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Advances in Fertility Preservation

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 25 November 2025 | Viewed by 884

Special Issue Editor


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Guest Editor
Department of Obstetrics/Gynecology and Reproductive Endocrinology and Infertility (UniKiD), University of Duesseldorf Medical Center, Moorenstrasse 5, 40225 Duesseldorf, Germany
Interests: assisted reproductive techniques; embryology; endocrinology; assisted reproductive technology; embryo implantation; implantation; immunology; immunohistochemistry

Special Issue Information

Dear Colleagues,

Many female and male patients face gonadotoxic treatment during childhood, juvenescence, or adolescence, usually including recidives or a surgery for benign reasons. Fortunately, new treatment options improve the survival rate, but less is known about the possible risk of infertility after the modern treatment regimes. Furthermore, transgender medicine is a new field in fertility preservation. Moreover, the imitation of puberty in cell culture models and mimicking the development of follicles or testis in vitro is still challenging next to culturing GV-oocytes in maturation protocols. A new approach might include use of ovarian tissue that was cryopreserved in young years to circumvent menopausal complaints after the transplantation of ovarian cortex strips.

In this Special Issue, we welcome authors to submit papers on the basic and clinical advances of fertility preservation in terms of research, treatment, and new techniques.

Dr. Dunja Maria Baston-Büst
Guest Editor

Manuscript Submission Information

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Keywords

  • fertility preservation
  • gonadotoxic treatment
  • chemotherapy
  • transgender
  • cryopreservation
  • ejaculate
  • testicular tissue
  • mature oocytes
  • immature oocytes
  • ovarian tissue
  • ovarian cortex

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Published Papers (1 paper)

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Research

15 pages, 1011 KB  
Article
Interest in Fertility Preservation Among Adults Seen at a Gender Care Clinic
by Quinnette Jones, Scott M. Carlson, Shilpi Agrawala, Andrew Weinhold, Heather E. Parnell, Katelyn M. Holliday and Carly E. Kelley
J. Clin. Med. 2025, 14(17), 6175; https://doi.org/10.3390/jcm14176175 - 1 Sep 2025
Viewed by 571
Abstract
Introduction/Background: Medical treatments received by transgender and/or gender diverse (TGD) people can impact fertility, yet the literature lacks data on factors that influence fertility decisions among TGD people. Specific Aim(s): This study aimed to identify predictors of interest in fertility preservation (IFP). [...] Read more.
Introduction/Background: Medical treatments received by transgender and/or gender diverse (TGD) people can impact fertility, yet the literature lacks data on factors that influence fertility decisions among TGD people. Specific Aim(s): This study aimed to identify predictors of interest in fertility preservation (IFP). Materials and Methods: This retrospective observational study utilized data from 2021–2023 from an adult gender registry for patients receiving care at academic medical center (n = 206). Patient demographic data and survey responses to questions about fertility were queried and analyzed. Bivariate and multivariate analyses were conducted using logistic regression. Results: Most patients (73.8%, n = 152) were not interested in fertility preservation (FP) and 16.5% (n = 34) were unsure. Reasons most often cited were not wanting biological children (55.9%, n = 104), preferring adoption (20.4%, n = 38), cost (19.9%, n = 37), and dysphoria (19.4%, n = 36). Bivariate analyses showed that increasing age, being married, and already having children were significantly inversely associated with IFP (p = 0.03, 0.01, 0.02, respectively). Non-Hispanic Black race/ethnicity (OR (95% CI): 3.43 (1.19, 9.84)) and disability or unemployment (OR (95% CI): 4.19 (1.42, 13.00)) were significantly associated with IFP vs. Non-Hispanic White race/ethnicity and full-time employment, respectively. In multivariate models, being married was significantly inversely associated with IFP, e.g., OR (95% CI): 0.30, (0.07, 0.99), when accounting for age and already having children. Race/ethnicity and employment comparisons remained significant after adjusting for other factors. Conclusions: Most patients did not desire FP. Among those IFP, potential predictors include age, marital status, already having children, race and ethnicity, and employment and disability status. Full article
(This article belongs to the Special Issue Advances in Fertility Preservation)
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