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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Gastroesophageal Cancer: Advances in Clinical Diagnosis and Management

edited by

Tania Triantafyllou

and Maximos Frountzas

submission deadline 15 May 2026 | 5 articles | Viewed by 9439 | Submission Open

Keywords: gastroesophageal cancer; endoscopic therapy; minimally invasive surgery; multimodality treatment; immunotherapy

(This special issue belongs to the Section Oncology)

Clinical Advances in Trauma and Emergency Medicine

edited by Viktoria Bogner-Flatz

submission deadline 15 May 2026 | 5 articles | Viewed by 5186 | Submission Open

Keywords: resuscitation; trauma emergency management; disaster response; mild traumatic brain injury emergency management; critical emergency care

(This special issue belongs to the Section Emergency Medicine)

Integrated Clinical Approaches to Managing Multimorbidity and Multiple Disabilities: Advances in Rehabilitation and Therapeutic Strategies

edited by

Masahiro Kohzuki

submission deadline 15 May 2026 | 2 articles | Viewed by 3935 | Submission Open

Keywords: heart; lung; kidney; liver; bone; brain

(This special issue belongs to the Section Clinical Rehabilitation)

Chronic Kidney Disease Management: Integrating Pharmacotherapy, Biomarkers, and Lifestyle Interventions for Improved Outcomes

edited by

Ioannis Bellos

submission deadline 15 May 2026 | 2 articles | Viewed by 1982 | Submission Open

Keywords: nephrology; chronic kidney disease; cardiovascular risk; risk stratification; biomarkers; evidence-based treatment

(This special issue belongs to the Section Nephrology & Urology)

Thyroid Disorders: New Clinical Diagnosis and Management

edited by

Ioannis P. Iakovou

Rodis D. Paparodis

and

Nicholaos G. Angelopoulos

submission deadline 15 May 2026 | Viewed by 997 | Submission Open

Keywords: thyroid disorders; clinical diagnosis; ultrasound; elastography; thyroid cancer; thyroiditis; hyperthyroidism; hypothyroidism; advanced imaging

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Research in Management of Corneal Diseases

edited by Massimo Busin and Angeli Christy Yu

submission deadline 15 May 2026 | 1 articles | Viewed by 482 | Submission Open

Keywords: corneal surgery; corneal transplant; lamellar keratoplasty; deep anterior lamellar keratoplasty; descemet membrane endothelial keratoplasty; descemet stripping automated endothelial keratoplasty; corneal neurotization

(This special issue belongs to the Section Ophthalmology)

Clinical Management of Attention Deficit Hyperactivity Disorder (ADHD)

edited by

Alessandro Pallucchini

submission deadline 15 May 2026 | Viewed by 313 | Submission Open

Keywords: ADHD; addiction; neurodevelopmental disorders; levomethadone

(This special issue belongs to the Section Mental Health)

Neuroendocrine Neoplasms: Epidemiology, Clinical Management, and Emerging Therapies

edited by

H. Christian Weber

submission deadline 15 May 2026 | Viewed by 252 | Submission Open

Keywords: neuroendocrine neoplasms (NENs); epidemiology; biomarkers for NENs; targeted therapies for NENs; carcinoid syndrome; precision medicine; gastrointestinal NENs; advanced endoscopic approaches to NEN treatment; imaging modalities for NENs; survival risk factors in NENs

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Mechanisms and Management of Intracerebral Hemorrhage

edited by Emanuela Crobeddu

submission deadline 15 May 2026 | Viewed by 198 | Submission Open

Keywords: intracerebral hemorrhage; arteriovenous malformation (AVM); dural arteriovenous fistula (DAVF); cavernoma; neuroinflammation; blood– brain barrier; hematoma evacuation; neuroprotection; imaging technologies; vascular lesions

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates on Pediatric Surgery

edited by Carlos Theodore Huerta and Eduardo Alfonso Perez

submission deadline 15 May 2026 | Viewed by 186 | Submission Open

Keywords: pediatric surgery; robotic-assisted surgery; artificial intelligence; enhanced recovery after surgery; minimally inva-sive surgery; augmented reality

(This special issue belongs to the Section Clinical Pediatrics)

Pediatric Pulmonology: Current Hurdles and Future Perspectives

edited by Isabel Delgado-Pecellín and Anselmo Andrés-Martín

submission deadline 15 May 2026 | Viewed by 143 | Submission Open

Keywords: interstitial lung diseases; neonatal screening; complex chronic patients; home mechanical ventilation; severe asthma; telemonitoring; lung development; cystic fibrosis; genetics

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Updates on Maternal Fetal Medicine: 2nd Edition

edited by

Roberta Granese

and

Gabriele Tonni

submission deadline 15 May 2026 | Viewed by 133 | Submission Open

Keywords: diabetes in pregnancy; hypertension in pregnancy; cholestasis in pregnancy; endocrine disorder in pregnancy; sepsis in pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Damage Control Surgery: New Insights into Resuscitation, Operative Strategies and Complications

edited by

Bruno de La Villéon

submission deadline 15 May 2026 | Viewed by 128 | Submission Open

Keywords: damage control surgery; damage control resuscitation; polytrauma management; massive transfusion protocol; hemorrhagic shock; trauma laparotomy; staged laparotomy; temporary abdominal closure; multidisciplinary trauma care

(This special issue belongs to the Section General Surgery)

Root Canal Treatment and Healing Outcomes: Clinical Application of Endodontic Biomaterials and Postoperative Management

edited by

Fausto Zamparini

Carlo Prati

and

Andrea Spinelli

submission deadline 15 May 2026 | Viewed by 101 | Submission Open

Keywords: root canal treatment; healing outcomes; endodontic biomaterials; bioceramic sealers; postoperative management; clinical evidence; periapical healing; post operative pain; dentistry

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Heart Failure: Challenges and Future Options

edited by Pedro Caravaca-Pérez and Marta Farrero-Torres

submission deadline 15 May 2026 | Viewed by 70 | Submission Open

Keywords: heart failure; cardiorenal syndrome; heart transplantation; ventricular assist devices; biomarkers; precision medicine; advanced therapies; diuretic resistance; risk stratification; multidisciplinary care

(This special issue belongs to the Section Cardiovascular Medicine)

Head and Neck Cancer: Clinical Diagnosis and Treatment

edited by Enrique Sanz-Garcia, Nicole Chau and Neus Baste

submission deadline 15 May 2026 | Viewed by 49 | Submission Open

Keywords: head and neck; multidisciplinary approaches; biomarkers; early detection; therapies

(This special issue belongs to the Section Otolaryngology)

Comprehensive Hernia Surgery: From Clinical Diagnosis to Postoperative Care

edited by Luca Regusci

submission deadline 15 May 2026 | Viewed by 44 | Submission Open

Keywords: ventral hernia; complexe hernias; botox treatment; laparoscopic surgery; robotic surgery

(This special issue belongs to the Section General Surgery)

Hypertrophic Cardiomyopathy: Lights and Shadows of Structural Pharmacological Treatment

edited by Daniel Dalos

submission deadline 15 May 2026 | Viewed by 42 | Submission Open

Keywords: hypertrophic cardiomyopathy; treatment; myosin inhibition; ventricular arrhythmia; atrial fibrillation

(This special issue belongs to the Section Cardiology)

Spinal Disorders: Current Treatment and Future Opportunities: Third Edition

edited by

Alan H Daniels

submission deadline 15 May 2026 | Viewed by 29 | Submission Open

Keywords: spine; spine surgery; spondylolisthesis; scoliosis; cervical myelopathy; spine surgery training; disc replacement; spine trauma; spine infection; spine fracture; spinal epidural abscess

(This special issue belongs to the Section Orthopedics)

PET Imaging in Bone and Non-Bone Diseases

edited by

Tanuj Puri

and

Glen Blake

submission deadline 19 May 2026 | 2 articles | Viewed by 4288 | Submission Open

Keywords: PET; bone metabolism; bone diseases; metabolic bone diseases; image analysis; radiomics; artificial intelligence

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Bruxism and Temporomandibular Disorders: Current Advances and Future Challenges

edited by

Grzegorz Zieliński

and

Eiji Tanaka

submission deadline 20 May 2026 | 24 articles | Viewed by 49449 | Submission Open

Keywords: TMDs; TMJ; rehabilitation; physiotherapy; craniofacial disorder; oral health; biomechanics; masticatory muscles; electromyography; parafunction; nocturnal bruxism; tooth contact habit

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Cardiovascular Disease in the Elderly: Prevention and Diagnosis

edited by Ioana Dana Alexa, Gabriel Ioan Prada and

Ciprian Rezus

submission deadline 20 May 2026 | 7 articles | Viewed by 20701 | Submission Open

Keywords: cardiovascular risk factors; elderly patients; frailty; sarcopenia; heart rate variability; insulin resistance; physical resilience; intrinsic capacity; diastolic dysfunction

(This special issue belongs to the Section Cardiovascular Medicine)

New Advances in Wound Healing and Skin Wound Treatment

edited by Hajime Matsumura

submission deadline 20 May 2026 | 8 articles | Viewed by 14732 | Submission Open

Keywords: trauma wound; burns; chronic wound; DFU; VLU; ischemic wound; regenerative medicine in wound care; debridement; biofilm; wound dressing; antimicrobial treatment

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Pediatric Dentistry: Recent Advances, Current Issues and Future Challenges

edited by

Liliana Szyszka-Sommerfeld

and

Krzysztof Woźniak

submission deadline 20 May 2026 | 6 articles | Viewed by 12800 | Submission Open

Keywords: pediatric dentistry; recent advances; current issues; future challenges; orthodontic issues; preventive strategies; access to care disparities; behavioral management; multidisciplinary collaboration; oral health

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Endometriosis: Clinical Challenges and Prognosis

edited by

Francisco Artacho-Cordon

submission deadline 20 May 2026 | 5 articles | Viewed by 9146 | Submission Open

Keywords: endometriosis; therapy; rehabilitation; psychology; diagnostics; ultrasound imaging; metabolomics; prognosis

(This special issue belongs to the Section Obstetrics & Gynecology)

Cardiac Imaging in the Diagnosis and Management of Heart Failure

edited by Mahi Lakshmi Ashwath and Allen S. Anderson

submission deadline 20 May 2026 | 2 articles | Viewed by 8603 | Submission Open

Keywords: echocardiography; cardiac MRI; myocardial viability; tissue characterization; ischemic and non-ischemic cardiomyopathy; HFpEF; myocardial strain

(This special issue belongs to the Section Cardiology)

Chronic Lung Conditions: Integrative Approaches to Long-Term Care

edited by

Antigona Carmen Trofor

submission deadline 20 May 2026 | 4 articles | Viewed by 8527 | Submission Open

Keywords: chronic lung conditions: chronic non-infectious lung disease and post-respiratory infectious syndromes; including TB sequelae; TB MDR; post-COVID-19; and bronchiectasis; long-term care; integrative approach; multidisciplinary; multimorbidity; outcomes

(This special issue belongs to the Section Respiratory Medicine)

Novel Insights into the Prevention and Treatment of Contact Dermatitis

edited by

Cara Bieck

, Christoph Skudlik, Swen Malte John and

Albert Nienhaus

submission deadline 20 May 2026 | 4 articles | Viewed by 8188 | Submission Open

Keywords: allergic; allergy; contact dermatitis; irritant; occupation; prevention; sensitization; skin; therapy; treatment

(This special issue belongs to the Section Dermatology)

Effect of Long-Term Insomnia on Mental Health—2nd Edition

edited by

Aleksandra Rogowska

submission deadline 20 May 2026 | 1 articles | Viewed by 7708 | Submission Open

Keywords: anxiety; alcohol and substance use disorders; behavioral addiction; burnout; cognitive dysfunction; depression; eating disorders; gaming addiction; problematic internet/social media use; insomnia; long-term insomnia; mood disorders; post-traumatic stress disorder; stress

(This special issue belongs to the Section Mental Health)

State of the Art in Neuromodulation or Spinal Cord Stimulation Therapy

edited by Marco Mercieri

submission deadline 20 May 2026 | 3 articles | Viewed by 7691 | Submission Open

Keywords: neuromodulation; spinal cord stimulation; chronic pain management; stimulation waveforms; long-term efficacy; loss of efficacy; outcome prediction; opioid-sparing techniques; neurostimulation mechanisms; psychological predictors; therapeutic targets

(This special issue belongs to the Section Clinical Neurology)

Advances in Spine Surgery: Best Practices and Future Directions

edited by Martin N. Stienen and

Stefan Motov

submission deadline 20 May 2026 | 6 articles | Viewed by 7218 | Submission Open

Keywords: minimally invasive spine surgery; spinal endoscopy; spinal robotics; spinal navigation; ERAS; machine learning; artificial intelligence; complication management; revision surgery; spinal deformity; innovation; future direction

(This special issue belongs to the Section Clinical Neurology)

Transcatheter Aortic Valve Implantation: Recent Advances and Future Directions

edited by

Alon Shechter

and Pablo Codner

submission deadline 20 May 2026 | 6 articles | Viewed by 6737 | Submission Open

Keywords: transcatheter aortic valve implantation; transcatheter aortic valve replacement; aortic valve stenosis; aortic valve regurgitation; aoric valve disease; cardiac imaging; artifical intelligence; machine learning

(This special issue belongs to the Section Cardiovascular Medicine)

New Advances in Myasthenia Gravis

edited by Shingo Konno

submission deadline 20 May 2026 | 3 articles | Viewed by 5240 | Submission Open

Keywords: myasthenia gravis; clinical trials; translational research; drug repurposing; biological markers; experimental autoimmune myasthenia gravis

(This special issue belongs to the Section Clinical Neurology)

Advances in Retinal Diseases—Mechanisms, Diagnostics, and Emerging Therapies

edited by

Minzhong Yu

submission deadline 20 May 2026 | 2 articles | Viewed by 3813 | Submission Open

Keywords: inherited retinal diseases; age-related macular degeneration; diabetic retinopathy; multimodal retinal imaging; treatment

(This special issue belongs to the Section Ophthalmology)

Updates on Cardiac Pacing and Electrophysiology

edited by

Axel Brandes

submission deadline 20 May 2026 | 3 articles | Viewed by 3731 | Submission Open

Keywords: pacemaker; conduction system pacing; leadless pacemaker; implantable cardioverter– defibrillator; ICD; extravascular ICD; S-ICD; lead extraction; supraventricular tachycardia; ventricular tachycardia; cardio-neuro ablation

(This special issue belongs to the Section Cardiology)

New Advances in Uterus and Ovarian Transplantation: 2nd Edition

edited by

Elliott G. Richards

submission deadline 20 May 2026 | 2 articles | Viewed by 3689 | Submission Open

Keywords: uterus transplantation; gynaecological surgery; endometriosis; IVF; fibroids; reproductive medicine; laparoscopic surgery; assisted reproductive technology; reproductive endocrinology

(This special issue belongs to the Section Obstetrics & Gynecology)

Challenges in Reproductive Health

edited by

Loris Marin

and Guido Ambrosini

submission deadline 20 May 2026 | 2 articles | Viewed by 3515 | Submission Open

Keywords: fertility preservation; oocytes cryopreservation; embryo cryopreservation; ovarian tissue transplantation; gonadotoxic therapy

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Prostate Cancer: Diagnosis, Clinical Management and Prognosis

edited by Giovanni Muto

submission deadline 20 May 2026 | 3 articles | Viewed by 3450 | Submission Open

Keywords: prostate cancer; diagnosis; clinical management; prognosis; treatments

(This special issue belongs to the Section Nephrology & Urology)

Clinical Update in Pulmonary Rehabilitation

edited by Akira Tamaki

submission deadline 20 May 2026 | 3 articles | Viewed by 3148 | Submission Open

Keywords: pulmonary rehabilitation; chronic obstructive pulmonary disease; interstitial lung disease; sarcopenia; respiratory sarcopenia; respiratory muscle training; nutritional intervention

(This special issue belongs to the Section Respiratory Medicine)

Clinical Application of Knee Arthroscopy

edited by

Francesco Bosco

and Alessandro Carrozzo

submission deadline 20 May 2026 | 3 articles | Viewed by 2259 | Submission Open

Keywords: knee surgery; arthroscopy; orthopedics; sport medicine; clinical outcomes; ligament reconstruction; meniscal repair; cartilage; postoperative rehabilitation; knee joint; tissue repair; joint preservation

(This special issue belongs to the Section Orthopedics)

Cirrhosis and Its Complications: Prognosis and Clinical Management

edited by

Ana-Maria Singeap

submission deadline 20 May 2026 | 2 articles | Viewed by 2239 | Submission Open

Keywords: cirrhosis; complications; spontaneous bacterial peritonitis; portal hypertension; ascites; hepatorenal syndrome; hepatic encephalopathy; liver transplantation; acute-on-chronic liver failure; hepatocellular carcinoma; quality of life; prognosis; clinical management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Research Progress in Pediatric Endocrinology

edited by

Federico Baronio

submission deadline 20 May 2026 | 2 articles | Viewed by 1637 | Submission Open

Keywords: pediatric endocrinology; rare endocrine disorders; precision medicine; congenital adrenal hyperplasia (CAH); short stature genetics; severe childhood obesity; glp-1 receptor agonists; endocrine disruptors; artificial intelligence (AI) in endocrinology; newborn screening

(This special issue belongs to the Section Clinical Pediatrics)

Acute Ischemic Stroke: Current Status and Future Challenges—2nd Edition

edited by

Lucio D'Anna

submission deadline 20 May 2026 | 2 articles | Viewed by 1150 | Submission Open

Keywords: acute ischemic stroke; atrial fibrillation; endovascular thrombectomy; intravenous thrombolysis; direct oral anticoagulants

(This special issue belongs to the Section Clinical Neurology)

Advances in Fertility Preservation

edited by Dunja Maria Baston-Büst

submission deadline 20 May 2026 | 1 articles | Viewed by 1098 | Submission Open

Keywords: fertility preservation; gonadotoxic treatment; chemotherapy; transgender; cryopreservation; ejaculate; testicular tissue; mature oocytes; immature oocytes; ovarian tissue; ovarian cortex

(This special issue belongs to the Section Obstetrics & Gynecology)

Current Advances and Future Perspectives in Interventional Cardiology

edited by

Jacob Zeitani

submission deadline 20 May 2026 | 1 articles | Viewed by 1055 | Submission Open

Keywords: trans-catheter valve repair and replacement; advanced coronary intervention; AI in decision making for trans-catheter aortic root and arch replacement; LAA occlusion; anti-arrhythmic therapy; right side of the heart

(This special issue belongs to the Section Cardiology)

Challenges and Opportunities in Application of Laparoscopic, Robotic and Other Technological Advances in Gastrointestinal Surgery

edited by

Gianluca Cassese

and Fabrizio Panaro

submission deadline 20 May 2026 | 1 articles | Viewed by 1012 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; artificial intelligence; technological advances

(This special issue belongs to the Section General Surgery)

Diagnosis and Treatment of Ocular Surface Diseases

edited by

Stuti Misra

and

Sònia Travé-Huarte

submission deadline 20 May 2026 | 1 articles | Viewed by 1008 | Submission Open

Keywords: dry eye disease; ocular surface; anterior segment imaging; biomarkers; artificial intelligence; diagnostic tools; novel therapeutic agents; anterior eye care

(This special issue belongs to the Section Ophthalmology)

Recent Advances in Adverse Pregnancy and Neonatal Outcomes

edited by

Sae-kyung Choi

submission deadline 20 May 2026 | 1 articles | Viewed by 1000 | Submission Open

Keywords: maternal and fetal; adverse pregnancy; neonatal outcomes; newborns; cesarean section

(This special issue belongs to the Section Obstetrics & Gynecology)

New Updates in Pediatric Gastroenterology

edited by

Laura Trandafir

, Alina Stanescu-Popp and Oana Belei

submission deadline 20 May 2026 | Viewed by 924 | Submission Open

Keywords: pediatric gastroenterology and hepatology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; esophageal diseases; endoscopy; gut microbiome; inflammatory bowel disease; functional GI disorders; nutritional management; precision medicine; gut– brain axis; transitional care

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Management and Long-Term Prognosis in Intensive Care

edited by