | 3 articles | Viewed by 3482 | Submission Open
Keywords: pelvic oncology; cancer imaging; CT; MRI; tumor staging; treatment response; morphological criteria; gynecologic cancer; bladder cancer; rectal cancer; artificial intelligence; radiomics; texture analysis; image biomarkers; clinical imaging
(This special issue belongs to the Section Oncology)
Interventional Cardiology: Recent Developments and Future Challenges
edited by and George Kassimis
submission deadline 15 Dec 2026 | 3 articles | Viewed by 3419 | Submission Open
Keywords: percutaneous coronary intervention (PCI); drug-eluting stents (DES); high risk percutaneous coronary intervention (CHIP); chronic total occlusions (CTO); intravascular imaging (IVUS, OCT); coronary physiology (FFR, iFR); antiplatelet therapy; complex coronary interventions; mechanical circulatory support (MCS)
(This special issue belongs to the Section Cardiology)
Surgical Treatment for Lung Cancer—2nd Edition
edited by , Cezary Piwkowski and Marek Ochman
submission deadline 15 Dec 2026 | 1 articles | Viewed by 847 | Submission Open
Keywords: lung cancer; surgery; minimally invasive surgery; immunotherapy; enhanced recovery after surgery; segmentectomy
(This special issue belongs to the Section Respiratory Medicine)
Integrating Mental Health Into Chronic Illness Care: Interdisciplinary Clinical Strategies submission deadline 15 Dec 2026 | 1 articles | Viewed by 564 | Submission Open
Keywords: clinical psychology; psychosomatic medicine; assessment; chronic illness; mental health; patient-centred care
(This special issue belongs to the Section Mental Health)
Clinical Outcomes and Emerging Strategies in Neovascualr Age-Related Macular Degeneration submission deadline 15 Dec 2026 | Viewed by 511 | Submission Open
Keywords: neovascular age-related macular degeneration; exudative retinal disease; anti-VEGF therapy; tyrosine kinase inhibitors; angiopoietin/Tie-2 modulation; gene therapy; sustained-release platforms; complement pathway inhibition; real-world clinical outcomes
(This special issue belongs to the Section Ophthalmology)
Beyond Survival: Precision, Innovation, and Lifelong Care in Congenital Heart Disease
edited by
submission deadline 15 Dec 2026 | 1 articles | Viewed by 433 | Submission Open
Keywords: congenital heart disease; adult congenital heart disease; lifespan care; precision medicine; advanced cardiac imaging; transcatheter interventions; neurodevelopmental outcomes; arrhythmia management; digital health and artificial intelligence
(This special issue belongs to the Section Cardiology)
Inherited Cardiac Disorders in Pediatrics: Present Challenges and Future Innovations
edited by Sara Moscatelli, and
submission deadline 15 Dec 2026 | Viewed by 245 | Submission Open
Keywords: paediatric cardiomyopathy; inherited cardiac diseases; cardiomyopathies; cardiovascular genetics; arthropathies; channelopathies
(This special issue belongs to the Section Cardiology)
Coronary CT Angiography, Cardiac MRI and PET/CT Scan: Advancing Cardiac Imaging and Clinical Decision Making in Cardiomyopathies submission deadline 15 Dec 2026 | Viewed by 245 | Submission Open
Keywords: coronary CT angiography; cardiac magnetic resonance imaging; cardiac positron emission tomography; cardiac imaging; cardiomyopathies; cardiac amyloidosis; cardiac sarcoidosis; hypertrophic cardiomyopathy; dilated cardiomyopathy; non-dilated left ventricular cardiomyopathy; arrhythmogenic right ventricular cardiomyopathy; restrictive cardiomyopathy; risk stratification; clinical decision making; artificial intelligence; radiomics
(This special issue belongs to the Section Cardiology)
Self-Injurious Thoughts and Behaviors: Risk, Mechanisms, and Clinical Intervention
edited by
submission deadline 15 Dec 2026 | Viewed by 242 | Submission Open
Keywords: self-injurious thoughts and behaviors; suicide; suicidal ideation; suicide attempts; non-suicidal self-injury; NSSI; self-harm; emotion dysregulation; trauma; risk factors; resilience; prevention; clinical intervention; adolescents; young adults
(This special issue belongs to the Section Mental Health)
Clinical Advances in Cardiac Arrhythmias and Electrophysiology
edited by Giovanni Volpato and
submission deadline 15 Dec 2026 | Viewed by 211 | Submission Open
Keywords: atrial fibrillation; conduction system pacing; ablation; ventricular tachycardia; electroanatomical mapping; endomyocardial biopsy
(This special issue belongs to the Section Cardiology)
Advances in Monitoring and Optimization of Non-Invasive Respiratory Support in Acute and Chronic Respiratory Failure
edited by and Teresa Renda
submission deadline 15 Dec 2026 | Viewed by 192 | Submission Open
Keywords: acute and chronic respiratory failure; acute hypoxemic respiratory failure (AHRF); acute respiratory distress syndrome (ARDS); respiratory monitoring; respiratory drive; inspiratory effort; non-invasive ventilation (NIV); high-flow nasal cannula (HFNC); home ventilation; telemonitoring
(This special issue belongs to the Section Respiratory Medicine)
Gynecologic Oncology: Current Therapies and New Frontiers
edited by Laura Paleari and Mariangela Rutigliani
submission deadline 18 Dec 2026 | 2 articles | Viewed by 1845 | Submission Open
Keywords: ovarian cancers; gynecological cancer; drug delivery; AI; screening; new therapies
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Advances in Rhinitis and Sinusitis: Diagnosis, Therapy and Multimorbidity Management
edited by , and Veronica Seccia
submission deadline 18 Dec 2026 | 2 articles | Viewed by 1485 | Submission Open
Keywords: allergy; asthma; biologics; chronic rhinosinusitis; chronic rhinosinusitis with nasal polyps; endoscopic sinus surgery; NSAID-ERD; olfaction; personalized treatment; precision medicine; quality of life; respiratory disease; rhinitis; sinusitis; type-2 inflammation
(This special issue belongs to the Section Otolaryngology)
Evidence-Based Diagnosis and Clinical Management of Low Back Pain submission deadline 20 Dec 2026 | 7 articles | Viewed by 14702 | Submission Open
Keywords: low back pain; classification systems; risk stratification; health services research; management strategies; timing and sequencing; prognosis; predictor; clinical decision making; primary care
(This special issue belongs to the Section Clinical Rehabilitation)
Advances in Clinical Approaches to Breast Cancer Diagnosis and Treatment
edited by
submission deadline 20 Dec 2026 | 12 articles | Viewed by 13924 | Submission Open
Keywords: breast cancer; diagnosis; precision medicine; molecular profiling; targeted therapy; breast-conserving surgery; minimally invasive techniques; artificial intelligence; personalized medicine; radiation therapy
(This special issue belongs to the Section Oncology)
Scoliosis: Advances in Diagnosis and Management
edited by Michal Latalski
submission deadline 20 Dec 2026 | 8 articles | Viewed by 13910 | Submission Open
Keywords: scoliosis; adolescent idiopathic scoliosis; adult scoliosis; congenital scoliosis; neuromuscular scoliosis; diagnosis; imaging; treatment; surgery; bracing; rehabilitation; patient-reported outcomes; quality of life
(This special issue belongs to the Section Orthopedics)
Autoimmune Diseases and Multisystem Inflammation: Pathophysiology and Therapeutic Strategies
edited by
submission deadline 20 Dec 2026 | 2 articles | Viewed by 10050 | Submission Open
Keywords: autoimmune diseases; cardiovascular diseases; cutaneous diseases; gastrointestinal diseases; pulmonary diseases; renal diseases; systemic manifestation; rheumatoid arthritis; systemic lupus erythematosus; vasculitis
(This special issue belongs to the Section Immunology & Rheumatology)
Imaging and Molecular Biomarkers: The New Approach to Degenerative Retinal Diseases submission deadline 20 Dec 2026 | 7 articles | Viewed by 9848 | Submission Open
Keywords: ophthalmology; degenerative retinal diseases; imaging biomarkers; multimodal imaging; OCT; OCT angiography; molecular biomarkers; precision medicine; translational ophthalmic research
(This special issue belongs to the Section Ophthalmology)
Spine Surgery: Current Practice and Future Directions
edited by Claudio Bernucci and Francesco Costa
submission deadline 20 Dec 2026 | 4 articles | Viewed by 9741 | Submission Open
Keywords: degenerative; spinal trauma; spine tumors; neurosurgery; spine surgery; spinal deformity; scoliosis; robotics surgery; spinal cord injury; clinical practices; regenerative therapies
(This special issue belongs to the Section Clinical Neurology)
Imaging and Surgery in Endometriosis—Recent Advances submission deadline 20 Dec 2026 | 3 articles | Viewed by 9499 | Submission Open
Keywords: robotic-assisted surgery; MR imaging; radiomics; transvaginal ultrasound; deep endometriosis; ovarian endometriosis; fluorescence-guided surgery; artificial intelligence; adhesions in endometriosis; infertility; classification systems
(This special issue belongs to the Section Obstetrics & Gynecology)
Updates on the Clinical Applications of Dental Restorative Materials
edited by
submission deadline 20 Dec 2026 | 5 articles | Viewed by 7295 | Submission Open
Keywords: restorative dentistry; restorations; adhesive dentistry; resin composites; ceramics; aesthetics; dental materials; direct restorations; indirect restorations; conservative dentistry; prosthetic dentistry; partial restorations; total restorations
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Heart Failure Management Innovations, Evidence, and the Patient Perspective submission deadline 20 Dec 2026 | 12 articles | Viewed by 6810 | Submission Open
Keywords: Pharmacological advances across HFrEF, HFmrEF, and HFpEF;; SGLT2 inhibitors and emerging drug classes;; Devices, resynchronization therapy, and mechanical circulatory support;; Digital health, telemedicine, and remote monitoring;; AI and machine learning in HF diagnosis and prognosis;; Biomarkers and imaging for risk stratification;; Multidisciplinary and integrated care models;; HF in special populations;; Acute decompensated HF management;; Cardiac rehabilitation and exercise interventions.
(This special issue belongs to the Section Cardiology)
Advances in Clinical Rheumatology—2nd Edition
edited by
submission deadline 20 Dec 2026 | 5 articles | Viewed by 6062 | Submission Open
Keywords: rheumatoid arthritis; spondylarthritis; interventional; osteoporosis; complex regional pain syndrome
(This special issue belongs to the Section Immunology & Rheumatology)
Physiotherapy in Clinical Practice: From Assessment to Rehabilitation submission deadline 20 Dec 2026 | 6 articles | Viewed by 5569 | Submission Open
Keywords: clinical assessment; rehabilitation; clinical practice; patient-centered care; physiotherapy innovation
(This special issue belongs to the Section Clinical Rehabilitation)
Advances and Innovations in Reconstructive Microsurgery: Techniques, Outcomes, and Future Directions
edited by Youn Hwan Kim
submission deadline 20 Dec 2026 | 8 articles | Viewed by 5154 | Submission Open
Keywords: microsurgery; free flap; perforator flap; supermicrosurgery; reconstructive surgery; lymphatic surgery; chimeric flap; flow-through flap; surgical innovation; functional outcomes
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Current Perspectives and Innovations in Urogynecology
edited by
submission deadline 20 Dec 2026 | 3 articles | Viewed by 4908 | Submission Open
Keywords: urogynecology; pelvic organ prolapse; urinary incontinence; overactive bladder; pelvic floor surgery; reconstructive surgery; minimally invasive surgery; pelvic floor disorders; innovative surgical techniques; quality of life
(This special issue belongs to the Section Obstetrics & Gynecology)
Acute Endocarditis: Clinical Advances in Diagnosis, Treatment, and Management
edited by
submission deadline 20 Dec 2026 | 2 articles | Viewed by 4718 | Submission Open
Keywords: acute endocarditis; disease natural history; surgical treatment; postoperative outcome; long term follow up
(This special issue belongs to the Section Cardiology)
New Perspectives in Maternal–Fetal Medicine
edited by Catalina de Paco-Matallana
submission deadline 20 Dec 2026 | 2 articles | Viewed by 4671 | Submission Open
Keywords: maternal–fetal medicine; prenatal diagnostics; fetal therapy; precision medicine; neonatal outcomes; maternal health
(This special issue belongs to the Section Obstetrics & Gynecology)
State of the Art in Cardiac Surgery: Progress, Challenges and Opportunities
edited by Tomasz Plonek and Sleiman Sebastian Aboul-Hassan
submission deadline 20 Dec 2026 | 3 articles | Viewed by 4416 | Submission Open
Keywords: aorta ascendens; minimally invasive surgery; aortic arch surgery; off pump coronary surgery; arterial grafts
(This special issue belongs to the Section Cardiology)
Diagnosis and Treatment of Connective Tissue Diseases: A Clinician's Perspective: 2nd Edition
edited by , and Aleksandra Dańczak-Pazdrowska
submission deadline 20 Dec 2026 | 3 articles | Viewed by 4259 | Submission Open
Keywords: connective tissue diseases; lupus erythematosus; scleroderma; dermatomyositis; MCTD; clinical picture; spectrum of clinical symptoms; treatment; complications; clinical follow-up
(This special issue belongs to the Section Immunology & Rheumatology)
Oral and Maxillofacial Surgery: Clinical Progress, Challenges and Opportunities
edited by Janet Hayes Southerland and Leslie Robin Halpern
submission deadline 20 Dec 2026 | 4 articles | Viewed by 4215 | Submission Open
Keywords: OMFS; surgery; research; innovation; interdisciplinary; cosmetic; pharmacology; cancer; repair; nerve; TMJ; rehabilitation; orthognathic; disorder; bleeding
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
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