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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cardiovascular Disease in the Elderly: Cardiogeriatric Assessment, Prevention, Treatment Outcomes and Perspectives

edited by Georgia Vamvakou

submission deadline 20 Jun 2026 | Viewed by 73 | Submission Open

Keywords: cardiovascular diseases; elderly patients; cardiogeriatric assessment; diagnosis and therapeutic planning; healthy aging; digital medicine

(This special issue belongs to the Section Cardiovascular Medicine)

Aortic Valve Replacement: Current Trends, Future Perspectives, and Emerging Technologies

edited by

Jorge Nuche

submission deadline 20 Jun 2026 | Viewed by 72 | Submission Open

Keywords: aortic valve; heart valve prosthesis; transcatheter aortic valve replacement; surgical aortic valve replacement; aortic valve insufficiency; minimally invasive surgical procedures; treatment outcome; vulnerable populations

(This special issue belongs to the Section Cardiology)

Current and Emerging Management Strategies in Gynecologic Oncology

edited by Grzegorz Szewczyk

submission deadline 20 Jun 2026 | Viewed by 72 | Submission Open

Keywords: gynecologic oncology; surgical approach; molecular diagnostics; novel therapies; rare gynecological cancers; risk factors

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Rhinosinusitis and Nasal Polyposis: From Emerging Trends and Therapeutic Opportunities to Surgery

edited by Gian Luca Fadda, Giovanni Cavallo and

Giuseppe Guida

submission deadline 20 Jun 2026 | Viewed by 71 | Submission Open

Keywords: nasal polyps; chronic rhinosinusitis; asthma; endoscopic sinus surgery; anatomical variation; biologic treatment; type-2 inflammation; paranasal sinuses; CRSwNP; late response; long term; remission; dupilumab; control

(This special issue belongs to the Section Otolaryngology)

Stroke Care: From Acute Interventions to Long-Term Recovery

edited by

Aikaterini Theodorou

and

Georgios Tsivgoulis

submission deadline 20 Jun 2026 | Viewed by 67 | Submission Open

Keywords: cerebrovascular diseases; acute ischemic stroke; intravenous thrombolysis; endovascular thrombectomy; intracerebral hemorrhage; etiology; cerebral amyloid angiopathy; stroke rehabilitation

(This special issue belongs to the Section Clinical Neurology)

Recent Progress in Anterior Cruciate Ligament Injury and Reconstruction

edited by Patrick Weninger

submission deadline 20 Jun 2026 | Viewed by 67 | Submission Open

Keywords: anterior cruciate ligament; ACL reconstruction; ACL repair; ACL preservation; orthobiologics; stem cells; rehabilitation

(This special issue belongs to the Section Sports Medicine)

Clinical Advancements in Anesthesia and Pain Management

edited by Brittany L. Willer and Vidya T. Raman

submission deadline 20 Jun 2026 | Viewed by 67 | Submission Open

Keywords: perioperative innovation; regional and multimodal analgesia; translational anesthesiology; artificial intelligence in anesthesia; patient-centered pain management

(This special issue belongs to the Section Anesthesiology)

New Concepts in the Diagnosis and Treatment of Orthopedic Diseases in Children—2nd Edition

edited by

Sergio De Salvatore

and

Laura Ruzzini

submission deadline 20 Jun 2026 | Viewed by 67 | Submission Open

Keywords: pediatric orthopedics; flatfoot; genu valgum; genu varum; hip dysplasia; clubfoot; early onset scoliosis; Scheuermann disease; perthes; epiphysiolysis; scoliosis; pediatric trauma

(This special issue belongs to the Section Clinical Pediatrics)

Assisted Knee Arthroplasty: From Preoperative Planning to Postoperative Outcomes

edited by

Luigi Zanna

and Matteo Innocenti

submission deadline 20 Jun 2026 | Viewed by 66 | Submission Open

Keywords: assisted knee arthroplasty; robotic-assisted surgery; computer navigation; preoperative planning; patient-specific alignment; minimally invasive surgery; digital health technologies

(This special issue belongs to the Section Orthopedics)

Endoscopic Management of Pancreaticobiliary Disease: Updates and Future Directions

edited by

Keisuke Iwata

submission deadline 20 Jun 2026 | Viewed by 65 | Submission Open

Keywords: pancreaticobiliary disease; ERCP; interventional EUS; tissue acquisition; early detection of pancreaticobiliary malignancy; management of AEs

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Rehabilitation Strategies and Exercise for Stroke Recovery

edited by

Dimitrios I. Tsiptsios

submission deadline 20 Jun 2026 | Viewed by 65 | Submission Open

Keywords: stroke; stroke rehabilitation; exercise; biomarkers; rehabilitation outcomes

(This special issue belongs to the Section Clinical Rehabilitation)

Current and Emerging Treatment Options in Pancreatic Cancer

edited by Venkata C.K. Sunkesula

submission deadline 20 Jun 2026 | Viewed by 63 | Submission Open

Keywords: pancreas surgery; pancreatic cystic lesions; chronic pancreatitis; pancreatic cancer; EUS-guided; fine-needle ablation; endoscopic radiofrequency ablation; minimal invasive surgery; pancreatic intraepithelial neoplasia

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Research Advances in Gynecologic Oncology

edited by

Maciej Skrzypczak

submission deadline 20 Jun 2026 | Viewed by 63 | Submission Open

Keywords: ovarian cancer; endometrial cancer; breast cancer; molecular biology; gynecological cancers

(This special issue belongs to the Section Oncology)

Focus on Multiple Myeloma: Diagnosis, Therapy and Clinical Outcome

edited by

Martina Kleber

submission deadline 20 Jun 2026 | Viewed by 63 | Submission Open

Keywords: multiple myeloma; novel therapies; treatment approach; prognosis; clinical outcome

(This special issue belongs to the Section Hematology)

The Changing Landscape of Biliary Cancers

edited by Arvind Arora

submission deadline 20 Jun 2026 | Viewed by 62 | Submission Open

Keywords: biliary tract cancer; cholangiocarcinoma; gallbladder cancer; precision oncology; molecular profiling; immunotherapy; targeted therapy; clinical trials; multidisciplinary care; early detection; global oncology

(This special issue belongs to the Section Oncology)

Hematoinflammatory Diseases: Bridging Autoimmunity and Autoinflammation

edited by Andrés González García and

José Hernández-Rodríguez

submission deadline 20 Jun 2026 | Viewed by 58 | Submission Open

Keywords: hematoinflammatory diseases; clonal hematopoiesis; vexas syndrome; castleman disease; Igg4-related disease; cytokine storm; autoinflammatory syndromes; immunopathogenesis; targeted therapies; biomarkers

(This special issue belongs to the Section Immunology & Rheumatology)

Cardiotoxicity Within Cardio-Oncology: Clinical Advances from Prediction to Management

edited by

Massimiliano Camilli

submission deadline 20 Jun 2026 | Viewed by 58 | Submission Open

Keywords: cardio-oncology; cardiotoxicity; cancer therapy– related cardiac dysfunction; heart failure in cancer patients; biomarkers; multimodality imaging; risk stratification; cardioprotection; cancer survivors' care; multidisciplinary approach

(This special issue belongs to the Section Cardiology)

Clinical Advances in Endocarditis: From Diagnosis to Treatment

edited by Ram Sharony and Katia Orvin

submission deadline 20 Jun 2026 | Viewed by 53 | Submission Open

Keywords: endocarditis; infective endocarditis; prosthetic valve endocarditis; TAVR endocarditis; advanced cardiac imaging

(This special issue belongs to the Section Cardiology)

Clinical Frontiers in Myocardial Infarction: From Acute Revascularization to Long-Term Secondary Prevention

edited by

Nikolaos Stalikas

submission deadline 20 Jun 2026 | Viewed by 52 | Submission Open

Keywords: complete revascularization; myocardial infarction; vulnerable plaque; imaging guided PCI; biomarkers; secondary prevention; microvascular disease; endothelial dysfunction

(This special issue belongs to the Section Cardiology)

Atrial Fibrillation and Its Complications: Preventive Strategies and Relative Evidence—2nd Edition

edited by Roberto Galea

submission deadline 20 Jun 2026 | Viewed by 52 | Submission Open

Keywords: atrial fibrillation; catheter ablation; oral anticoagulation; left atrial appendage closure; stroke prevent

(This special issue belongs to the Section Cardiology)

Advances in the Field of Cariology

edited by

Aline de Castilho

and

Frank Lippert

submission deadline 20 Jun 2026 | Viewed by 49 | Submission Open

Keywords: dental caries; caries diagnosis; caries risk assessment; minimally invasive dentistry; preventive strategies

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances and Future Challenges for Occupational Health

edited by

Gabriele D’Ettorre

and Vincenza Pellicani

submission deadline 20 Jun 2026 | Viewed by 47 | Submission Open

Keywords: work-related disease; precision medicine; gender differences; aging workforce; preventive strategies

(This special issue belongs to the Section Epidemiology & Public Health)

Advances in Peripheral Vascular Disease: Diagnosis, Management and Surgical Interventions

edited by Nikolaos Zacharias

submission deadline 20 Jun 2026 | Viewed by 47 | Submission Open

Keywords: atherosclerosis; peripheral artery disease; claudication; critical limb threatening ischemia; infrainguinal bypass; femoral stenting

(This special issue belongs to the Section Vascular Medicine)

Innovative Interventional Approaches in the Treatment of Cardiac Arrhythmias

edited by Karolina Weinmann-Emhardt and Jonas Wormann

submission deadline 20 Jun 2026 | Viewed by 45 | Submission Open

Keywords: cardiac electrophysiology; catheter ablation; atrial fibrillation; ventricular tachycardia; pulmonary vein isolation; three-dimensional mapping; pulsed field ablation; radiofrequency ablation; clinical perspectives

(This special issue belongs to the Section Cardiovascular Medicine)

Arterial Stiffness and Cardiovascular Risk: New Advances and Challenges

edited by

Andrea Grillo

submission deadline 20 Jun 2026 | Viewed by 42 | Submission Open

Keywords: arterial stiffness; vascular aging; anti-inflammation; cardiovascular risk; personalized medicine

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Management of Vitreous and Retinal Disorders

edited by Samuel Asanad

submission deadline 20 Jun 2026 | Viewed by 41 | Submission Open

Keywords: OCT; OCTA; AMD; neurodegenerative disease; surgical techniques; retinal detachment; retinal blood flow; retinal biomarkers; gene therapy

(This special issue belongs to the Section Ophthalmology)

Towards a Better Understanding of Neuroinflammation in Mental Health

edited by Jesus Cobo

submission deadline 20 Jun 2026 | Viewed by 40 | Submission Open

Keywords: neuroinflammation; biomarkers; peripheral biomarkers; outcomes; bipolar disorders; major depression; mental health; schizophrenia; blood-based inflammatory index; lymphocyte subpopulation

(This special issue belongs to the Section Mental Health)

Cancer Stem Cells and Cellular Therapies in Cancer: Advances and Clinical Prospects

edited by Agnieszka Rybarczyk and Piotr Wierzbicki

submission deadline 20 Jun 2026 | Viewed by 39 | Submission Open

Keywords: cancer stem cells; cell based therapies; innovative therapies in cancer; tumor microenvironment; cell based therapies; preclinical models; immune-based therapies; treatment resistance

(This special issue belongs to the Section Oncology)

Endovascular Stroke Treatment: Latest Advances and Challenges

edited by Daniele Giuseppe Romano and Giulia Frauenfelder

submission deadline 20 Jun 2026 | Viewed by 34 | Submission Open

Keywords: EVT (endovascular stroke treatment); thromboaspiration; thrombectomy; tandem lesion; rescue stenting; ICAD

(This special issue belongs to the Section Clinical Neurology)

Current Challenges and Innovations in the Treatment of Pancreatitis

edited by Nirav Thosani and Vaibhav Wadhwa

submission deadline 20 Jun 2026 | Viewed by 28 | Submission Open

Keywords: pancreatitis; acute; chronic; biomarkers; endoscopic therapy; minimally invasive interventions; fibrosis; AI modeling

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Insights into Transcatheter Mitral Valve Therapy

edited by Antonio Sisinni and

Rodrigo Estévez-Loureiro

submission deadline 20 Jun 2026 | Viewed by 27 | Submission Open

Keywords: mitral regurgitation; transcatheter mitral valve therapy; TEER; TMVR; MitraClip; pascal; valve-in-valve; multimodality imaging; outcomes; structural heart interventions

(This special issue belongs to the Section Cardiovascular Medicine)

Current Practices and Future Challenges in Organ Transplantation

edited by

Al-Faraaz Kassam

and Mackenzie Morris

submission deadline 20 Jun 2026 | Viewed by 26 | Submission Open

Keywords: liver transplantation; kidney transplantation; pancreas transplantation; xenotransplantation; immunosuppression; robotic surgery; disparities; machine perfusion; organ preservation; organ allocation

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Current Concepts and Emerging Treatments in Allergic Rhinitis

edited by

Young Joon Jun

submission deadline 20 Jun 2026 | Viewed by 18 | Submission Open

Keywords: rhinitis; allergic; molecular targeted therapy; cryotherapy; treatment outcome

(This special issue belongs to the Section Otolaryngology)

Oral Surgery: Recent Advances and Future Perspectives

edited by

Carlo Barausse

and

Gerardo Pellegrino

submission deadline 22 Jun 2026 | 1 articles | Viewed by 4328 | Submission Open

Keywords: oral surgery; implant dentistry; atrophic jaws; bone regeneration; digital dentistry

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Ablation, Embolization, and Stenting: Current Trends in Interventional Radiology

edited by Praveen Peddu

submission deadline 22 Jun 2026 | 1 articles | Viewed by 900 | Submission Open

Keywords: interventional radiology; ablation; embolization; stenting; minimally invasive therapy

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Clinical Advances and New Perspectives in the Diagnosis and Treatment of Schizophrenia

edited by Pierre S. Chue and Oloruntoba J. Oluboka

submission deadline 22 Jun 2026 | Viewed by 50 | Submission Open

Keywords: psychopharmacology; schizophrenia; long-acting injectable therapy; recovery; team approach to care; integrated care; clozapine; habilitation; rehabilitation; early intervention

(This special issue belongs to the Section Mental Health)

Clinical Insights and Challenges into Cognitive and Mental Health in Older Adults

edited by Dariusz Krok

submission deadline 23 Jun 2026 | 1 articles | Viewed by 78 | Submission Open

Keywords: clinical insights; cognitive and mental health; older adults; psychosomatic interventions; person-centered care

(This special issue belongs to the Section Mental Health)

Headache: Updates on the Assessment, Diagnosis and Treatment

edited by

Ernesto Anarte-Lazo

and

Carlos Bernal-Utrera

submission deadline 25 Jun 2026 | 7 articles | Viewed by 13614 | Submission Open

Keywords: headache; migraine; tension-type headache; cervicogenic headache; therapeutic exercise

(This special issue belongs to the Section Clinical Neurology)

Advancements in Emergency Medicine Practices and Protocols

edited by Vincenzo G. Menditto and Beatrice Gasperini

submission deadline 25 Jun 2026 | 4 articles | Viewed by 4776 | Submission Open

Keywords: emergency; pulmonary embolism; trauma; management; guidelines; frailty; emergency department observation unit

(This special issue belongs to the Section Emergency Medicine)

Advances in Gastroenterology and Hepatology: Bridging Basic Science, Clinical Insights, and Translational Medicine

edited by

Abdulrahman Ismaiel

and

Ștefan Lucian Popa

submission deadline 25 Jun 2026 | 2 articles | Viewed by 3072 | Submission Open

Keywords: hepatology; gastroenterology; IBD; IBS; MASLD; liver cirrhosis; artificial intelligence; disorders of gut– brain interaction; cancer; gut microbiota; diagnosis; management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Aspects of Cardiac Arrhythmias and Arrhythmogenic Disorders

edited by

Piotr Bienias

and Jakub Baran

submission deadline 25 Jun 2026 | 3 articles | Viewed by 2360 | Submission Open

Keywords: non-invasive arrhythmia assessment; electrocardiography; invasive arrhythmia assessment; invasive electrophysiology; catheter ablation; implantable devices; rare diseases and arrhythmias; arrhythmia risk stratification; genetics aspects of arrhythmogenesis; channelopathy

(This special issue belongs to the Section Cardiology)

Joint Repair and Replacement: Current Challenges and Opportunities

edited by Bartosz Gonera and Kacper Ruzik

submission deadline 25 Jun 2026 | 1 articles | Viewed by 1012 | Submission Open

Keywords: orthopedic biomechanics; knee injuries; joint replacement; anterior cruciate ligament; arthroscopy; sports medicine; prosthetic implants

(This special issue belongs to the Section Orthopedics)

Advanced Image-Enhanced Endoscopy and Colonoscopy

edited by

Giuseppinella Melita

Marcello F. Maida

and Simona Di Caro

submission deadline 25 Jun 2026 | Viewed by 175 | Submission Open

Keywords: gastrointestinal endoscopy; colorectal cancer; endoscopic screening; artificial intelligence; chromoendoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Myocardial Infarction: Clinical Management and Future Options

edited by

Kenichi Sakakura

submission deadline 25 Jun 2026 | Viewed by 174 | Submission Open

Keywords: myocardial infarction; percutaneous coronary intervention; optimal medical therapy; clinical outcomes; cardiogenic shock; mechanical cardiac support device

(This special issue belongs to the Section Cardiology)

Clinical Advances of Aesthetic Plastic Surgery and Aesthetic Medicine

edited by Valentina Pinto and Rosalba Russo

submission deadline 25 Jun 2026 | Viewed by 157 | Submission Open

Keywords: aesthetic plastic surgery; aesthetic medicine; emerging technologies and devices in aesthetics; regenerative medicine and surgery; vulvovaginal surgery; complications in aesthetic medicine

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Multidisciplinary Care in Severe Traumatic Brain Injury Across the Continuum of Care: Acute, Rehabilitative, and Chronic Management

edited by Ryan Martin, Davin Quinn and Nicholas Race

submission deadline 25 Jun 2026 | Viewed by 109 | Submission Open

Keywords: severe traumatic brain injury; multidisciplinary; rehabilitation; advance practice providers; ancillary health; therapy; neuropsychology; nutrition

(This special issue belongs to the Section Brain Injury)

Cardiometabolic Disease and Atherosclerosis: Epidemiology, Prevention, Diagnosis, and Clinical Treatment—2nd Edition

edited by

Evangelos Oikonomou

and Konstantinos Mourouzis

submission deadline 25 Jun 2026 | Viewed by 98 | Submission Open

Keywords: atherosclerosis; obesity; cardiometabolic disease; prevention; diabetes mellitus; endothelium; arteriosclerosis; coronary artery disease

(This special issue belongs to the Section Cardiology)

Diet and Nutritional Aspects in Cardiovascular-Kidney-Metabolic Diseases (CKM)

edited by Krishnaswami Vijayaraghavan

submission deadline 25 Jun 2026 | Viewed by 94 | Submission Open

Keywords: cardiovascular-kidney-metabolic diseases (CKM); obesity; diabetes and metabolic syndrome; dietary factors; nutritional aspects; food policy and food security; chronic kidney disease; heart disease; technology

(This special issue belongs to the Section Clinical Nutrition & Dietetics)

Geriatric Cardiology: Clinical Advances and Comprehensive Management

edited by

Iris Parrini

submission deadline 25 Jun 2026 | Viewed by 88 | Submission Open

Keywords: geriatric assessment; management of cardiovascular disease; cardiovascular health; geriatric cardiology; frailty evaluation and management

(This special issue belongs to the Section Geriatric Medicine)

Advances in Minimally Invasive and Endoscopic Neurosurgery

edited by Shunsuke Shibao

submission deadline 25 Jun 2026 | Viewed by 88 | Submission Open

Keywords: minimally invasive; endoscopic; keyhole; endonasal; transorbital; skull base; complications; surgical outcomes; technical innovations; robotic neurosurgery

(This special issue belongs to the Section Clinical Neurology)

Displaying special issue 1301-1350 on page 27 of 32.

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